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John Katzenellenbogen

April 23, 2024

John Albert Katzenellenbogen (born May 10, 1944) is an American Professor of Chemistry at the University of Illinois at Urbana-Champaign. He studies the development of novel agents for the treatment of hormone-responsive and non-responsive breast and prostate cancers and the design of estrogens and antiestrogens that have a favorable balance of beneficial versus detrimental effects.[1]

Early life edit

John Katzenellenbogen was born May 10, 1944, in Poughkeepsie, New York. His parents taught at Vassar College, his father a professor of art history and his mother a pianist. In 1958, his family moved to Baltimore, Maryland, where his father became Head of the Department of Art History at Johns Hopkins University[2] and his mother joined the faculty at Peabody Conservatory[3] and Goucher College.[4] He began playing the cello at age 10. Katzenellenbogen attended Gilman School[5] and held various summer jobs: in 1960, he worked at the Research Institute for Advanced Studies in the photosynthesis lab of Dr. Bessel Kok,[6] and, in 1961, he was a General Electric Student Research Fellow at Union College in Schenectady, New York. As an undergraduate at Harvard, he majored in chemistry, going on to complete a PhD in chemistry in 1969 at Harvard under the direction of Dr. E. J. Corey.[7]

Career edit

Katzenellenbogen began his academic career as an Assistant Professor of Chemistry at the University of Illinois at Urbana-Champaign[8] in 1969 and was promoted to Associate Professor in 1975 and to Full Professor in 1979. He was named the Roger Adams Professor and subsequently the chaired Swanlund Professor of Chemistry. He was one of the first academic chemists to work in the field of chemical biology. His major research efforts have focused on the study of steroid hormones and their biological receptors, the estrogen receptor in particular.

Katzenellenbogen's research is highly collaborative, and he works with other scientists locally, nationally, and internationally. He has published more than 550 articles[9] and has trained over 130 PhD's and Postdoctoral Associates. He is a member of the American Association for the Advancement of Science and a fellow of the American Academy of Arts and Sciences, on whose National Council he served for many years. He has received numerous awards from scientific societies, including the Arthur C. Cope Scholar Award,[10] the E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances from the American Chemical Society,[11] the Endocrine Society's Fred Conrad Koch Lifetime Achievement Award,[12] which he shared with Dr. Benita Katzenellenbogen, and the Award for Outstanding Achievements in Chemistry in Cancer Research from the American Association for Cancer Research In 2018, Katzenellenbogen was inducted into the Medicinal Chemistry Hall of Fame of the American Chemical Society.

Research edit

Katzenellenbogen developed the first affinity label for the estrogen receptor that was widely used to characterize its physical and biochemical properties,[13][14] and he elucidated the metabolic activation of antiestrogens and characterized their sites of action.[15] He also pioneered the development of positron emission tomography (PET) imaging agents for estrogen, androgen, and progesterone receptors.[16][17][18][19] The PET imaging agents he developed, FES,[20] FDHT,[21] and FFNP,[22] continue to be utilized to improve the prediction of patient response to endocrine therapy agents and to assist in the development of new cancer therapeutics. His more recent work is focused on developing novel antiestrogens effective against endocrine therapy-resistant forms of breast cancer[23][24] and dissecting the mechanisms and signaling pathways that underlie the selective actions of estrogens in different target tissues.[25][26][27][28]

