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Matthias Lütolf

January 01, 1970

Matthias Lutolf (born in 1973, also known as Matthias Lütolf) is a bio-engineer and a professor at EPFL (École Polytechnique Fédérale de Lausanne) where he leads the Laboratory of Stem Cell Bioengineering.[1][2] He is specialised in biomaterials, and in combining stem cell biology and engineering to develop improved organoid models.[3][4] In 2021, he became the scientific director for Roche's Institute for Translation Bioengineering in Basel.[5]

Professor
Matthias Lütolf
Born1973 (age 50–51)
CitizenshipSwiss
EducationMaterials engineering
Biomedical engineering
Alma materETH Zurich
Stanford University
Known forBiomaterials
stem cell biology
Organoid models
Scientific career
FieldsStem Cells
Biomaterials
Tissue Engineering
Microfluidics
Single-Cell Analysis
High-Throughput Screening
InstitutionsEPFL (École Polytechnique Fédérale de Lausanne)
ThesisCell-responsive synthetic hydrogels (2002)
Doctoral advisorJeffrey Hubbell
Websitewww.epfl.ch/labs/lutolf-lab/

Career edit

Lutolf studied materials engineering at ETH Zurich where he graduated in 1998. In 2002, he received his PhD in biomedical engineering from ETH Zurich for his studies on cell-responsive hydrogels for tissue engineering and cell culture, in the group of Jeffrey Hubbell.[6][7] He completed postdoctoral studies in the laboratory of Helen Blau at Stanford University, where he worked on novel cell culture approaches for blood and muscle stem cells, so called synthetic niches.[8][9] In 2007, he founded his own laboratory at EPFL, where he was promoted to associate professor in 2014 and full professor in 2018.[1] From 2014 to 2018, he was director of EPFL's Institute of Bioengineering.[10] In June 2021, Lutolf became scientific director of the newly established Roche Institute for Translational Bioengineering in Basel, Switzerland.[5]

Research edit

Lutolf's laboratory develops in vitro organoids mimicking healthy and diseased tissues and organs.[2] Specifically, Lutolf uses bioengineering strategies to guide stem cell-based development to build novel organoids with improved reproducibility and physiological relevance for basic science and in vitro testing of drug candidates. His team has developed approaches to generate organoids in fully controllable 3D matrices,[11][12] and has contributed to the understanding of how extrinsic biochemical and physical factors control stem cell fate and organogenesis.[13][14] His team has developed concepts based on microfabrication,[15] bioprinting,[16] and microfluidics[17] to improve the reproducibility, size, shape, and function of organoids.

Distinctions edit

In 2007, Lutolf received the European Young Investigator (EURYI) Award by the European Science Foundation.[18] Since 2018, he is elected as member of the European Molecular Biology Organization (EMBO).[19] He serves as associate editor of The Company of Biologists' journal Development.[20]

