PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM][5]
It was found that aggressive metastasized cancer cells produced more of the PITPNC1 protein. In contrast, tumor cells that had not spread had lower expression of PITPNC1. Studies reveal that PITPNC1 promotes malignant secretion by binding Golgi-resident PI4P and localizing RAB1B to the Golgi. RAB1B localization to the Golgi allows for the recruitment of GOLPH3 (Golgi phosphoprotein 3), which facilitates Golgi extension and enhanced vesicular release. PITPNC1-mediated vesicular release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators HTRA1, MMP1, FAM3C, PDGFA, and ADAM10.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000110697 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (1997). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct. 1 (3): 205–13. doi:10.1046/j.1365-4624.1997.00015.x. PMID 9680295.
^ ab"Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1".
^Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF (2016). "PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion". Cancer Cell. 29 (3): 339–353. doi:10.1016/j.ccell.2016.02.013. PMC5300038. PMID 26977884.
^Lev S; Hernandez J; Martinez R; Chen A; Plowman G; Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. (published March 1999). 19 (3): 2278–88. doi:10.1128/mcb.19.3.2278. ISSN 0270-7306. PMC84020. PMID 10022914. Wikidata Q22008764.
Further readingedit
Vihtelic TS, Hyde DR, O'Tousa JE (1991). "Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene". Genetics. 127 (4): 761–8. doi:10.1093/genetics/127.4.761. PMC1204403. PMID 1903119.
Aikawa Y, Hara H, Watanabe T (1997). "Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene". Biochem. Biophys. Res. Commun. 236 (3): 559–64. doi:10.1006/bbrc.1997.7009. PMID 9245688.
Tian D; Litvak V; Toledo-Rodriguez M; Carmon S; Lev, S (2002). "Nir2, a novel regulator of cell morphogenesis". Mol. Cell. Biol. 22 (8): 2650–62. doi:10.1128/MCB.22.8.2650-2662.2002. PMC133726. PMID 11909959.
Litvak V; Tian D; Carmon S; Lev, S (2002). "Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis". Mol. Cell. Biol. 22 (14): 5064–75. doi:10.1128/MCB.22.14.5064-5075.2002. PMC139767. PMID 12077336.
Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S (2002). "Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain". Curr. Biol. 12 (17): 1513–8. doi:10.1016/S0960-9822(02)01107-7. PMID 12225667. S2CID 5639384.
Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S (2004). "Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion". Mol. Cell. 14 (3): 319–30. doi:10.1016/S1097-2765(04)00214-X. PMID 15125835.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC514446. PMID 15302935.
Amarilio R, Ramachandran S, Sabanay H, Lev S (2005). "Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction". J. Biol. Chem. 280 (7): 5934–44. doi:10.1074/jbc.M409566200. PMID 15545272.
Ocaka L, Spalluto C, Wilson DI, Hunt DM, Halford S (2005). "Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3". Cytogenet. Genome Res. 108 (4): 293–302. doi:10.1159/000081519. PMID 15627748. S2CID 20792950.
Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S (2005). "Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function". Nat. Cell Biol. 7 (3): 225–34. doi:10.1038/ncb1221. PMID 15723057. S2CID 5881790.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Burgis NE, Cunningham RP (2007). "Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase". J. Biol. Chem. 282 (6): 3531–8. doi:10.1074/jbc.M608708200. PMID 17090528.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
pitpnm1, membrane, associated, phosphatidylinositol, transfer, protein, protein, that, humans, encoded, gene, identifiersaliases, dres9, nir2, pitpnm, rdgb, rdgb1, rdgba, rdgba1, phosphatidylinositol, transfer, protein, membrane, associated, 1external, idsomim. Membrane associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene 4 5 PITPNM1IdentifiersAliasesPITPNM1 DRES9 NIR2 PITPNM RDGB RDGB1 RDGBA RDGBA1 Rd9 phosphatidylinositol transfer protein membrane associated 1External IDsOMIM 608794 MGI 1197524 HomoloGene 3608 GeneCards PITPNM1Gene location Human Chr Chromosome 11 human 1 Band11q13 2Start67 491 768 bp 1 End67 506 263 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubeanterior pituitarymonocytecingulate gyrusprefrontal cortexBrodmann area 10amygdalaright lobe of thyroid glandspleenfrontal polen aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding metal ion binding phosphatidylinositol transfer activity phosphatidylcholine binding phosphatidylinositol binding phosphatidic acid binding phospholipid transporter activity calcium ion binding receptor tyrosine kinase binding phosphatidylcholine transporter activityCellular componentGolgi cisterna membrane lipid droplet Golgi apparatus midbody cleavage furrow intracellular anatomical structure