in differentiating iron deficiency anemia from beta thalassemia
The index is calculated from the results of a complete blood count. If the quotient of the mean corpuscular volume (MCV, in fL) divided by the red blood cell count (RBC, in million per microliter) is less than 13, β-thalassemia trait is said to be more likely. If the result is greater than 13, then iron-deficiency anemia is said to be more likely.[4][3]
The principle involved is as follows: In iron deficiency, the marrow cannot produce as many RBCs and they are small (microcytic), so the RBC count and the MCV will both be low, and as a result, the index will be greater than 13. Conversely, in thalassemia, which is a disorder of globin synthesis, the number of RBCs produced is normal, but the cells are smaller and more fragile. Therefore, the RBC count is normal, but the MCV is low, so the index will be less than 13.[5]
Referencesedit
^Mentzer WC (April 1973). "Differentiation of iron deficiency from thalassaemia trait". Lancet. 1 (7808): 882. doi:10.1016/S0140-6736(73)91446-3. PMID 4123424.
^Ntaios G, Chatzinikolaou A, Saouli Z, et al. (July 2007). "Discrimination indices as screening tests for beta-thalassemic trait". Ann. Hematol. 86 (7): 487–91. doi:10.1007/s00277-007-0302-x. PMID 17476506. S2CID 10499303.
mentzer, index, described, 1973, william, mentzer, divided, count, said, helpful, differentiating, iron, deficiency, anemia, from, beta, thalassemia, trait, purposein, differentiating, iron, deficiency, anemia, from, beta, thalassemia, index, calculated, from,. The Mentzer index described in 1973 by William C Mentzer 1 is the MCV divided by the RBC count It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia trait 2 3 Mentzer indexPurposein differentiating iron deficiency anemia from beta thalassemia The index is calculated from the results of a complete blood count If the quotient of the mean corpuscular volume MCV in fL divided by the red blood cell count RBC in million per microliter is less than 13 b thalassemia trait is said to be more likely If the result is greater than 13 then iron deficiency anemia is said to be more likely 4 3 The principle involved is as follows In iron deficiency the marrow cannot produce as many RBCs and they are small microcytic so the RBC count and the MCV will both be low and as a result the index will be greater than 13 Conversely in thalassemia which is a disorder of globin synthesis the number of RBCs produced is normal but the cells are smaller and more fragile Therefore the RBC count is normal but the MCV is low so the index will be less than 13 5 References edit Mentzer WC April 1973 Differentiation of iron deficiency from thalassaemia trait Lancet 1 7808 882 doi 10 1016 S0140 6736 73 91446 3 PMID 4123424 Ntaios G Chatzinikolaou A Saouli Z et al July 2007 Discrimination indices as screening tests for beta thalassemic trait Ann Hematol 86 7 487 91 doi 10 1007 s00277 007 0302 x PMID 17476506 S2CID 10499303 a b Beta Thalassemia Differential Diagnoses emedicine medscape com Retrieved 2023 06 28 Joseph Mazza 15 January 2002 Manual of clinical hematology Lippincott Williams amp Wilkins pp 152 ISBN 978 0 7817 2980 2 Retrieved 4 June 2010 Mentzer Index reference medscape com Retrieved 2023 06 28 nbsp This medical diagnostic article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Mentzer index amp oldid 1162351052, wikipedia, wiki, book, books, library,
