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Wikipedia

PLA2G4A

May 08, 2024

Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene.[5][6]

PLA2G4A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLA2G4A, PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP
External IDsOMIM: 600522 MGI: 1195256 HomoloGene: 32059 GeneCards: PLA2G4A
Orthologs
SpeciesHumanMouse
Entrez

5321

18783

Ensembl

ENSG00000116711

ENSMUSG00000056220

UniProt

P47712

P47713

RefSeq (mRNA)

NM_001311193
NM_024420

NM_008869
NM_001305632

RefSeq (protein)

NP_001298122
NP_077734

NP_001292561
NP_032895

Location (UCSC)Chr 1: 186.83 – 186.99 MbChr 1: 149.71 – 149.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.[6]

Interactions edit

PLA2G4A has been shown to interact with HTATIP.[7]

Clinical significance edit

Mutations in this gene have been associated with multifocal stenosing ulceration of the small intestine.[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116711 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056220 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dennis EA (Jun 1994). "Diversity of group types, regulation, and function of phospholipase A2". Journal of Biological Chemistry. 269 (18): 13057–13060. doi:10.1016/S0021-9258(17)36794-7. PMID 8175726.
  6. ^ a b "Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)".
  7. ^ Sheridan AM, Force T, Yoon HJ, O'Leary E, Choukroun G, Taheri MR, Bonventre JV (July 2001). "PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production". Molecular and Cellular Biology. 21 (14): 4470–4481. doi:10.1128/MCB.21.14.4470-4481.2001. PMC 87107. PMID 11416127.
  8. ^ Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP, Macdonald TT (December 2012). "Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α". Gut. 63 (1): 96–104. doi:10.1136/gutjnl-2012-303581. PMID 23268370. S2CID 206957682.

Further reading edit

  • Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–688. PMID 9745929.
  • Hirabayashi T, Murayama T, Shimizu T (2005). "Regulatory mechanism and physiological role of cytosolic phospholipase A2". Biological and Pharmaceutical Bulletin. 27 (8): 1168–1173. doi:10.1248/bpb.27.1168. PMID 15305015.
  • Law MH, Cotton RG, Berger GE (2006). "The role of phospholipases A2 in schizophrenia". Molecular Psychiatry. 11 (6): 547–556. doi:10.1038/sj.mp.4001819. PMID 16585943.
  • Shimizu T, Ohto T, Kita Y (2006). "Cytosolic phospholipase A2: biochemical properties and physiological roles". IUBMB Life. 58 (5–6): 328–333. doi:10.1080/15216540600702289. PMID 16754327. S2CID 36287675.
  • Sharp JD, White DL, Chiou XG, et al. (1991). "Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2". Journal of Biological Chemistry. 266 (23): 14850–14853. doi:10.1016/S0021-9258(18)98550-9. PMID 1869522.
  • Clark JD, Lin LL, Kriz RW, et al. (1991). "A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP". Cell. 65 (6): 1043–1051. doi:10.1016/0092-8674(91)90556-E. PMID 1904318. S2CID 134332.
  • Tay A, Simon JS, Squire J, et al. (1995). "Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers". Genomics. 26 (1): 138–141. doi:10.1016/0888-7543(95)80093-2. PMID 7782073.
  • Wu T, Ikezono T, Angus CW, Shelhamer JH (1995). "Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene". Nucleic Acids Research. 22 (23): 5093–5098. doi:10.1093/nar/22.23.5093. PMC 523783. PMID 7800505.
  • Miyashita A, Crystal RG, Hay JG (1995). "Identification of a 27 bp 5'-flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene". Nucleic Acids Research. 23 (2): 293–301. doi:10.1093/nar/23.2.293. PMC 306668. PMID 7862535.
  • Morri H, Ozaki M, Watanabe Y (1995). "5'-flanking region surrounding a human cytosolic phospholipase A2 gene". Biochemical and Biophysical Research Communications. 205 (1): 6–11. doi:10.1006/bbrc.1994.2621. PMID 7999086.
  • Sharp JD, Pickard RT, Chiou XG, et al. (1994). "Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2". Journal of Biological Chemistry. 269 (37): 23250–23254. doi:10.1016/S0021-9258(17)31645-9. PMID 8083230.
  • Lin LL, Wartmann M, Lin AY, et al. (1993). "cPLA2 is phosphorylated and activated by MAP kinase". Cell. 72 (2): 269–78. doi:10.1016/0092-8674(93)90666-E. PMID 8381049. S2CID 1500909.
  • Flati V, Haque SJ, Williams BR (1996). "Interferon-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon-stimulated gene factor three". EMBO Journal. 15 (7): 1566–1571. doi:10.1002/j.1460-2075.1996.tb00501.x. PMC 450066. PMID 8612580.
  • de Carvalho MG, McCormack AL, Olson E, et al. (1996). "Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes". Journal of Biological Chemistry. 271 (12): 6987–6997. doi:10.1074/jbc.271.12.6987. PMID 8636128.
  • Freed KA, Moses EK, Brennecke SP, Rice GE (1997). "Differential expression of type II, IV and cytosolic PLA2 messenger RNA in human intrauterine tissues at term". Molecular Human Reproduction. 3 (6): 493–499. doi:10.1093/molehr/3.6.493. PMID 9239738.
  • Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
  • Perisic O, Fong S, Lynch DE, et al. (1998). "Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2". Journal of Biological Chemistry. 273 (3): 1596–1604. doi:10.1074/jbc.273.3.1596. PMID 9430701.
  • Börsch-Haubold AG, Bartoli F, Asselin J, et al. (1998). "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells". Journal of Biological Chemistry. 273 (8): 4449–4458. doi:10.1074/jbc.273.8.4449. PMID 9468497.

