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Proglumetacin

Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a nonsteroidal anti-inflammatory drug (NSAID). It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

Proglumetacin
Clinical data
Other names3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
MetabolismHepatic. Undergoes enterohepatic recirculation
Identifiers
  • 3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N2-benzoyl-N,N-dipropyl-α-glutaminate
CAS Number
  • 57132-53-3 59209-40-4
PubChem CID
  • 4921
ChemSpider
  • 4752 Y
UNII
  • FV919079LU
ChEBI
  • CHEBI:76263
CompTox Dashboard (EPA)
  • DTXSID0048842
Chemical and physical data
FormulaC46H58ClN5O8
Molar mass844.45 g·mol−1
3D model (JSmol)
  • Interactive image
  • Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)OCCN4CCN(CC4)CCCOC(=O)CCC(C(=O)N(CCC)CCC)NC(=O)c5ccccc5
  • InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55) Y
  • Key:PTXGHCGBYMQQIG-UHFFFAOYSA-N Y
  (verify)

References edit

  1. ^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung. 37 (6): 698–702. PMID 3663267.


proglumetacin, usually, maleate, salt, trade, names, afloxan, protaxon, proxil, nonsteroidal, anti, inflammatory, drug, nsaid, metabolized, body, indometacin, proglumide, drug, with, antisecretory, effects, that, helps, prevent, injury, stomach, lining, clinic. Proglumetacin usually as the maleate salt trade names Afloxan Protaxon and Proxil is a nonsteroidal anti inflammatory drug NSAID It is metabolized in the body to indometacin and proglumide 1 a drug with antisecretory effects that helps prevent injury to the stomach lining ProglumetacinClinical dataOther names3 4 2 2 1 4 chlorobenzoyl 5 methoxy 2 methylindol 3 yl acetyl oxyethyl piperazin 1 yl propyl 4 benzoylamino 5 dipropylamino 5 oxopentanoateAHFS Drugs comInternational Drug NamesATC codeM01AB14 WHO Pharmacokinetic dataMetabolismHepatic Undergoes enterohepatic recirculationIdentifiersIUPAC name 3 4 2 1 4 chlorobenzoyl 5 methoxy 2 methyl 1H indol 3 yl acetyl oxy ethyl piperazin 1 yl propyl N2 benzoyl N N dipropyl a glutaminateCAS Number57132 53 3 59209 40 4PubChem CID4921ChemSpider4752 YUNIIFV919079LUChEBICHEBI 76263CompTox Dashboard EPA DTXSID0048842Chemical and physical dataFormulaC 46H 58Cl N 5O 8Molar mass844 45 g mol 13D model JSmol Interactive imageSMILES Clc1ccc cc1 C O n3c2ccc OC cc2c c3C CC O OCCN4CCN CC4 CCCOC O CCC C O N CCC CCC NC O c5ccccc5InChI InChI 1S C46H58ClN5O8 c1 5 21 51 22 6 2 46 57 40 48 44 55 34 11 8 7 9 12 34 18 20 42 53 59 29 10 23 49 24 26 50 27 25 49 28 30 60 43 54 32 38 33 3 52 41 19 17 37 58 4 31 39 38 41 45 56 35 13 15 36 47 16 14 35 h7 9 11 17 19 31 40H 5 6 10 18 20 30 32H2 1 4H3 H 48 55 YKey PTXGHCGBYMQQIG UHFFFAOYSA N Y verify References edit Setnikar I Arigoni R Chiste R Makovec F Revel L 1987 Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog Arzneimittel Forschung 37 6 698 702 PMID 3663267 nbsp This drug article relating to the musculoskeletal system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Proglumetacin amp oldid 1182082011, wikipedia, wiki, book, books, library,

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