This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional corepressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Paradoxically, the expression of EBP1 is decreased in prostate cancer,[6] but increased in Acute Myelogneous Leukemia.[7] Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000170515 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025364 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lamartine J, Seri M, Cinti R, Heitzmann F, Creaven M, Radomski N, Jost E, Lenoir GM, Romeo G, Sylla BS (November 1997). "Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4". Cytogenetics and Cell Genetics. 78 (1): 31–5. doi:10.1159/000134621. PMID 9345902.
^Zhang Y, Linn D, Liu Z, Melamed J, Tavora F, Young CY, Burger AM, Hamburger AW (October 2008). "EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance". Molecular Cancer Therapeutics. 7 (10): 3176–86. doi:10.1158/1535-7163.MCT-08-0526. PMC2629587. PMID 18852121.
^Nguyen le XT, Zhu L, Lee Y, Ta L, Mitchell BS (July 2016). "Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells". Clinical Cancer Research. 22 (13): 3320–7. doi:10.1158/1078-0432.CCR-15-2282. PMID 26813358.
^Lessor TJ, Hamburger AW (April 2001). "Regulation of the ErbB3 binding protein Ebp1 by protein kinase C". Molecular and Cellular Endocrinology. 175 (1–2): 185–91. doi:10.1016/S0303-7207(01)00387-2. PMID 11325528. S2CID 43143635.
^Yoo JY, Wang XW, Rishi AK, Lessor T, Xia XM, Gustafson TA, Hamburger AW (February 2000). "Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin". British Journal of Cancer. 82 (3): 683–90. doi:10.1054/bjoc.1999.0981. PMC2363329. PMID 10682683.
^Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation". Journal of Cellular Physiology. 187 (2): 209–17. doi:10.1002/jcp.1075. PMID 11268000. S2CID 42721280.
^Zhang Y, Fondell JD, Wang Q, Xia X, Cheng A, Lu ML, Hamburger AW (August 2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860.
Further readingedit
Radomski N, Jost E (October 1995). "Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle". Experimental Cell Research. 220 (2): 434–45. doi:10.1006/excr.1995.1335. PMID 7556453.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Froesch BA, Takayama S, Reed JC (May 1998). "BAG-1L protein enhances androgen receptor function". The Journal of Biological Chemistry. 273 (19): 11660–6. doi:10.1074/jbc.273.19.11660. PMID 9565586.
Kim ST, Lim DS, Canman CE, Kastan MB (December 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". The Journal of Biological Chemistry. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
Yoo JY, Wang XW, Rishi AK, Lessor T, Xia XM, Gustafson TA, Hamburger AW (February 2000). "Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin". British Journal of Cancer. 82 (3): 683–90. doi:10.1054/bjoc.1999.0981. PMC2363329. PMID 10682683.
Lessor TJ, Yoo JY, Xia X, Woodford N, Hamburger AW (June 2000). "Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines". Journal of Cellular Physiology. 183 (3): 321–9. doi:10.1002/(SICI)1097-4652(200006)183:3<321::AID-JCP4>3.0.CO;2-O. PMID 10797306. S2CID 1973521.
Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation". Journal of Cellular Physiology. 187 (2): 209–17. doi:10.1002/jcp.1075. PMID 11268000. S2CID 42721280.
Lessor TJ, Hamburger AW (April 2001). "Regulation of the ErbB3 binding protein Ebp1 by protein kinase C". Molecular and Cellular Endocrinology. 175 (1–2): 185–91. doi:10.1016/S0303-7207(01)00387-2. PMID 11325528. S2CID 43143635.
Xia X, Lessor TJ, Zhang Y, Woodford N, Hamburger AW (November 2001). "Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein". Biochemical and Biophysical Research Communications. 289 (1): 240–4. doi:10.1006/bbrc.2001.5942. PMID 11708806.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Zhang Y, Fondell JD, Wang Q, Xia X, Cheng A, Lu ML, Hamburger AW (August 2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC133617. PMID 12429849.
Zhang Y, Woodford N, Xia X, Hamburger AW (April 2003). "Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases". Nucleic Acids Research. 31 (8): 2168–77. doi:10.1093/nar/gkg318. PMC153746. PMID 12682367.
Squatrito M, Mancino M, Donzelli M, Areces LB, Draetta GF (May 2004). "EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes". Oncogene. 23 (25): 4454–65. doi:10.1038/sj.onc.1207579. PMID 15064750.
Zhang Y, Hamburger AW (June 2004). "Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription". The Journal of Biological Chemistry. 279 (25): 26126–33. doi:10.1074/jbc.M314305200. PMID 15073182.
Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC442147. PMID 15231747.
Zhang Y, Hamburger AW (January 2005). "Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling". British Journal of Cancer. 92 (1): 140–6. doi:10.1038/sj.bjc.6602257. PMC2361729. PMID 15583694.
