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Prednimustine

Prednimustine, sold under the brand names Mostarina and Sterecyst, is a medication which is used in chemotherapy in the treatment of leukemias and lymphomas.[1][2][3] It is the ester formed from two other drugs, prednisolone and chlorambucil.[1][2][3] Rarely, it has been associated with myoclonus.[4]

Prednimustine
Clinical data
Trade namesMostarina, Sterecyst
Other namesEORTC 1502; Leo 1031; NSC 134087; Prednisolone 21-(4-(4-(bis(2-chloroethyl)-amino)phenyl)butanoate); 11β,17α-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl 4-{4-[bis(2-chloroethyl)amino]-phenyl}butanoate
ATC code
Identifiers
  • [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoate
CAS Number
  • 29069-24-7 Y
PubChem CID
  • 34457
ChemSpider
  • 31708 N
UNII
  • 9403SIO2S8
KEGG
  • C19512 Y
CompTox Dashboard (EPA)
  • DTXSID4021183
ECHA InfoCard100.044.904
Chemical and physical data
FormulaC35H45Cl2NO6
Molar mass646.65 g·mol−1
3D model (JSmol)
  • Interactive image
  • C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COC(=O)CCCc4ccc(cc4)N(CCCl)CCCl)O)CCC5=CC(=O)C=C[C@]35C)O
  • InChI=1S/C35H45Cl2NO6/c1-33-14-12-26(39)20-24(33)8-11-27-28-13-15-35(43,34(28,2)21-29(40)32(27)33)30(41)22-44-31(42)5-3-4-23-6-9-25(10-7-23)38(18-16-36)19-17-37/h6-7,9-10,12,14,20,27-29,32,40,43H,3-5,8,11,13,15-19,21-22H2,1-2H3/t27-,28-,29-,32+,33-,34-,35-/m0/s1 N
  • Key:HFVNWDWLWUCIHC-GUPDPFMOSA-N N
 NY (what is this?)  (verify)

See also edit

References edit

  1. ^ a b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1012–. ISBN 978-1-4757-2085-3.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 868–. ISBN 978-3-88763-075-1.
  3. ^ a b Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 230–. ISBN 978-94-011-4439-1.
  4. ^ Monnerat C, Gander M, Leyvraz S (January 1997). "A rare case of prednimustine-induced myoclonus". Journal of the National Cancer Institute. 89 (2): 173–174. doi:10.1093/jnci/89.2.173. PMID 8998190.

prednimustine, sold, under, brand, names, mostarina, sterecyst, medication, which, used, chemotherapy, treatment, leukemias, lymphomas, ester, formed, from, other, drugs, prednisolone, chlorambucil, rarely, been, associated, with, myoclonus, clinical, datatrad. Prednimustine sold under the brand names Mostarina and Sterecyst is a medication which is used in chemotherapy in the treatment of leukemias and lymphomas 1 2 3 It is the ester formed from two other drugs prednisolone and chlorambucil 1 2 3 Rarely it has been associated with myoclonus 4 PrednimustineClinical dataTrade namesMostarina SterecystOther namesEORTC 1502 Leo 1031 NSC 134087 Prednisolone 21 4 4 bis 2 chloroethyl amino phenyl butanoate 11b 17a Dihydroxy 3 20 dioxopregna 1 4 dien 21 yl 4 4 bis 2 chloroethyl amino phenyl butanoateATC codeL01AA08 WHO IdentifiersIUPAC name 2 8S 9S 10R 11S 13S 14S 17R 11 17 Dihydroxy 10 13 dimethyl 3 oxo 7 8 9 11 12 14 15 16 octahydro 6H cyclopenta a phenanthren 17 yl 2 oxoethyl 4 4 bis 2 chloroethyl amino phenyl butanoateCAS Number29069 24 7 YPubChem CID34457ChemSpider31708 NUNII9403SIO2S8KEGGC19512 YCompTox Dashboard EPA DTXSID4021183ECHA InfoCard100 044 904Chemical and physical dataFormulaC 35H 45Cl 2N O 6Molar mass646 65 g mol 13D model JSmol Interactive imageSMILES C C 12C C H C H 3 C H C H 1CC C 2 C O COC O CCCc4ccc cc4 N CCCl CCCl O CCC5 CC O C C C 35C OInChI InChI 1S C35H45Cl2NO6 c1 33 14 12 26 39 20 24 33 8 11 27 28 13 15 35 43 34 28 2 21 29 40 32 27 33 30 41 22 44 31 42 5 3 4 23 6 9 25 10 7 23 38 18 16 36 19 17 37 h6 7 9 10 12 14 20 27 29 32 40 43H 3 5 8 11 13 15 19 21 22H2 1 2H3 t27 28 29 32 33 34 35 m0 s1 NKey HFVNWDWLWUCIHC GUPDPFMOSA N N N Y what is this verify See also editList of hormonal cytostatic antineoplastic agents List of corticosteroid estersReferences edit a b Elks J 14 November 2014 The Dictionary of Drugs Chemical Data Chemical Data Structures and Bibliographies Springer pp 1012 ISBN 978 1 4757 2085 3 a b Index Nominum 2000 International Drug Directory Taylor amp Francis 2000 pp 868 ISBN 978 3 88763 075 1 a b Morton IK Hall JM 6 December 2012 Concise Dictionary of Pharmacological Agents Properties and Synonyms Springer Science amp Business Media pp 230 ISBN 978 94 011 4439 1 Monnerat C Gander M Leyvraz S January 1997 A rare case of prednimustine induced myoclonus Journal of the National Cancer Institute 89 2 173 174 doi 10 1093 jnci 89 2 173 PMID 8998190 nbsp This antineoplastic or immunomodulatory drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Prednimustine amp oldid 1191724694, wikipedia, wiki, book, books, library,

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