References edit

  1. ^ "John Katzenellenbogen". illinois.edu. Retrieved December 5, 2017.
  2. ^ "Dr. Adolf Katzenellenbogen, Johns Hopkins Professor, Dies". The New York Times. 1964-10-01. ISSN 0362-4331. Retrieved 2017-11-23.
  3. ^ "Scott Foglesong | SFCM". sfcm.edu. Retrieved 2017-11-23.
  4. ^ "Members of the Society". College Music Symposium. 10: 182. 1970. JSTOR 40376030.
  5. ^ "Fall 2015 Gilman Bulletin". issuu. Retrieved 2017-11-23.
  6. ^ "Notes: Elias James Corey". www.hcs.harvard.edu. Retrieved 2017-11-23.
  7. ^ . www.hcs.harvard.edu. Archived from the original on 2021-04-22. Retrieved 2017-11-23.
  8. ^ "John A. Katzenellenbogen | Chemistry at Illinois". chemistry.illinois.edu. Retrieved 2017-11-22.
  9. ^ pubmeddev. "Katzenellenbogen JA - PubMed - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-11-22.
  10. ^ "Arthur C. Cope Scholar Awards - American Chemical Society". American Chemical Society. Retrieved 2017-11-22.
  11. ^ "E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances - American Chemical Society". American Chemical Society. Retrieved 2017-11-22.
  12. ^ "Katzenellenbogens Awarded Fred Conrad Koch Lifetime Achievement Award by the Endocrine Society | Chemistry at Illinois". chemistry.illinois.edu. Retrieved 2017-11-22.
  13. ^ Harlow, K. W.; Smith, D. N.; Katzenellenbogen, J. A.; Greene, G. L.; Katzenellenbogen, B. S. (1989-10-15). "Identification of cysteine 530 as the covalent attachment site of an affinity-labeling estrogen (ketononestrol aziridine) and antiestrogen (tamoxifen aziridine) in the human estrogen receptor". The Journal of Biological Chemistry. 264 (29): 17476–17485. doi:10.1016/S0021-9258(18)71519-6. ISSN 0021-9258. PMID 2793867.
  14. ^ Robertson, D. W.; Wei, L. L.; Hayes, J. R.; Carlson, K. E.; Katzenellenbogen, J. A.; Katzenellenbogen, B. S. (October 1981). "Tamoxifen aziridines: effective inactivators of the estrogen receptor". Endocrinology. 109 (4): 1298–1300. doi:10.1210/endo-109-4-1298. ISSN 0013-7227. PMID 7285873.
  15. ^ Robertson, D. W.; Katzenellenbogen, J. A.; Long, D. J.; Rorke, E. A.; Katzenellenbogen, B. S. (January 1982). "Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen". Journal of Steroid Biochemistry. 16 (1): 1–13. doi:10.1016/0022-4731(82)90137-6. ISSN 0022-4731. PMID 7062732.
  16. ^ Katzenellenbogen, J. A.; Welch, M. J.; Dehdashti, F. (May 1997). "The development of estrogen and progestin radiopharmaceuticals for imaging breast cancer". Anticancer Research. 17 (3B): 1573–1576. ISSN 0250-7005. PMID 9179196.
  17. ^ Mortimer, J. E.; Dehdashti, F.; Siegel, B. A.; Trinkaus, K.; Katzenellenbogen, J. A.; Welch, M. J. (2001-06-01). "Metabolic flare: indicator of hormone responsiveness in advanced breast cancer". Journal of Clinical Oncology. 19 (11): 2797–2803. doi:10.1200/JCO.2001.19.11.2797. ISSN 0732-183X. PMID 11387350.
  18. ^ Dehdashti, Farrokh; Picus, Joel; Michalski, Jeff M.; Dence, Carmen S.; Siegel, Barry A.; Katzenellenbogen, John A.; Welch, Michael J. (March 2005). "Positron tomographic assessment of androgen receptors in prostatic carcinoma". European Journal of Nuclear Medicine and Molecular Imaging. 32 (3): 344–350. doi:10.1007/s00259-005-1764-5. ISSN 1619-7070. PMID 15726353. S2CID 24329403.