May 08, 2024
pla2g4a, cytosolic, phospholipase, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1bci, 1cjy, 1rlwidentifiersaliases, pla2g4, cpla2, alpha, cpla2, phospholipase, group, gurdpexternal, idsomim, 600522, 119525. Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene 5 6 PLA2G4AAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1BCI 1CJY 1RLWIdentifiersAliasesPLA2G4A PLA2G4 cPLA2 alpha cPLA2 phospholipase A2 group IVA GURDPExternal IDsOMIM 600522 MGI 1195256 HomoloGene 32059 GeneCards PLA2G4AGene location Human Chr Chromosome 1 human 1 Band1q31 1Start186 828 949 bp 1 End186 988 981 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 G1 1 63 51 cMStart149 705 369 bp 2 End149 837 041 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inseminal vesicularight uterine tubeurinary bladdercaput epididymismucosa of urinary bladdergerminal epitheliumAchilles tendonparietal pleurajejunal mucosaurethraTop expressed inmucous cell of stomachurotheliumcervixepithelium of stomachPaneth cellcumulus cellirisleft colonlateral recessvas deferensMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmetal ion binding calcium ion binding hydrolase activity calcium dependent phospholipid binding phospholipase activity phospholipase A2 activity phospholipase A1 activity lysophospholipase activity calcium dependent phospholipase A2 activityCellular componentGolgi apparatus endoplasmic reticulum endoplasmic reticulum membrane cytoplasmic vesicle mitochondrial inner membrane cytoplasm lipid droplet cytosol nucleusBiological processphospholipid metabolic process phosphatidylinositol acyl chain remodeling platelet activating factor biosynthetic process arachidonic acid secretion icosanoid metabolic process lipid metabolism phosphatidylserine acyl chain remodeling phospholipid catabolic process phosphatidylglycerol acyl chain remodeling cellular response to antibiotic lipid catabolic process phosphatidic acid biosynthetic process phosphatidylcholine acyl chain remodeling metabolism regulation of cell population proliferation phosphatidylethanolamine acyl chain remodeling cardiolipin acyl chain remodeling icosanoid biosynthetic process arachidonic acid metabolic process glycerophospholipid catabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez532118783EnsemblENSG00000116711ENSMUSG00000056220UniProtP47712P47713RefSeq mRNA NM 001311193NM 024420NM 008869NM 001305632RefSeq protein NP 001298122NP 077734NP 001292561NP 032895Location UCSC Chr 1 186 83 186 99 MbChr 1 149 71 149 84 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 Clinical significance 4 References 5 Further readingFunction editThis gene encodes a member of the cytosolic phospholipase A2 group IV family The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids Eicosanoids including prostaglandins and leukotrienes are lipid based cellular hormones that regulate hemodynamics inflammatory responses and other intracellular pathways The hydrolysis reaction also produces lysophospholipids that are converted into platelet activating factor The enzyme is activated by increased intracellular Ca2 levels and phosphorylation resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles 6 Interactions editPLA2G4A has been shown to interact with HTATIP 7 Clinical significance editMutations in this gene have been associated with multifocal stenosing ulceration of the small intestine 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000116711 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000056220 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Dennis EA Jun 1994 Diversity of group types regulation and function of phospholipase A2 Journal of Biological Chemistry 269 18 13057 13060 doi 10 1016 S0021 9258 17 36794 7 PMID 8175726 a b Entrez Gene PLA2G4A phospholipase A2 group IVA cytosolic calcium dependent Sheridan AM Force T Yoon HJ O Leary E Choukroun G Taheri MR Bonventre JV July 2001 PLIP a novel splice variant of Tip60 interacts with group IV cytosolic phospholipase A 2 induces apoptosis and potentiates prostaglandin production Molecular and Cellular Biology 21 14 4470 4481 doi 10 1128 MCB 21 14 4470 4481 2001 PMC 87107 PMID 