Publications edit

  • Hofer M, Lutolf MP (May 2021). "Engineering organoids". Nature Reviews. Materials. 6 (5): 402–420. Bibcode:2021NatRM...6..402H. doi:10.1038/s41578-021-00279-y. PMC 7893133. PMID 33623712.
  • Lutolf, M P; Hubbell, J A (January 2005). "Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering". Nature Biotechnology. 23 (1): 47–55. doi:10.1038/nbt1055. ISSN 1087-0156. PMID 15637621. S2CID 6706970.
  • Lutolf, M. P.; Lauer-Fields, J. L.; Schmoekel, H. G.; Metters, A. T.; Weber, F. E.; Fields, G. B.; Hubbell, J. A. (2003-04-09). "Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics". Proceedings of the National Academy of Sciences. 100 (9): 5413–5418. Bibcode:2003PNAS..100.5413L. doi:10.1073/pnas.0737381100. ISSN 0027-8424. PMC 154359. PMID 12686696.
  • Lutolf, Matthias P.; Gilbert, Penney M.; Blau, Helen M. (November 2009). "Designing materials to direct stem-cell fate". Nature. 462 (7272): 433–441. Bibcode:2009Natur.462..433L. doi:10.1038/nature08602. ISSN 0028-0836. PMC 2908011. PMID 19940913.
  • Gilbert, P. M.; Havenstrite, K. L.; Magnusson, K. E. G.; Sacco, A.; Leonardi, N. A.; Kraft, P.; Nguyen, N. K.; Thrun, S.; Lutolf, M. P.; Blau, H. M. (2010-07-15). "Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture". Science. 329 (5995): 1078–1081. Bibcode:2010Sci...329.1078G. doi:10.1126/science.1191035. ISSN 0036-8075. PMC 2929271. PMID 20647425.
  • Lutolf, Matthias P.; Weber, Franz E.; Schmoekel, Hugo G.; Schense, Jason C.; Kohler, Thomas; Müller, Ralph; Hubbell, Jeffrey A. (2003-04-21). "Repair of bone defects using synthetic mimetics of collagenous extracellular matrices". Nature Biotechnology. 21 (5): 513–518. doi:10.1038/nbt818. ISSN 1087-0156. PMID 12704396. S2CID 7144594.
  • Lutolf, M. P.; Hubbell, J. A. (May 2003). "Synthesis and Physicochemical Characterization of End-Linked Poly(ethylene glycol)-co-peptide Hydrogels Formed by Michael-Type Addition". Biomacromolecules. 4 (3): 713–722. doi:10.1021/bm025744e. ISSN 1525-7797. PMID 12741789.
  • Gjorevski, Nikolce; Sachs, Norman; Manfrin, Andrea; Giger, Sonja; Bragina, Maiia E.; Ordóñez-Morán, Paloma; Clevers, Hans; Lutolf, Matthias P. (2016-11-16). "Designer matrices for intestinal stem cell and organoid culture". Nature. 539 (7630): 560–564. doi:10.1038/nature20168. ISSN 0028-0836. PMID 27851739. S2CID 4470849.
  • Zhang, H.; Ryu, D.; Wu, Y.; Gariani, K.; Wang, X.; Luan, P.; DAmico, D.; Ropelle, E. R.; Lutolf, M. P.; Aebersold, R.; Schoonjans, K. (2016-06-17). "NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice". Science. 352 (6292): 1436–1443. Bibcode:2016Sci...352.1436Z. doi:10.1126/science.aaf2693. ISSN 0036-8075. PMID 27127236.

External links edit

  • Matthias Lütolf publications indexed by Google Scholar
  • Website of the Laboratory of Stem Cell Bioengineering

