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Wikipedia

Liver X receptor alpha

January 01, 1970

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3).[5][6]

NR1H3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNR1H3, LXR-a, LXRA, RLD-1, Liver X receptor alpha, nuclear receptor subfamily 1 group H member 3
External IDsOMIM: 602423 MGI: 1352462 HomoloGene: 21165 GeneCards: NR1H3
Orthologs
SpeciesHumanMouse
Entrez

10062

22259

Ensembl

ENSG00000025434

ENSMUSG00000002108

UniProt

Q13133

Q9Z0Y9

RefSeq (mRNA)

NM_001130101
NM_001130102
NM_001251934
NM_001251935
NM_005693

NM_001177730
NM_013839
NM_001355279

RefSeq (protein)

NP_001171201
NP_038867
NP_001342208

Location (UCSC)Chr 11: 47.25 – 47.27 MbChr 2: 91.01 – 91.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Expression edit

miRNA hsa-miR-613 autoregulates the human LXRα gene by targeting the endogenous LXRα through its specific miRNA response element (613MRE) within the LXRα 3′-untranslated region. LXRα autoregulates its own suppression via induction of SREBP1c which upregulates miRNA has-miR-613.[7]

Function edit

The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. Additionally, they play an important role in the local activation of thyroid hormones via deiodinases.[8] The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs) and regulate expression of target genes containing LXR response elements.[9][10] Restoration of LXR-alpha expression/function within a psoriatic lesion may help to switch the transition from psoriatic to symptomless skin.[11]

Interactions edit

Liver X receptor alpha has been shown to interact with EDF1[12] and Small heterodimer partner.[13] LXRα activates the transcription factor SREBP-1c, resulting in lipogenesis.[14]

Link to multiple sclerosis edit

In 2016, a study found 70% of individuals in two families with a rare form of rapidly progressing multiple sclerosis had a mutation in NR1H3.[15] However, an analysis from The International Multiple Sclerosis Genetics Consortium using a 13-fold larger sample size could not find any evidence that the mutation in question (p.Arg415Gln) associated with multiple sclerosis, refuting these findings.[16]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000025434 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002108 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP (Apr 1996). "The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling". The Journal of Biological Chemistry. 271 (16): 9189–92. doi:10.1074/jbc.271.16.9189. PMID 8621574.
  6. ^ Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ (May 1995). "LXR, a nuclear receptor that defines a distinct retinoid response pathway". Genes & Development. 9 (9): 1033–45. doi:10.1101/gad.9.9.1033. PMID 7744246.
  7. ^ http://mend.endojournals.org/content/25/4/584.abstract [dead link]
  8. ^ Christoffolete MA, Doleschall M, Egri P, Liposits Z, Zavacki AM, Bianco AC, et al. (2010). "Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway". The Journal of Endocrinology. 205 (2): 179–86. doi:10.1677/JOE-09-0448. PMC 3133926. PMID 20176747.
  9. ^ Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA, et al. (Jun 2009). "Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice". The Journal of Clinical Investigation. 119 (6): 1626–37. doi:10.1172/JCI35288. PMC 2689129. PMID 19436111.
  10. ^ "Entrez Gene: nuclear receptor subfamily 1".
  11. ^ Gupta DS, Kaul D, Kanwar AJ, Parsad D (Jan 2010). "Psoriasis: crucial role of LXR-alpha RNomics". Genes and Immunity. 11 (1): 37–44. doi:10.1038/gene.2009.63. PMID 19798078.
  12. ^ Brendel C, Gelman L, Auwerx J (Jun 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Molecular Endocrinology. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
  13. ^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (Sep 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.
  14. ^ Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, et al. (2010). "Leptin therapy in insulin-deficient type I diabetes". Proceedings of the National Academy of Sciences of the United States of America. 107 (11): 4813–9. Bibcode:2010PNAS..107.4813W. doi:10.1073/pnas.0909422107. PMC 2841945. PMID 20194735.
  15. ^ Wang Z, Sadovnick AD, Traboulsee AL, Ross JP, Bernales CQ, Encarnacion M, et al. (2016). "Nuclear Receptor NR1H3 in Familial Multiple Sclerosis". Neuron. 90 (5): 948–54. doi:10.1016/j.neuron.2016.04.039. PMC 5092154. PMID 27253448.
  16. ^ Antel J, Ban M, Baranzini S, Barcellos L, Barizzone N, Beecham A, et al. (International Multiple Sclerosis Genetics Consortium) (October 2016). "NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk". Neuron. 92 (2): 333–335. doi:10.1016/j.neuron.2016.09.052. PMC 5641967. PMID 27764667.

