"hveC" redirects here. For Harbourview Estates C, see CityPlace, Toronto.
Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins.[5] It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).
PVRL1 is an adhesion molecule found in a wide range of tissues where it localizes in various junctions such as the adherens junction of epithelial tissue or the chemical synapse of neurons. The cytoplasmic tail of PVRL1 can bind the protein afadin which is a scaffolding protein that binds actin.
In the chemical synapse PVRL1 interacts with PVRL3 (nectin-3) and both proteins can be found in neuronal tissue already in early stages of brain development as well as in aging brains. The two proteins have been found to localize asymmetrically along the chemical synapse, with PVRL1 primarily on the axonal side and PVRL3 on the dendritic side.
The protein has been revealed as one of the key players in mediating cellular entry of the Herpes simplex virus by interacting with the viral glycoprotein D (gD).[6]
^Cocchi F, Lopez M, Menotti L, Aoubala M, Dubreuil P, Campadelli-Fiume G (1999). "The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D". Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15700–5. doi:10.1073/pnas.95.26.15700. PMC28107. PMID 9861033.
^Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y (May 1999). "Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein". J. Cell Biol. 145 (3): 539–49. doi:10.1083/jcb.145.3.539. PMC2185068. PMID 10225955.
Further readingedit
Bustos T, Simosa V, Pinto-Cisternas J, Abramovits W, Jolay L, Rodriguez L, Fernandez L, Ramela M (1992). "Autosomal recessive ectodermal dysplasia: I. An undescribed dysplasia/malformation syndrome". Am. J. Med. Genet. 41 (4): 398–404. doi:10.1002/ajmg.1320410403. PMID 1776626.
Lopez M, Eberlé F, Mattei MG, Gabert J, Birg F, Bardin F, Maroc C, Dubreuil P (1995). "Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene". Gene. 155 (2): 261–5. doi:10.1016/0378-1119(94)00842-G. PMID 7721102.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG (1998). "Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor". Science. 280 (5369): 1618–20. Bibcode:1998Sci...280.1618G. doi:10.1126/science.280.5369.1618. PMID 9616127.
Suzuki K, Bustos T, Spritz RA (1998). "Linkage disequilibrium mapping of the gene for Margarita Island ectodermal dysplasia (ED4) to 11q23". Am. J. Hum. Genet. 63 (4): 1102–7. doi:10.1086/302072. PMC1377504. PMID 9758630.
Cocchi F, Menotti L, Mirandola P, Lopez M, Campadelli-Fiume G (1998). "The Ectodomain of a Novel Member of the Immunoglobulin Subfamily Related to the Poliovirus Receptor Has the Attributes of a Bona Fide Receptor for Herpes Simplex Virus Types 1 and 2 in Human Cells". J. Virol. 72 (12): 9992–10002. doi:10.1128/JVI.72.12.9992-10002.1998. PMC110516. PMID 9811737.
Cocchi F, Lopez M, Menotti L, Aoubala M, Dubreuil P, Campadelli-Fiume G (1999). "The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D". Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15700–5. doi:10.1073/pnas.95.26.15700. PMC28107. PMID 9861033.
Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y (1999). "Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein". J. Cell Biol. 145 (3): 539–49. doi:10.1083/jcb.145.3.539. PMC2185068. PMID 10225955.
Miyahara M, Nakanishi H, Takahashi K, Satoh-Horikawa K, Tachibana K, Takai Y (2000). "Interaction of nectin with afadin is necessary for its clustering at cell–cell contact sites but not for its cis dimerization or trans interaction". J. Biol. Chem. 275 (1): 613–8. doi:10.1074/jbc.275.1.613. PMID 10617658.
Suzuki K, Hu D, Bustos T, Zlotogora J, Richieri-Costa A, Helms JA, Spritz RA (2000). "Mutations of PVRL1, encoding a cell–cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia". Nat. Genet. 25 (4): 427–30. doi:10.1038/78119. PMID 10932188. S2CID 6169893.
Lopez M, Cocchi F, Avitabile E, Leclerc A, Adelaide J, Campadelli-Fiume G, Dubreuil P (2001). "Novel, Soluble Isoform of the Herpes Simplex Virus (HSV) Receptor Nectin1 (or PRR1-HIgR-HveC) Modulates Positively and Negatively Susceptibility to HSV Infection". J. Virol. 75 (12): 5684–91. doi:10.1128/JVI.75.12.5684-5691.2001. PMC114282. PMID 11356977.
