Professor Hanson noted that PEPCK-Cmus mice, dubbed "the mighty mice", "are metabolically similar to Lance Armstrong biking up the Pyrenees. They utilize mainly fatty acids for energy and produce very little lactic acid. Without eating or drinking, they can run for four or five hours. They are 10 times more active than ordinary mice in their home cage. They also live longer – up to three years of age – and are reproductively active for almost three years. In short, they are remarkable animals." However, "they eat twice as much as control mice, but they are half the weight, and are very aggressive. Why this is the case, we are not really sure."[5]
^Hakimi, P.; Yang, J.; Casadesus, G.; Massillon, D.; Tolentino-Silva, F.; Nye, C. K.; Cabrera, M. E.; Hagen, D. R.; Utter, C. B.; Baghdy, Y.; Johnson, D. H.; Wilson, D. L.; Kirwan, J. P.; Kalhan, S. C.; Hanson, R. W. (23 August 2007). "Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse". Journal of Biological Chemistry. 282 (45): 32844–32855. doi:10.1074/jbc.M706127200. PMC4484620. PMID 17716967.
^Hanson, R. W. & Hakimi, P. (2008). "Born to run; the story of the PEPCK-Cmus mouse". Biochimie. 90 (6): 383–42. doi:10.1016/j.biochi.2008.03.009. PMC2491496. PMID 18394430.
^Connor, Steve (2007-11-02). "The mouse that shook the world". The Independent. Archived from the original on 2022-05-24.
^Highfield, Roger (2007-11-02). "Genetically engineered 'mighty mouse' is the rodent Lance Armstrong". Telegraph.
^Hanson, R. W.; Hakimi, P. (2008). "Born to run; the story of the PEPCK-Cmus mouse". Biochimie. 90 (6): 838–842. doi:10.1016/j.biochi.2008.03.009. PMC2491496. PMID 18394430.
August 25, 2023
pepck, cmus, mouse, pepck, cmus, mice, genetically, modified, mice, musculus, which, result, their, modification, have, times, concentration, pepck, enzyme, their, muscles, compared, ordinary, mice, they, were, created, team, american, scientists, richard, han. PEPCK Cmus mice are genetically modified mice Mus musculus which as a result of their modification have up to 100 times the concentration of the PEPCK C enzyme in their muscles compared to ordinary mice 1 They were created by a team of American scientists led by Richard Hanson professor of biochemistry at Case Western Reserve University at Cleveland Ohio to gain a greater understanding of the PEPCK C enzyme which is present mainly in the liver and kidneys 2 3 4 Professor Hanson noted that PEPCK Cmus mice dubbed the mighty mice are metabolically similar to Lance Armstrong biking up the Pyrenees They utilize mainly fatty acids for energy and produce very little lactic acid Without eating or drinking they can run for four or five hours They are 10 times more active than ordinary mice in their home cage They also live longer up to three years of age and are reproductively active for almost three years In short they are remarkable animals However they eat twice as much as control mice but they are half the weight and are very aggressive Why this is the case we are not really sure 5 See also EditOncomouse Knockout mice TranshumanismReferences Edit Hakimi P Yang J Casadesus G Massillon D Tolentino Silva F Nye C K Cabrera M E Hagen D R Utter C B Baghdy Y Johnson D H Wilson D L Kirwan J P Kalhan S C Hanson R W 23 August 2007 Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase GTP in Skeletal Muscle Repatterns Energy Metabolism in the Mouse Journal of Biological Chemistry 282 45 32844 32855 doi 10 1074 jbc M706127200 PMC 4484620 PMID 17716967 Hanson R W amp Hakimi P 2008 Born to run the story of the PEPCK Cmus mouse Biochimie 90 6 383 42 doi 10 1016 j biochi 2008 03 009 PMC 2491496 PMID 18394430 Connor Steve 2007 11 02 The mouse that shook the world The Independent Archived from the original on 2022 05 24 Highfield Roger 2007 11 02 Genetically engineered mighty mouse is the rodent Lance Armstrong Telegraph Hanson R W Hakimi P 2008 Born to run the story of the PEPCK Cmus mouse Biochimie 90 6 838 842 doi 10 1016 j biochi 2008 03 009 PMC 2491496 PMID 18394430 Retrieved from https en wikipedia org w index php title PEPCK Cmus mouse amp oldid 1125479903, wikipedia, wiki, book, books, library,