Further reading edit

  • Lehmann JM, Kliewer SA, Moore LB, Smith-Oliver TA, Oliver BB, Su JL, et al. (Feb 1997). "Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway". The Journal of Biological Chemistry. 272 (6): 3137–40. doi:10.1074/jbc.272.6.3137. PMID 9013544.
  • Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, et al. (Aug 1997). "Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients". Diabetes. 46 (8): 1319–27. doi:10.2337/diabetes.46.8.1319. PMID 9231657.
  • Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, et al. (May 1998). "Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha". Cell. 93 (5): 693–704. doi:10.1016/S0092-8674(00)81432-4. PMID 9630215. S2CID 5856580.
  • Miyata KS, McCaw SE, Meertens LM, Patel HV, Rachubinski RA, Capone JP (Nov 1998). "Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor alpha and liver-X-receptor alpha". Molecular and Cellular Endocrinology. 146 (1–2): 69–76. doi:10.1016/S0303-7207(98)00196-8. PMID 10022764. S2CID 53253694.
  • Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, et al. (Oct 2000). "Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha". Proceedings of the National Academy of Sciences of the United States of America. 97 (22): 12097–102. Bibcode:2000PNAS...9712097V. doi:10.1073/pnas.200367697. PMC 17300. PMID 11035776.
  • Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, Torra IP, et al. (Jan 2001). "PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway". Nature Medicine. 7 (1): 53–8. doi:10.1038/83348. PMID 11135616. S2CID 20558311.
  • Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, et al. (Jan 2001). "LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes". Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 507–12. doi:10.1073/pnas.021488798. PMC 14617. PMID 11149950.
  • Li Y, Bolten C, Bhat BG, Woodring-Dietz J, Li S, Prayaga SK, et al. (Mar 2002). "Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism". Molecular Endocrinology. 16 (3): 506–14. doi:10.1210/mend.16.3.0789. PMID 11875109.
  • Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, et al. (Aug 2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta". The Journal of Biological Chemistry. 277 (35): 31900–8. doi:10.1074/jbc.M202993200. PMID 12032151.
  • Brendel C, Gelman L, Auwerx J (Jun 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Molecular Endocrinology. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
  • Steffensen KR, Schuster GU, Parini P, Holter E, Sadek CM, Cassel T, et al. (May 2002). "Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins". Biochemical and Biophysical Research Communications. 293 (5): 1333–40. doi:10.1016/S0006-291X(02)00390-X. PMID 12054659.
  • Gbaguidi GF, Agellon LB (Jul 2002). "The atypical interaction of peroxisome proliferator-activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1583 (2): 229–36. doi:10.1016/s1388-1981(02)00217-2. PMID 12117567.
  • Pawar A, Xu J, Jerks E, Mangelsdorf DJ, Jump DB (Oct 2002). "Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells". The Journal of Biological Chemistry. 277 (42): 39243–50. doi:10.1074/jbc.M206170200. PMID 12161442.
  • Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (Sep 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.
  • Oberkofler H, Schraml E, Krempler F, Patsch W (Apr 2003). "Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha". The Biochemical Journal. 371 (Pt 1): 89–96. doi:10.1042/BJ20021665. PMC 1223253. PMID 12470296.
  • Wang M, Thomas J, Burris TP, Schkeryantz J, Michael LF (Nov 2003). "Molecular determinants of LXRalpha agonism". Journal of Molecular Graphics & Modelling. 22 (2): 173–81. doi:10.1016/S1093-3263(03)00159-1. PMID 12932788.
  • Fukuchi J, Song C, Ko AL, Liao S (Sep 2003). "Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors". Steroids. 68 (7–8): 685–91. doi:10.1016/S0039-128X(03)00100-4. PMID 12957674. S2CID 6023862.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