endoplasmic reticulum membrane membrane endoplasmic reticulum cytoplasm cytosol cytoplasmic ribonucleoprotein granule microtubule organizing center cell bodyBiological processprotein transport brain development lipid metabolism phototransduction phosphatidylinositol biosynthetic process phospholipid transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez960018739EnsemblENSG00000110697ENSMUSG00000024851UniProtO00562O35954RefSeq mRNA NM 001130848NM 004910NM 001136078NM 008851RefSeq protein NP 001124320NP 004901NP 032877Location UCSC Chr 11 67 49 67 51 Mbn aPubMed search 2 3 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editPITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B rdgB protein supplied by OMIM 5 It was found that aggressive metastasized cancer cells produced more of the PITPNC1 protein In contrast tumor cells that had not spread had lower expression of PITPNC1 Studies reveal that PITPNC1 promotes malignant secretion by binding Golgi resident PI4P and localizing RAB1B to the Golgi RAB1B localization to the Golgi allows for the recruitment of GOLPH3 Golgi phosphoprotein 3 which facilitates Golgi extension and enhanced vesicular release PITPNC1 mediated vesicular release drives metastasis by increasing the secretion of pro invasive and pro angiogenic mediators HTRA1 MMP1 FAM3C PDGFA and ADAM10 6 Interactions editPITPNM1 has been shown to interact with PTK2B 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000110697 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Rubboli F Bulfone A Bogni S Marchitiello A Zollo M Borsani G Ballabio A Banfi S 1997 A mammalian homologue of the Drosophila retinal degeneration B gene implications for the evolution of phototransduction mechanisms Genes Funct 1 3 205 13 doi 10 1046 j 1365 4624 1997 00015 x PMID 9680295 a b Entrez Gene PITPNM1 phosphatidylinositol transfer protein membrane associated 1 Halberg N Sengelaub CA Navrazhina K Molina H Uryu K Tavazoie SF 2016 PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion Cancer Cell 29 3 339 353 doi 10 1016 j ccell 2016 02 013 PMC 5300038 PMID 26977884 Lev S Hernandez J Martinez R Chen A Plowman G Schlessinger J Mar 1999 Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B rdgB protein Mol Cell Biol published March 1999 19 3 2278 88 doi 10 1128 mcb 19 3 2278 ISSN 0270 7306 PMC 84020 PMID 10022914 Wikidata Q22008764 Further reading editVihtelic TS Hyde DR O Tousa JE 1991 Isolation and characterization of the Drosophila retinal degeneration B rdgB gene Genetics 127 4 761 8 doi 10 1093 genetics 127 4 761 PMC 1204403 PMID 1903119 Aikawa Y Hara H Watanabe T 1997 Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene Biochem Biophys Res Commun 236 3 559 64 doi 10 1006 bbrc 1997 7009 PMID 9245688 Tian D Litvak V Toledo Rodriguez M Carmon S Lev S 2002 Nir2 a novel regulator of cell morphogenesis Mol Cell Biol 22 8 2650 62 doi 10 1128 MCB 22 8 2650 2662 2002 PMC 133726 PMID 11909959 Litvak V Tian D Carmon S Lev S 2002 Nir2 a human homolog of Drosophila melanogaster retinal degeneration B protein is essential for cytokinesis Mol Cell Biol 22 14 5064 75 doi 10 1128 MCB 22 14 5064 5075 2002 PMC 139767 PMID 12077336 Litvak V Shaul YD Shulewitz M Amarilio R Carmon S Lev S 2002 Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI transfer domain Curr Biol 12 17 1513 8 doi 10 1016 S0960 9822 02 01107 7 PMID 12225667 S2CID 5639384 Litvak V Argov R Dahan N Ramachandran S Amarilio R Shainskaya A Lev S 2004 Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion Mol Cell 14 3 319 30 doi 10 1016 S1097 2765 04 00214 X PMID 15125835 Beausoleil SA Jedrychowski M Schwartz D Elias JE Villen J Li J Cohn MA Cantley LC Gygi SP 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Amarilio R Ramachandran S Sabanay H Lev S 2005 Differential regulation of endoplasmic reticulum structure through VAP Nir protein interaction J Biol Chem 280 7 5934 44 doi 10 1074 jbc M409566200 PMID 15545272 Ocaka L Spalluto C Wilson DI Hunt DM Halford S 2005 Chromosomal localization genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane associated PITPNM 1 2 and 3 Cytogenet Genome Res 108 4 293 302 doi 10 1159 000081519 PMID 15627748 S2CID 20792950 Litvak V Dahan N Ramachandran S Sabanay H Lev S 2005 Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function Nat Cell Biol 7 3 225 34 doi 10 1038 ncb1221 PMID 15723057 S2CID 5881790 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Olsen JV Blagoev B Gnad F Macek B Kumar C Mortensen P Mann M 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Burgis NE Cunningham RP 2007 Substrate specificity of RdgB protein a deoxyribonucleoside triphosphate pyrophosphohydrolase J Biol Chem 282 6 3531 8 doi 10 1074 jbc M608708200 PMID 17090528 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PITPNM1 amp oldid 1147863289, wikipedia, wiki, book, books, library,
