^ abcGRCh38: Ensembl release 89: ENSG00000132911 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037393 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tate CG, Grisshammer R (Jan 1997). "Heterologous expression of G-protein-coupled receptors". Trends Biotechnol. 14 (11): 426–30. doi:10.1016/0167-7799(96)10059-7. PMID 8940772.
^Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q (Jul 2000). "Identification of receptors for neuromedin U and its role in feeding". Nature. 406 (6791): 70–4. doi:10.1038/35017610. PMID 10894543. S2CID 205007370.
^Zheng X, Guo L, Wang D, Deng X (2014). "p-Synephrine: a novel agonist for neuromedin U2 receptor". Biol Pharm Bull. 37 (5): 764–70. doi:10.1248/bpb.b13-00788. PMID 24598981.
Further readingedit
Hosoya M, Moriya T, Kawamata Y, et al. (2000). "Identification and functional characterization of a novel subtype of neuromedin U receptor". J. Biol. Chem. 275 (38): 29528–32. doi:10.1074/jbc.M004261200. PMID 10887190.
Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system". J. Biol. Chem. 275 (42): 32452–9. doi:10.1074/jbc.M004613200. PMID 10899166.
Shan L, Qiao X, Crona JH, et al. (2001). "Identification of a novel neuromedin U receptor subtype expressed in the central nervous system". J. Biol. Chem. 275 (50): 39482–6. doi:10.1074/jbc.C000522200. PMID 11010960.
Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B (2003). "Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin". Peptides. 23 (9): 1617–23. doi:10.1016/S0196-9781(02)00099-2. PMID 12217422. S2CID 9986371.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Bhattacharyya S, Luan J, Farooqi IS, et al. (2004). "Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor". J. Endocrinol. 183 (1): 115–20. doi:10.1677/joe.1.05830. PMID 15525579.
Mori K, Miyazato M, Ida T, et al. (2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system". EMBO J. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC545815. PMID 15635449.
Fang L, Zhang M, Li C, et al. (2006). "Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones". Neurosci. Lett. 404 (1–2): 148–53. doi:10.1016/j.neulet.2006.05.034. PMID 16781063. S2CID 26500367.
External linksedit
. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
neuromedin, receptor, neuromedin, receptor, protein, that, humans, encoded, nmur2, gene, nmur2identifiersaliasesnmur2, nmu2r, tgr1, external, idsomim, 605108, 2441765, homologene, 49618, genecards, nmur2gene, location, human, chromosome, human, band5q33, 1star. Neuromedin U receptor 2 is a protein that in humans is encoded by the NMUR2 gene 5 6 7 NMUR2IdentifiersAliasesNMUR2 FM 4 FM4 NMU R2 NMU2R TGR 1 TGR1 Neuromedin U receptor 2External IDsOMIM 605108 MGI 2441765 HomoloGene 49618 GeneCards NMUR2Gene location Human Chr Chromosome 5 human 1 Band5q33 1Start152 391 546 bp 1 End152 433 368 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 B1 3Start55 915 813 bp 2 End55 931 836 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed intibialis anterior muscledeltoid musclecorpus callosuminternal globus pallidusright lunghypothalamusright lobe of thyroid glandBrodmann area 9left lobe of thyroid glandgallbladderTop expressed insubmandibular glandcervixjejunumduodenumskin of abdomentracheastomachMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding signal transducer activity neuromedin U binding neuropeptide receptor activity neuromedin U receptor activity intracellular calcium activated chloride channel activity GTP binding G protein coupled receptor activityCellular componentintegral component of membrane membrane plasma membrane intracellular anatomical structureBiological processreduction of food intake in response to dietary excess calcium ion transport phospholipase C activating G protein coupled receptor signaling pathway activation of phospholipase A2 activity feeding behavior inositol phosphate mediated signaling regulation of smooth muscle contraction arachidonic acid secretion positive regulation of cytosolic calcium ion concentration cell cell signaling response to pain calcium mediated signaling signal transduction grooming behavior central nervous system development G protein coupled receptor signaling pathway neuropeptide signaling pathway ion transmembrane transport regulation of sensory perception of painSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez56923216749EnsemblENSG00000132911ENSMUSG00000037393UniProtQ9GZQ4Q8BZ39RefSeq mRNA NM 020167NM 153079RefSeq protein NP 064552NP 694719Location UCSC Chr 5 152 39 152 43 MbChr 11 55 92 55 93 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Ligands 1 1 Agonists 2 See also 3 References 4 Further reading 5 External linksLigands editAgonists edit synephrine 8 See also editNeuromedin U receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000132911 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000037393 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Tate CG Grisshammer R Jan 1997 Heterologous expression of G protein coupled receptors Trends Biotechnol 14 11 426 30 doi 10 1016 0167 7799 96 10059 7 PMID 8940772 Howard AD Wang R Pong SS Mellin TN Strack A Guan XM Zeng Z Williams DL Jr Feighner SD Nunes CN Murphy B Stair JN Yu H Jiang Q Clements MK Tan CP McKee KK Hreniuk DL McDonald TP Lynch KR Evans JF Austin CP Caskey CT Van der Ploeg LH Liu Q Jul 2000 Identification of receptors for neuromedin U and its role in feeding Nature 406 6791 70 4 doi 10 1038 35017610 PMID 10894543 S2CID 205007370 Entrez Gene NMUR2 neuromedin U receptor 2 Zheng X Guo L Wang D Deng X 2014 p Synephrine a novel agonist for neuromedin U2 receptor Biol Pharm Bull 37 5 764 70 doi 10 1248 bpb b13 00788 PMID 24598981 Further reading editHosoya M Moriya T Kawamata Y et al 2000 Identification and functional characterization of a novel subtype of neuromedin U receptor J Biol Chem 275 38 29528 32 doi 10 1074 jbc M004261200 PMID 10887190 Raddatz R Wilson AE Artymyshyn R et al 2000 Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system J Biol Chem 275 42 32452 9 doi 10 1074 jbc M004613200 PMID 10899166 Shan L Qiao X Crona JH et al 2001 Identification of a novel neuromedin U receptor subtype expressed in the central nervous system J Biol Chem 275 50 39482 6 doi 10 1074 jbc C000522200 PMID 11010960 Fernandez Alvarez C Debeljuk L Diaz Rodriguez E Diaz Lopez B 2003 Developmental pattern of tachykinins during aging in several organs effect of exogenous melatonin Peptides 23 9 1617 23 doi 10 1016 S0196 9781 02 00099 2 PMID 12217422 S2CID 9986371 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Bhattacharyya S Luan J Farooqi IS et al 2004 Studies of the neuromedin U 2 receptor gene in human obesity evidence for the existence of two ancestral forms of the receptor J Endocrinol 183 1 115 20 doi 10 1677 joe 1 05830 PMID 15525579 Mori K Miyazato M Ida T et al 2005 Identification of neuromedin S and its possible role in the mammalian circadian oscillator system EMBO J 24 2 325 35 doi 10 1038 sj emboj 7600526 PMC 545815 PMID 15635449 Fang L Zhang M Li C et al 2006 Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones Neurosci Lett 404 1 2 148 53 doi 10 1016 j neulet 2006 05 034 PMID 16781063 S2CID 26500367 External links edit Neuromedin U Receptors NMU2 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Archived from the original on 2016 03 03 Retrieved 2008 12 05 nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Neuromedin U receptor 2 amp oldid 1212960885, wikipedia, wiki, book, books, library,
