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Philip A. Beachy

Philip Arden Beachy (born October 25, 1958)[3] is Ernest and Amelia Gallo Professor at Stanford University School of Medicine in Palo Alto, California and an Associate at Stanford's Institute of Stem Cell Biology and Regenerative Medicine.[1][4][5]

Philip Beachy
Born
Philip Arden Beachy

(1958-10-25) October 25, 1958 (age 65)
Alma mater
Known forHedgehog signaling pathway[2]
AwardsNAS Award in Molecular Biology (1998)
March of Dimes Prize in Developmental Biology (2008)
Keio Medical Science Prize (2011)
Scientific career
FieldsBiochemistry
Institutions
ThesisThe UBX Domain in the Bithorax Complex of Drosophila (1986)
Doctoral advisorDavid Hogness[1]
Website
  • people.stanford.edu/pbeachy
  • med.stanford.edu/profiles/philip-beachy
  • www.hhmi.org/research/hedgehog-signaling-development-and-disease

Early life edit

Beachy was born in Red Lake, Ontario, on October 25, 1958.[6] Beachy spent eight of his early years of life in the hills of central Puerto Rico. His father was a pastor of a rural church. He attended a school taught in Spanish during the day and then learned to read and write English once he came home from school. At nine, Beachy and his family returned to their home base of Goshen, Indiana where he began attending public school. At the early age of 16, Beachy headed off to Goshen College which was very close to home. At this time, Beachy still did not know of his love for science. “Unlike many people who knew they were going to be scientists from a very early age, I didn't decide that I would try to become a scientist until fairly late on in college,” he says.[1]

Education edit

Beachy received his bachelor's degree in natural sciences at Goshen College. Beachy first envisioned himself as a doctor, but after his first year of college, he decided against pursuing that career. He then decided to focus on biological research. He became interested in this field after reading a serialized form of Horace Freeland Judson's book, The Eighth Day of Creation in The New Yorker. "Reading those articles got me excited about molecular biology," says Beachy. After graduating, he decided to take chemistry courses and do more research at the nearby South Bend campus of Indiana University. A year later, he decided to attend graduate school at Stanford University. There, he studied the molecular genetics behind fruit fly development with David Hogness.[1][5] Beachy earned his Ph.D in biochemistry in 1986 at Stanford for research into the UBX protein domain.

Career edit

 
Visually representation of the hedgehog signaling pathway
Another example of a hedgehog signaling pathway
 
Concentration gradient of sonic hedgehog gene

After receiving his Ph.D, he began working at the Carnegie Institution's Department of Embryology in Baltimore for two years. After his short time there, he accepted a faculty position at the Johns Hopkins University School of Medicine. Beachy began focusing on the Drosophila hedgehog gene, for which he's known for, in 1990. The gene's name originated because fly embryos look spikey if the hedgehog gene is faulty or mutated. The hedgehog gene's main function is to create protein signals in specific cells. These signals, in turn, allow for the formation of embryonic tissues. They do this by instructing neighboring cells to become a certain type of differentiated cell or to simply divide. In other words, this gene is responsible for the development of the appendages and body segments in Drosophila or fruit flies. Humans and other invertebrates have hedgehog genes that behave slightly different than the same gene in the fruit fly. In vertebrates, the hedgehog gene codes for the fingers and toes on the limbs. It also functions in organizing the brain and the spinal cord. Consequently, mutated hedgehog genes often cause birth defects. Also, if it is activated later in life, certain cancers can be triggered and begin to spread.[5]

In 2006, Beachy moved from Johns Hopkins to Stanford University's Department of Developmental Biology and its Institute for Stem Cell Biology and Regenerative Medicine. He is interested in the function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation) and in injury repair and regeneration (pattern maintenance), in particular the normal roles of such signals in stem cell physiology and their abnormal roles in the formation and expansion of cancer stem cells. He is also interested in how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution.[5]

Research edit

Beachy's research focuses on understanding the molecular mechanisms behind the growth of multicellular embryos, especially the role of the Hedgehog signaling pathway.[7][8][9]

Awards and honors edit

Beachy has received numerous awards and prizes for his work, including the Outstanding Young Scientist Award from the Maryland Academy of Sciences in 1997 and the National Academy of Sciences Award in Molecular Biology in 1998. In 2008, Beachy received the March of Dimes Prize in Developmental Biology jointly with Cliff Tabin.[10] In 2011, Beachy received the Keio Medical Science Prize.

Beachy was elected a member of the United States National Academy of Sciences in 2002, and a Fellow of the American Academy of Arts and Sciences (2003).[11]

Personal life edit

Beachy is the brother of the historian, Robert M. Beachy, and a cousin of biologist Roger N. Beachy and author Stephen Beachy.

