IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RB is also found in some immune cells.[7] The subunit has been linked with multiple diseases, including gastrointestinal diseases and glaucoma.
IL20RB is a β-chain with a short intracellulardomain. IL20RB, along with the IL-20 receptor, alpha subunit, form the heterodimeric type I interleukin-20 receptor, which binds the cytokinesIL-20 and IL-24. IL20RB also associates with IL-22 receptor, to form the heterodimeric type II interleukin-20 receptor, which also binds IL-20 and IL-24.[6]
Signalingedit
After a cytokine binds both the IL20RB and the alpha subunit of the IL20 receptor, a signal is sent through the JAK-STAT signaling pathway. This signaling pathway leads STAT to act as a transcription factor, which can gene expression.[6]
IL20RB mRNA is expressed in retinal ganglion cells and optic nerves in rats. Mutations in the IL20RB gene are associated with glaucoma. The specific links between IL20RB and glaucoma are unknown, but IL20RB does not have a causative effect on the disease, instead contributing to an increased risk of the disease along with other factors, such as intraocular pressure.[5][8]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000174564 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000044244 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abRutz S, Wang X, Ouyang W (December 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology. 14 (12): 783–795. doi:10.1038/nri3766. PMID 25421700.
^ abcdeWegenka UM (October 2010). "IL-20: biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. PMID 20864382.
^Kragstrup TW, Andersen T, Heftdal LD, Hvid M, Gerwien J, Sivakumar P, et al. (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9: 2226. doi:10.3389/fimmu.2018.02226. PMC6167463. PMID 30319661.
^Wirtz MK, Keller KE (2016-01-20). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 4083735. doi:10.1155/2016/4083735. PMC4745377. PMID 26903709.
Further readingedit
Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC (October 2001). "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types". Journal of Immunology. 167 (7): 3545–3549. doi:10.4049/jimmunol.167.7.3545. PMID 11564763.
Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J, et al. (December 2002). "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions". The Journal of Biological Chemistry. 277 (49): 47517–47523. doi:10.1074/jbc.M205114200. PMID 12351624.
Pletnev S, Magracheva E, Kozlov S, Tobin G, Kotenko SV, Wlodawer A, Zdanov A (November 2003). "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20". Biochemistry. 42 (43): 12617–12624. doi:10.1021/bi0354583. PMID 14580208.
Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
External linksedit
Overview of all the structural information available in the PDB for UniProt: Q6UXL0 (Interleukin-20 receptor subunit beta) at the PDBe-KB.
This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
interleukin, receptor, beta, subunit, il20r2, il20rb, subunit, interleukin, receptor, interleukin, receptor, believed, involved, both, inflammatory, anti, inflammatory, responses, il20rbavailable, structurespdbortholog, search, pdbe, rcsblist, codes4dohidentif. Interleukin 20 receptor beta subunit IL20R2 or IL20RB is a subunit of the interleukin 20 receptor and interleukin 22 receptor It is believed to be involved in both pro inflammatory and anti inflammatory responses 5 6 IL20RBAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4DOHIdentifiersAliasesIL20RB DIRS1 FNDC6 IL 20R2 Interleukin 20 receptor beta subunit interleukin 20 receptor subunit betaExternal IDsOMIM 605621 MGI 2143266 HomoloGene 86034 GeneCards IL20RBGene location Human Chr Chromosome 3 human 1 Band3q22 3Start136 946 230 bp 1 End137 011 085 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 E3 3Start100 339 772 bp 2 End100 368 841 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomenhuman penisvulvanipplecavity of mouthvaginabody of tonguetibial nervepalpebral conjunctivathymusTop expressed inlipesophaguscerebellar cortexskin of backskin of abdomenmorulacerebellar vermisbelly cordthymusankleMore reference expression dataBioGPSn aGene ontologyMolecular functioninterleukin 20 binding interleukin 10 receptor activity protein binding cytokine receptor activityCellular componentintegral component of membrane membrane plasma membraneBiological processhomeostasis of number of cells within a tissue immune response inhibiting signal transduction negative regulation of T cell proliferation negative regulation of interferon gamma production negative regulation of interleukin 2 production