January 01, 1970
liver, receptor, alpha, alpha, nuclear, receptor, protein, that, humans, encoded, nr1h3, gene, nuclear, receptor, subfamily, group, member, nr1h3available, structurespdbortholog, search, pdbe, rcsblist, codes1uhl, 3ipq, 3ips, 3ipu, 5avi, 5avl, 5hjsidentifiersa. Liver X receptor alpha LXR alpha is a nuclear receptor protein that in humans is encoded by the NR1H3 gene nuclear receptor subfamily 1 group H member 3 5 6 NR1H3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJSIdentifiersAliasesNR1H3 LXR a LXRA RLD 1 Liver X receptor alpha nuclear receptor subfamily 1 group H member 3External IDsOMIM 602423 MGI 1352462 HomoloGene 21165 GeneCards NR1H3Gene location Human Chr Chromosome 11 human 1 Band11p11 2Start47 248 300 bp 1 End47 269 032 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 E1 2 50 52 cMStart91 014 406 bp 2 End91 033 179 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of liverspleentibial nervesubcutaneous adipose tissuecanal of the cervixgallbladderlymph noderight lobe of thyroid glandgastric mucosaright uterine tubeTop expressed inleft lobe of liverproximal tubulebrown adipose tissuewhite adipose tissuesubcutaneous adipose tissueduodenumyolk sacjejunumspleenfemale urethraMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncholesterol binding protein binding zinc ion binding nuclear receptor activity sterol response element binding steroid hormone receptor activity DNA binding sequence specific DNA binding metal ion binding DNA binding transcription factor activity DNA binding transcription factor activity RNA polymerase II specific transcription coactivator activity transcription cis regulatory region binding RNA polymerase II transcription regulatory region sequence specific DNA binding transcription factor binding nuclear receptor coactivator activity signaling receptor activityCellular componentreceptor complex nucleoplasm RNA polymerase II transcription regulator complex nucleus cytoplasmBiological processpositive regulation of toll like receptor 4 signaling pathway sterol homeostasis negative regulation of pancreatic juice secretion negative regulation of inflammatory response cellular response to lipopolysaccharide negative regulation of lipid transport positive regulation of lipoprotein lipase activity lipid homeostasis triglyceride homeostasis negative regulation of macrophage activation negative regulation of macrophage derived foam cell differentiation positive regulation of cholesterol transport negative regulation of cholesterol storage regulation of transcription DNA templated positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux positive regulation of protein metabolic process negative regulation of interferon gamma mediated signaling pathway regulation of circadian rhythm transcription DNA templated negative regulation of transcription by RNA polymerase II response to progesterone steroid hormone mediated signaling pathway apoptotic cell clearance positive regulation of fatty acid biosynthetic process transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II negative regulation of secretion of lysosomal enzymes negative regulation of pinocytosis positive regulation of transcription DNA templated intracellular receptor signaling pathway cholesterol homeostasis lipid metabolism multicellular organism development cell differentiation negative regulation of cold induced thermogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1006222259EnsemblENSG00000025434ENSMUSG00000002108UniProtQ13133Q9Z0Y9RefSeq mRNA NM 001130101NM 001130102NM 001251934NM 001251935NM 005693NM 001177730NM 013839NM 001355279RefSeq protein NP 001123573NP 001123574NP 001238863NP 001238864NP 005684NP 001350524NP 005684 2NP 001171201NP 038867NP 001342208Location UCSC Chr 11 47 25 47 27 MbChr 2 91 01 91 03 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Expression 2 Function 3 Interactions 4 Link to multiple sclerosis 5 References 6 Further reading 7 External linksExpression editmiRNA hsa miR 613 autoregulates the human LXRa gene by targeting the endogenous LXRa through its specific miRNA response element 613MRE within the LXRa 3 untranslated region LXRa autoregulates its own suppression via induction of SREBP1c which upregulates miRNA has miR 613 7 Function editThe liver X receptors LXRa this protein and LXRb