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Mercapturic acid

Mercapturic acids are condensation products formed from the coupling of cysteine with aromatic compounds.[1] They are formed as conjugates in the liver and are excreted in the urine.[1]

Glutathione adducts lose glutamate and glycine portions, and are acetylated to form mercapturic acids, which are excreted.

Levels of mercapturic acids in urine may be used as an indicator of exposure to, e.g., ethylene dibromide,[2] acrylamide, and terbuthylazine.[3]

References edit

  1. ^ a b medical-dictionary.thefreedictionary.com Retrieved on June 25, 2009
  2. ^ Kim DH, Guengerich FP (November 1989). "Excretion of the mercapturic acid S-[2-(N7-guanyl)ethyl]-N-acetylcysteine in urine following administration of ethylene dibromide to rats". Cancer Res. 49 (21): 5843–7. PMID 2790795.
  3. ^ Mercadante R, Polledri E, Fustinoni S (July 2012). "Determination of terbuthylazine and desethylterbuthylazine in human urine and hair samples by eletrospray ionization-liquid chromatography/triple quadrupole mass spectrometry". Analytical and Bioanalytical Chemistry. 404 (3): 875–86. doi:10.1007/s00216-012-6184-3. PMID 22752446. S2CID 2087135.

mercapturic, acid, this, article, technical, most, readers, understand, please, help, improve, make, understandable, experts, without, removing, technical, details, september, 2015, learn, when, remove, this, template, message, condensation, products, formed, . This article may be too technical for most readers to understand Please help improve it to make it understandable to non experts without removing the technical details September 2015 Learn how and when to remove this template message Mercapturic acids are condensation products formed from the coupling of cysteine with aromatic compounds 1 They are formed as conjugates in the liver and are excreted in the urine 1 Glutathione adducts lose glutamate and glycine portions and are acetylated to form mercapturic acids which are excreted Levels of mercapturic acids in urine may be used as an indicator of exposure to e g ethylene dibromide 2 acrylamide and terbuthylazine 3 References edit a b medical dictionary thefreedictionary com Retrieved on June 25 2009 Kim DH Guengerich FP November 1989 Excretion of the mercapturic acid S 2 N7 guanyl ethyl N acetylcysteine in urine following administration of ethylene dibromide to rats Cancer Res 49 21 5843 7 PMID 2790795 Mercadante R Polledri E Fustinoni S July 2012 Determination of terbuthylazine and desethylterbuthylazine in human urine and hair samples by eletrospray ionization liquid chromatography triple quadrupole mass spectrometry Analytical and Bioanalytical Chemistry 404 3 875 86 doi 10 1007 s00216 012 6184 3 PMID 22752446 S2CID 2087135 nbsp This human digestive system article is a stub You can help Wikipedia by expanding it vte nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Mercapturic acid amp oldid 1195193903, wikipedia, wiki, book, books, library,

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