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
pa2g4, proliferation, associated, protein, also, known, erbb3, binding, protein, ebp1, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2q8k, 3j2iidentifiersaliases, ebp1, proliferation, associated, 2g4extern. Proliferation associated protein 2G4 PA2G4 also known as ErbB3 binding protein 1 EBP1 is a protein that in humans is encoded by the PA2G4 gene 5 PA2G4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2Q8K 3J2IIdentifiersAliasesPA2G4 EBP1 HG4 1 p38 2G4 proliferation associated 2G4External IDsOMIM 602145 MGI 894684 HomoloGene 4513 GeneCards PA2G4 OMA PA2G4 orthologsGene location Human Chr Chromosome 12 human 1 Band12q13 2Start56 104 537 bp 1 End56 113 910 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 D3Start128 393 635 bp 2 End128 401 856 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomenrectumganglionic eminenceislet of Langerhansgastrocnemius musclebody of pancreaslymph nodeleft uterine tubepopliteal arteryright coronary arteryTop expressed inmorulasomiteabdominal wallyolk sacotic placodethymusmedial ganglionic eminencelipmaxillary prominenceparotid glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding DNA binding transcription factor activity protein binding ubiquitin protein ligase binding RNA binding nucleic acid bindingCellular componentcytoplasm membrane nucleolus extracellular exosome nucleus extracellular region azurophil granule lumenBiological processregulation of transcription DNA templated transcription DNA templated rRNA processing cell population proliferation negative regulation of transcription DNA templated regulation of translation neutrophil degranulation negative regulation of apoptotic process positive regulation of cell differentiation ribosomal large subunit export from nucleusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez503618813EnsemblENSG00000170515ENSMUSG00000025364UniProtQ9UQ80P50580RefSeq mRNA NM 006191NM 011119RefSeq protein NP 006182NP 035249Location UCSC Chr 12 56 1 56 11 MbChr 10 128 39 128 4 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis gene encodes an RNA binding protein that is involved in growth regulation This protein is present in pre ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals This protein is also a transcriptional corepressor of androgen receptor regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells Paradoxically the expression of EBP1 is decreased in prostate cancer 6 but increased in Acute Myelogneous Leukemia 7 Six pseudogenes located on chromosomes 3 6 9 18 20 and X have been identified 8 Interactions editPA2G4 has been shown to interact with ERBB3 9 10 retinoblastoma protein 11 and androgen receptor 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000170515 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025364 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lamartine J Seri M Cinti R Heitzmann F Creaven M Radomski N Jost E Lenoir GM Romeo G Sylla BS November 1997 Molecular cloning and mapping of a human cDNA PA2G4 that encodes a protein highly homologous to the mouse cell cycle protein p38 2G4 Cytogenetics and Cell Genetics 78 1 31 5 doi 10 1159 000134621 PMID 9345902 Zhang Y Linn D Liu Z Melamed J Tavora F Young CY Burger AM Hamburger AW October 2008 EBP1 an ErbB3 binding protein is decreased in prostate cancer and implicated in hormone resistance Molecular Cancer Therapeutics 7 10 3176 86 doi 10 1158 1535 7163 MCT 08 0526 PMC 2629587 PMID 18852121 Nguyen le XT Zhu L Lee Y Ta L Mitchell BS July 2016 Expression and Role of the ErbB3 Binding Protein 1 in Acute Myelogenous Leukemic Cells Clinical Cancer Research 22 13 3320 7 doi 10 1158 1078 0432 CCR 15 2282 PMID 26813358 Entrez Gene PA2G4 proliferation associated 2G4 38kDa Lessor TJ Hamburger AW April 2001 Regulation of the ErbB3 binding protein Ebp1 by protein kinase C Molecular and Cellular Endocrinology 175 1 2 185 91 doi 10 1016 S0303 7207 01 00387 2 PMID 11325528 S2CID 43143635 Yoo JY Wang XW Rishi AK Lessor T Xia XM Gustafson TA Hamburger AW February 2000 Interaction of the PA2G4 EBP1 protein with ErbB 3 and regulation of this binding by heregulin British Journal of Cancer 82 3 683 90 doi 10 1054 bjoc 1999 0981 PMC 2363329 PMID 10682683 Xia X Cheng A Lessor T Zhang Y Hamburger AW May 2001 Ebp1 an ErbB 3 binding protein interacts with Rb and affects Rb