  19. ^ Dehdashti, Farrokh; Mortimer, Joanne E.; Trinkaus, Kathryn; Naughton, Michael J.; Ellis, Matthew; Katzenellenbogen, John A.; Welch, Michael J.; Siegel, Barry A. (February 2009). "PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer". Breast Cancer Research and Treatment. 113 (3): 509–517. doi:10.1007/s10549-008-9953-0. ISSN 1573-7217. PMC 3883567. PMID 18327670.
  20. ^ Kiesewetter, D. O.; Kilbourn, M. R.; Landvatter, S. W.; Heiman, D. F.; Katzenellenbogen, J. A.; Welch, M. J. (November 1984). "Preparation of four fluorine- 18-labeled estrogens and their selective uptakes in target tissues of immature rats". Journal of Nuclear Medicine. 25 (11): 1212–1221. ISSN 0161-5505. PMID 6092569.
  21. ^ Liu, A.; Carlson, K. E.; Katzenellenbogen, J. A. (1992-05-29). "Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography". Journal of Medicinal Chemistry. 35 (11): 2113–2129. doi:10.1021/jm00089a024. ISSN 0022-2623. PMID 1597861.
  22. ^ Kochanny, M. J.; VanBrocklin, H. F.; Kym, P. R.; Carlson, K. E.; O'Neil, J. P.; Bonasera, T. A.; Welch, M. J.; Katzenellenbogen, J. A. (1993-04-30). "Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors". Journal of Medicinal Chemistry. 36 (9): 1120–1127. doi:10.1021/jm00061a002. ISSN 0022-2623. PMID 8487253.
  23. ^ Min, Jian; Guillen, Valeria Sanabria; Sharma, Abhishek; Zhao, Yuechao; Ziegler, Yvonne; Gong, Ping; Mayne, Christopher G.; Srinivasan, Sathish; Kim, Sung Hoon (2017-07-27). "Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells". Journal of Medicinal Chemistry. 60 (14): 6321–6336. doi:10.1021/acs.jmedchem.7b00585. ISSN 1520-4804. PMC 6039301. PMID 28657320.
  24. ^ Zhao, Yuechao; Laws, Mary J.; Guillen, Valeria Sanabria; Ziegler, Yvonne; Min, Jian; Sharma, Abhishek; Kim, Sung Hoon; Chu, David; Park, Ben Ho (2017-10-15). "Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors". Cancer Research. 77 (20): 5602–5613. doi:10.1158/0008-5472.CAN-17-1265. ISSN 1538-7445. PMC 5645250. PMID 28904064.
  25. ^ Madak-Erdogan, Zeynep; Kim, Sung Hoon; Gong, Ping; Zhao, Yiru C.; Zhang, Hui; Chambliss, Ken L.; Carlson, Kathryn E.; Mayne, Christopher G.; Shaul, Philip W. (2016-05-24). "Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues". Science Signaling. 9 (429): ra53. doi:10.1126/scisignal.aad8170. ISSN 1937-9145. PMC 4896643. PMID 27221711.
  26. ^ Zhao, Yuechao; Gong, Ping; Chen, Yiru; Nwachukwu, Jerome C.; Srinivasan, Sathish; Ko, CheMyong; Bagchi, Milan K.; Taylor, Robert N.; Korach, Kenneth S. (2015-01-21). "Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis". Science Translational Medicine. 7 (271): 271ra9. doi:10.1126/scitranslmed.3010626. ISSN 1946-6242. PMC 4790140. PMID 25609169.
  27. ^ Saijo, Kaoru; Collier, Jana G.; Li, Andrew C.; Katzenellenbogen, John A.; Glass, Christopher K. (2011-05-13). "An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation". Cell. 145 (4): 584–595. doi:10.1016/j.cell.2011.03.050. ISSN 1097-4172. PMC 3433492. PMID 21565615.
  28. ^ Moore, Spencer M.; Khalaj, Anna J.; Kumar, Shalini; Winchester, Zachary; Yoon, JaeHee; Yoo, Timothy; Martinez-Torres, Leonardo; Yasui, Norio; Katzenellenbogen, John A. (2014-12-16). "Multiple functional therapeutic effects of the estrogen receptor β agonist indazole-Cl in a mouse model of multiple sclerosis". Proceedings of the National Academy of Sciences of the United States of America. 111 (50): 18061–18066. Bibcode:2014PNAS..11118061M. doi:10.1073/pnas.1411294111. ISSN 1091-6490. PMC 4273334. PMID 25453074.