negative regulation of type IV hypersensitivity positive regulation of interleukin 4 production inflammatory response to antigenic stimulus regulation of T cell activation positive regulation of interleukin 10 production cytokine mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez53833213208EnsemblENSG00000174564ENSMUSG00000044244UniProtQ6UXL0E9Q9A6RefSeq mRNA NM 144717NM 001033543NM 001037246RefSeq protein NP 653318NP 001028715Location UCSC Chr 3 136 95 137 01 MbChr 9 100 34 100 37 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseIL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis osteoclasts found in bones and epithelial cells of the intestine and trachea IL20RB is also found in some immune cells 7 The subunit has been linked with multiple diseases including gastrointestinal diseases and glaucoma Contents 1 Structure and function 2 Signaling 3 Link to Immune System and Disease 4 Glaucoma 5 References 6 Further reading 7 External linksStructure and function editIL20RB is a b chain with a short intracellular domain IL20RB along with the IL 20 receptor alpha subunit form the heterodimeric type I interleukin 20 receptor which binds the cytokines IL 20 and IL 24 IL20RB also associates with IL 22 receptor to form the heterodimeric type II interleukin 20 receptor which also binds IL 20 and IL 24 6 Signaling editAfter a cytokine binds both the IL20RB and the alpha subunit of the IL20 receptor a signal is sent through the JAK STAT signaling pathway This signaling pathway leads STAT to act as a transcription factor which can gene expression 6 Link to Immune System and Disease editIL20RB mRNA is present in some immune cells including monocytes natural killer cells B cells T cells and some hematopoietic stem cells It is known what role IL20RB plays in these cells 6 IL20RB is linked with atherosclerosis and gastrointestinal diseases although its specific roles are unknown 6 Glaucoma editIL20RB mRNA is expressed in retinal ganglion cells and optic nerves in rats Mutations in the IL20RB gene are associated with glaucoma The specific links between IL20RB and glaucoma are unknown but IL20RB does not have a causative effect on the disease instead contributing to an increased risk of the disease along with other factors such as intraocular pressure 5 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000174564 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000044244 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Rutz S Wang X Ouyang W December 2014 The IL 20 subfamily of cytokines from host defence to tissue homeostasis Nature Reviews Immunology 14 12 783 795 doi 10 1038 nri3766 PMID 25421700 a b c d e Wegenka UM October 2010 IL 20 biological functions mediated through two types of receptor complexes Cytokine amp Growth Factor Reviews 21 5 353 363 doi 10 1016 j cytogfr 2010 08 001 PMID 20864382 Kragstrup TW Andersen T Heftdal LD Hvid M Gerwien J Sivakumar P et al 2018 09 25 The IL 20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis Frontiers in Immunology 9 2226 doi 10 3389 fimmu 2018 02226 PMC 6167463 PMID 30319661 Wirtz MK Keller KE 2016 01 20 The Role of the IL 20 Subfamily in Glaucoma Mediators of Inflammation 2016 4083735 doi 10 1155 2016 4083735 PMC 4745377 PMID 26903709 Further reading editDumoutier L Leemans C Lejeune D Kotenko SV Renauld JC October 2001 Cutting edge STAT activation by IL 19 IL 20 and mda 7 through IL 20 receptor complexes of two types Journal of Immunology 167 7 3545 3549 doi 10 4049 jimmunol 167 7 3545 PMID 11564763 Parrish Novak J Xu W Brender T Yao L Jones C West J et al December 2002 Interleukins 19 20 and 24 signal through two distinct receptor complexes Differences in receptor ligand interactions mediate unique biological functions The Journal of Biological Chemistry 277 49 47517 47523 doi 10 1074 jbc M205114200 PMID 12351624 Pletnev S Magracheva E Kozlov S Tobin G Kotenko SV Wlodawer A Zdanov A November 2003 Characterization of the recombinant extracellular domains of human interleukin 20 receptors and their complexes with interleukin 19 and interleukin 20 Biochemistry 42 43 12617 12624 doi 10 1021 bi0354583 PMID 14580208 Zhang Z Henzel WJ October 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Science 13 10 2819 2824 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 External links editOverview of all the structural information available in the PDB for UniProt Q6UXL0 Interleukin 20 receptor subunit beta at the PDBe KB nbsp This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Interleukin 20 receptor beta subunit amp oldid 1188033235, wikipedia, wiki, book, books, library,