Sözen MA, Suzuki K, Tolarova MM, Bustos T, Fernández Iglesias JE, Spritz RA (2001). "Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela". Nat. Genet. 29 (2): 141–2. doi:10.1038/ng740. PMID 11559849. S2CID 8641206.
Struyf F, Posavad CM, Keyaerts E, Van Ranst M, Corey L, Spear PG (2002). "Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals". J. Infect. Dis. 185 (1): 36–44. doi:10.1086/338116. PMID 11756979.
Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P, Campadelli-Fiume G, Lopez M (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.
Yoon M, Spear PG (2002). "Disruption of Adherens Junctions Liberates Nectin-1 To Serve as Receptor for Herpes Simplex Virus and Pseudorabies Virus Entry". J. Virol. 76 (14): 7203–8. doi:10.1128/JVI.76.14.7203-7208.2002. PMC136315. PMID 12072519.
Struyf F, Martinez WM, Spear PG (2002). "Mutations in the N-Terminal Domains of Nectin-1 and Nectin-2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin-Nectin Interactions". J. Virol. 76 (24): 12940–50. doi:10.1128/JVI.76.24.12940-12950.2002. PMC136698. PMID 12438620.
Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 to cell–cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
Krummenacher C, Baribaud I, Eisenberg RJ, Cohen GH (2003). "Cellular Localization of Nectin-1 and Glycoprotein D during Herpes Simplex Virus Infection". J. Virol. 77 (16): 8985–99. doi:10.1128/JVI.77.16.8985-8999.2003. PMC167240. PMID 12885915.
Bender FC, Whitbeck JC, Ponce de Leon M, Lou H, Eisenberg RJ, Cohen GH (2003). "Specific Association of Glycoprotein B with Lipid Rafts during Herpes Simplex Virus Entry". J. Virol. 77 (17): 9542–52. doi:10.1128/JVI.77.17.9542-9552.2003. PMC187402. PMID 12915568.
poliovirus, receptor, related, hvec, redirects, here, harbourview, estates, cityplace, toronto, pvrl1, also, known, nectin, cd111, formerly, herpesvirus, entry, mediator, hvec, human, protein, immunoglobulin, superfamily, igsf, also, considered, member, nectin. hveC redirects here For Harbourview Estates C see CityPlace Toronto Poliovirus receptor related 1 PVRL1 also known as nectin 1 and CD111 formerly herpesvirus entry mediator C HVEC is a human protein of the immunoglobulin superfamily IgSF also considered a member of the nectins 5 It is a membrane protein with three extracellular immunoglobulin domains a single transmembrane helix and a cytoplasmic tail The protein can mediate Ca2 independent cellular adhesion further characterizing it as IgSF cell adhesion molecule IgSF CAM NECTIN1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3ALP 3SKU 3U83 4FMF 4MYWIdentifiersAliasesNECTIN1 CD111 CLPED1 ED4 HIgR HV1S HVEC OFC7 PRR PRR1 PVRR PVRR1 SK 12 nectin 1 PVRL1 nectin cell adhesion molecule 1External IDsOMIM 600644 MGI 1926483 HomoloGene 2138 GeneCards NECTIN1Gene location Human Chr Chromosome 11 human 1 Band11q23 3Start119 623 408 bp 1 End119 729 200 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 A5 1Start43 655 281 bp 2 End43 743 955 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomennipplebody of tonguesubthalamic nucleusvulvaexternal globus pallidusvena cavainferior ganglion of vagus nerveprefrontal cortexsuperior surface of tongueTop expressed inlipmolarvisual cortexcerebellar cortexstellate reticulumdorsomedial hypothalamic nucleusparaventricular nucleus of hypothalamusinferior colliculussubiculumpiriform cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein homodimerization activity coreceptor activity virus receptor activity protein binding protein heterodimerization activity virion binding signaling receptor binding carbohydrate binding cell adhesion molecule binding identical protein binding signaling receptor activityCellular componentintegral component of membrane membrane intracellular membrane bounded organelle plasma membrane growth cone membrane synapse integral component of plasma membrane extracellular region axon cell junction neuron projection catenin complex presynaptic membrane apical junction complex cell cell contact zone cell cell junction adherens junction