form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function controlling transcriptional programs involved in lipid homeostasis and inflammation Additionally they play an important role in the local activation of thyroid hormones via deiodinases 8 The inducible LXRa is highly expressed in liver adrenal gland intestine adipose tissue macrophages lung and kidney whereas LXRb is ubiquitously expressed Ligand activated LXRs form obligate heterodimers with retinoid X receptors RXRs and regulate expression of target genes containing LXR response elements 9 10 Restoration of LXR alpha expression function within a psoriatic lesion may help to switch the transition from psoriatic to symptomless skin 11 Interactions editLiver X receptor alpha has been shown to interact with EDF1 12 and Small heterodimer partner 13 LXRa activates the transcription factor SREBP 1c resulting in lipogenesis 14 Link to multiple sclerosis editIn 2016 a study found 70 of individuals in two families with a rare form of rapidly progressing multiple sclerosis had a mutation in NR1H3 15 However an analysis from The International Multiple Sclerosis Genetics Consortium using a 13 fold larger sample size could not find any evidence that the mutation in question p Arg415Gln associated with multiple sclerosis refuting these findings 16 References edit a b c GRCh38 Ensembl release 89 ENSG00000025434 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000002108 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Miyata KS McCaw SE Patel HV Rachubinski RA Capone JP Apr 1996 The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator activated receptor and inhibits peroxisome proliferator signaling The Journal of Biological Chemistry 271 16 9189 92 doi 10 1074 jbc 271 16 9189 PMID 8621574 Willy PJ Umesono K Ong ES Evans RM Heyman RA Mangelsdorf DJ May 1995 LXR a nuclear receptor that defines a distinct retinoid response pathway Genes amp Development 9 9 1033 45 doi 10 1101 gad 9 9 1033 PMID 7744246 http mend endojournals org content 25 4 584 abstract dead link Christoffolete MA Doleschall M Egri P Liposits Z Zavacki AM Bianco AC et al 2010 Regulation of thyroid hormone activation via the liver X receptor retinoid X receptor pathway The Journal of Endocrinology 205 2 179 86 doi 10 1677 JOE 09 0448 PMC 3133926 PMID 20176747 Korf H Vander Beken S Romano M Steffensen KR Stijlemans B Gustafsson JA et al Jun 2009 Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice The Journal of Clinical Investigation 119 6 1626 37 doi 10 1172 JCI35288 PMC 2689129 PMID 19436111 Entrez Gene nuclear receptor subfamily 1 Gupta DS Kaul D Kanwar AJ Parsad D Jan 2010 Psoriasis crucial role of LXR alpha RNomics Genes and Immunity 11 1 37 44 doi 10 1038 gene 2009 63 PMID 19798078 Brendel C Gelman L Auwerx J Jun 2002 Multiprotein bridging factor 1 MBF 1 is a cofactor for nuclear receptors that regulate lipid metabolism Molecular Endocrinology 16 6 1367 77 doi 10 1210 mend 16 6 0843 PMID 12040021 Brendel C Schoonjans K Botrugno OA Treuter E Auwerx J Sep 2002 The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity Molecular Endocrinology 16 9 2065 76 doi 10 1210 me 2001 0194 PMID 12198243 Wang MY Chen L Clark GO Lee Y Stevens RD Ilkayeva OR et al 2010 Leptin therapy in insulin deficient type I diabetes Proceedings of the National Academy of Sciences of the United States of America 107 11 4813 9 Bibcode 2010PNAS 107 4813W doi 10 1073 pnas 0909422107 PMC 2841945 PMID 20194735 Wang Z Sadovnick AD Traboulsee AL Ross JP Bernales CQ Encarnacion M et al 2016 Nuclear Receptor NR1H3 in Familial Multiple Sclerosis Neuron 90 5 948 54 doi 10 1016 j neuron 2016 04 039 PMC 5092154 PMID 27253448 Antel J Ban M Baranzini S Barcellos L Barizzone N Beecham A et al International Multiple Sclerosis Genetics Consortium October 2016 NR1H3 p Arg415Gln Is Not Associated to Multiple Sclerosis Risk Neuron 92 2 333 335 doi 10 1016 j neuron 2016 09 052 PMC 5641967 PMID 27764667 Further reading editLehmann JM Kliewer SA Moore LB Smith Oliver TA Oliver BB Su JL et al Feb 1997 Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway The Journal of Biological Chemistry 272 6 3137 40 doi 10 1074 jbc 272 6 3137 PMID 9013544 Auboeuf D Rieusset J Fajas L Vallier P Frering V Riou JP et al Aug 1997 Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator activated receptors and