N,N-Dimethylphenethylamine (N,N-DMPEA) is a substituted phenethylamine that is used as a flavoring agent. It is an alkaloid that was first isolated from the orchid Eria jarensis.[1] Its aroma is described as "sweet, fishy". It is mainly used in cereal, cheese, dairy products, fish, fruit and meat.[2] It is also being used in pre-workout and bodybuilding supplements with claims of a stimulant effect.[3]
There is also evidence suggesting that N,N-DMPEA acts as a TAAR1agonist in humans,[4] and as a 5-HT1Aligand in rats. Some less conclusive research also indicated that it had interaction with MAO-B, most likely as an enzyme substrate and not an inhibitor.[5]
^K. Hedman, K. Leander and B. Luning (1969). "Studies on Orchidaceae Alkaloids. XV. Phenethylamines from Eria jarensis Ames". Acta Chem. Scand. 23: 3261. doi:10.3891/acta.chem.scand.23-3261.
^Burdock, G.A. (2016). Fenaroli's Handbook of Flavor Ingredients, Sixth Edition. CRC Press. p. 499. ISBN9781420090864. Retrieved 2016-09-13.
^"Eria Jarensis Extract / N-phenethyl dimethylamine: The Next Big Thing?". blog.priceplow.com. Retrieved 2016-10-05.
^Wainscott DB, Little SP, Yin T, Tu Y, Rocco VP, He JX, Nelson DL (January 2007). "Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1". The Journal of Pharmacology and Experimental Therapeutics. 320 (1): 475–485. doi:10.1124/jpet.106.112532. PMID 17038507. S2CID 10829497.
^"Flavor and Extract Manufacturers Association (FEMA) GRAS Flavoring Substances 22". www.femaflavor.org. Retrieved 2019-01-14.
^"Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)". apps.who.int. Retrieved 2019-01-14.
^"The Joint FAO/WHO Expert Committee on Food Additives (JECFA)". www.fao.org. Retrieved 2019-01-14. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) is an international expert scientific committee that is administered jointly by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO).
January 24, 2023
dimethylphenethylamine, dmpea, substituted, phenethylamine, that, used, flavoring, agent, alkaloid, that, first, isolated, from, orchid, eria, jarensis, aroma, described, sweet, fishy, mainly, used, cereal, cheese, dairy, products, fish, fruit, meat, also, bei. N N Dimethylphenethylamine N N DMPEA is a substituted phenethylamine that is used as a flavoring agent It is an alkaloid that was first isolated from the orchid Eria jarensis 1 Its aroma is described as sweet fishy It is mainly used in cereal cheese dairy products fish fruit and meat 2 It is also being used in pre workout and bodybuilding supplements with claims of a stimulant effect 3 N N Dimethylphenethylamine NamesPreferred IUPAC name N N Dimethyl 2 phenylethan 1 amineOther names N N Dimethyl 2 phenylethanamineN N Dimethyl b phenylethylamineN N DMPEAIdentifiersCAS Number 1126 71 23D model JSmol Interactive imageChemSpider 23470ECHA InfoCard 100 156 869PubChem CID 25125UNII I4C10U12C8 YCompTox Dashboard EPA DTXSID40150114InChI InChI 1S C10H15N c1 11 2 9 8 10 6 4 3 5 7 10 h3 7H 8 9H2 1 2H3Key TXOFSCODFRHERQ UHFFFAOYSA NSMILES CN C CCC1 CC CC C1PropertiesChemical formula C 10H 15NMolar mass 149 237 g mol 1Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox references There is also evidence suggesting that N N DMPEA acts as a TAAR1 agonist in humans 4 and as a 5 HT1A ligand in rats Some less conclusive research also indicated that it had interaction with MAO B most likely as an enzyme substrate and not an inhibitor 5 N N DMPEA is a positional isomer of methamphetamine Safety EditN N DMPEA has been found to be safe for use as a flavoring agent by the Flavor and Extract Manufacturers Association FEMA Expert Panel 6 and also by the Joint Expert Committee on Food Additives JECFA 7 a collaboration between the Food and Agricultural Organization of the United Nations FAO and the World Health Organization 8 References Edit K Hedman K Leander and B Luning 1969 Studies on Orchidaceae Alkaloids XV Phenethylamines from Eria jarensis Ames Acta Chem Scand 23 3261 doi 10 3891 acta chem scand 23 3261 Burdock G A 2016 Fenaroli s Handbook of Flavor Ingredients Sixth Edition CRC Press p 499 ISBN 9781420090864 Retrieved 2016 09 13 Eria Jarensis Extract N phenethyl dimethylamine The Next Big Thing blog priceplow com Retrieved 2016 10 05 Wainscott DB Little SP Yin T Tu Y Rocco VP He JX Nelson DL January 2007 Pharmacologic characterization of the cloned human trace amine associated receptor1 TAAR1 and evidence for species differences with the rat TAAR1 The Journal of Pharmacology and Experimental Therapeutics 320 1 475 485 doi 10 1124 jpet 106 112532 PMID 17038507 S2CID 10829497 Pubchem N N Dimethylphenethylamine C10H15N PubChem pubchem ncbi nlm nih gov Retrieved 2016 10 05 Flavor and Extract Manufacturers Association FEMA GRAS Flavoring Substances 22 www femaflavor org Retrieved 2019 01 14 Evaluations of the Joint FAO WHO Expert Committee on Food Additives JECFA apps who int Retrieved 2019 01 14 The Joint FAO WHO Expert Committee on Food Additives JECFA www fao org Retrieved 2019 01 14 The Joint FAO WHO Expert Committee on Food Additives JECFA is an international expert scientific committee that is administered jointly by the Food and Agriculture Organization of the United Nations FAO and the World Health Organization WHO Retrieved from https en wikipedia org w index php title N N Dimethylphenethylamine amp oldid 1102758256, wikipedia, wiki, book, books, library,
