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Wikipedia

KCNJ5

January 01, 1970

G protein-activated inward rectifier potassium channel 4 (GIRK-4) is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.[5][6]

KCNJ5
Identifiers
AliasesKCNJ5, CIR, GIRK4, KATP1, KIR3.4, LQT13, potassium voltage-gated channel subfamily J member 5, potassium inwardly rectifying channel subfamily J member 5
External IDsOMIM: 600734 MGI: 104755 HomoloGene: 20248 GeneCards: KCNJ5
Orthologs
SpeciesHumanMouse
Entrez

3762

16521

Ensembl

ENSG00000120457

ENSMUSG00000032034

UniProt

P48544

P48545

RefSeq (mRNA)

NM_000890
NM_001354169

NM_010605

RefSeq (protein)

NP_000881
NP_001341098

NP_034735

Location (UCSC)Chr 11: 128.89 – 128.92 MbChr 9: 32.23 – 32.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with other G-protein-activated potassium channel subunits to form a heterotetrameric pore-forming complex.[6]

In humans KCNJ5 is mainly expressed in adrenal gland and pituitary, although it is also detected at low levels in pancreas, spleen, lung, heart and brain.[7] Consistent with this expression pattern, mutations in KCNJ5/Kir3.4 can cause familial hyperaldosteronism type III and a type of long QT syndrome.[8]

Interactions edit

KCNJ5 has been shown to interact with KCNJ3.[9][10]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120457 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032034 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
  6. ^ a b "Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5".
  7. ^ "Gtexportal". GETEX portal.
  8. ^ Online Mendelian Inheritance in Man (OMIM): potassium channel, inwardly rectifying, subfamily j, member 5; KCNJ5 - 600734
  9. ^ Huang CL, Jan YN, Jan LY (April 1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Letters. 405 (3): 291–8. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307. S2CID 44072628.
  10. ^ He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (February 2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". The Journal of Biological Chemistry. 277 (8): 6088–96. doi:10.1074/jbc.M104851200. PMID 11741896.

Further reading edit

  • Zhuo ML, Huang Y, Liu DP, Liang CC (April 2005). "KATP channel: relation with cell metabolism and role in the cardiovascular system". The International Journal of Biochemistry & Cell Biology. 37 (4): 751–64. doi:10.1016/j.biocel.2004.10.008. PMID 15694835.
  • Tucker SJ, James MR, Adelman JP (July 1995). "Assignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24". Genomics. 28 (1): 127–8. doi:10.1006/geno.1995.1121. PMID 7590741.
  • Ashford ML, Bond CT, Blair TA, Adelman JP (1996). "Cloning and functional expression of a rat heart KATP channel". Nature. 378 (6559): 792. doi:10.1038/378792a0. PMID 8524415.
  • Spauschus A, Lentes KU, Wischmeyer E, Dissmann E, Karschin C, Karschin A (February 1996). "A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels". The Journal of Neuroscience. 16 (3): 930–8. doi:10.1523/JNEUROSCI.16-03-00930.1996. PMC 6578796. PMID 8558261.
  • Iizuka M, Kubo Y, Tsunenari I, Pan CX, Akiba I, Kono T (1996). "Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel". Receptors & Channels. 3 (4): 299–315. PMID 8834003.
  • Chan KW, Langan MN, Sui JL, Kozak JA, Pabon A, Ladias JA, Logothetis DE (March 1996). "A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins". The Journal of General Physiology. 107 (3): 381–97. doi:10.1085/jgp.107.3.381. PMC 2216996. PMID 8868049.
  • Huang CL, Jan YN, Jan LY (April 1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Letters. 405 (3): 291–8. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307. S2CID 44072628.
  • Kanzaki M, Lindorfer MA, Garrison JC, Kojima I (June 1997). "Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein". The Journal of Biological Chemistry. 272 (23): 14733–9. doi:10.1074/jbc.272.23.14733. PMID 9169438.
  • Wischmeyer E, Döring F, Wischmeyer E, Spauschus A, Thomzig A, Veh R, Karschin A (1997). "Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels". Molecular and Cellular Neurosciences. 9 (3): 194–206. doi:10.1006/mcne.1997.0614. PMID 9245502. S2CID 8455396.
  • Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE (July 1998). "Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation". The Journal of Biological Chemistry. 273 (27): 16946–52. doi:10.1074/jbc.273.27.16946. PMID 9642257.
  • Corey S, Clapham DE (October 1998). "Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers". The Journal of Biological Chemistry. 273 (42): 27499–504. doi:10.1074/jbc.273.42.27499. PMID 9765280.
  • Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE (January 1999). "GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels". The Journal of Biological Chemistry. 274 (4): 2571–82. doi:10.1074/jbc.274.4.2571. PMID 9891030.
  • Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH (December 1999). "Co-expression of human Kir3 subunits can yield channels with different functional properties". Cellular Signalling. 11 (12): 871–83. doi:10.1016/S0898-6568(99)00059-5. PMID 10659995.
  • He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (February 2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". The Journal of Biological Chemistry. 277 (8): 6088–96. doi:10.1074/jbc.M104851200. PMID 11741896.
  • Ma D, Zerangue N, Raab-Graham K, Fried SR, Jan YN, Jan LY (February 2002). "Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart". Neuron. 33 (5): 715–29. doi:10.1016/S0896-6273(02)00614-1. PMID 11879649. S2CID 10459917.
  • Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (November 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.
  • Shankar H, Murugappan S, Kim S, Jin J, Ding Z, Wickman K, Kunapuli SP (September 2004). "Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses". Blood. 104 (5): 1335–43. doi:10.1182/blood-2004-01-0069. PMID 15142872.

