Polyozellin

Polyozellin is a chemical which occurs in the mushroom Polyozellus multiplex. It inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.^[1] Structurally related dibenzofuranyl derivatives of polyozellin are known as kynapcins.^[2]

Polyozellin

Names
Preferred IUPAC name 2,3,8,9-Tetrahydroxybenzo[1,2-b:4,5-b′]bis([1]benzofuran)-6,12-diyl diacetate
Identifiers
CAS Number	197703-46-1^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL458248^N
ChemSpider	338925^N
PubChem CID	382514
UNII	B7DFS96VZB^Y
CompTox Dashboard (EPA)	DTXSID30327611
InChI InChI=1S/C22H14O10/c1-7(23)29-19-17-9-3-11(25)13(27)5-15(9)31-21(17)22-18(20(19)30-8(2)24)10-4-12(26)14(28)6-16(10)32-22/h3-6,25-28H,1-2H3 Key: NOBAAHRLFGFAOS-UHFFFAOYSA-N InChI=1/C22H14O10/c1-7(23)29-19-17-9-3-11(25)13(27)5-15(9)32-22(17)20(30-8(2)24)18-10-4-12(26)14(28)6-16(10)31-21(18)19/h3-6,25-28H,1-2H3 Key: NOBAAHRLFGFAOS-UHFFFAOYSA
SMILES CC(=O)OC1=C(OC(C)=O)C2=C(OC3=CC(O)=C(O)C=C23)C4=C1C5=CC(O)=C(O)C=C5O4
Properties
Chemical formula	C22H14O10
Molar mass	438.344 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

References

1. Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID (1997). "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics. 50 (9): 773–77. doi:10.7164/antibiotics.50.773. PMID 9360624.
2. Kim SI, Park IH, Song KS (2002). "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex". The Journal of Antibiotics. 55 (7): 623–28. doi:10.7164/antibiotics.55.623. PMID 12243451.