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Lori Ann Setton

January 01, 1970

Lori Ann Setton is an American biomechanical engineer noted for her research on mechanics and mechanobiology of the intervertebral disc, articular cartilage mechanics, drug delivery, and pathomechanisms of osteoarthritis. She is currently the department chair as well as the Lucy and Stanley Lopata Distinguished Professor of Biomedical Engineering at McKelvey School of Engineering at Washington University in St. Louis.

Lori Ann Setton
Born
Queens, New York, US
NationalityAmerican
Alma materPrinceton University
Columbia University
Known formechanics
mechanobiology of the intervertebral disc
articular cartilagemechanics
drug delivery
pathomechanisms of osteoarthritis
AwardsAIMBE Fellow (2005)
BMES Fellow (2009)
Van C. Mow Medal(2007)
Scientific career
FieldsBiomechanical Engineer
InstitutionsWashington University in St. Louis, Duke University
Doctoral advisorVan C. Mow
Websiteengineering.wustl.edu/Profiles/Pages/Lori-Setton.aspx

Biography edit

Setton was born in Queens, New York. She received a B.S.E. in Mechanical and Aerospace Engineering from Princeton University in 1984. Subsequently, she pursued graduate degrees under the tutelage of Professor Van C. Mow at Columbia University. She received an M.S. degree and Ph.D degree in Mechanical Engineering/Biomechanics in 1988 and 1993, respectively.

She joined the Department of Biomedical Engineering at Duke University as an assistant professor in 1995. Promotions to tenured associate professor in and professor followed in 2004 and 2007.

Her most noticeable work has documented the biological responses of cartilage and intervertebral disc to mechanical loading,[1] [2] [3] [4] [5] [6] understanding a role for collagen genetic mutations in onset of arthritis and intervertebral disc pathology,[7] [8] development of injectable hydrogels for articular cartilage repair,[9][10][11][12] and development of injectable drug delivery vehicles for fighting inflammation in musculoskeletal disease.[13][14][15][16][17] As of June 1, 2017, her work has been cited over 17,500 times.[18] She has an h-index of 65.

Awards edit

Setton has several awards:

  • AIMBE Fellow (2005)[19]
  • BMES Fellow (2009)[20]
  • Van C. Mow Medal (2007)[21]
  • ASME Fellow (2018)[22]
  • Presidential Early Career Awards for Scientists and Engineers (PECASE) (1997) for "Leadership in education and research in understanding and restoring biomechanical functions to tissue degenerated by injury or aging, especially in the spine[23]