References edit

  1. ^ a b c d Marino, M (2004). "Biography of Philip A. Beachy". Proceedings of the National Academy of Sciences. 101 (52): 17897–9. doi:10.1073/pnas.0408740102. PMC 539818. PMID 15611474.
  2. ^ Porter, J. A.; Young, K. E.; Beachy, P. A. (1996). "Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development". Science. 274 (5285): 255–9. Bibcode:1996Sci...274..255P. doi:10.1126/science.274.5285.255. PMID 8824192. S2CID 11125394.
  3. ^ Marquis Who's Who TM. Marquis Who's Who, 2008.
  4. ^ Beachy, P. A.; Karhadkar, S. S.; Berman, D. M. (2004). "Tissue repair and stem cell renewal in carcinogenesis". Nature. 432 (7015): 324–31. Bibcode:2004Natur.432..324B. doi:10.1038/nature03100. PMID 15549094. S2CID 4428056.
  5. ^ a b c d "Philip A. Beachy, PhD". HHMI.org. Retrieved 2014-06-17.
  6. ^ "Philip A. Beachy - Stanford University". Yatedo.com. 1958-10-25. Retrieved 2014-06-17.
  7. ^ Chiang, C; Litingtung, Y; Lee, E; Young, K. E.; Corden, J. L.; Westphal, H; Beachy, P. A. (1996). "Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function". Nature. 383 (6599): 407–13. Bibcode:1996Natur.383..407C. doi:10.1038/383407a0. PMID 8837770. S2CID 4339131.
  8. ^ Berman, D. M.; Karhadkar, S. S.; Maitra, A; Montes De Oca, R; Gerstenblith, M. R.; Briggs, K; Parker, A. R.; Shimada, Y; Eshleman, J. R.; Watkins, D. N.; Beachy, P. A. (2003). "Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours". Nature. 425 (6960): 846–51. Bibcode:2003Natur.425..846B. doi:10.1038/nature01972. PMID 14520411. S2CID 2877022.
  9. ^ Taipale, J; Beachy, P. A. (2001). "The Hedgehog and Wnt signalling pathways in cancer". Nature. 411 (6835): 349–54. Bibcode:2001Natur.411..349T. doi:10.1038/35077219. PMID 11357142. S2CID 4414768.
  10. ^ Anon (2008). "An Interview With... Cliff Tabin". Nature Reviews Genetics. 9 (6): 420. doi:10.1038/nrg2863. PMID 18504824. S2CID 45619315.
  11. ^ "Book of Members, 1780-2010: Chapter B" (PDF). American Academy of Arts and Sciences. Retrieved May 28, 2011.