dendrite hippocampal mossy fiber to CA3 synapse integral component of presynaptic active zone membraneBiological processheterophilic cell cell adhesion via plasma membrane cell adhesion molecules cell recognition desmosome organization regulation of synapse assembly axon guidance cell adhesion iron ion transport lens morphogenesis in camera type eye retina development in camera type eye immune response viral entry into host cell enamel mineralization viral process adherens junction organization camera type eye morphogenesis homophilic cell adhesion via plasma membrane adhesion molecules signal transduction protein localization to cell junction cell cell adhesion virion attachment to host cellSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez581858235EnsemblENSG00000110400ENSMUSG00000032012UniProtQ15223Q9JKF6RefSeq mRNA NM 203286NM 002855NM 032767NM 203285NM 021424RefSeq protein NP 002846NP 976030NP 976031NP 067399Location UCSC Chr 11 119 62 119 73 MbChr 9 43 66 43 74 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 Interactions 4 References 5 Further reading 6 External linksFunction editPVRL1 is an adhesion molecule found in a wide range of tissues where it localizes in various junctions such as the adherens junction of epithelial tissue or the chemical synapse of neurons The cytoplasmic tail of PVRL1 can bind the protein afadin which is a scaffolding protein that binds actin In the chemical synapse PVRL1 interacts with PVRL3 nectin 3 and both proteins can be found in neuronal tissue already in early stages of brain development as well as in aging brains The two proteins have been found to localize asymmetrically along the chemical synapse with PVRL1 primarily on the axonal side and PVRL3 on the dendritic side The protein has been revealed as one of the key players in mediating cellular entry of the Herpes simplex virus by interacting with the viral glycoprotein D gD 6 See also editCluster of differentiationInteractions editPVRL1 has been shown to interact with MLLT4 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000110400 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032012 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene PVRL1 poliovirus receptor related 1 herpesvirus entry mediator C nectin Cocchi F Lopez M Menotti L Aoubala M Dubreuil P Campadelli Fiume G 1999 The V domain of herpesvirus Ig like receptor HIgR contains a major functional region in herpes simplex virus 1 entry into cells and interacts physically with the viral glycoprotein D Proc Natl Acad Sci U S A 95 26 15700 5 doi 10 1073 pnas 95 26 15700 PMC 28107 PMID 9861033 Takahashi K Nakanishi H Miyahara M Mandai K Satoh K Satoh A Nishioka H Aoki J Nomoto A Mizoguchi A Takai Y May 1999 Nectin PRR An Immunoglobulin like Cell Adhesion Molecule Recruited to Cadherin based Adherens Junctions through Interaction with Afadin a PDZ Domain containing Protein J Cell Biol 145 3 539 49 doi 10 1083 jcb 145 3 539 PMC 2185068 PMID 10225955 Further reading editBustos T Simosa V Pinto Cisternas J Abramovits W Jolay L Rodriguez L Fernandez L Ramela M 1992 Autosomal recessive ectodermal dysplasia I An undescribed dysplasia malformation syndrome Am J Med Genet 41 4 398 404 doi 10 1002 ajmg 1320410403 PMID 1776626 Lopez M Eberle F Mattei MG Gabert J Birg F Bardin F Maroc C Dubreuil P 1995 Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor encoding gene Gene 155 2 261 5 doi 10 1016 0378 1119 94 00842 G PMID 7721102 Bonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Geraghty RJ Krummenacher C Cohen GH Eisenberg RJ Spear PG 1998 Entry of alphaherpesviruses mediated by poliovirus receptor related protein 1 and poliovirus receptor Science 280 5369 1618 20 Bibcode 1998Sci 280 1618G doi 10 1126 science 280 5369 1618 PMID 9616127 Suzuki K Bustos T Spritz RA 1998 Linkage disequilibrium mapping of the gene for Margarita Island ectodermal dysplasia ED4 to 11q23 Am J Hum Genet 63 4 1102 7 doi 10 1086 302072 PMC 1377504 PMID 9758630 Cocchi F Menotti L Mirandola P Lopez M Campadelli Fiume G 1998 The Ectodomain