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Wikipedia

Norgestomet

Norgestomet, or norgestamet, sold under the brand name Syncro-Mate B and Crestar, is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle.[1][2]

Norgestomet
Clinical data
Trade namesSyncro-Mate B, Crestar
Other namesNorgestamet; SC-21009; 11β-Methyl-17α-acetoxy-19-norprogesterone; 17α-Hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate
Drug classProgestogen; Progestin; Progestogen ester
Identifiers
  • [(8R,9S,10R,11S,13S,14S,17R)-17-acetyl-11,13-dimethyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
CAS Number
  • 25092-41-5
PubChem CID
  • 9820838
ChemSpider
  • 7996587
UNII
  • 3L33UD42X4
ECHA InfoCard100.042.359
Chemical and physical data
FormulaC23H32O4
Molar mass372.505 g·mol−1
3D model (JSmol)
  • Interactive image
  • CC1CC2(C(CCC2(C(=O)C)OC(=O)C)C3C1C4CCC(=O)C=C4CC3)C
  • InChI=1S/C23H32O4/c1-13-12-22(4)20(9-10-23(22,14(2)24)27-15(3)25)19-7-5-16-11-17(26)6-8-18(16)21(13)19/h11,13,18-21H,5-10,12H2,1-4H3/t13-,18-,19-,20-,21+,22-,23-/m0/s1
  • Key:IWSXBCZCPVUWHT-VIFKTUCRSA-N

Uses edit

Veterinary edit

Norgestomet is used in veterinary medicine.

Pharmacology edit

Pharmacodynamics edit

Norgestomet is a progestogen. In addition to the progesterone receptor, it possesses weak (micromolar) affinity for the glucocorticoid receptor.[3]

Chemistry edit

Norgestomet, also known as 11β-methyl-17α-acetoxy-19-norprogesterone or as 17α-hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate, is a synthetic norpregnane steroid and a derivative of progesterone.[1][4]

History edit

Norgestomet was developed and introduced for veterinary use in the mid-1970s.[5]

Society and culture edit

Generic names edit

Norgestomet is the generic name of the drug and its INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, and BANTooltip British Approved Name.[1][4] It also known as norgestamet and is known by its developmental code name SC-21009.[1][4][6]

Brand names edit

Norgestomet is marketed under the brand names Syncro-Mate B and Crestar.[1][4]

References edit

  1. ^ a b c d e Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 887–. ISBN 978-1-4757-2085-3.
  2. ^ Favero RJ, Henderson EA, Kesler DJ (1 July 1990). "The Ability of Norgesomet Impregnated Poly(dimethylsiloxane) to Maintain Pregnancy Subsequent to Ovarietomy". In Gebelein CG, Dunn RL (eds.). Progress in Biomedical Polymers. Springer Science & Business Media. pp. 356–. ISBN 978-0-306-43523-2.
  3. ^ Moffatt RJ, Zollers WG, Welshons WV, Kieborz KR, Garverick HA, Smith MF (January 1993). "Basis of norgestomet action as a progestogen in cattle". Domestic Animal Endocrinology. 10 (1): 21–30. doi:10.1016/0739-7240(93)90005-v. PMID 8467644.
  4. ^ a b c d . Drugs.com. Archived from the original on 28 February 2018.
  5. ^ Gordon U (22 October 2013). "Artificial Control O Oestrus and Ovulation". Controlled Breeding in Farm Animals. Elsevier. pp. 40–. ISBN 978-1-4832-8569-6.
  6. ^ Houghton PL (1979). "Effect of time of insemination and calf removal after estrus synchronization in beef cattle".

