Oxipurinol (INN, or oxypurinolUSAN) is an inhibitor of xanthine oxidase.[1] It is an active metabolite of allopurinol and it is cleared renally.[2] In cases of renal disease, this metabolite will accumulate to toxic levels. By inhibiting xanthine oxidase, it reduces uric acid production. High serum uric acid levels may result in gout, kidney stones, and other medical conditions.
^Stocker, Sophie L; McLachlan, Andrew J; Savic, Radojka M; Kirkpatrick, Carl M; Graham, Garry G; Williams, Kenneth M; Day, Richard O (2012). "The pharmacokinetics of oxypurinol in people with gout". British Journal of Clinical Pharmacology. 74 (3): 477–489. doi:10.1111/j.1365-2125.2012.04207.x. PMC3477349. PMID 22300439.
^Elion, Gertrude B; Yü, Ts'ai-Fan; Gutman, Alexander B; Hitchings, George H (1968). "Renal clearance of oxipurinol, the chief metabolite of allopurinol". The American Journal of Medicine. 45 (1): 69–77. doi:10.1016/0002-9343(68)90008-9. PMID 5658870.
oxipurinol, oxypurinol, usan, inhibitor, xanthine, oxidase, active, metabolite, allopurinol, cleared, renally, cases, renal, disease, this, metabolite, will, accumulate, toxic, levels, inhibiting, xanthine, oxidase, reduces, uric, acid, production, high, serum. Oxipurinol INN or oxypurinol USAN is an inhibitor of xanthine oxidase 1 It is an active metabolite of allopurinol and it is cleared renally 2 In cases of renal disease this metabolite will accumulate to toxic levels By inhibiting xanthine oxidase it reduces uric acid production High serum uric acid levels may result in gout kidney stones and other medical conditions Oxipurinol NamesPreferred IUPAC name 1H pyrazolo 3 4 d pyrimidine 4 6 2H 5H dioneOther names 2 5 Dihydro 1H pyrazolo 3 4 d pyrimidine 4 6 dione AlloxanthineIdentifiersCAS Number 2465 59 03D model JSmol Interactive imageBeilstein Reference 139956ChEBI CHEBI 28315ChEMBL ChEMBL859 YChemSpider 4483ECHA InfoCard 100 017 792EC Number 219 570 9KEGG C07599MeSH OxypurinolPubChem CID 4644UNII G97OZE5068CompTox Dashboard EPA DTXSID4035209InChI InChI 1S C5H4N4O2 c10 4 2 1 6 9 3 2 7 5 11 8 4 h1H H3 6 7 8 9 10 11 Key HXNFUBHNUDHIGC UHFFFAOYSA NSMILES O C1NC O C2 CNNC2 N1PropertiesChemical formula C5H4N4O2Molar mass 152 11086Appearance white crystalsExcept where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox referencesReferences edit Stocker Sophie L McLachlan Andrew J Savic Radojka M Kirkpatrick Carl M Graham Garry G Williams Kenneth M Day Richard O 2012 The pharmacokinetics of oxypurinol in people with gout British Journal of Clinical Pharmacology 74 3 477 489 doi 10 1111 j 1365 2125 2012 04207 x PMC 3477349 PMID 22300439 Elion Gertrude B Yu Ts ai Fan Gutman Alexander B Hitchings George H 1968 Renal clearance of oxipurinol the chief metabolite of allopurinol The American Journal of Medicine 45 1 69 77 doi 10 1016 0002 9343 68 90008 9 PMID 5658870 nbsp This article about a heterocyclic compound is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Oxipurinol amp oldid 1014325281, wikipedia, wiki, book, books, library,
