Lentinan is a β-1,3 beta-glucan with β-1,6 branching. It has a molecular weight of 500,000 Da and specific rotation of +14-22° (NaOH).
Researchedit
Preclinical studiesedit
An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937.[1] Lentinan is thought to be inactive in humans when given orally and is therefore administered intravenously. The authors of an in vivo study of lentinan suggested that the compound may be active when administered orally in mice.[2]
Human clinical trialsedit
Lentinan has been the subject of a limited number of clinical studies in cancer patients in Japan;[3][4][5][6][7][8][9][10] however, evidence of efficacy is lacking.[11][12]
^Sia GM, Candlish JK (March 1999). "Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line". Phytotherapy Research. 13 (2): 133–137. doi:10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O. PMID 10190187.
^Ng ML, Yap AT (October 2002). "Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes)". Journal of Alternative and Complementary Medicine. 8 (5): 581–589. doi:10.1089/107555302320825093. PMID 12470439.
^Yang P, Liang M, Zhang Y, Shen B (August 2008). "Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC". Advances in Therapy. 25 (8): 787–794. doi:10.1007/s12325-008-0079-x. PMID 18670743. S2CID 33140754.
^Nimura H, Mitsumori N, Takahashi N, Kashimura H, Takayama S, Kashiwagi H, Yanaga K (June 2006). "[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]". Gan to Kagaku Ryoho. Cancer & Chemotherapy (in Japanese). 33 Suppl 1 (1): 106–109. PMID 16897983.
^Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K (1999). "A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group". Hepato-Gastroenterology. 46 (28): 2662–2668. PMID 10522061.
^Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (July 2009). "Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer". Anticancer Research. 29 (7): 2739–2745. PMID 19596954.
^Hazama S, Watanabe S, Ohashi M, Yagi M, Suzuki M, Matsuda K, et al. (July 2009). "Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer". Anticancer Research. 29 (7): 2611–2617. PMID 19596936.
^Kataoka H, Shimura T, Mizoshita T, Kubota E, Mori Y, Mizushima T, et al. (2009). "Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life". Hepato-Gastroenterology. 56 (90): 547–550. PMID 19579640.
^Isoda N, Eguchi Y, Nukaya H, Hosho K, Suga Y, Suga T, et al. (2009). "Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma". Hepato-Gastroenterology. 56 (90): 437–441. PMID 19579616.
^Shimizu K, Watanabe S, Watanabe S, Matsuda K, Suga T, Nakazawa S, Shiratori K (2009). "Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer". Hepato-Gastroenterology. 56 (89): 240–244. PMID 19453066.
Memorial Sloan-Kettering Cancer Center's page for Lentinan.
February 15, 2024
lentinan, polysaccharide, isolated, from, fruit, body, shiitake, mushroom, lentinula, edodes, clinical, dataahfs, drugs, cominternational, drug, namesatc, codel03ax01, identifierscas, number37339, ychemspidernoneunii6751655d1dkeggd01695, ychebichebi, 31770comp. Lentinan is a polysaccharide isolated from the fruit body of shiitake mushroom Lentinula edodes LentinanClinical dataAHFS Drugs comInternational Drug NamesATC codeL03AX01 WHO IdentifiersCAS Number37339 90 5 YChemSpidernoneUNII6751655D1DKEGGD01695 YChEBICHEBI 31770CompTox Dashboard EPA DTXSID30190781Chemical and physical dataMolar mass 500 000 Da N Y what is this verify Contents 1 Chemistry 2 Research 2 1 Preclinical studies 2 2 Human clinical trials 2 3 Adverse effects 3 See also 4 References 5 External linksChemistry editLentinan is a b 1 3 beta glucan with b 1 6 branching It has a molecular weight of 500 000 Da and specific rotation of 14 22 NaOH Research editPreclinical studies edit An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937 1 Lentinan is thought to be inactive in humans when given orally and is therefore administered intravenously The authors of an in vivo study of lentinan suggested that the compound may be active when administered orally in mice 2 Human clinical trials edit Lentinan has been the subject of a limited number of clinical studies in cancer patients in Japan 3 4 5 6 7 8 9 10 however evidence of efficacy is lacking 11 12 Adverse effects edit Lentinan has been reported to cause shiitake mushroom dermatitis 13 See also editMedicinal mushroomsReferences edit Sia GM Candlish JK March 1999 Effects of shiitake Lentinus edodes extract on human neutrophils and the U937 monocytic cell line Phytotherapy Research 13 2 133 137 doi 10 1002 SICI 1099 1573 199903 13 2 lt 133 AID PTR398 gt 3 0 CO 2 O PMID 10190187 Ng ML Yap AT October 2002 Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms Lentinus edodes Journal of Alternative and Complementary Medicine 8 5 581 589 doi 10 1089 107555302320825093 PMID 12470439 Yang P Liang M Zhang Y Shen B August 2008 Clinical application of a combination therapy of lentinan multi electrode RFA and TACE in HCC Advances in Therapy 25 8 787 794 doi 10 1007 s12325 008 0079 x PMID 18670743 S2CID 33140754 Nimura H Mitsumori N Takahashi N Kashimura H Takayama S Kashiwagi H Yanaga K June 2006 S 1 combined with lentinan in patients with unresectable or recurrent gastric cancer Gan to Kagaku Ryoho Cancer amp Chemotherapy in Japanese 33 Suppl 1 1 106 109 PMID 16897983 Nakano H Namatame K Nemoto H Motohashi H Nishiyama K Kumada K 1999 A multi institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases effect on prolongation of survival and improvement of quality of life Kanagawa Lentinan Research Group Hepato Gastroenterology 46 28 2662 2668 PMID 10522061 Oba K Kobayashi M Matsui T Kodera Y Sakamoto J July 2009 Individual patient based meta analysis of lentinan for unresectable recurrent gastric cancer Anticancer Research 29 7 2739 2745 PMID 19596954 Hazama S Watanabe S Ohashi M Yagi M Suzuki M Matsuda K et al July 2009 Efficacy of orally administered superfine dispersed lentinan beta 1 3 glucan for the treatment of advanced colorectal cancer Anticancer Research 29 7 2611 2617 PMID 19596936 Kataoka H Shimura T Mizoshita T Kubota E Mori Y Mizushima T et al 2009 Lentinan with S 1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life Hepato Gastroenterology 56 90 547 550 PMID 19579640 Isoda N Eguchi Y Nukaya H Hosho K Suga Y Suga T et al 2009 Clinical efficacy of superfine dispersed lentinan beta 1 3 glucan in patients with hepatocellular carcinoma Hepato Gastroenterology 56 90 437 441 PMID 19579616 Shimizu K Watanabe S Watanabe S Matsuda K Suga T Nakazawa S Shiratori K 2009 Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer Hepato Gastroenterology 56 89 240 244 PMID 19453066 Lentinan WebMD Retrieved June 10 2017 Lentinan Memorial Sloan Kettering Cancer Center Retrieved June 10 2017 Nakamura T August 1992 Shiitake Lentinus edodes dermatitis Contact Dermatitis 27 2 65 70 doi 10 1111 j 1600 0536 1992 tb05211 x PMID 1395630 S2CID 7320474 External links editLentinan effects antitumor and others Memorial Sloan Kettering Cancer Center s page for Lentinan Retrieved from https en wikipedia org w index php title Lentinan amp oldid 1188022326, wikipedia, wiki, book, books, library,
