microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000284370 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
mir4640, microrna, 4640, coding, humans, that, encoded, gene, identifiersaliases, microrna, 4640external, idsgenecards, orthologsgene, location, human, chromosome, human, band6p21, 33start30, end30, expression, patternbgeehumanmouse, ortholog, expressed, ingas. MicroRNA 4640 is a non coding RNA in humans that is encoded by the MIR4640 gene 3 MIR4640IdentifiersAliasesMIR4640 microRNA 4640External IDsGeneCards MIR4640 OMA MIR4640 orthologsGene location Human Chr Chromosome 6 human 1 Band6p21 33Start30 890 883 bp 1 End30 890 972 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscleputamenBrodmann area 9left coronary arteryleft ventriclesmooth muscle tissuebody of stomachkidneyhippocampus properascending aortan aMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez100616237n aEnsemblENSG00000284370n aUniProtnan aRefSeq mRNA n an aRefSeq protein n an aLocation UCSC Chr 6 30 89 30 89 Mbn aPubMed search 2 n aWikidataView Edit Human microRNAs miRNAs are short 20 24 nt non coding RNAs that are involved in post transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts pri miRNAs that can be either protein coding or non coding The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70 nt stem loop precursor miRNA pre miRNA which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star miRNA products The mature miRNA is incorporated into a RNA induced silencing complex RISC which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA The RefSeq represents the predicted microRNA stem loop provided by RefSeq Sep 2009 References edit a b c GRCh38 Ensembl release 89 ENSG00000284370 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene MicroRNA 4640 Retrieved 2013 06 27 Further reading edit nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MIR4640 amp oldid 1005905194, wikipedia, wiki, book, books, library,