External links edit

  • KCNJ5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • GTEX portal: KCNJ5 expression in human tissue

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

January 01, 1970
kcnj5, protein, activated, inward, rectifier, potassium, channel, girk, protein, that, humans, encoded, gene, type, protein, gated, channel, identifiersaliases, girk4, katp1, kir3, lqt13, potassium, voltage, gated, channel, subfamily, member, potassium, inward. G protein activated inward rectifier potassium channel 4 GIRK 4 is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein gated ion channel 5 6 KCNJ5IdentifiersAliasesKCNJ5 CIR GIRK4 KATP1 KIR3 4 LQT13 potassium voltage gated channel subfamily J member 5 potassium inwardly rectifying channel subfamily J member 5External IDsOMIM 600734 MGI 104755 HomoloGene 20248 GeneCards KCNJ5Gene location Human Chr Chromosome 11 human 1 Band11q24 3Start128 891 356 bp 1 End128 921 163 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 A4 9 17 65 cMStart32 226 003 bp 2 End32 255 646 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendothelial celladrenal cortexright adrenal glandleft adrenal glandright ventriclemyocardiumseminal vesiculainternal globus pallidusatriumright atriumTop expressed inatriumatrioventricular valveaortic valveolfactory epitheliumendocardial cushionright lobe of livermyocardium of ventriclesupraoptic nucleusright ventriclebloodMore reference expression dataBioGPSn aGene ontologyMolecular functionG protein activated inward rectifier potassium channel activity protein binding inward rectifier potassium channel activity voltage gated ion channel activity voltage gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationCellular componentintegral component of membrane T tubule plasma membrane membrane external side of plasma membrane voltage gated potassium channel complexBiological processpotassium ion transport regulation of ion transmembrane transport ion transport regulation of heart rate by cardiac conduction membrane repolarization during atrial cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential ventricular cardiac muscle cell membrane repolarization potassium ion import across plasma membraneSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez376216521EnsemblENSG00000120457ENSMUSG00000032034UniProtP48544P48545RefSeq mRNA NM 000890NM 001354169NM 010605RefSeq protein NP 000881NP 001341098NP 034735Location UCSC Chr 11 128 89 128 92 MbChr 9 32 23 32 26 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 See also 4 References 5 Further reading 6 External linksFunction editPotassium channels are present in most mammalian cells where they participate in a wide range of physiologic responses The protein encoded by this gene is an integral membrane protein and inward rectifier type potassium channel The encoded protein which has a greater tendency to allow potassium to flow into a cell rather than out of a cell is controlled by G proteins It may associate with other G protein activated potassium channel subunits to form a heterotetrameric pore forming complex 6 In humans KCNJ5 is mainly expressed in adrenal gland and pituitary although it is also detected at low levels in pancreas spleen lung heart and brain 7 Consistent with this expression pattern mutations in KCNJ5 Kir3 4 can cause familial hyperaldosteronism type III and a type of long QT syndrome 8 Interactions editKCNJ5 has been shown to interact with KCNJ3 9 10 See also editG protein coupled inwardly rectifying potassium channel Inward rectifier potassium ion channelReferences edit a b c GRCh38 Ensembl release 89 ENSG00000120457 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032034 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kubo Y Adelman JP Clapham DE Jan LY Karschin A Kurachi Y Lazdunski M Nichols CG Seino S Vandenberg CA December 2005 International Union of Pharmacology LIV Nomenclature and molecular relationships of inwardly rectifying potassium channels Pharmacological Reviews 57 4 509 26 doi 10 1124 pr 57 4 11 PMID 16382105 S2CID 11588492 a b Entrez Gene KCNJ5 potassium inwardly rectifying channel subfamily J member 5 Gtexportal GETEX portal Online Mendelian Inheritance in Man OMIM potassium channel inwardly rectifying subfamily j member 5 KCNJ5 600734 Huang CL Jan YN Jan LY April 1997 Binding of the G protein betagamma subunit to multiple regions of G protein gated inward rectifying K channels FEBS Letters 405 3 291 8 doi 10 1016 S0014 5793 97 00197 X PMID 9108307 S2CID 44072628 He C Yan X Zhang H Mirshahi T Jin T Huang A Logothetis DE February 2002 Identification of critical residues controlling G protein gated inwardly rectifying K channel activity through interactions with