liver X receptor alpha in humans no alteration in adipose tissue of obese and NIDDM patients Diabetes 46 8 1319 27 doi 10 2337 diabetes 46 8 1319 PMID 9231657 Peet DJ Turley SD Ma W Janowski BA Lobaccaro JM Hammer RE et al May 1998 Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha Cell 93 5 693 704 doi 10 1016 S0092 8674 00 81432 4 PMID 9630215 S2CID 5856580 Miyata KS McCaw SE Meertens LM Patel HV Rachubinski RA Capone JP Nov 1998 Receptor interacting protein 140 interacts with and inhibits transactivation by peroxisome proliferator activated receptor alpha and liver X receptor alpha Molecular and Cellular Endocrinology 146 1 2 69 76 doi 10 1016 S0303 7207 98 00196 8 PMID 10022764 S2CID 53253694 Venkateswaran A Laffitte BA Joseph SB Mak PA Wilpitz DC Edwards PA et al Oct 2000 Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha Proceedings of the National Academy of Sciences of the United States of America 97 22 12097 102 Bibcode 2000PNAS 9712097V doi 10 1073 pnas 200367697 PMC 17300 PMID 11035776 Chinetti G Lestavel S Bocher V Remaley AT Neve B Torra IP et al Jan 2001 PPAR alpha and PPAR gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway Nature Medicine 7 1 53 8 doi 10 1038 83348 PMID 11135616 S2CID 20558311 Laffitte BA Repa JJ Joseph SB Wilpitz DC Kast HR Mangelsdorf DJ et al Jan 2001 LXRs control lipid inducible expression of the apolipoprotein E gene in macrophages and adipocytes Proceedings of the National Academy of Sciences of the United States of America 98 2 507 12 doi 10 1073 pnas 021488798 PMC 14617 PMID 11149950 Li Y Bolten C Bhat BG Woodring Dietz J Li S Prayaga SK et al Mar 2002 Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism Molecular Endocrinology 16 3 506 14 doi 10 1210 mend 16 3 0789 PMID 11875109 Mak PA Laffitte BA Desrumaux C Joseph SB Curtiss LK Mangelsdorf DJ et al Aug 2002 Regulated expression of the apolipoprotein E C I C IV C II gene cluster in murine and human macrophages A critical role for nuclear liver X receptors alpha and beta The Journal of Biological Chemistry 277 35 31900 8 doi 10 1074 jbc M202993200 PMID 12032151 Brendel C Gelman L Auwerx J Jun 2002 Multiprotein bridging factor 1 MBF 1 is a cofactor for nuclear receptors that regulate lipid metabolism Molecular Endocrinology 16 6 1367 77 doi 10 1210 mend 16 6 0843 PMID 12040021 Steffensen KR Schuster GU Parini P Holter E Sadek CM Cassel T et al May 2002 Different regulation of the LXRalpha promoter activity by isoforms of CCAAT enhancer binding proteins Biochemical and Biophysical Research Communications 293 5 1333 40 doi 10 1016 S0006 291X 02 00390 X PMID 12054659 Gbaguidi GF Agellon LB Jul 2002 The atypical interaction of peroxisome proliferator activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha hydroxylase gene promoter Biochimica et Biophysica Acta BBA Molecular and Cell Biology of Lipids 1583 2 229 36 doi 10 1016 s1388 1981 02 00217 2 PMID 12117567 Pawar A Xu J Jerks E Mangelsdorf DJ Jump DB Oct 2002 Fatty acid regulation of liver X receptors LXR and peroxisome proliferator activated receptor alpha PPARalpha in HEK293 cells The Journal of Biological Chemistry 277 42 39243 50 doi 10 1074 jbc M206170200 PMID 12161442 Brendel C Schoonjans K Botrugno OA Treuter E Auwerx J Sep 2002 The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity Molecular Endocrinology 16 9 2065 76 doi 10 1210 me 2001 0194 PMID 12198243 Oberkofler H Schraml E Krempler F Patsch W Apr 2003 Potentiation of liver X receptor transcriptional activity by peroxisome proliferator activated receptor gamma co activator 1 alpha The Biochemical Journal 371 Pt 1 89 96 doi 10 1042 BJ20021665 PMC 1223253 PMID 12470296 Wang M Thomas J Burris TP Schkeryantz J Michael LF Nov 2003 Molecular determinants of LXRalpha agonism Journal of Molecular Graphics amp Modelling 22 2 173 81 doi 10 1016 S1093 3263 03 00159 1 PMID 12932788 Fukuchi J Song C Ko AL Liao S Sep 2003 Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors Steroids 68 7 8 685 91 doi 10 1016 S0039 128X 03 00100 4 PMID 12957674 S2CID 6023862 External links editNR1H3 human gene location in the UCSC Genome Browser NR1H3 human gene details in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Liver X receptor alpha amp oldid 1217123020, wikipedia, wiki, book, books, library,

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