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Wikipedia

PDE2A

January 01, 1970

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.[4][5]

PDE2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDE2A, CGS-PDE, PDE2A1, PED2A4, cGSPDE, phosphodiesterase 2A, IDDPADS
External IDsOMIM: 602658; MGI: 2446107; HomoloGene: 1952; GeneCards: PDE2A; OMA:PDE2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5138

207728

Ensembl

ENSG00000186642

ENSMUSG00000030653

UniProt

O00408

Q922S4

RefSeq (mRNA)

NM_001143839
NM_001146209
NM_001243784
NM_002599

NM_001008548
NM_001143848
NM_001143849
NM_001243757
NM_001243758

RefSeq (protein)

NP_001137311
NP_001139681
NP_001230713
NP_002590

NP_001008548
NP_001137320
NP_001137321
NP_001230686
NP_001230687

Location (UCSC)Chr 11: 72.58 – 72.67 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse


References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186642 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.
  5. ^ "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

Further reading edit

  • Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, Van Laak V (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. 37 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892. S2CID 1060183.
  • Seybold J, Thomas D, Witzenrath M, Boral S, Hocke AC, Bürger A, Hatzelmann A, Tenor H, Schudt C (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood. 105 (9): 3569–3576. doi:10.1182/blood-2004-07-2729. PMID 15650061.
  • Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. Bibcode:2002PNAS...9913260M. doi:10.1073/pnas.192374899. PMC 130621. PMID 12271124.
  • Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. doi:10.1055/s-0037-1613099. PMID 12038792. S2CID 4637804.
  • Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
  • Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi:10.1177/002215549904700707. PMID 10375378.


 

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
pde2a, cgmp, dependent, cyclic, phosphodiesterase, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1z1l, 3ibj, 3itm, 3itu, 4c1i, 4d08, 4d09, 4htx, 4htz, 4jibidentifiersaliases, ped2a4, cgspde, phosphodiestera. cGMP dependent 3 5 cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene 4 5 PDE2AAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIBIdentifiersAliasesPDE2A CGS PDE PDE2A1 PED2A4 cGSPDE phosphodiesterase 2A IDDPADSExternal IDsOMIM 602658 MGI 2446107 HomoloGene 1952 GeneCards PDE2A OMA PDE2A orthologsGene location Human Chr Chromosome 11 human 1 Band11q13 4Start72 576 141 bp 1 End72 674 591 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inspleenprefrontal cortexdorsolateral prefrontal cortexcingulate gyrusBrodmann area 9orbitofrontal cortexRegion I of hippocampus propernucleus accumbenssubcutaneous adipose tissueputamenn aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding 3 5 cyclic nucleotide phosphodiesterase activity calcium channel activity cGMP binding metal ion binding cyclic nucleotide phosphodiesterase activity protein binding phosphoric diester hydrolase activity TPR domain binding hydrolase activity cGMP stimulated cyclic nucleotide phosphodiesterase activity cAMP binding protein homodimerization activity 3 5 cyclic AMP phosphodiesterase activity 3 5 cyclic GMP phosphodiesterase activity identical protein binding magnesium ion binding zinc ion binding phosphate ion bindingCellular componentcytoplasm cytosol Golgi apparatus membrane plasma membrane endoplasmic reticulum mitochondrion perinuclear region of cytoplasm presynaptic membrane nucleus mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrixBiological processestablishment of endothelial barrier cellular response to transforming growth factor beta stimulus positive regulation of inflammatory response cellular response to cGMP negative regulation of transcription by RNA polymerase II monocyte differentiation cGMP mediated signaling cellular response to macrophage colony stimulating factor stimulus cellular response to mechanical stimulus positive regulation of vascular permeability cellular response to granulocyte macrophage colony stimulating factor stimulus cAMP mediated signaling signal transduction negative regulation of vascular permeability cGMP catabolic process cAMP catabolic process calcium ion transmembrane transport G protein coupled receptor signaling pathway negative regulation of cAMP mediated signaling cellular response to cAMP cellular response to 2 3 7 8 tetrachlorodibenzodioxine adenylate cyclase inhibiting G protein coupled receptor signaling pathway positive regulation of gene expression negative regulation of cGMP mediated signaling regulation of mitochondrion organization heart valve development ventricular septum development aorta developmentSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5138207728EnsemblENSG00000186642ENSMUSG00000030653UniProtO00408Q922S4RefSeq mRNA NM 001143839NM 001146209NM 001243784NM 002599NM 001008548NM 001143848NM 001143849NM 001243757NM 001243758RefSeq protein NP 001137311NP 001139681NP 001230713NP 002590NP 001008548NP 001137320NP 001137321NP 001230686NP 001230687Location UCSC Chr 11 72 58 72 67 Mbn aPubMed search 2 3 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000186642 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Rosman GJ Martins TJ Sonnenburg WK Beavo JA Ferguson K Loughney K Aug 1997 Isolation and characterization of human cDNAs encoding a cGMP stimulated 3 5 cyclic nucleotide phosphodiesterase Gene 191 1 89 95 doi 10 1016 S0378 1119 97 00046 2 PMID 9210593 Entrez Gene PDE2A phosphodiesterase 2A cGMP stimulated Further reading editWitzenrath M Gutbier B Schmeck B Tenor H Seybold J Kuelzer R Grentzmann G Hatzelmann A Van Laak V 2005 Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia Critical Care Medicine 37 9 584 590 doi 10 1097 CCM 0b013e3181959814 PMID 19114892 S2CID 1060183 Seybold J Thomas D Witzenrath M Boral S Hocke AC Burger A Hatzelmann A Tenor H Schudt C 2009 Tumor necrosis factor alpha dependent expression of phosphodiesterase 2 role in endothelial hyperpermeability Blood 105 9 3569 3576 doi 10 1182 blood 2004 07 2729 PMID 15650061 Ota T Suzuki Y Nishikawa T Otsuki T Sugiyama T Irie R Wakamatsu A Hayashi K Sato H 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 45 doi 10 1038 ng1285 PMID 14702039 Strausberg RL Feingold EA Grouse LH Derge JG Klausner RD Collins FS Wagner L Shenmen CM Schuler GD 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Martinez SE Wu AY Glavas NA Tang XB Turley S Hol WG Beavo JA 2002 The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding Proc Natl Acad Sci U S A 99 20 13260 13265 Bibcode 2002PNAS 9913260M doi 10 1073 pnas 192374899 PMC 130621 PMID 12271124 Manns JM Brenna KJ Colman RW Sheth SB 2002 Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases Thromb Haemost 87 5 873 9 doi 10 1055 s 0037 1613099 PMID 12038792 S2CID 4637804 Zauli G Milani D Mirandola P Mazzoni M Secchiero P Miscia S Capitani S 2001 HIV 1 Tat protein down regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3 kinase AKT cyclic nucleoside phosphodiesterase pathway FASEB J 15 2 483 491 doi 10 1096 fj 00 0354com PMID 11156964 S2CID 26315564 Sadhu K Hensley K Florio VA Wolda SL 1999 Differential expression of the cyclic GMP stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells J Histochem Cytochem 47 7 895 906 doi 10 1177 002215549904700707 PMID 10375378 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PDE2A amp oldid 1199609548, wikipedia, wiki, book, books, library,

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