References edit

  1. ^ a b "13 new professors appointed at ETH Zurich and EPFL | ETH-Board". www.ethrat.ch. Retrieved 2021-08-20.
  2. ^ a b "Laboratory of Stem Cell Bioengineering ‐ EPFL". www.epfl.ch. Retrieved 2021-08-20.
  3. ^ "Institute of Chemical Sciences and Engineering – ISIC". www.epfl.ch. Retrieved 2020-08-24.
  4. ^ "Laboratory of Stem Cell Bioengineering ‐ EPFL". www.epfl.ch. Retrieved 2020-08-24.
  5. ^ a b "The Roche Institute for Translational Bioengineering". www.roche.com. Retrieved 2021-08-20.
  6. ^ Lütolf, Matthias (2002). Cell-responsive synthetic hydrogels (Doctoral Thesis thesis). ETH Zurich.
  7. ^ Lutolf, Matthias P.; Weber, Franz E.; Schmoekel, Hugo G.; Schense, Jason C.; Kohler, Thomas; Müller, Ralph; Hubbell, Jeffrey A. (May 2003). "Repair of bone defects using synthetic mimetics of collagenous extracellular matrices". Nature Biotechnology. 21 (5): 513–518. doi:10.1038/nbt818. ISSN 1087-0156. PMID 12704396. S2CID 7144594.
  8. ^ Lutolf, Matthias P.; Gilbert, Penney M.; Blau, Helen M. (November 2009). "Designing materials to direct stem-cell fate". Nature. 462 (7272): 433–441. Bibcode:2009Natur.462..433L. doi:10.1038/nature08602. ISSN 1476-4687. PMC 2908011. PMID 19940913.
  9. ^ Gilbert, P. M.; Havenstrite, K. L.; Magnusson, K. E. G.; Sacco, A.; Leonardi, N. A.; Kraft, P.; Nguyen, N. K.; Thrun, S.; Lutolf, M. P.; Blau, H. M. (2010-08-27). "Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture". Science. 329 (5995): 1078–1081. Bibcode:2010Sci...329.1078G. doi:10.1126/science.1191035. ISSN 0036-8075. PMC 2929271. PMID 20647425.
  10. ^ Bhagwat, V. M.; Ramachandran, B. V. (1975-09-15). "Malathion A and B esterases of mouse liver-I". Biochemical Pharmacology. 24 (18): 1713–1717. doi:10.1016/0006-2952(75)90011-8. ISSN 0006-2952. PMID 14.
  11. ^ Gjorevski, Nikolce; Sachs, Norman; Manfrin, Andrea; Giger, Sonja; Bragina, Maiia E.; Ordóñez-Morán, Paloma; Clevers, Hans; Lutolf, Matthias P. (November 2016). "Designer matrices for intestinal stem cell and organoid culture". Nature. 539 (7630): 560–564. doi:10.1038/nature20168. ISSN 1476-4687. PMID 27851739. S2CID 4470849.
  12. ^ Caiazzo, Massimiliano; Okawa, Yuya; Ranga, Adrian; Piersigilli, Alessandra; Tabata, Yoji; Lutolf, Matthias P. (March 2016). "Defined three-dimensional microenvironments boost induction of pluripotency". Nature Materials. 15 (3): 344–352. Bibcode:2016NatMa..15..344C. doi:10.1038/nmat4536. ISSN 1476-4660. PMID 26752655.
  13. ^ Gobaa, Samy; Hoehnel, Sylke; Roccio, Marta; Negro, Andrea; Kobel, Stefan; Lutolf, Matthias P. (November 2011). "Artificial niche microarrays for probing single stem cell fate in high throughput". Nature Methods. 8 (11): 949–955. doi:10.1038/nmeth.1732. ISSN 1548-7105. PMID 21983923. S2CID 310516.
  14. ^ Ranga, A.; Gobaa, S.; Okawa, Y.; Mosiewicz, K.; Negro, A.; Lutolf, M. P. (2014-07-14). "3D niche microarrays for systems-level analyses of cell fate". Nature Communications. 5 (1): 4324. Bibcode:2014NatCo...5.4324R. doi:10.1038/ncomms5324. ISSN 2041-1723. PMC 4104440. PMID 25027775.
  15. ^ Brandenberg, Nathalie; Hoehnel, Sylke; Kuttler, Fabien; Homicsko, Krisztian; Ceroni, Camilla; Ringel, Till; Gjorevski, Nikolce; Schwank, Gerald; Coukos, George; Turcatti, Gerardo; Lutolf, Matthias P. (September 2020). "High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays". Nature Biomedical Engineering. 4 (9): 863–874. doi:10.1038/s41551-020-0565-2. ISSN 2157-846X. PMID 32514094. S2CID 219543643.
  16. ^ Brassard, Jonathan A.; Nikolaev, Mike; Hübscher, Tania; Hofer, Moritz; Lutolf, Matthias P. (January 2021). "Recapitulating macro-scale tissue self-organization through organoid bioprinting". Nature Materials. 20 (1): 22–29. Bibcode:2021NatMa..20...22B. doi:10.1038/s41563-020-00803-5. ISSN 1476-4660. PMID 32958879. S2CID 221825383.
  17. ^ Nikolaev, Mikhail; Mitrofanova, Olga; Broguiere, Nicolas; Geraldo, Sara; Dutta, Devanjali; Tabata, Yoji; Elci, Bilge; Brandenberg, Nathalie; Kolotuev, Irina; Gjorevski, Nikolce; Clevers, Hans (September 2020). "Homeostatic mini-intestines through scaffold-guided organoid morphogenesis". Nature. 585 (7826): 574–578. Bibcode:2020Natur.585..574N. doi:10.1038/s41586-020-2724-8. ISSN 1476-4687. PMID 32939089. S2CID 221769498.
  18. ^ "2007 : European Science Foundation". archives.esf.org. Retrieved 2021-08-20.
  19. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 2021-08-20.
  20. ^ "Editors and Board | Development | The Company of Biologists | Development | The Company of Biologists". journals.biologists.com. Retrieved 2021-08-20.