norgestomet, confused, with, norgestimate, norgestamet, sold, under, brand, name, syncro, mate, crestar, progestin, medication, which, used, veterinary, medicine, control, estrus, ovulation, cattle, clinical, datatrade, namessyncro, mate, crestarother, namesno. Not to be confused with norgestimate Norgestomet or norgestamet sold under the brand name Syncro Mate B and Crestar is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle 1 2 NorgestometClinical dataTrade namesSyncro Mate B CrestarOther namesNorgestamet SC 21009 11b Methyl 17a acetoxy 19 norprogesterone 17a Hydroxy 11b methyl 19 norpregn 4 ene 3 20 dione acetateDrug classProgestogen Progestin Progestogen esterIdentifiersIUPAC name 8R 9S 10R 11S 13S 14S 17R 17 acetyl 11 13 dimethyl 3 oxo 1 2 6 7 8 9 10 11 12 14 15 16 dodecahydrocyclopenta a phenanthren 17 yl acetateCAS Number25092 41 5PubChem CID9820838ChemSpider7996587UNII3L33UD42X4ECHA InfoCard100 042 359Chemical and physical dataFormulaC 23H 32O 4Molar mass372 505 g mol 13D model JSmol Interactive imageSMILES CC1CC2 C CCC2 C O C OC O C C3C1C4CCC O C C4CC3 CInChI InChI 1S C23H32O4 c1 13 12 22 4 20 9 10 23 22 14 2 24 27 15 3 25 19 7 5 16 11 17 26 6 8 18 16 21 13 19 h11 13 18 21H 5 10 12H2 1 4H3 t13 18 19 20 21 22 23 m0 s1Key IWSXBCZCPVUWHT VIFKTUCRSA N Contents 1 Uses 1 1 Veterinary 2 Pharmacology 2 1 Pharmacodynamics 3 Chemistry 4 History 5 Society and culture 5 1 Generic names 5 2 Brand names 6 ReferencesUses editVeterinary edit Norgestomet is used in veterinary medicine Pharmacology editPharmacodynamics edit Norgestomet is a progestogen In addition to the progesterone receptor it possesses weak micromolar affinity for the glucocorticoid receptor 3 Chemistry editSee also List of progestogens Progestogen ester and List of progestogen esters Norgestomet also known as 11b methyl 17a acetoxy 19 norprogesterone or as 17a hydroxy 11b methyl 19 norpregn 4 ene 3 20 dione acetate is a synthetic norpregnane steroid and a derivative of progesterone 1 4 History editNorgestomet was developed and introduced for veterinary use in the mid 1970s 5 Society and culture editGeneric names edit Norgestomet is the generic name of the drug and its INNTooltip International Nonproprietary Name USANTooltip United States Adopted Name and BANTooltip British Approved Name 1 4 It also known as norgestamet and is known by its developmental code name SC 21009 1 4 6 Brand names edit Norgestomet is marketed under the brand names Syncro Mate B and Crestar 1 4 References edit a b c d e Elks J 14 November 2014 The Dictionary of Drugs Chemical Data Chemical Data Structures and Bibliographies Springer pp 887 ISBN 978 1 4757 2085 3 Favero RJ Henderson EA Kesler DJ 1 July 1990 The Ability of Norgesomet Impregnated Poly dimethylsiloxane to Maintain Pregnancy Subsequent to Ovarietomy In Gebelein CG Dunn RL eds Progress in Biomedical Polymers Springer Science amp Business Media pp 356 ISBN 978 0 306 43523 2 Moffatt RJ Zollers WG Welshons WV Kieborz KR Garverick HA Smith MF January 1993 Basis of norgestomet action as a progestogen in cattle Domestic Animal Endocrinology 10 1 21 30 doi 10 1016 0739 7240 93 90005 v PMID 8467644 a b c d Norgestomet Drugs com Archived from the original on 28 February 2018 Gordon U 22 October 2013 Artificial Control O Oestrus and Ovulation Controlled Breeding in Farm Animals Elsevier pp 40 ISBN 978 1 4832 8569 6 Houghton PL 1979 Effect of time of insemination and calf removal after estrus synchronization in beef cattle Retrieved from https en wikipedia org w index php title Norgestomet amp oldid 1191939881, wikipedia, wiki, book, books, library,

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