April 23, 2024
john, katzenellenbogen, john, albert, katzenellenbogen, born, 1944, american, professor, chemistry, university, illinois, urbana, champaign, studies, development, novel, agents, treatment, hormone, responsive, responsive, breast, prostate, cancers, design, est. John Albert Katzenellenbogen born May 10 1944 is an American Professor of Chemistry at the University of Illinois at Urbana Champaign He studies the development of novel agents for the treatment of hormone responsive and non responsive breast and prostate cancers and the design of estrogens and antiestrogens that have a favorable balance of beneficial versus detrimental effects 1 Contents 1 Early life 2 Career 3 Research 4 ReferencesEarly life editJohn Katzenellenbogen was born May 10 1944 in Poughkeepsie New York His parents taught at Vassar College his father a professor of art history and his mother a pianist In 1958 his family moved to Baltimore Maryland where his father became Head of the Department of Art History at Johns Hopkins University 2 and his mother joined the faculty at Peabody Conservatory 3 and Goucher College 4 He began playing the cello at age 10 Katzenellenbogen attended Gilman School 5 and held various summer jobs in 1960 he worked at the Research Institute for Advanced Studies in the photosynthesis lab of Dr Bessel Kok 6 and in 1961 he was a General Electric Student Research Fellow at Union College in Schenectady New York As an undergraduate at Harvard he majored in chemistry going on to complete a PhD in chemistry in 1969 at Harvard under the direction of Dr E J Corey 7 Career editKatzenellenbogen began his academic career as an Assistant Professor of Chemistry at the University of Illinois at Urbana Champaign 8 in 1969 and was promoted to Associate Professor in 1975 and to Full Professor in 1979 He was named the Roger Adams Professor and subsequently the chaired Swanlund Professor of Chemistry He was one of the first academic chemists to work in the field of chemical biology His major research efforts have focused on the study of steroid hormones and their biological receptors the estrogen receptor in particular Katzenellenbogen s research is highly collaborative and he works with other scientists locally nationally and internationally He has published more than 550 articles 9 and has trained over 130 PhD s and Postdoctoral Associates He is a member of the American Association for the Advancement of Science and a fellow of the American Academy of Arts and Sciences on whose National Council he served for many years He has received numerous awards from scientific societies including the Arthur C Cope Scholar Award 10 the E B Hershberg Award for Important Discoveries in Medicinally Active Substances from the American Chemical Society 11 the Endocrine Society s Fred Conrad Koch Lifetime Achievement Award 12 which he shared with Dr Benita Katzenellenbogen and the Award for Outstanding Achievements in Chemistry in Cancer Research from the American Association for Cancer Research In 2018 Katzenellenbogen was inducted into the Medicinal Chemistry Hall of Fame of the American Chemical Society Research editKatzenellenbogen developed the first affinity label for the estrogen receptor that was widely used to characterize its physical and biochemical properties 13 14 and he elucidated the metabolic activation of antiestrogens and characterized their sites of action 15 He also pioneered the development of positron emission tomography PET imaging agents for estrogen