January 01, 1970
matthias, lütolf, major, contributor, this, article, appears, have, close, connection, with, subject, require, cleanup, comply, with, wikipedia, content, policies, particularly, neutral, point, view, please, discuss, further, talk, page, august, 2020, learn, w. A major contributor to this article appears to have a close connection with its subject It may require cleanup to comply with Wikipedia s content policies particularly neutral point of view Please discuss further on the talk page August 2020 Learn how and when to remove this message Matthias Lutolf born in 1973 also known as Matthias Lutolf is a bio engineer and a professor at EPFL Ecole Polytechnique Federale de Lausanne where he leads the Laboratory of Stem Cell Bioengineering 1 2 He is specialised in biomaterials and in combining stem cell biology and engineering to develop improved organoid models 3 4 In 2021 he became the scientific director for Roche s Institute for Translation Bioengineering in Basel 5 ProfessorMatthias LutolfBorn1973 age 50 51 CitizenshipSwissEducationMaterials engineeringBiomedical engineeringAlma materETH ZurichStanford UniversityKnown forBiomaterialsstem cell biology Organoid modelsScientific careerFieldsStem Cells Biomaterials Tissue Engineering Microfluidics Single Cell Analysis High Throughput ScreeningInstitutionsEPFL Ecole Polytechnique Federale de Lausanne ThesisCell responsive synthetic hydrogels 2002 Doctoral advisorJeffrey HubbellWebsitewww wbr epfl wbr ch wbr labs wbr lutolf lab wbr Contents 1 Career 2 Research 3 Distinctions 4 Publications 5 External links 6 ReferencesCareer editLutolf studied materials engineering at ETH Zurich where he graduated in 1998 In 2002 he received his PhD in biomedical engineering from ETH Zurich for his studies on cell responsive hydrogels for tissue engineering and cell culture in the group of Jeffrey Hubbell 6 7 He completed postdoctoral studies in the laboratory of Helen Blau at Stanford University where he worked on novel cell culture approaches for blood and muscle stem cells so called synthetic niches 8 9 In 2007 he founded his own laboratory at EPFL where he was promoted to associate professor in 2014 and full professor in 2018 1 From 2014 to 2018 he was director of EPFL s Institute of Bioengineering 10 In June 2021 Lutolf became scientific director of the newly established Roche Institute for Translational Bioengineering in Basel Switzerland 5 Research editLutolf s laboratory develops in vitro organoids mimicking healthy and diseased tissues and organs 2 Specifically Lutolf uses bioengineering strategies to guide stem cell based development to build novel organoids with improved reproducibility and physiological relevance for basic science and in vitro testing of drug candidates His team has developed approaches to generate organoids in fully controllable 3D matrices 11 12 and has contributed to the understanding of how extrinsic biochemical and physical factors control stem cell fate and organogenesis 13 14 His team has developed concepts based on microfabrication 15 bioprinting 16 and microfluidics 17 to improve the reproducibility size shape and function of organoids Distinctions editIn 2007 Lutolf received the European Young Investigator EURYI Award by the European Science Foundation 18 Since 2018 he is elected as member of the European Molecular Biology Organization EMBO 19 He serves as associate editor