Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1Ggene.[5] MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain.[6] MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.
MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010].
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000136286 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020437 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: Myosin IG". Retrieved 24 December 2019.
^Olety B, Wälte M, Honnert U, Schillers H, Bähler M (February 2010). "Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity". FEBS Letters. 584 (3): 493–9. doi:10.1016/j.febslet.2009.11.096. PMID 19968988. S2CID 27557093.,
Further readingedit
Patino-Lopez G, Aravind L, Dong X, Kruhlak MJ, Ostap EM, Shaw S (March 2010). "Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH)". J. Biol. Chem. 285 (12): 8675–86. doi:10.1074/jbc.M109.086959. PMC2838290. PMID 20071333.
Larsen ME, Kornblit B, Larsen MV, Masmas TN, Nielsen M, Thiim M, Garred P, Stryhn A, Lund O, Buus S, Vindelov L (October 2010). "Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation". Biol. Blood Marrow Transplant. 16 (10): 1370–81. doi:10.1016/j.bbmt.2010.03.022. PMID 20353833.
Lio HY, Tang JL, Wu J, Wu SJ, Lin CY, Yang YC (September 2010). "Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation". Clin. Chem. Lab. Med. 48 (9): 1287–93. doi:10.1515/CCLM.2010.246. PMID 20509834. S2CID 32914575.
Sellami MH, Torjemane L, Espadas de Arias A, Kaabi H, Ladeb S, Ben Othman T, Poli F, Hmida S (2010). "Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs". Immunol. Invest. 39 (6): 611–20. doi:10.3109/08820131003775029. PMID 20653428. S2CID 38774267.
myo1g, myosin, also, known, myosin, protein, that, humans, encoded, gene, member, class, unconventional, myosins, expression, highly, restricted, hematopoietic, tissues, cells, localises, exclusively, plasma, membrane, dependent, both, motor, domain, tail, dom. Myosin IG also known as myosin 1G and MYO1G is a protein that in humans is encoded by the MYO1G gene 5 MYO1G is a member of class I unconventional myosins Its expression is highly restricted to hematopoietic tissues and cells It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain 6 MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T cells MYO1GIdentifiersAliasesMYO1G HA2 HLA HA2 MHAG myosin IGExternal IDsOMIM 600642 MGI 1927091 HomoloGene 27996 GeneCards MYO1GGene location Human Chr Chromosome 7 human 1 Band7p13Start44 962 662 bp 1 End44 979 088 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 A1Start6 456 548 bp 2 End6 470 965 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytethymusbloodlymph nodececumappendixspleenpylorusbone marrow cellscardiaTop expressed inlymph nodespleenthymusbone marrowbloodsubcutaneous adipose tissuewhite adipose tissueright lung lobesubmandibular glandcarotid bodyMore reference expression dataBioGPSn aGene ontologyMolecular functionnucleotide binding calmodulin binding phosphatidylinositol 3 4 bisphosphate binding actin binding phosphatidylinositol 4 5 bisphosphate binding cytoskeletal motor activity ATP binding phosphatidylinositol 3 4 5 trisphosphate binding lipid bindingCellular componentcell projection membrane filopodium plasma membrane microvillus phagocytic cup extracellular exosome leading edge membrane myosin complex lamellipodiumBiological processT cell migration T cell mediated immunity adaptive immune response Fc gamma receptor signaling pathway involved in phagocytosis cell gliding immune system process cell substrate adhesion phagocytosis exocytosis T cell meandering migrationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez64005246177EnsemblENSG00000136286ENSMUSG00000020437UniProtB0I1T2Q5SUA5RefSeq mRNA NM 033054NM 178440RefSeq protein NP 149043NP 848534Location UCSC Chr 7 44 96 44 98 MbChr 11 6 46 6 47 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editMYO1G is a plasma membrane associated class I myosin see MIM 601478 that is abundant in T and B lymphocytes and mast cells Pierce et al 2001 PubMed 11544309 Patino Lopez et al 2010 PubMed 20071333 supplied by OMIM Jun 2010 References edit a b c GRCh38 Ensembl release 89 ENSG00000136286 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020437 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Myosin IG Retrieved 24 December 2019 Olety B Walte M Honnert U Schillers H Bahler M February 2010 Myosin 1G Myo1G is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity FEBS Letters 584 3 493 9 doi 10 1016 j febslet 2009 11 096 PMID 19968988 S2CID 27557093 Further reading editPatino Lopez G Aravind L Dong X Kruhlak MJ Ostap EM Shaw S March 2010 Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology PH domain Myo1PH J Biol Chem 285 12 8675 86 doi 10 1074 jbc M109 086959 PMC 2838290 PMID 20071333 Larsen ME Kornblit B Larsen MV Masmas TN Nielsen M Thiim M Garred P Stryhn A Lund O Buus S Vindelov L October 2010 Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation Biol Blood Marrow Transplant 16 10 1370 81 doi 10 1016 j bbmt 2010 03 022 PMID 20353833 Lio HY Tang JL Wu J Wu SJ Lin CY Yang YC September 2010 Minor histocompatibility antigen HA 1 and HA 2 polymorphisms in Taiwan frequency and application in hematopoietic stem cell transplantation Clin Chem Lab Med 48 9 1287 93 doi 10 1515 CCLM 2010 246 PMID 20509834 S2CID 32914575 Sellami MH Torjemane L Espadas de Arias A Kaabi H Ladeb S Ben Othman T Poli F Hmida S 2010 Mismatch for the minor histocompatibility antigen HA 2 and GVHD occurrence in HLA A 0201 positive Tunisian recipients of HSCs Immunol Invest 39 6 611 20 doi 10 3109 08820131003775029 PMID 20653428 S2CID 38774267 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MYO1G amp oldid 1187457163, wikipedia, wiki, book, books, library,