the beta gamma subunits of G proteins The Journal of Biological Chemistry 277 8 6088 96 doi 10 1074 jbc M104851200 PMID 11741896 Further reading editZhuo ML Huang Y Liu DP Liang CC April 2005 KATP channel relation with cell metabolism and role in the cardiovascular system The International Journal of Biochemistry amp Cell Biology 37 4 751 64 doi 10 1016 j biocel 2004 10 008 PMID 15694835 Tucker SJ James MR Adelman JP July 1995 Assignment of KATP 1 the cardiac ATP sensitive potassium channel gene KCNJ5 to human chromosome 11q24 Genomics 28 1 127 8 doi 10 1006 geno 1995 1121 PMID 7590741 Ashford ML Bond CT Blair TA Adelman JP 1996 Cloning and functional expression of a rat heart KATP channel Nature 378 6559 792 doi 10 1038 378792a0 PMID 8524415 Spauschus A Lentes KU Wischmeyer E Dissmann E Karschin C Karschin A February 1996 A G protein activated inwardly rectifying K channel GIRK4 from human hippocampus associates with other GIRK channels The Journal of Neuroscience 16 3 930 8 doi 10 1523 JNEUROSCI 16 03 00930 1996 PMC 6578796 PMID 8558261 Iizuka M Kubo Y Tsunenari I Pan CX Akiba I Kono T 1996 Functional characterization and localization of a cardiac type inwardly rectifying K channel Receptors amp Channels 3 4 299 315 PMID 8834003 Chan KW Langan MN Sui JL Kozak JA Pabon A Ladias JA Logothetis DE March 1996 A recombinant inwardly rectifying potassium channel coupled to GTP binding proteins The Journal of General Physiology 107 3 381 97 doi 10 1085 jgp 107 3 381 PMC 2216996 PMID 8868049 Huang CL Jan YN Jan LY April 1997 Binding of the G protein betagamma subunit to multiple regions of G protein gated inward rectifying K channels FEBS Letters 405 3 291 8 doi 10 1016 S0014 5793 97 00197 X PMID 9108307 S2CID 44072628 Kanzaki M Lindorfer MA Garrison JC Kojima I June 1997 Activation of the calcium permeable cation channel CD20 by alpha subunits of the Gi protein The Journal of Biological Chemistry 272 23 14733 9 doi 10 1074 jbc 272 23 14733 PMID 9169438 Wischmeyer E Doring F Wischmeyer E Spauschus A Thomzig A Veh R Karschin A 1997 Subunit interactions in the assembly of neuronal Kir3 0 inwardly rectifying K channels Molecular and Cellular Neurosciences 9 3 194 206 doi 10 1006 mcne 1997 0614 PMID 9245502 S2CID 8455396 Krapivinsky G Kennedy ME Nemec J Medina I Krapivinsky L Clapham DE July 1998 Gbeta binding to GIRK4 subunit is critical for G protein gated K channel activation The Journal of Biological Chemistry 273 27 16946 52 doi 10 1074 jbc 273 27 16946 PMID 9642257 Corey S Clapham DE October 1998 Identification of native atrial G protein regulated inwardly rectifying K GIRK4 channel homomultimers The Journal of Biological Chemistry 273 42 27499 504 doi 10 1074 jbc 273 42 27499 PMID 9765280 Kennedy ME Nemec J Corey S Wickman K Clapham DE January 1999 GIRK4 confers appropriate processing and cell surface localization to G protein gated potassium channels The Journal of Biological Chemistry 274 4 2571 82 doi 10 1074 jbc 274 4 2571 PMID 9891030 Schoots O Wilson JM Ethier N Bigras E Hebert TE Van Tol HH December 1999 Co expression of human Kir3 subunits can yield channels with different functional properties Cellular Signalling 11 12 871 83 doi 10 1016 S0898 6568 99 00059 5 PMID 10659995 He C Yan X Zhang H Mirshahi T Jin T Huang A Logothetis DE February 2002 Identification of critical residues controlling G protein gated inwardly rectifying K channel activity through interactions with the beta gamma subunits of G proteins The Journal of Biological Chemistry 277 8 6088 96 doi 10 1074 jbc M104851200 PMID 11741896 Ma D Zerangue N Raab Graham K Fried SR Jan YN Jan LY February 2002 Diverse trafficking patterns due to multiple traffic motifs in G protein activated inwardly rectifying potassium channels from brain and heart Neuron 33 5 715 29 doi 10 1016 S0896 6273 02 00614 1 PMID 11879649 S2CID 10459917 Lavine N Ethier N Oak JN Pei L Liu F Trieu P Rebois RV Bouvier M Hebert TE Van Tol HH November 2002 G protein coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase The Journal of Biological Chemistry 277 48 46010 9 doi 10 1074 jbc M205035200 PMID 12297500 Shankar H Murugappan S Kim S Jin J Ding Z Wickman K Kunapuli SP September 2004 Role of G protein gated inwardly rectifying potassium channels in P2Y12 receptor mediated platelet functional responses Blood 104 5 1335 43 doi 10 1182 blood 2004 01 0069 PMID 15142872 External links editKCNJ5 protein human at the U S National Library of Medicine Medical Subject Headings MeSH GTEX portal KCNJ5 expression in human tissue This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title KCNJ5 amp oldid 1170979030, wikipedia, wiki, book, books, library,

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