of The Company of Biologists journal Development 20 Publications editHofer M Lutolf MP May 2021 Engineering organoids Nature Reviews Materials 6 5 402 420 Bibcode 2021NatRM 6 402H doi 10 1038 s41578 021 00279 y PMC 7893133 PMID 33623712 Lutolf M P Hubbell J A January 2005 Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering Nature Biotechnology 23 1 47 55 doi 10 1038 nbt1055 ISSN 1087 0156 PMID 15637621 S2CID 6706970 Lutolf M P Lauer Fields J L Schmoekel H G Metters A T Weber F E Fields G B Hubbell J A 2003 04 09 Synthetic matrix metalloproteinase sensitive hydrogels for the conduction of tissue regeneration Engineering cell invasion characteristics Proceedings of the National Academy of Sciences 100 9 5413 5418 Bibcode 2003PNAS 100 5413L doi 10 1073 pnas 0737381100 ISSN 0027 8424 PMC 154359 PMID 12686696 Lutolf Matthias P Gilbert Penney M Blau Helen M November 2009 Designing materials to direct stem cell fate Nature 462 7272 433 441 Bibcode 2009Natur 462 433L doi 10 1038 nature08602 ISSN 0028 0836 PMC 2908011 PMID 19940913 Gilbert P M Havenstrite K L Magnusson K E G Sacco A Leonardi N A Kraft P Nguyen N K Thrun S Lutolf M P Blau H M 2010 07 15 Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self Renewal in Culture Science 329 5995 1078 1081 Bibcode 2010Sci 329 1078G doi 10 1126 science 1191035 ISSN 0036 8075 PMC 2929271 PMID 20647425 Lutolf Matthias P Weber Franz E Schmoekel Hugo G Schense Jason C Kohler Thomas Muller Ralph Hubbell Jeffrey A 2003 04 21 Repair of bone defects using synthetic mimetics of collagenous extracellular matrices Nature Biotechnology 21 5 513 518 doi 10 1038 nbt818 ISSN 1087 0156 PMID 12704396 S2CID 7144594 Lutolf M P Hubbell J A May 2003 Synthesis and Physicochemical Characterization of End Linked Poly ethylene glycol co peptide Hydrogels Formed by Michael Type Addition Biomacromolecules 4 3 713 722 doi 10 1021 bm025744e ISSN 1525 7797 PMID 12741789 Gjorevski Nikolce Sachs Norman Manfrin Andrea Giger Sonja Bragina Maiia E Ordonez Moran Paloma Clevers Hans Lutolf Matthias P 2016 11 16 Designer matrices for intestinal stem cell and organoid culture Nature 539 7630 560 564 doi 10 1038 nature20168 ISSN 0028 0836 PMID 27851739 S2CID 4470849 Zhang H Ryu D Wu Y Gariani K Wang X Luan P DAmico D Ropelle E R Lutolf M P Aebersold R Schoonjans K 2016 06 17 NAD repletion improves mitochondrial and stem cell function and enhances life span in mice Science 352 6292 1436 1443 Bibcode 2016Sci 352 1436Z doi 10 1126 science aaf2693 ISSN 0036 8075 PMID 27127236 External links editMatthias Lutolf publications indexed by Google Scholar Website of the Laboratory of Stem Cell BioengineeringReferences edit a b 13 new professors appointed at ETH Zurich and EPFL ETH Board www ethrat ch Retrieved 2021 08 20 a b Laboratory of Stem Cell Bioengineering EPFL www epfl ch Retrieved 2021 08 20 Institute of Chemical Sciences and Engineering ISIC www epfl ch Retrieved 2020 08 24 Laboratory of Stem Cell Bioengineering EPFL www epfl ch Retrieved 2020 08 24 a b The Roche Institute for Translational Bioengineering www roche com Retrieved 2021 08 20 Lutolf Matthias 2002 Cell responsive synthetic hydrogels Doctoral Thesis thesis ETH Zurich Lutolf Matthias P Weber Franz E Schmoekel Hugo G Schense Jason C Kohler Thomas Muller Ralph Hubbell Jeffrey A May 2003 Repair of bone defects using synthetic mimetics of collagenous extracellular matrices Nature Biotechnology 