In pharmacology and biochemistry, mode of action (MoA) describes a functional or anatomical change, resulting from the exposure of a living organism to a substance.[1] In comparison, a mechanism of action (MOA) describes such changes at the molecular level.[2][1]
A mode of action is important in classifying chemicals, as it represents an intermediate level of complexity in between molecular mechanisms and physiological outcomes, especially when the exact molecular target has not yet been elucidated or is subject to debate. A mechanism of action of a chemical could be "binding to DNA" while its broader mode of action would be "transcriptional regulation".[3] However, there is no clear consensus and the term mode of action is also often used, especially in the study of pesticides, to describe molecular mechanisms such as action on specific nuclear receptors or enzymes.[4][5][6][7][8][9][10]
^ abGrant RL, Combs AB, Acosta D (2010). "Experimental Models for the Investigation of Toxicological Mechanisms". In McQueen CA (ed.). Comprehensive Toxicology (2nd ed.). Oxford: Elsevier. p. 204. ISBN978-0-08-046884-6.
^(PDF). US EPA. Archived from the original (PDF) on 26 February 2015. Retrieved 11 June 2012.
^Ng, Wai-Leung; Krystyna M. Kazmierczak; Gregory T. Robertson; Raymond Gilmour; Malcolm E. Winkler (Jan 2003). "Transcriptional Regulation and Signature Patterns Revealed by Microarray Analyses of Streptococcus Pneumoniae R6 Challenged with Sublethal Concentrations of Translation Inhibitors". Journal of Bacteriology. 185 (1): 359–70. doi:10.1128/JB.185.1.359-370.2003. PMC141824. PMID 12486074.
^. Alberta Agriculture and Rural Development. Archived from the original on 2019-01-23. Retrieved 11 June 2012.
^United States Environmental Protection Agency. "PESTICIDE REGISTRATION NOTICE (PRN) 2017-1 NOTICE TO MANUFACTURERS, PRODUCERS, PRODUCERS AND REGISTRANTS OF PESTICIDE PRODUCTS AND DEVICES" (PDF).
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mode, action, pharmacology, biochemistry, mode, action, describes, functional, anatomical, change, resulting, from, exposure, living, organism, substance, comparison, mechanism, action, describes, such, changes, molecular, level, mode, action, important, class. In pharmacology and biochemistry mode of action MoA describes a functional or anatomical change resulting from the exposure of a living organism to a substance 1 In comparison a mechanism of action MOA describes such changes at the molecular level 2 1 A mode of action is important in classifying chemicals as it represents an intermediate level of complexity in between molecular mechanisms and physiological outcomes especially when the exact molecular target has not yet been elucidated or is subject to debate A mechanism of action of a chemical could be binding to DNA while its broader mode of action would be transcriptional regulation 3 However there is no clear consensus and the term mode of action is also often used especially in the study of pesticides to describe molecular mechanisms such as action on specific nuclear receptors or enzymes 4 5 6 7 8 9 10 See also EditMechanism of action in pharmaceuticals Adverse outcome pathwayReferences Edit a b Grant RL Combs AB Acosta D 2010 Experimental Models for the Investigation of Toxicological Mechanisms In McQueen CA ed Comprehensive Toxicology 2nd ed Oxford Elsevier p 204 ISBN 978 0 08 046884 6 Mechanisms and mode of dioxin action PDF US EPA Archived from the original PDF on 26 February 2015 Retrieved 11 June 2012 Ng Wai Leung Krystyna M Kazmierczak Gregory T Robertson Raymond Gilmour Malcolm E Winkler Jan 2003 Transcriptional Regulation and Signature Patterns Revealed by Microarray Analyses of Streptococcus Pneumoniae R6 Challenged with Sublethal Concentrations of Translation Inhibitors Journal of Bacteriology 185 1 359 70 doi 10 1128 JB 185 1 359 370 2003 PMC 141824 PMID 12486074 Herbicide Group Classification by Mode of Action Alberta Agriculture and Rural Development Archived from the original on 2019 01 23 Retrieved 11 June 2012 FRAC Fungicide Resistance Action Committee March 2021 FRAC Code List c 2021 Fungal control agents sorted by cross resistance pattern and mode of action including coding for FRAC Groups on product labels PDF Weed Science Society of America Summary of Herbicide Mechanism of Action According to the Weed Science Society of America WSSA PDF Heap Ian HERBICIDE MODE OF ACTION TABLE HRAC MOA 2020 Revision Description and Master Herbicide List Herbicide Resistance Action Committee 2020 09 14 Retrieved 2021 04 01 Interactive MoA Classification Insecticide Resistance Action Committee 2020 09 16 Retrieved 2021 04 01 United States Environmental Protection Agency PESTICIDE REGISTRATION NOTICE PRN 2017 1 NOTICE TO MANUFACTURERS PRODUCERS PRODUCERS AND REGISTRANTS OF PESTICIDE PRODUCTS AND DEVICES PDF This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Mode of action amp oldid 1146912427, wikipedia, wiki, book, books, library,
