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K. C. Nicolaou

October 28, 2023

Kyriacos Costa Nicolaou (Greek: Κυριάκος Κ. Νικολάου; born July 5, 1946) is a Cypriot-American chemist known for his research in the area of natural products total synthesis. He is currently Harry C. and Olga K. Wiess Professor of Chemistry at Rice University, having previously held academic positions at The Scripps Research Institute/UC San Diego and the University of Pennsylvania.

Biography edit

K. C. Nicolaou was born on July 5, 1946, in Karavas, Cyprus where he grew up and went to school until the age of 18. In 1964, he went to England where he spent two years learning English and preparing to enter University. He studied chemistry at the University of London (B.Sc., 1969, Bedford College; Ph.D. 1972, University College London, with Professors F. Sondheimer and P. J. Garratt). In 1972, he moved to the United States and, after postdoctoral appointments at Columbia University (1972–1973, Professor T. J. Katz) and Harvard University (1973–1976, Professor E. J. Corey), he joined the faculty at the University of Pennsylvania where he became the Rhodes-Thompson Professor of Chemistry. While at Penn, he won the prestigious Sloan Fellowship.[1]

In 1989, he relocated to San Diego, where he took up a joint appointment at the University of California, San Diego, where he served as Professor of Chemistry, and The Scripps Research Institute, where he was Darlene Shiley Professor of Chemistry and Chairman of the Department of Chemistry. In 1996, he was appointed Aline W. and L.S. Skaggs Professor of Chemical Biology in The Skaggs Institute for Chemical Biology, The Scripps Research Institute. From 2005 to 2011, he directed Chemical Synthesis Laboratory @ ICES-A*STAR, Singapore. In 2013, Nicolaou moved to Rice University.

The Nicolaou group is active in the field of organic chemistry with research interests in methodology development and total synthesis. He is responsible for the synthesis of many complex molecules found in nature, such as Taxol and vancomycin. His group's route to Taxol, completed in 1994 at roughly the same time as a synthesis by the group of Robert A. Holton, attracted national news media attention due to Taxol's structural complexity and its potent anti-cancer activity.[2][3]

Total syntheses accomplished edit

Books edit

He is also the co-author of three popular books on total synthesis:

  1. Classics in Total Synthesis I, 1996[1]
  2. Classics in Total Synthesis II, 2003[2]
  3. Classics in Total Synthesis III, 2011[3]

Additionally, he authored or co-authored several other books:

  1. Molecules That Changed the World, 2008
  2. Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials, 2002
  3. Selenium in Natural Products Synthesis, 1984

Awards edit

K. C. Nicolaou has received numerous awards and honors including:

References edit

  1. ^ "K.C. Nicolaou". Retrieved May 27, 2020.
  2. ^ Borman, Stu (February 21, 1994). "Total Synthesis of Anticancer Agent Taxol Achieved by Two Different Routes". Chemical & Engineering News. Vol. 72, no. 8. pp. 32–34. doi:10.1021/cen-v072n008.p032.
  3. ^ Blakeslee, Sandra (February 15, 1994). "Race to Synthesize Cancer Drug Molecule Has Photo Finish". The New York Times. Retrieved August 22, 2013.
  4. ^ "Arthur C. Cope Award". ACS. Retrieved January 19, 2015.
  5. ^ "APS Member History". search.amphilsoc.org. Retrieved April 2, 2021.
  6. ^ "New Fellows 2013". Royal Society. Retrieved July 30, 2013.
  1. ^ Nicolaou, Kyriacos Costa; E. J. Sorensen (1996). Classics in Total Synthesis: Targets, Strategies, Methods. Wiley-VCH. ISBN 978-3-527-29231-8.
  2. ^ Nicolaou, Kyriacos Costa; S. A. Snyder (2003). Classics in Total Synthesis II: More Targets, Strategies, Methods. Wiley-VCH. ISBN 978-3-527-30684-8.
  3. ^ Nicolaou, Kyriacos Costa; J.S. Chen (2011). Classics in Total Synthesis III: Further Targets, Strategies, Methods. Wiley-VCH. ISBN 978-3-527-32957-1.
  4. ^ "Benjamin Franklin Medal in Chemistry". Franklin Institute. 2011. Archived from the original on July 30, 2012. Retrieved December 23, 2011.

External links edit

  • The Nicolaou group at Rice University
  • A video interview of Professor Nicolaou