21 5 513 518 doi 10 1038 nbt818 ISSN 1087 0156 PMID 12704396 S2CID 7144594 Lutolf Matthias P Gilbert Penney M Blau Helen M November 2009 Designing materials to direct stem cell fate Nature 462 7272 433 441 Bibcode 2009Natur 462 433L doi 10 1038 nature08602 ISSN 1476 4687 PMC 2908011 PMID 19940913 Gilbert P M Havenstrite K L Magnusson K E G Sacco A Leonardi N A Kraft P Nguyen N K Thrun S Lutolf M P Blau H M 2010 08 27 Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self Renewal in Culture Science 329 5995 1078 1081 Bibcode 2010Sci 329 1078G doi 10 1126 science 1191035 ISSN 0036 8075 PMC 2929271 PMID 20647425 Bhagwat V M Ramachandran B V 1975 09 15 Malathion A and B esterases of mouse liver I Biochemical Pharmacology 24 18 1713 1717 doi 10 1016 0006 2952 75 90011 8 ISSN 0006 2952 PMID 14 Gjorevski Nikolce Sachs Norman Manfrin Andrea Giger Sonja Bragina Maiia E Ordonez Moran Paloma Clevers Hans Lutolf Matthias P November 2016 Designer matrices for intestinal stem cell and organoid culture Nature 539 7630 560 564 doi 10 1038 nature20168 ISSN 1476 4687 PMID 27851739 S2CID 4470849 Caiazzo Massimiliano Okawa Yuya Ranga Adrian Piersigilli Alessandra Tabata Yoji Lutolf Matthias P March 2016 Defined three dimensional microenvironments boost induction of pluripotency Nature Materials 15 3 344 352 Bibcode 2016NatMa 15 344C doi 10 1038 nmat4536 ISSN 1476 4660 PMID 26752655 Gobaa Samy Hoehnel Sylke Roccio Marta Negro Andrea Kobel Stefan Lutolf Matthias P November 2011 Artificial niche microarrays for probing single stem cell fate in high throughput Nature Methods 8 11 949 955 doi 10 1038 nmeth 1732 ISSN 1548 7105 PMID 21983923 S2CID 310516 Ranga A Gobaa S Okawa Y Mosiewicz K Negro A Lutolf M P 2014 07 14 3D niche microarrays for systems level analyses of cell fate Nature Communications 5 1 4324 Bibcode 2014NatCo 5 4324R doi 10 1038 ncomms5324 ISSN 2041 1723 PMC 4104440 PMID 25027775 Brandenberg Nathalie Hoehnel Sylke Kuttler Fabien Homicsko Krisztian Ceroni Camilla Ringel Till Gjorevski Nikolce Schwank Gerald Coukos George Turcatti Gerardo Lutolf Matthias P September 2020 High throughput automated organoid culture via stem cell aggregation in microcavity arrays Nature Biomedical Engineering 4 9 863 874 doi 10 1038 s41551 020 0565 2 ISSN 2157 846X PMID 32514094 S2CID 219543643 Brassard Jonathan A Nikolaev Mike Hubscher Tania Hofer Moritz Lutolf Matthias P January 2021 Recapitulating macro scale tissue self organization through organoid bioprinting Nature Materials 20 1 22 29 Bibcode 2021NatMa 20 22B doi 10 1038 s41563 020 00803 5 ISSN 1476 4660 PMID 32958879 S2CID 221825383 Nikolaev Mikhail Mitrofanova Olga Broguiere Nicolas Geraldo Sara Dutta Devanjali Tabata Yoji Elci Bilge Brandenberg Nathalie Kolotuev Irina Gjorevski Nikolce Clevers Hans September 2020 Homeostatic mini intestines through scaffold guided organoid morphogenesis Nature 585 7826 574 578 Bibcode 2020Natur 585 574N doi 10 1038 s41586 020 2724 8 ISSN 1476 4687 PMID 32939089 S2CID 221769498 2007 European Science Foundation archives esf org Retrieved 2021 08 20 Find people in the EMBO Communities people embo org Retrieved 2021 08 20 Editors and Board Development The Company of Biologists Development The Company of Biologists journals biologists com Retrieved 2021 08 20 Retrieved from https en wikipedia org w index php title Matthias Lutolf amp 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