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Indenolol

Indenolol is a beta-adrenergic blocker[1] for the treatment of hypertension (high blood pressure). It was investigated in the 1980s,[2] but is not known to be marketed as of 2021.[3] It is a derivative of a phenolic 4-indenol.

Indenolol
Names
IUPAC name
1-(1H-Inden-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
Identifiers
  • 60607-68-3 Y
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL153585
ChemSpider
  • 64962
DrugBank
  • DB08952 N
EC Number
  • 262-323-5
KEGG
  • D08078
  • 71955
UNII
  • 3MZM7RWW00 Y
  • InChI=1S/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
    Key: MPGBPFMOOXKQRX-UHFFFAOYSA-N
  • InChI=1/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
    Key: MPGBPFMOOXKQRX-UHFFFAOYAY
  • CC(C)NCC(COC1=CC=CC2=C1C=CC2)O
Properties
C15H21NO2
Molar mass 247.338 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

References edit

  1. ^ Ali, I; Gaitonde, VD; Aboul-Enein, HY; Hussain, A (2009). "Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC". Talanta. 78 (2): 458–63. doi:10.1016/j.talanta.2008.11.043. PMID 19203609.
  2. ^ Trimarco, Bruno; Cuocolo, Alberto; Groothold, Gisela; Ricciardelli, Bruno; De Luca, Nicola; Volpe, Massimo; Veniero, Anna Maria; Condorelli, Mario (1985). "Indenolol: A New Antihypertensive Agent: Efficacy, Toxicity, and Hemodynamic Effects in a Crossover Double-Blind Study with Metoprolol". The Journal of Clinical Pharmacology. 25 (5): 328–336. doi:10.1002/j.1552-4604.1985.tb02850.x. PMID 4031109. S2CID 22844379.
  3. ^ DrugBank DB08952 . Accessed 2021-03-18.


indenolol, beta, adrenergic, blocker, treatment, hypertension, high, blood, pressure, investigated, 1980s, known, marketed, 2021, update, derivative, phenolic, indenol, namesiupac, name, inden, yloxy, propan, ylamino, propan, olidentifierscas, number, 60607, m. Indenolol is a beta adrenergic blocker 1 for the treatment of hypertension high blood pressure It was investigated in the 1980s 2 but is not known to be marketed as of 2021 update 3 It is a derivative of a phenolic 4 indenol Indenolol NamesIUPAC name 1 1H Inden 4 yloxy 3 propan 2 ylamino propan 2 olIdentifiersCAS Number 60607 68 3 Y3D model JSmol Interactive imageChEMBL ChEMBL153585ChemSpider 64962DrugBank DB08952 NEC Number 262 323 5KEGG D08078PubChem CID 71955UNII 3MZM7RWW00 YInChI InChI 1S C15H21NO2 c1 11 2 16 9 13 17 10 18 15 8 4 6 12 5 3 7 14 12 15 h3 4 6 8 11 13 16 17H 5 9 10H2 1 2H3Key MPGBPFMOOXKQRX UHFFFAOYSA NInChI 1 C15H21NO2 c1 11 2 16 9 13 17 10 18 15 8 4 6 12 5 3 7 14 12 15 h3 4 6 8 11 13 16 17H 5 9 10H2 1 2H3Key MPGBPFMOOXKQRX UHFFFAOYAYSMILES CC C NCC COC1 CC CC2 C1C CC2 OPropertiesChemical formula C 15H 21N O 2Molar mass 247 338 g mol 1Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox referencesReferences edit Ali I Gaitonde VD Aboul Enein HY Hussain A 2009 Chiral separation of beta adrenergic blockers on CelluCoat column by HPLC Talanta 78 2 458 63 doi 10 1016 j talanta 2008 11 043 PMID 19203609 Trimarco Bruno Cuocolo Alberto Groothold Gisela Ricciardelli Bruno De Luca Nicola Volpe Massimo Veniero Anna Maria Condorelli Mario 1985 Indenolol A New Antihypertensive Agent Efficacy Toxicity and Hemodynamic Effects in a Crossover Double Blind Study with Metoprolol The Journal of Clinical Pharmacology 25 5 328 336 doi 10 1002 j 1552 4604 1985 tb02850 x PMID 4031109 S2CID 22844379 DrugBank DB08952 Accessed 2021 03 18 nbsp This drug article relating to the cardiovascular system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Indenolol amp oldid 1142741001, wikipedia, wiki, book, books, library,

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