References edit

  1. ^ Setton, LA; Chen, J (2006). "Mechanobiology of the intervertebral disc and relevance to disc degeneration". J Bone Joint Surg Am. 88 (2): 52–57. doi:10.2106/JBJS.F.00001. PMID 16595444.(cited 154 times)
  2. ^ Setton, LA; Mow, VC; Müller, FJ; Pita, JC; Howell, DS (1994). "Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament". Journal of Orthopaedic Research. 12 (4): 451–463. doi:10.1002/jor.1100120402. PMID 8064477. S2CID 41257875.(cited 168 times)
  3. ^ LeRoux, MA; Arokoski, J; Vail, TP; Guilak, F; Hyttinen, MM; Kiviranta, I; Setton, LA (2000). "Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy". Journal of Orthopaedic Research. 18 (3): 383–392. doi:10.1002/jor.1100180309. PMID 10937624. S2CID 1697626.(cited 122 times)
  4. ^ Leroux, MA; Cheung, HS; Bau, JL; Wang, JY; Howell, DS; Setton, LA (2001). "Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization". Osteoarthritis and Cartilage. 9 (7): 633–640. doi:10.1053/joca.2001.0432. PMID 11597176.(cited 62 times)
  5. ^ Boyd, LM; Richardson, WJ; Chen, J; Kraus, VB; Tewari, A; Setton, LA (2005). "Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR". Annals of Biomedical Engineering. 33 (8): 1071–1077. CiteSeerX 10.1.1.419.5226. doi:10.1007/s10439-005-5775-y. PMID 16133915. S2CID 18286177.(cited 35 times)
  6. ^ Chen, J; Yan, W; Setton, LA (2004). "Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro". Matrix Biology. 22 (7): 573–583. doi:10.1016/j.matbio.2003.11.008. PMID 14996437.(cited 74 times)
  7. ^ Boyd, LM; Richardson, WJ; Allen, KD; Flahiff, C; Jing, L; Li, Y; Chen, J; Setton, LA (2008). "Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen". Arthritis Rheum. 58 (1): 164–171. doi:10.1002/art.23231. PMID 18163498.(cited 40 times)
  8. ^ Allen, KD; Griffin, TM; Rodriguiz, RM; Wetsel, WC; Kraus, VB; Huebner, JL; Boyd LM; Setton, LA (2009). "Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen". Arthritis Rheum. 60 (9): 2684–2693. doi:10.1002/art.24783. PMC 2760314. PMID 19714629.(cited 29 times)
  9. ^ Nettles, DL; Chilkoti, A; Setton, LA (2010). "Applications of elastin-like polypeptides in tissue engineering". Adv Drug Deliv Rev. 62 (15): 1479–1485. doi:10.1016/j.addr.2010.04.002. PMC 2935943. PMID 20385185.(cited 114 times)
  10. ^ Nettles DL; Kitaoka, K; Hanson, NA; Flahiff, CM; Mata, BA; Hsu, EW; Chilkoti, A; Setton, LA (2008). "In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model". Tissue Eng Part A. 14 (7): 1133–1140. doi:10.1089/tea.2007.0245. PMC 3312393. PMID 18433311.(cited 50times)
  11. ^ Betre, H; Ong, SR; Guilak, F; Chilkoti, A; Fermor, B; Setton, LA (2006). "Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide". Biomaterials. 27 (1): 91–99. doi:10.1016/j.biomaterials.2005.05.071. PMID 16023192.
  12. ^ Nettles, DL; Vail, TP; Morgan, MT; Grinstaff, MW; Setton, LA (2004). "Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair". Ann Biomed Eng. 32 (3): 391–397. doi:10.1023/b:abme.0000017552.65260.94 (inactive 2024-05-17). PMID 15095813. S2CID 1334471.{{cite journal}}: CS1 maint: DOI inactive as of May 2024 (link)
  13. ^ Allen, KD; Adams, SB Jr; Mata, BA; Shamji, MF; Gouze, E; Jing, L; Nettles, DL; Latt, LD; Setton, LA (2010). "Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist". Journal of Orthopaedic Research. 29 (5): 694–703. doi:10.1002/jor.21309. PMC 3100769. PMID 21437948.
  14. ^ Shamji, MF; Chen, J; Friedman, AH; Richardson, WJ; Chilkoti, A; Setton, LA (2008). "Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist". J Control Release. 129 (3): 179–186. doi:10.1016/j.jconrel.2008.04.021. PMC 2637771. PMID 18547669.
  15. ^ Shamji, MF; Betre, H; Kraus, VB; Chen, J; Chilkoti, A; Pichika, R; Masuda, K; Setton LA (2007). "Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic". Arthritis Rheum. 56 (11): 3650–3661. doi:10.1002/art.22952. PMID 17968946. S2CID 32108692.
  16. ^ Betre, H; Liu, W; Zalutsky, MR; Chilkoti, A; Kraus, VB; Setton, LA (2006). "A thermally responsive biopolymer for intra-articular drug delivery". J Control Release. 115 (2): 175–182. doi:10.1016/j.jconrel.2006.07.022. PMID 16959360.
  17. ^ Allen, KD; Shamji, MF; Mata, BA; Gabr, MA; Sinclair, SM; Schmitt, DO; Richardson, WJ; Setton LA (2011). "Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism". Arthritis Research & Therapy. 13 (4): R137. doi:10.1186/ar3451. PMC 3239380. PMID 21871102.
  18. ^ Google Scholar Citations for Lori Setton
  19. ^ Duke University Graduate School (2005). . gradschool.duke.edu. Archived from the original on 2013-10-20. Retrieved 2013-05-22.
  20. ^ bmes.org (2009). "BMES Fellows". Biomedical Engineering Society. Retrieved 2013-05-23.
  21. ^ asme.org (2007). "Van C. Mow Medal Recipients". American Society of Mechanical Engineers. Retrieved 2013-05-23.
  22. ^ "All Fellows" (PDF). ASME. 2022.
  23. ^ www.nsf.gov (1997-10-24). "Twenty NSF-Supported Young Scientists and Engineers Receive Presidential Award". National Science Foundation. Retrieved 2013-05-25.