October 28, 2023
nicolaou, this, article, includes, list, general, references, lacks, sufficient, corresponding, inline, citations, please, help, improve, this, article, introducing, more, precise, citations, february, 2013, learn, when, remove, this, template, message, kyriac. This article includes a list of general references but it lacks sufficient corresponding inline citations Please help to improve this article by introducing more precise citations February 2013 Learn how and when to remove this template message Kyriacos Costa Nicolaou Greek Kyriakos K Nikolaoy born July 5 1946 is a Cypriot American chemist known for his research in the area of natural products total synthesis He is currently Harry C and Olga K Wiess Professor of Chemistry at Rice University having previously held academic positions at The Scripps Research Institute UC San Diego and the University of Pennsylvania K C NicolaouBornJuly 5 1946 1946 07 05 age 77 Karavas CyprusAlma materUniversity College LondonKnown forTotal synthesisNicolaou Taxol total synthesisCorey Nicolaou macrolactonizationAwardsErnest Guenther Award 1996 Wolf Prize in Chemistry 2016 Scientific careerFieldsChemistryInstitutionsRice UniversityScripps Research InstituteUniversity of California San DiegoUniversity of Pennsylvania ICES A STARDoctoral studentsTushar Kanti ChakrabortyOther notable studentsPhil BaranGovindasamy Mugesh Contents 1 Biography 2 Total syntheses accomplished 3 Books 4 Awards 5 References 6 External linksBiography editK C Nicolaou was born on July 5 1946 in Karavas Cyprus where he grew up and went to school until the age of 18 In 1964 he went to England where he spent two years learning English and preparing to enter University He studied chemistry at the University of London B Sc 1969 Bedford College Ph D 1972 University College London with Professors F Sondheimer and P J Garratt In 1972 he moved to the United States and after postdoctoral appointments at Columbia University 1972 1973 Professor T J Katz and Harvard University 1973 1976 Professor E J Corey he joined the faculty at the University of Pennsylvania where he became the Rhodes Thompson Professor of Chemistry While at Penn he won the prestigious Sloan Fellowship 1 In 1989 he relocated to San Diego where he took up a joint appointment at the University of California San Diego where he served as Professor of Chemistry and The Scripps Research Institute where he was Darlene Shiley Professor of Chemistry and Chairman of the Department of Chemistry In 1996 he was appointed Aline W and L S Skaggs Professor of Chemical Biology in The Skaggs Institute for Chemical Biology The Scripps Research Institute From 2005 to 2011 he directed Chemical Synthesis Laboratory ICES A STAR Singapore In 2013 Nicolaou moved to Rice University The Nicolaou group is active in the field of organic chemistry with research interests in methodology development and total synthesis He is responsible for the synthesis of many complex molecules found in nature such as Taxol and vancomycin His group s route to Taxol completed in 1994 at roughly the same time as a synthesis by the group of Robert A Holton attracted national news media attention due to Taxol s structural complexity and its potent anti cancer activity 2 3 Total syntheses accomplished editEndiandric acids A D 1982 Amphoteronolide B and Amphotericin B 1987 Calicheamicin g1 1992 Sirolimus 1993 Taxol 1994 Zaragozic acid A 1994 Brevetoxin B 1995 Vancomycin 1998 Uncialamycin 2008 Sporolide B 2009 Viridicatumtoxin B 2013 Shishijimicin A 2015 Thailanstatin A 2016 Gukulenin B 2022 Books editHe is also the co author of three popular books on total synthesis Classics in Total Synthesis I 1996 1 Classics in Total Synthesis II 2003 2 Classics in Total Synthesis III 2011 3 Additionally he authored or co authored several other books Molecules That Changed the World 2008 Handbook of Combinatorial Chemistry Drugs Catalysts Materials 2002 Selenium in Natural Products Synthesis 1984Awards editK C Nicolaou has received numerous awards and honors including 2021 Robert Koch Gold Medal Germany 2016 Wolf Prize in Chemistry Israel 2011 Benjamin Franklin Medal in Chemistry Franklin Institute USA 4 2005 Arthur C Cope Award USA 4 2003 Nobel Laureate Signature Award in Graduate Education with Phil S Baran 2002 Tetrahedron Prize 2001 Ernst Schering Prize Germany 2000 Paul Karrer Gold Medal Switzerland 1998 Esselen Award USA 1996 Linus Pauling Award USA 1996 William H Nichols Medal USA Aspirin Prize Spain Max Tishler Prize Lecture Harvard Yamada Prize Japan Janssen Prize Belgium Nagoya Medal Japan Centenary Medal Royal Society UK Inhoffen Medal Germany ACS Award for Creative Work in Synthetic Organic Chemistry USA ACS Guenther Award in Natural Products Chemistry USA Fellow of the American Academy of Arts and Sciences Member of the National Academy of Sciences Member of the American Philosophical Society 5 Foreign Member of the Royal Society 2013 6 Several honorary degreesReferences edit K C Nicolaou Retrieved May 27 2020 Borman Stu February 21 1994 Total Synthesis of Anticancer Agent Taxol Achieved by Two Different Routes Chemical amp Engineering News Vol 72 no 8 pp 32 34 doi 10 1021 cen v072n008 p032 Blakeslee Sandra February 15 1994 Race to Synthesize Cancer Drug Molecule Has Photo Finish The New York Times Retrieved August 22 2013 Arthur C Cope Award ACS Retrieved January 19 2015 APS Member History search amphilsoc org Retrieved April 2 2021 New Fellows 2013 Royal Society Retrieved July 30 2013 Nicolaou Kyriacos Costa E J Sorensen 1996 Classics in Total Synthesis Targets Strategies Methods Wiley VCH ISBN 978 3 527 29231 8 Nicolaou Kyriacos Costa S A Snyder 2003 Classics in Total Synthesis II More Targets Strategies Methods Wiley VCH ISBN 978 3 527 30684 8 Nicolaou Kyriacos Costa J S Chen 2011 Classics in Total Synthesis III Further Targets Strategies Methods Wiley VCH ISBN 978 3 527 32957 1 Benjamin Franklin Medal in Chemistry Franklin Institute 2011 Archived from the original on July 30 2012 Retrieved December 23 2011 External links editThe Nicolaou group at Rice University A video interview of Professor Nicolaou Retrieved from https en wikipedia org w index php title K C Nicolaou amp oldid 1181799509, wikipedia, wiki, book, books, library,

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