External links edit

  • Philip A. Beachy Profile at Stanford University

philip, beachy, philip, arden, beachy, born, october, 1958, ernest, amelia, gallo, professor, stanford, university, school, medicine, palo, alto, california, associate, stanford, institute, stem, cell, biology, regenerative, medicine, philip, beachybornphilip,. Philip Arden Beachy born October 25 1958 3 is Ernest and Amelia Gallo Professor at Stanford University School of Medicine in Palo Alto California and an Associate at Stanford s Institute of Stem Cell Biology and Regenerative Medicine 1 4 5 Philip BeachyBornPhilip Arden Beachy 1958 10 25 October 25 1958 age 65 Red Lake OntarioAlma materGoshen College Stanford UniversityKnown forHedgehog signaling pathway 2 AwardsNAS Award in Molecular Biology 1998 March of Dimes Prize in Developmental Biology 2008 Keio Medical Science Prize 2011 Scientific careerFieldsBiochemistryInstitutionsStanford University School of Medicine Howard Hughes Medical InstituteThesisThe UBX Domain in the Bithorax Complex of Drosophila 1986 Doctoral advisorDavid Hogness 1 Websitepeople wbr stanford wbr edu wbr pbeachy med wbr stanford wbr edu wbr profiles wbr philip beachy www wbr hhmi wbr org wbr research wbr hedgehog signaling development and diseaseContents 1 Early life 2 Education 3 Career 4 Research 5 Awards and honors 6 Personal life 7 References 8 External linksEarly life editBeachy was born in Red Lake Ontario on October 25 1958 6 Beachy spent eight of his early years of life in the hills of central Puerto Rico His father was a pastor of a rural church He attended a school taught in Spanish during the day and then learned to read and write English once he came home from school At nine Beachy and his family returned to their home base of Goshen Indiana where he began attending public school At the early age of 16 Beachy headed off to Goshen College which was very close to home At this time Beachy still did not know of his love for science Unlike many people who knew they were going to be scientists from a very early age I didn t decide that I would try to become a scientist until fairly late on in college he says 1 Education editBeachy received his bachelor s degree in natural sciences at Goshen College Beachy first envisioned himself as a doctor but after his first year of college he decided against pursuing that career He then decided to focus on biological research He became interested in this field after reading a serialized form of Horace Freeland Judson s book The Eighth Day of Creation in The New Yorker Reading those articles got me excited about molecular biology says Beachy After graduating he decided to take chemistry courses and do more research at the nearby South Bend campus of Indiana University A year later he decided to attend graduate school at Stanford University There he studied the molecular genetics behind fruit fly development with David Hogness 1 5 Beachy earned his Ph D in biochemistry in 1986 at Stanford for research into the UBX protein domain Career edit nbsp Visually representation of the hedgehog signaling pathway source source source source Another example of a hedgehog signaling pathway nbsp Concentration gradient of sonic hedgehog gene After receiving his Ph D he began working at the Carnegie Institution s Department of Embryology in Baltimore for two years After his short time there he accepted a faculty position at the Johns Hopkins University School of Medicine Beachy began focusing on the Drosophila hedgehog gene for which he s known for in 1990 The gene s name originated because fly embryos look spikey if the hedgehog gene is faulty or mutated The hedgehog gene s main function is to create protein signals in specific cells These signals in turn allow for the formation of embryonic tissues They do this by instructing neighboring cells to become a certain type of differentiated cell or to simply divide In other words this gene is responsible for the development of the appendages and body segments in Drosophila or fruit flies Humans and other invertebrates have hedgehog genes that behave slightly different than the same gene in the fruit fly In vertebrates the hedgehog gene codes for the fingers and toes on the limbs It also functions in organizing the brain and the spinal cord Consequently mutated hedgehog genes often cause birth defects Also if it is activated later in life certain cancers can be triggered and begin to spread 5 In 2006 Beachy moved from Johns Hopkins to Stanford University s Department of Developmental Biology and its Institute for Stem Cell Biology and Regenerative Medicine He is interested in the function of Hedgehog proteins and other extracellular signals in morphogenesis pattern formation and in injury repair and regeneration pattern maintenance in particular the normal roles of such signals in stem cell physiology and their abnormal roles in the formation and expansion of cancer stem cells He is also interested in how the distribution of such signals is regulated in tissues how cells perceive and respond to distinct concentrations of signals and how such signaling pathways arose in evolution 5 Research editBeachy s research focuses on understanding the molecular mechanisms behind the growth of multicellular embryos especially the role of the Hedgehog signaling pathway 7 8 9 Awards and honors editBeachy has received numerous awards and prizes for his work including the Outstanding Young Scientist Award from the Maryland Academy of Sciences in 1997 and the National Academy of Sciences Award in Molecular Biology in 1998 In 2008 Beachy received the March of Dimes Prize in Developmental Biology jointly with Cliff Tabin 10 In 2011 Beachy received the Keio Medical Science Prize Beachy was elected a member of the United States National Academy of Sciences in 2002 and a Fellow of the American Academy of Arts and Sciences 2003 11 Personal life editBeachy is the brother of the historian Robert M Beachy and a cousin of biologist Roger N Beachy and author Stephen Beachy References edit a b c d Marino M 2004 Biography of Philip A Beachy Proceedings of the National Academy of Sciences 101 52 17897 9 doi 10 1073 pnas 0408740102 PMC 539818 PMID 15611474 Porter J A Young K E Beachy P A 1996 Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development Science 274 5285 255 9 Bibcode 1996Sci 274 255P doi 10 1126 science 274 5285 255 PMID 8824192 S2CID 11125394 Marquis Who s Who TM Marquis Who s Who 2008 Beachy P A Karhadkar S S Berman D M 2004 Tissue repair and stem cell renewal in carcinogenesis Nature 432 7015 324 31 Bibcode 2004Natur 432 324B doi 10 1038 nature03100 PMID 15549094 S2CID 4428056 a b c d Philip A Beachy PhD HHMI org Retrieved 2014 06 17 Philip A Beachy Stanford University Yatedo com 1958 10 25 Retrieved 2014 06 17 Chiang C Litingtung Y Lee E Young K E Corden J L Westphal H Beachy P A 1996 Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function Nature 383 6599 407 13 Bibcode 1996Natur 383 407C doi 10 1038 383407a0 PMID 8837770 S2CID 4339131 Berman D M Karhadkar S S Maitra A Montes De Oca R Gerstenblith M R Briggs K Parker A R Shimada Y Eshleman J R Watkins D N Beachy P A 2003 Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours Nature 425 6960 846 51 Bibcode 2003Natur 425 846B doi 10 1038 nature01972 PMID 14520411 S2CID 2877022 Taipale J Beachy P A 2001 The Hedgehog and Wnt signalling pathways in cancer Nature 411 6835 349 54 Bibcode 2001Natur 411 349T doi 10 1038 35077219 PMID 11357142 S2CID 4414768 Anon 2008 An Interview With Cliff Tabin Nature Reviews Genetics 9 6 420 doi 10 1038 nrg2863 PMID 18504824 S2CID 45619315 Book of Members 1780 2010 Chapter B PDF American Academy of Arts and Sciences Retrieved May 28 2011 External links editPhilip A Beachy Profile at Stanford University Retrieved from https en wikipedia org w index php title Philip A Beachy amp oldid 1114614693, wikipedia, wiki, book, books, library,

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