External links edit

  • Washington University: [1] Lori A. Setton, Department of Biomedical Engineering

January 01, 1970
lori, setton, american, biomechanical, engineer, noted, research, mechanics, mechanobiology, intervertebral, disc, articular, cartilage, mechanics, drug, delivery, pathomechanisms, osteoarthritis, currently, department, chair, well, lucy, stanley, lopata, dist. Lori Ann Setton is an American biomechanical engineer noted for her research on mechanics and mechanobiology of the intervertebral disc articular cartilage mechanics drug delivery and pathomechanisms of osteoarthritis She is currently the department chair as well as the Lucy and Stanley Lopata Distinguished Professor of Biomedical Engineering at McKelvey School of Engineering at Washington University in St Louis Lori Ann SettonBornQueens New York USNationalityAmericanAlma materPrinceton UniversityColumbia UniversityKnown formechanics mechanobiology of the intervertebral disc articular cartilagemechanics drug delivery pathomechanisms of osteoarthritisAwardsAIMBE Fellow 2005 BMES Fellow 2009 Van C Mow Medal 2007 Scientific careerFieldsBiomechanical EngineerInstitutionsWashington University in St Louis Duke UniversityDoctoral advisorVan C MowWebsiteengineering wbr wustl wbr edu wbr Profiles wbr Pages wbr Lori Setton wbr aspx Contents 1 Biography 2 Awards 3 References 4 External linksBiography editSetton was born in Queens New York She received a B S E in Mechanical and Aerospace Engineering from Princeton University in 1984 Subsequently she pursued graduate degrees under the tutelage of Professor Van C Mow at Columbia University She received an M S degree and Ph D degree in Mechanical Engineering Biomechanics in 1988 and 1993 respectively She joined the Department of Biomedical Engineering at Duke University as an assistant professor in 1995 Promotions to tenured associate professor in and professor followed in 2004 and 2007 Her most noticeable work has documented the biological responses of cartilage and intervertebral disc to mechanical loading 1 2 3 4 5 6 understanding a role for collagen genetic mutations in onset of arthritis and intervertebral disc pathology 7 8 development of injectable hydrogels for articular cartilage repair 9 10 11 12 and development of injectable drug delivery vehicles for fighting inflammation in musculoskeletal disease 13 14 15 16 17 As of June 1 2017 her work has been cited over 17 500 times 18 She has an h index of 65 Awards editSetton has several awards AIMBE Fellow 2005 19 BMES Fellow 2009 20 Van C Mow Medal 2007 21 ASME Fellow 2018 22 Presidential Early Career Awards for Scientists and Engineers PECASE 1997 for Leadership in education and research in understanding and restoring biomechanical functions to tissue degenerated by injury or aging especially in the spine 23 References edit Setton LA Chen J 2006 Mechanobiology of the intervertebral disc and relevance to disc degeneration J Bone Joint Surg Am 88 2 52 57 doi 10 2106 JBJS F 00001 PMID 16595444 cited 154 times Setton LA Mow VC Muller FJ Pita JC Howell DS 1994 Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament Journal of Orthopaedic Research 12 4 451 463 doi 10 1002 jor 1100120402 PMID 8064477 S2CID 41257875 cited 168 times LeRoux MA Arokoski J Vail TP Guilak F Hyttinen MM Kiviranta I Setton LA 2000 Simultaneous changes in the mechanical properties quantitative collagen organization and proteoglycan concentration of articular cartilage following canine meniscectomy Journal of Orthopaedic Research 18 3 383 392 doi 10 1002 jor 1100180309 PMID 10937624 S2CID 1697626 cited 122 times Leroux MA Cheung HS Bau JL Wang JY Howell DS Setton LA 2001 Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization Osteoarthritis and Cartilage 9 7 633 640 doi 10 1053 joca 2001 0432 PMID 11597176 cited 62 times Boyd LM Richardson WJ Chen J Kraus VB Tewari A Setton LA 2005 Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real time quantitative RT PCR Annals of Biomedical Engineering 33 8 