A progesterone synthesis inhibitor, or progestogen synthesis inhibitor, is a type of drug which inhibits the enzymaticsynthesis of progesterone. They include:
Progesterone synthesis inhibitors have been researched for medical applications including use as contraceptives, abortifacients, and oxytocics, though ultimately they have never been marketed for such indications.[1] Examples of such agents include the 3β-HSD inhibitors azastene (WIN-17625) and epostane (WIN-32729). Since progesterone is a precursor of many other steroid hormones, progesterone synthesis inhibitors can also be used medically as inhibitors of the synthesis of these other steroid hormones, including of androgens, estrogens, glucocorticoids, mineralocorticoids, and neurosteroids.
^Ray S, Sharma I (1987). "Development of progesterone antagonists as fertility regulating agents". Pharmazie. 42 (10): 656–61. PMID 3325988.
January 01, 1970
progesterone, synthesis, inhibitor, progesterone, synthesis, inhibitor, progestogen, synthesis, inhibitor, type, drug, which, inhibits, enzymatic, synthesis, progesterone, they, include, cholesterol, side, chain, cleavage, enzyme, inhibitors, p450scc, cyp11a1,. A progesterone synthesis inhibitor or progestogen synthesis inhibitor is a type of drug which inhibits the enzymatic synthesis of progesterone They include Cholesterol side chain cleavage enzyme inhibitors P450SCC CYP11A1 inhibitors inhibit the synthesis of pregnenolone from cholesterol thereby inhibiting the synthesis of most steroid hormones which are derived from pregnenolone including progesterone 3b Hydroxysteroid dehydrogenase inhibitors 3b HSD inhibitors inhibit the conversion of pregnenolone into progesterone Inhibitors of cholesterol synthesis can also reduce progesterone production by inhibiting cholesterol production Progesterone synthesis inhibitors have been researched for medical applications including use as contraceptives abortifacients and oxytocics though ultimately they have never been marketed for such indications 1 Examples of such agents include the 3b HSD inhibitors azastene WIN 17625 and epostane WIN 32729 Since progesterone is a precursor of many other steroid hormones progesterone synthesis inhibitors can also be used medically as inhibitors of the synthesis of these other steroid hormones including of androgens estrogens glucocorticoids mineralocorticoids and neurosteroids See also editSteroidogenesis inhibitor Androgen synthesis inhibitor Estrogen synthesis inhibitorReferences edit Ray S Sharma I 1987 Development of progesterone antagonists as fertility regulating agents Pharmazie 42 10 656 61 PMID 3325988 Retrieved from https en wikipedia org w index php title Progesterone synthesis inhibitor amp oldid 1112654473, wikipedia, wiki, book, books, library,