of a Novel Member of the Immunoglobulin Subfamily Related to the Poliovirus Receptor Has the Attributes of a Bona Fide Receptor for Herpes Simplex Virus Types 1 and 2 in Human Cells J Virol 72 12 9992 10002 doi 10 1128 JVI 72 12 9992 10002 1998 PMC 110516 PMID 9811737 Cocchi F Lopez M Menotti L Aoubala M Dubreuil P Campadelli Fiume G 1999 The V domain of herpesvirus Ig like receptor HIgR contains a major functional region in herpes simplex virus 1 entry into cells and interacts physically with the viral glycoprotein D Proc Natl Acad Sci U S A 95 26 15700 5 doi 10 1073 pnas 95 26 15700 PMC 28107 PMID 9861033 Takahashi K Nakanishi H Miyahara M Mandai K Satoh K Satoh A Nishioka H Aoki J Nomoto A Mizoguchi A Takai Y 1999 Nectin PRR An Immunoglobulin like Cell Adhesion Molecule Recruited to Cadherin based Adherens Junctions through Interaction with Afadin a PDZ Domain containing Protein J Cell Biol 145 3 539 49 doi 10 1083 jcb 145 3 539 PMC 2185068 PMID 10225955 Miyahara M Nakanishi H Takahashi K Satoh Horikawa K Tachibana K Takai Y 2000 Interaction of nectin with afadin is necessary for its clustering at cell cell contact sites but not for its cis dimerization or trans interaction J Biol Chem 275 1 613 8 doi 10 1074 jbc 275 1 613 PMID 10617658 Suzuki K Hu D Bustos T Zlotogora J Richieri Costa A Helms JA Spritz RA 2000 Mutations of PVRL1 encoding a cell cell adhesion molecule herpesvirus receptor in cleft lip palate ectodermal dysplasia Nat Genet 25 4 427 30 doi 10 1038 78119 PMID 10932188 S2CID 6169893 Lopez M Cocchi F Avitabile E Leclerc A Adelaide J Campadelli Fiume G Dubreuil P 2001 Novel Soluble Isoform of the Herpes Simplex Virus HSV Receptor Nectin1 or PRR1 HIgR HveC Modulates Positively and Negatively Susceptibility to HSV Infection J Virol 75 12 5684 91 doi 10 1128 JVI 75 12 5684 5691 2001 PMC 114282 PMID 11356977 Sozen MA Suzuki K Tolarova MM Bustos T Fernandez Iglesias JE Spritz RA 2001 Mutation of PVRL1 is associated with sporadic non syndromic cleft lip palate in northern Venezuela Nat Genet 29 2 141 2 doi 10 1038 ng740 PMID 11559849 S2CID 8641206 Struyf F Posavad CM Keyaerts E Van Ranst M Corey L Spear PG 2002 Search for polymorphisms in the genes for herpesvirus entry mediator nectin 1 and nectin 2 in immune seronegative individuals J Infect Dis 185 1 36 44 doi 10 1086 338116 PMID 11756979 Fabre S Reymond N Cocchi F Menotti L Dubreuil P Campadelli Fiume G Lopez M 2002 Prominent role of the Ig like V domain in trans interactions of nectins Nectin3 and nectin 4 bind to the predicted C C C D beta strands of the nectin1 V domain J Biol Chem 277 30 27006 13 doi 10 1074 jbc M203228200 PMID 12011057 Yoon M Spear PG 2002 Disruption of Adherens Junctions Liberates Nectin 1 To Serve as Receptor for Herpes Simplex Virus and Pseudorabies Virus Entry J Virol 76 14 7203 8 doi 10 1128 JVI 76 14 7203 7208 2002 PMC 136315 PMID 12072519 Struyf F Martinez WM Spear PG 2002 Mutations in the N Terminal Domains of Nectin 1 and Nectin 2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin Nectin Interactions J Virol 76 24 12940 50 doi 10 1128 JVI 76 24 12940 12950 2002 PMC 136698 PMID 12438620 Takekuni K Ikeda W Fujito T Morimoto K Takeuchi M Monden M Takai Y 2003 Direct binding of cell polarity protein PAR 3 to cell cell adhesion molecule nectin at neuroepithelial cells of developing mouse J Biol Chem 278 8 5497 500 doi 10 1074 jbc C200707200 PMID 12515806 Krummenacher C Baribaud I Eisenberg RJ Cohen GH 2003 Cellular Localization of Nectin 1 and Glycoprotein D during Herpes Simplex Virus Infection J Virol 77 16 8985 99 doi 10 1128 JVI 77 16 8985 8999 2003 PMC 167240 PMID 12885915 Bender FC Whitbeck JC Ponce de Leon M Lou H Eisenberg RJ Cohen GH 2003 Specific Association of Glycoprotein B with Lipid Rafts during Herpes Simplex Virus Entry J Virol 77 17 9542 52 doi 10 1128 JVI 77 17 9542 9552 2003 PMC 187402 PMID 12915568 External links editPVRL1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Poliovirus receptor related 1 amp oldid 1142719838, wikipedia, wiki, book, books, library,