11416127 Brooke MA Longhurst HJ Plagnol V Kirkby NS Mitchell JA Ruschendorf F Warner TD Kelsell DP Macdonald TT December 2012 Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2 a Gut 63 1 96 104 doi 10 1136 gutjnl 2012 303581 PMID 23268370 S2CID 206957682 Further reading editSchroder HC Perovic S Kavsan V et al 1998 Mechanisms of prionSc and HIV 1 gp120 induced neuronal cell death Neurotoxicology 19 4 5 683 688 PMID 9745929 Hirabayashi T Murayama T Shimizu T 2005 Regulatory mechanism and physiological role of cytosolic phospholipase A2 Biological and Pharmaceutical Bulletin 27 8 1168 1173 doi 10 1248 bpb 27 1168 PMID 15305015 Law MH Cotton RG Berger GE 2006 The role of phospholipases A2 in schizophrenia Molecular Psychiatry 11 6 547 556 doi 10 1038 sj mp 4001819 PMID 16585943 Shimizu T Ohto T Kita Y 2006 Cytosolic phospholipase A2 biochemical properties and physiological roles IUBMB Life 58 5 6 328 333 doi 10 1080 15216540600702289 PMID 16754327 S2CID 36287675 Sharp JD White DL Chiou XG et al 1991 Molecular cloning and expression of human Ca 2 sensitive cytosolic phospholipase A2 Journal of Biological Chemistry 266 23 14850 14853 doi 10 1016 S0021 9258 18 98550 9 PMID 1869522 Clark JD Lin LL Kriz RW et al 1991 A novel arachidonic acid selective cytosolic PLA2 contains a Ca 2 dependent translocation domain with homology to PKC and GAP Cell 65 6 1043 1051 doi 10 1016 0092 8674 91 90556 E PMID 1904318 S2CID 134332 Tay A Simon JS Squire J et al 1995 Cytosolic phospholipase A2 gene in human and rat chromosomal localization and polymorphic markers Genomics 26 1 138 141 doi 10 1016 0888 7543 95 80093 2 PMID 7782073 Wu T Ikezono T Angus CW Shelhamer JH 1995 Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene Nucleic Acids Research 22 23 5093 5098 doi 10 1093 nar 22 23 5093 PMC 523783 PMID 7800505 Miyashita A Crystal RG Hay JG 1995 Identification of a 27 bp 5 flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene Nucleic Acids Research 23 2 293 301 doi 10 1093 nar 23 2 293 PMC 306668 PMID 7862535 Morri H Ozaki M Watanabe Y 1995 5 flanking region surrounding a human cytosolic phospholipase A2 gene Biochemical and Biophysical Research Communications 205 1 6 11 doi 10 1006 bbrc 1994 2621 PMID 7999086 Sharp JD Pickard RT Chiou XG et al 1994 Serine 228 is essential for catalytic activities of 85 kDa cytosolic phospholipase A2 Journal of Biological Chemistry 269 37 23250 23254 doi 10 1016 S0021 9258 17 31645 9 PMID 8083230 Lin LL Wartmann M Lin AY et al 1993 cPLA2 is phosphorylated and activated by MAP kinase Cell 72 2 269 78 doi 10 1016 0092 8674 93 90666 E PMID 8381049 S2CID 1500909 Flati V Haque SJ Williams BR 1996 Interferon alpha induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon stimulated gene factor three EMBO Journal 15 7 1566 1571 doi 10 1002 j 1460 2075 1996 tb00501 x PMC 450066 PMID 8612580 de Carvalho MG McCormack AL Olson E et al 1996 Identification of phosphorylation sites of human 85 kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes Journal of Biological Chemistry 271 12 6987 6997 doi 10 1074 jbc 271 12 6987 PMID 8636128 Freed KA Moses EK Brennecke SP Rice GE 1997 Differential expression of type II IV and cytosolic PLA2 messenger RNA in human intrauterine tissues at term Molecular Human Reproduction 3 6 493 499 doi 10 1093 molehr 3 6 493 PMID 9239738 Mavoungou E Georges Courbot MC Poaty Mavoungou V et al 1997 HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 16 1 1 9 doi 10 1097 00042560 199709010 00001 PMID 9377118 Perisic O Fong S Lynch DE et al 1998 Crystal structure of a calcium phospholipid binding domain from cytosolic phospholipase A2 Journal of Biological Chemistry 273 3 1596 1604 doi 10 1074 jbc 273 3 1596 PMID 9430701 Borsch Haubold AG Bartoli F Asselin J et al 1998 Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist stimulated human platelets and HeLa cells Journal of Biological Chemistry 273 8 4449 4458 doi 10 1074 jbc 273 8 4449 PMID 9468497 Portal nbsp Biology Retrieved from https en wikipedia org w index php title PLA2G4A amp oldid 1170063655, wikipedia, wiki, book, books, library,

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