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Methamnetamine

January 18, 2023

Methamnetamine (also known as methylnaphetamine, MNA, MNT and PAL-1046) is a triple monoamine releasing agent and N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine.[1][2][3] It has been sold online as a designer drug.[4][5]

Methamnetamine
Legal status
Legal status
Identifiers
  • N-Methyl-1-(naphthalen-2-yl)propan-2-amine
CAS Number
  • 1178720-66-5 Y
PubChem CID
  • 17802040
ChemSpider
  • 38754167
UNII
  • CAS64BB01B
Chemical and physical data
FormulaC14H17N
Molar mass199.297 g·mol−1
3D model (JSmol)
  • Interactive image
  • CNC(C)Cc1ccc2ccccc2c1
  • InChI=1S/C14H17N/c1-11(15-2)9-12-7-8-13-5-3-4-6-14(13)10-12/h3-8,10-11,15H,9H2,1-2H3
  • Key:BWWWOLYZMKACSB-UHFFFAOYSA-N

It acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively.[1]

Legal status

Methamnetamine is illegal in Japan.[6]

See also

References

  1. ^ a b Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE (April 2012). "Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters". The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251–62. doi:10.1124/jpet.111.188946. PMC 3364510. PMID 22271821.
  2. ^ Youn, Dong-Hyun; Kim, Jin Mook; Hong, Young-ki; Park, Seo-In; Lee, Jin-Moo; Kim, Young-Hoon; Park, Chang Won; Kang, Mi Sun (April 2021). "Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study". Psychopharmacology. 238 (8): 2155–2165. doi:10.1007/s00213-021-05840-9. ISSN 1432-2072. PMID 33811503. S2CID 232773019.
  3. ^ Hong, Young-ki; Kim, Young-Hoon; Lee, Jin-Moo; Yoo, Hye Hyun; Choi, Sun-Ok; Kang, Mi Sun (April 2021). "Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry". International Journal of Legal Medicine. 135 (4): 1471–1476. doi:10.1007/s00414-021-02594-z. ISSN 1437-1596. PMID 33928430. S2CID 233451101.
  4. ^ "Methamnetamine". WEDINOS.
  5. ^ "Methamnetamine". New Synthetic Drugs Database.
  6. ^ "指定薬物名称・構造式一覧（平成27年9月16日現在）" (PDF) (in Japanese). 厚生労働省. 16 September 2015. Retrieved 8 October 2015.
 

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

January 18, 2023
methamnetamine, also, known, methylnaphetamine, 1046, triple, monoamine, releasing, agent, methyl, analog, neurotoxic, experimental, drug, naphthylaminopropane, naphthalene, analog, methamphetamine, been, sold, online, designer, drug, legal, statuslegal, statu. Methamnetamine also known as methylnaphetamine MNA MNT and PAL 1046 is a triple monoamine releasing agent and N methyl analog of the non neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine 1 2 3 It has been sold online as a designer drug 4 5 MethamnetamineLegal statusLegal statusDE NpSG Industrial and scientific use only UK Under Psychoactive Substances Act Illegal in JapanIdentifiersIUPAC name N Methyl 1 naphthalen 2 yl propan 2 amineCAS Number1178720 66 5 YPubChem CID17802040ChemSpider38754167UNIICAS64BB01BChemical and physical dataFormulaC 14H 17NMolar mass199 297 g mol 13D model JSmol Interactive imageSMILES CNC C Cc1ccc2ccccc2c1InChI InChI 1S C14H17N c1 11 15 2 9 12 7 8 13 5 3 4 6 14 13 10 12 h3 8 10 11 15H 9H2 1 2H3Key BWWWOLYZMKACSB UHFFFAOYSA NIt acts as a releasing agent of serotonin norepinephrine and dopamine with EC50 values of 13 nM 34 nM and 10 nM respectively 1 Legal status EditMethamnetamine is illegal in Japan 6 See also Edit2 MAPB BMAPN Naphthylaminopropane HDEP 28 HDMP 28 Naphyrone WF 23References Edit a b Rothman RB Partilla JS Baumann MH Lightfoot Siordia C Blough BE April 2012 Studies of the biogenic amine transporters 14 Identification of low efficacy partial substrates for the biogenic amine transporters The Journal of Pharmacology and Experimental Therapeutics 341 1 251 62 doi 10 1124 jpet 111 188946 PMC 3364510 PMID 22271821 Youn Dong Hyun Kim Jin Mook Hong Young ki Park Seo In Lee Jin Moo Kim Young Hoon Park Chang Won Kang Mi Sun April 2021 Assessment of the abuse potential of methamnetamine in rodents a behavioral pharmacology study Psychopharmacology 238 8 2155 2165 doi 10 1007 s00213 021 05840 9 ISSN 1432 2072 PMID 33811503 S2CID 232773019 Hong Young ki Kim Young Hoon Lee Jin Moo Yoo Hye Hyun Choi Sun Ok Kang Mi Sun April 2021 Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography quadrupole time of flight mass spectrometry International Journal of Legal Medicine 135 4 1471 1476 doi 10 1007 s00414 021 02594 z ISSN 1437 1596 PMID 33928430 S2CID 233451101 Methamnetamine WEDINOS Methamnetamine New Synthetic Drugs Database 指定薬物名称 構造式一覧 平成27年9月16日現在 PDF in Japanese 厚生労働省 16 September 2015 Retrieved 8 October 2015 This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Methamnetamine amp oldid 1120771600, wikipedia, wiki, book, books, library,

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