androgen and progesterone receptors 16 17 18 19 The PET imaging agents he developed FES 20 FDHT 21 and FFNP 22 continue to be utilized to improve the prediction of patient response to endocrine therapy agents and to assist in the development of new cancer therapeutics His more recent work is focused on developing novel antiestrogens effective against endocrine therapy resistant forms of breast cancer 23 24 and dissecting the mechanisms and signaling pathways that underlie the selective actions of estrogens in different target tissues 25 26 27 28 References edit John Katzenellenbogen illinois edu Retrieved December 5 2017 Dr Adolf Katzenellenbogen Johns Hopkins Professor Dies The New York Times 1964 10 01 ISSN 0362 4331 Retrieved 2017 11 23 Scott Foglesong SFCM sfcm edu Retrieved 2017 11 23 Members of the Society College Music Symposium 10 182 1970 JSTOR 40376030 Fall 2015 Gilman Bulletin issuu Retrieved 2017 11 23 Notes Elias James Corey www hcs harvard edu Retrieved 2017 11 23 Group Members Elias James Corey www hcs harvard edu Archived from the original on 2021 04 22 Retrieved 2017 11 23 John A Katzenellenbogen Chemistry at Illinois chemistry illinois edu Retrieved 2017 11 22 pubmeddev Katzenellenbogen JA PubMed NCBI www ncbi nlm nih gov Retrieved 2017 11 22 Arthur C Cope Scholar Awards American Chemical Society American Chemical Society Retrieved 2017 11 22 E B Hershberg Award for Important Discoveries in Medicinally Active Substances American Chemical Society American Chemical Society Retrieved 2017 11 22 Katzenellenbogens Awarded Fred Conrad Koch Lifetime Achievement Award by the Endocrine Society Chemistry at Illinois chemistry illinois edu Retrieved 2017 11 22 Harlow K W Smith D N Katzenellenbogen J A Greene G L Katzenellenbogen B S 1989 10 15 Identification of cysteine 530 as the covalent attachment site of an affinity labeling estrogen ketononestrol aziridine and antiestrogen tamoxifen aziridine in the human estrogen receptor The Journal of Biological Chemistry 264 29 17476 17485 doi 10 1016 S0021 9258 18 71519 6 ISSN 0021 9258 PMID 2793867 Robertson D W Wei L L Hayes J R Carlson K E Katzenellenbogen J A Katzenellenbogen B S October 1981 Tamoxifen aziridines effective inactivators of the estrogen receptor Endocrinology 109 4 1298 1300 doi 10 1210 endo 109 4 1298 ISSN 0013 7227 PMID 7285873 Robertson D W Katzenellenbogen J A Long D J Rorke E A Katzenellenbogen B S January 1982 Tamoxifen antiestrogens A comparison of the activity pharmacokinetics and metabolic activation of the cis and trans isomers of tamoxifen Journal of Steroid Biochemistry 16 1 1 13 doi 10 1016 0022 4731 82 90137 6 ISSN 0022 4731 PMID 7062732 Katzenellenbogen J A Welch M J Dehdashti F May 1997 The development of estrogen and progestin radiopharmaceuticals for imaging breast cancer Anticancer Research 17 3B 1573 1576 ISSN 0250 7005 PMID 9179196 Mortimer J E Dehdashti F Siegel B A Trinkaus K Katzenellenbogen J A Welch M J 2001 06 01 Metabolic flare indicator of hormone responsiveness in advanced breast cancer Journal of Clinical Oncology 19 11 2797 2803 doi 10 1200 JCO 2001 19 11 2797 ISSN 0732 183X PMID 11387350 Dehdashti Farrokh Picus Joel Michalski Jeff M Dence Carmen S Siegel Barry A Katzenellenbogen John A Welch Michael J March 2005 Positron tomographic assessment of androgen receptors in prostatic carcinoma European Journal of Nuclear Medicine and Molecular Imaging 32 3 344 350 doi 10 1007 s00259 005 1764 5 ISSN 1619 7070 PMID 15726353 S2CID 24329403 Dehdashti Farrokh