transcriptional regulation Journal of Cellular Physiology 187 2 209 17 doi 10 1002 jcp 1075 PMID 11268000 S2CID 42721280 Zhang Y Fondell JD Wang Q Xia X Cheng A Lu ML Hamburger AW August 2002 Repression of androgen receptor mediated transcription by the ErbB 3 binding protein Ebp1 Oncogene 21 36 5609 18 doi 10 1038 sj onc 1205638 PMID 12165860 Further reading editRadomski N Jost E October 1995 Molecular cloning of a murine cDNA encoding a novel protein p38 2G4 which varies with the cell cycle Experimental Cell Research 220 2 434 45 doi 10 1006 excr 1995 1335 PMID 7556453 Bonaldo MF Lennon G Soares MB September 1996 Normalization and subtraction two approaches to facilitate gene discovery Genome Research 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Froesch BA Takayama S Reed JC May 1998 BAG 1L protein enhances androgen receptor function The Journal of Biological Chemistry 273 19 11660 6 doi 10 1074 jbc 273 19 11660 PMID 9565586 Kim ST Lim DS Canman CE Kastan MB December 1999 Substrate specificities and identification of putative substrates of ATM kinase family members The Journal of Biological Chemistry 274 53 37538 43 doi 10 1074 jbc 274 53 37538 PMID 10608806 Yoo JY Wang XW Rishi AK Lessor T Xia XM Gustafson TA Hamburger AW February 2000 Interaction of the PA2G4 EBP1 protein with ErbB 3 and regulation of this binding by heregulin British Journal of Cancer 82 3 683 90 doi 10 1054 bjoc 1999 0981 PMC 2363329 PMID 10682683 Lessor TJ Yoo JY Xia X Woodford N Hamburger AW June 2000 Ectopic expression of the ErbB 3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines Journal of Cellular Physiology 183 3 321 9 doi 10 1002 SICI 1097 4652 200006 183 3 lt 321 AID JCP4 gt 3 0 CO 2 O PMID 10797306 S2CID 1973521 Xia X Cheng A Lessor T Zhang Y Hamburger AW May 2001 Ebp1 an ErbB 3 binding protein interacts with Rb and affects Rb transcriptional regulation Journal of Cellular Physiology 187 2 209 17 doi 10 1002 jcp 1075 PMID 11268000 S2CID 42721280 Lessor TJ Hamburger AW April 2001 Regulation of the ErbB3 binding protein Ebp1 by protein kinase C Molecular and Cellular Endocrinology 175 1 2 185 91 doi 10 1016 S0303 7207 01 00387 2 PMID 11325528 S2CID 43143635 Xia X Lessor TJ Zhang Y Woodford N Hamburger AW November 2001 Analysis of the expression pattern of Ebp1 an ErbB 3 binding protein Biochemical and Biophysical Research Communications 289 1 240 4 doi 10 1006 bbrc 2001 5942 PMID 11708806 Andersen JS Lyon CE Fox AH Leung AK Lam YW Steen H Mann M Lamond AI January 2002 Directed proteomic analysis of the human nucleolus Current Biology 12 1 1 11 Bibcode 2002CBio 12 1A doi 10 1016 S0960 9822 01 00650 9 PMID 11790298 S2CID 14132033 Zhang Y Fondell JD Wang Q Xia X Cheng A Lu ML Hamburger AW August 2002 Repression of androgen receptor mediated transcription by the ErbB 3 binding protein Ebp1 Oncogene 21 36 5609 18 doi 10 1038 sj onc 1205638 PMID 12165860 Scherl A Coute Y Deon C Calle A Kindbeiter K Sanchez JC Greco A Hochstrasser D Diaz JJ November 2002 Functional proteomic analysis of human nucleolus Molecular Biology of the Cell 13 11 4100 9 doi 10 1091 mbc E02 05 0271 PMC 133617 PMID 12429849 Zhang Y Woodford N Xia X Hamburger AW April 2003 Repression of E2F1 mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases Nucleic Acids Research 31 8 2168 77 doi 10 1093 nar gkg318 PMC 153746 PMID 12682367 Squatrito M Mancino M Donzelli M Areces LB Draetta GF May 2004 EBP1 is a nucleolar growth regulating protein that is part of pre ribosomal ribonucleoprotein complexes Oncogene 23 25 4454 65 doi 10 1038 sj onc 1207579 PMID 15064750 Zhang Y Hamburger AW June 2004 Heregulin regulates the ability of the ErbB3 binding protein Ebp1 to bind E2F promoter elements and repress E2F mediated transcription The Journal of Biological Chemistry 279 25 26126 33 doi 10 1074 jbc M314305200 PMID 15073182 Lehner B Sanderson CM July 2004 A protein interaction framework for human mRNA degradation Genome Research 14 7 1315 23 doi 10 1101 gr 2122004 PMC 442147 PMID 15231747 Zhang Y Hamburger AW January 2005 Specificity and heregulin regulation of Ebp1 ErbB3 binding protein 1 mediated repression of androgen receptor signalling British Journal of Cancer 92 1 140 6 doi 10 1038 sj bjc 6602257 PMC 2361729 PMID 15583694 nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PA2G4 amp oldid 1217819098, wikipedia, wiki, book, books, library,
