Medications of this class, which go under a variety of names according to whether one looks at the American, British or European system of nomenclature, have as their primary function the antagonism of bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.[2]
Medications of this group are normally used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. There are several similar medications in the group; all appear to be equally effective. Pranlukast is also reported as potential inhibitor of Mycobacterium tuberculosis infection in experimental models.[3]
Referencesedit
^ abNakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S (April 2006). . Drug Metabolism and Pharmacokinetics. 21 (2): 133–139. doi:10.2133/dmpk.21.133. PMID 16702733. Archived from the original on 2008-09-17.
^Singh RK, Tandon R, Dastidar SG, Ray A (November 2013). "A review on leukotrienes and their receptors with reference to asthma". The Journal of Asthma. 50 (9): 922–931. doi:10.3109/02770903.2013.823447. PMID 23859232. S2CID 11433313.
^Mishra A, Mamidi AS, Rajmani RS, Ray A, Roy R, Surolia A (April 2018). "An allosteric inhibitor of Mycobacterium tuberculosis ArgJ: Implications to a novel combinatorial therapy". EMBO Molecular Medicine. 10 (4): e8038. doi:10.15252/emmm.201708038. PMC5887547. PMID 29483133.
October 27, 2023
pranlukast, brand, name, onon, オノン, cysteinyl, leukotriene, receptor, antagonist, this, drug, works, similarly, merck, montelukast, singulair, widely, used, japan, clinical, datatrade, namesonon, オノン, ahfs, drugs, cominternational, drug, namesroutes, ofadminis. Pranlukast brand name Onon オノン is a cysteinyl leukotriene receptor 1 antagonist This drug works similarly to Merck amp Co s montelukast Singulair It is widely used in Japan PranlukastClinical dataTrade namesOnon オノン AHFS Drugs comInternational Drug NamesRoutes ofadministrationOralATC codeR03DC02 WHO Pharmacokinetic dataMetabolismHepatic mainly CYP3A4 1 Elimination half life1 5 hours 1 IdentifiersIUPAC name N 4 oxo 2 1H tetrazol 5 yl 4H chromen 8 yl 4 4 phenylbutoxy benzamideCAS Number103177 37 3 YPubChem CID4887IUPHAR BPS3634DrugBankDB01411 YChemSpider4718 YUNIITB8Z891092ChEMBLChEMBL21333 YCompTox Dashboard EPA DTXSID3043782ECHA InfoCard100 236 084Chemical and physical dataFormulaC 27H 23N 5O 4Molar mass481 512 g mol 13D model JSmol Interactive imageSMILES O C Nc2cccc3c O cc c1nn nH n1 oc23 c5ccc OCCCCc4ccccc4 cc5InChI InChI 1S C27H23N5O4 c33 23 17 24 26 29 31 32 30 26 36 25 21 23 10 6 11 22 25 28 27 34 19 12 14 20 15 13 19 35 16 5 4 9 18 7 2 1 3 8 18 h1 3 6 8 10 15 17H 4 5 9 16H2 H 28 34 H 29 30 31 32 YKey NBQKINXMPLXUET UHFFFAOYSA N Y verify Medications of this class which go under a variety of names according to whether one looks at the American British or European system of nomenclature have as their primary function the antagonism of bronchospasm caused principally in asthmatics by an allergic reaction to accidentally or inadvertently encountered allergens 2 Medications of this group are normally used as an adjunct to the standard therapy of inhaled steroids with inhaled long and or short acting beta agonists There are several similar medications in the group all appear to be equally effective Pranlukast is also reported as potential inhibitor of Mycobacterium tuberculosis infection in experimental models 3 References edit a b Nakade S Ueda S Ohno T Nakayama K Miyata Y Yukawa E Higuchi S April 2006 Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma Drug Metabolism and Pharmacokinetics 21 2 133 139 doi 10 2133 dmpk 21 133 PMID 16702733 Archived from the original on 2008 09 17 Singh RK Tandon R Dastidar SG Ray A November 2013 A review on leukotrienes and their receptors with reference to asthma The Journal of Asthma 50 9 922 931 doi 10 3109 02770903 2013 823447 PMID 23859232 S2CID 11433313 Mishra A Mamidi AS Rajmani RS Ray A Roy R Surolia A April 2018 An allosteric inhibitor of Mycobacterium tuberculosis ArgJ Implications to a novel combinatorial therapy EMBO Molecular Medicine 10 4 e8038 doi 10 15252 emmm 201708038 PMC 5887547 PMID 29483133 Retrieved from https en wikipedia org w index php title Pranlukast amp oldid 1177202158, wikipedia, wiki, book, books, library,
