The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[5] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.[6]
^De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October 2017). "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut. 66 (10): 1748–1760. doi:10.1136/gutjnl-2015-310847. PMC5595104. PMID 27371534.
^Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
^Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.
Further reading
Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer and Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729. S2CID 26150860.
integrin, alpha, integrin, alpha, protein, that, humans, encoded, itga6, gene, itga6identifiersaliasesitga6, cd49f, itga6b, integrin, subunit, alpha, jeb6external, idsomim, 147556, 96605, homologene, 20091, genecards, itga6gene, location, human, chromosome, hu. Integrin alpha 6 is a protein that in humans is encoded by the ITGA6 gene ITGA6IdentifiersAliasesITGA6 CD49f ITGA6B VLA 6 integrin subunit alpha 6 JEB6External IDsOMIM 147556 MGI 96605 HomoloGene 20091 GeneCards ITGA6Gene location Human Chr Chromosome 2 human 1 Band2q31 1Start172 427 354 bp 1 End172 506 459 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 C2 C3 2 42 79 cMStart71 575 960 bp 2 End71 688 760 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed intibial nervesural nervespinal gangliatrigeminal ganglionAchilles tendonrectumpylorusduodenumjejunal mucosagumsTop expressed insciatic nerveEpithelium of stomachsecondary oocyteatriumleft lung lobecrypt of lieberkuhn of small intestinepyloric antrumleft colonmolarlacrimal glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmetal ion binding integrin binding protein binding laminin binding neuregulin binding protein containing complex binding insulin like growth factor I binding cadherin bindingCellular componentintegral component of membrane membrane focal adhesion basal part of cell plasma membrane hemidesmosome basement membrane cell surface integrin complex basal plasma membrane basolateral plasma membrane external side of plasma membrane integrin alpha6 beta4 complex filopodiumBiological processcellular response to extracellular stimulus hemidesmosome assembly renal system development nail development positive regulation of cell cell adhesion filopodium assembly negative regulation of extrinsic apoptotic signaling pathway extracellular matrix organization odontogenesis of dentin containing tooth cell substrate adhesion positive regulation of GTPase activity cell adhesion cell adhesion mediated by integrin brown fat cell differentiation positive regulation of apoptotic process cell substrate junction assembly integrin mediated signaling pathway positive regulation of phosphorylation cell matrix adhesion digestive tract development ectodermal cell differentiation leukocyte migration skin development positive regulation of transcription by RNA polymerase II amelogenesis cellular response to organic cyclic compound positive regulation of cell substrate adhesion positive regulation of cell migration cell cell adhesion positive regulation of neuron projection developmentSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez365516403EnsemblENSG00000091409ENSMUSG00000027111UniProtP23229Q61739RefSeq mRNA NM 000210NM 001079818NM 001316306NM 001365529NM 001365530NM 001394928NM 001277970NM 008397RefSeq protein NP 000201NP 001073286NP 001303235NP 001352458NP 001352459NP 001264899NP 032423NP 001393187Location UCSC Chr 2 172 43 172 51 MbChr 2 71 58 71 69 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 See also 4 References 5 Further reading 6 External linksFunction EditThe ITGA6 protein product is the integrin alpha chain alpha 6 Integrins are integral cell surface proteins composed of an alpha chain and a beta chain A given chain may combine with multiple partners resulting in different integrins For example alpha 6 may combine with beta 4 in the integrin referred to as TSP180 or with beta 1 in the integrin VLA 6 Integrins are known to participate in cell adhesion as well as cell surface mediated signalling Two transcript variants encoding different isoforms have been found for this gene 5 Specific loss of this integrin chain in the intestinal epithelium and thus of their hemidesmosomes induces long standing colitis and infiltrating adenocarcinomas 6 Interactions EditITGA6 has been shown to interact with TSPAN4 7 and GIPC1 8 See also EditCluster of differentiation IntegrinsReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000091409 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000027111 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene ITGA6 integrin alpha 6 De Arcangelis A Hamade H Alpy F Normand S Bruyere E Lefebvre O et al October 2017 Hemidesmosome integrity protects the colon against colitis and colorectal cancer Gut 66 10 1748 1760 doi 10 1136 gutjnl 2015 310847 PMC 5595104 PMID 27371534 Tachibana I Bodorova J Berditchevski F Zutter MM Hemler ME November 1997 NAG 2 a novel transmembrane 4 superfamily TM4SF protein that complexes with integrins and other TM4SF proteins The Journal of Biological Chemistry 272 46 29181 9 doi 10 1074 jbc 272 46 29181 PMID 9360996 Tani TT Mercurio AM September 2001 PDZ interaction sites in integrin alpha subunits T14853 TIP GIPC binds to a type I recognition sequence in alpha 6A alpha 5 and a novel sequence in alpha 6B The Journal of Biological Chemistry 276 39 36535 42 doi 10 1074 jbc M105785200 PMID 11479315 Further reading EditLipscomb EA Mercurio AM September 2005 Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression Cancer and Metastasis Reviews 24 3 413 23 doi 10 1007 s10555 005 5133 4 PMID 16258729 S2CID 26150860 External links EditCD49f Antigen at the US National Library of Medicine Medical Subject Headings MeSH ITGA6 Info with links in the Cell Migration Gateway Archived 11 December 2014 at the Wayback Machine This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Integrin alpha 6 amp oldid 1116899775, wikipedia, wiki, book, books, library,