Mortimer Joanne E Trinkaus Kathryn Naughton Michael J Ellis Matthew Katzenellenbogen John A Welch Michael J Siegel Barry A February 2009 PET based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen receptor positive breast cancer Breast Cancer Research and Treatment 113 3 509 517 doi 10 1007 s10549 008 9953 0 ISSN 1573 7217 PMC 3883567 PMID 18327670 Kiesewetter D O Kilbourn M R Landvatter S W Heiman D F Katzenellenbogen J A Welch M J November 1984 Preparation of four fluorine 18 labeled estrogens and their selective uptakes in target tissues of immature rats Journal of Nuclear Medicine 25 11 1212 1221 ISSN 0161 5505 PMID 6092569 Liu A Carlson K E Katzenellenbogen J A 1992 05 29 Synthesis of high affinity fluorine substituted ligands for the androgen receptor Potential agents for imaging prostatic cancer by positron emission tomography Journal of Medicinal Chemistry 35 11 2113 2129 doi 10 1021 jm00089a024 ISSN 0022 2623 PMID 1597861 Kochanny M J VanBrocklin H F Kym P R Carlson K E O Neil J P Bonasera T A Welch M J Katzenellenbogen J A 1993 04 30 Fluorine 18 labeled progestin ketals synthesis and target tissue uptake selectivity of potential imaging agents for receptor positive breast tumors Journal of Medicinal Chemistry 36 9 1120 1127 doi 10 1021 jm00061a002 ISSN 0022 2623 PMID 8487253 Min Jian Guillen Valeria Sanabria Sharma Abhishek Zhao Yuechao Ziegler Yvonne Gong Ping Mayne Christopher G Srinivasan Sathish Kim Sung Hoon 2017 07 27 Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells Journal of Medicinal Chemistry 60 14 6321 6336 doi 10 1021 acs jmedchem 7b00585 ISSN 1520 4804 PMC 6039301 PMID 28657320 Zhao Yuechao Laws Mary J Guillen Valeria Sanabria Ziegler Yvonne Min Jian Sharma Abhishek Kim Sung Hoon Chu David Park Ben Ho 2017 10 15 Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors Cancer Research 77 20 5602 5613 doi 10 1158 0008 5472 CAN 17 1265 ISSN 1538 7445 PMC 5645250 PMID 28904064 Madak Erdogan Zeynep Kim Sung Hoon Gong Ping Zhao Yiru C Zhang Hui Chambliss Ken L Carlson Kathryn E Mayne Christopher G Shaul Philip W 2016 05 24 Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues Science Signaling 9 429 ra53 doi 10 1126 scisignal aad8170 ISSN 1937 9145 PMC 4896643 PMID 27221711 Zhao Yuechao Gong Ping Chen Yiru Nwachukwu Jerome C Srinivasan Sathish Ko CheMyong Bagchi Milan K Taylor Robert N Korach Kenneth S 2015 01 21 Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis Science Translational Medicine 7 271 271ra9 doi 10 1126 scitranslmed 3010626 ISSN 1946 6242 PMC 4790140 PMID 25609169 Saijo Kaoru Collier Jana G Li Andrew C Katzenellenbogen John A Glass Christopher K 2011 05 13 An ADIOL ERb CtBP transrepression pathway negatively regulates microglia mediated inflammation Cell 145 4 584 595 doi 10 1016 j cell 2011 03 050 ISSN 1097 4172 PMC 3433492 PMID 21565615 Moore Spencer M Khalaj Anna J Kumar Shalini Winchester Zachary Yoon JaeHee Yoo Timothy Martinez Torres Leonardo Yasui Norio Katzenellenbogen John A 2014 12 16 Multiple functional therapeutic effects of the estrogen receptor b agonist indazole Cl in a mouse model of multiple sclerosis Proceedings of the National Academy of Sciences of the United States of America 111 50 18061 18066 Bibcode 2014PNAS 11118061M doi 10 1073 pnas 1411294111 ISSN 1091 6490 PMC 4273334 PMID 25453074 Retrieved from https en wikipedia org w index php title John Katzenellenbogen amp oldid 1146358130, wikipedia, wiki, book, books, library,

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