1071 1077 CiteSeerX 10 1 1 419 5226 doi 10 1007 s10439 005 5775 y PMID 16133915 S2CID 18286177 cited 35 times Chen J Yan W Setton LA 2004 Static compression induces zonal specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro Matrix Biology 22 7 573 583 doi 10 1016 j matbio 2003 11 008 PMID 14996437 cited 74 times Boyd LM Richardson WJ Allen KD Flahiff C Jing L Li Y Chen J Setton LA 2008 Early onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen Arthritis Rheum 58 1 164 171 doi 10 1002 art 23231 PMID 18163498 cited 40 times Allen KD Griffin TM Rodriguiz RM Wetsel WC Kraus VB Huebner JL Boyd LM Setton LA 2009 Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen Arthritis Rheum 60 9 2684 2693 doi 10 1002 art 24783 PMC 2760314 PMID 19714629 cited 29 times Nettles DL Chilkoti A Setton LA 2010 Applications of elastin like polypeptides in tissue engineering Adv Drug Deliv Rev 62 15 1479 1485 doi 10 1016 j addr 2010 04 002 PMC 2935943 PMID 20385185 cited 114 times Nettles DL Kitaoka K Hanson NA Flahiff CM Mata BA Hsu EW Chilkoti A Setton LA 2008 In situ crosslinking elastin like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model Tissue Eng Part A 14 7 1133 1140 doi 10 1089 tea 2007 0245 PMC 3312393 PMID 18433311 cited 50times Betre H Ong SR Guilak F Chilkoti A Fermor B Setton LA 2006 Chondrocytic differentiation of human adipose derived adult stem cells in elastin like polypeptide Biomaterials 27 1 91 99 doi 10 1016 j biomaterials 2005 05 071 PMID 16023192 Nettles DL Vail TP Morgan MT Grinstaff MW Setton LA 2004 Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair Ann Biomed Eng 32 3 391 397 doi 10 1023 b abme 0000017552 65260 94 inactive 2024 05 17 PMID 15095813 S2CID 1334471 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint DOI inactive as of May 2024 link Allen KD Adams SB Jr Mata BA Shamji MF Gouze E Jing L Nettles DL Latt LD Setton LA 2010 Gait and behavior in an IL1b mediated model of rat knee arthritis and effects of an IL1 antagonist Journal of Orthopaedic Research 29 5 694 703 doi 10 1002 jor 21309 PMC 3100769 PMID 21437948 Shamji MF Chen J Friedman AH Richardson WJ Chilkoti A Setton LA 2008 Synthesis and characterization of a thermally responsive tumor necrosis factor antagonist J Control Release 129 3 179 186 doi 10 1016 j jconrel 2008 04 021 PMC 2637771 PMID 18547669 Shamji MF Betre H Kraus VB Chen J Chilkoti A Pichika R Masuda K Setton LA 2007 Development and characterization of a fusion protein between thermally responsive elastin like polypeptide and interleukin 1 receptor antagonist sustained release of a local antiinflammatory therapeutic Arthritis Rheum 56 11 3650 3661 doi 10 1002 art 22952 PMID 17968946 S2CID 32108692 Betre H Liu W Zalutsky MR Chilkoti A Kraus VB Setton LA 2006 A thermally responsive biopolymer for intra articular drug delivery J Control Release 115 2 175 182 doi 10 1016 j jconrel 2006 07 022 PMID 16959360 Allen KD Shamji MF Mata BA Gabr MA Sinclair SM Schmitt DO Richardson WJ Setton LA 2011 Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor alpha antagonism Arthritis Research amp Therapy 13 4 R137 doi 10 1186 ar3451 PMC 3239380 PMID 21871102 Google Scholar Citations for Lori Setton Duke University Graduate School 2005 Dean s Awards for Excellence in Mentoring Past Recipients gradschool duke edu Archived from the original on 2013 10 20 Retrieved 2013 05 22 bmes org 2009 BMES Fellows Biomedical Engineering Society Retrieved 2013 05 23 asme org 2007 Van C Mow Medal Recipients American Society of Mechanical Engineers Retrieved 2013 05 23 All Fellows PDF ASME 2022 www nsf gov 1997 10 24 Twenty NSF Supported Young Scientists and Engineers Receive Presidential Award National Science Foundation Retrieved 2013 05 25 External links editWashington University 1 Lori A Setton Department of Biomedical Engineering Retrieved from https en wikipedia org w index php title Lori Ann Setton amp oldid 1224279461, wikipedia, wiki, book, books, library,

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