fbpx
Wikipedia

GIPC1

November 16, 2023

GIPC PDZ domain containing family, member 1 (GIPC1) is a protein that in humans is encoded by the GIPC1 gene.[5][6][7] GIPC was originally identified as it binds specifically to the C terminus of RGS-GAIP, a protein involved in the regulation of G protein signaling.[5] GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins. The human GIPC1 molecule is 333 amino acids or about 36 kDa in molecular size and consists of a central PDZ domain, a compact protein module which mediates specific protein-protein interactions. The RGS-GAIP protein interacts with this domain and many other proteins interact here or at other parts of the GIPC1 molecule. As a result, GIPC1 was independently discovered by several other groups and has a variety of alternate names, including synectin, C19orf3, RGS19IP1 and others. The GIPC1 gene family in mammals consisting of three members, so the first discovered, originally named GIPC, is now generally called GIPC1, with the other two being named GIPC2 and GIPC3.[8] The three human proteins are about 60% identical in protein sequence. GIPC1 has been shown to interact with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4, SEMA4C/semaphorin-4 and HTLV-I Tax. The general function of GIPC family proteins therefore appears to be mediating specific interactions between proteins involved in G protein signaling and membrane translocation.

GIPC1
Identifiers
AliasesGIPC1, C19orf3, GIPC, GLUT1CBP, Hs.6454, IIP-1, NIP, RGS19IP1, SEMCAP, SYNECTIIN, SYNECTIN, TIP-2, GIPC PDZ domain containing family member 1, OPDM2
External IDsOMIM: 605072 MGI: 1926252 HomoloGene: 21167 GeneCards: GIPC1
Orthologs
SpeciesHumanMouse
Entrez

10755

67903

Ensembl

ENSG00000123159

ENSMUSG00000019433

UniProt

O14908

Q9Z0G0

RefSeq (mRNA)

NM_018771

RefSeq (protein)

NP_005707
NP_974197
NP_974198
NP_974199
NP_974223

NP_061241

Location (UCSC)Chr 19: 14.48 – 14.5 MbChr 8: 84.38 – 84.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

GIPC1 has been shown to interact with:

See also edit

GIPC PDZ domain containing family, member 2, GIPC2

GIPC PDZ domain containing family, member 3, GIPC3

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123159 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019433 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b De Vries L, Lou X, Zhao G, Zheng B, Farquhar MG (November 1998). "GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12340–5. Bibcode:1998PNAS...9512340D. doi:10.1073/pnas.95.21.12340. PMC 22833. PMID 9770488.
  6. ^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (March 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.
  7. ^ "Entrez Gene: GIPC1 GIPC PDZ domain containing family, member 1".
  8. ^ Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med. 9 (6): 585–9. doi:10.3892/ijmm.9.6.585. PMID 12011974.
  9. ^ a b c Bunn RC, Jensen MA, Reed BC (April 1999). "Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton". Mol. Biol. Cell. 10 (4): 819–32. doi:10.1091/mbc.10.4.819. PMC 25204. PMID 10198040.
  10. ^ Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ (July 2003). "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation". J. Biol. Chem. 278 (28): 26295–301. doi:10.1074/jbc.M212352200. PMID 12724327.
  11. ^ a b Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.
  12. ^ a b Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
  13. ^ Petersen HH, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek AJ, Willnow TE (February 2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
  14. ^ Lou X, McQuistan T, Orlando RA, Farquhar MG (April 2002). "GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function". J. Am. Soc. Nephrol. 13 (4): 918–27. doi:10.1681/ASN.V134918. PMID 11912251.
  15. ^ Hirakawa T, Galet C, Kishi M, Ascoli M (December 2003). "GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR". J. Biol. Chem. 278 (49): 49348–57. doi:10.1074/jbc.M306557200. PMID 14507927.
  16. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  17. ^ Aschenbrenner L, Lee T, Hasson T (July 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Mol. Biol. Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.
  18. ^ Lou X, Yano H, Lee F, Chao MV, Farquhar MG (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. 12 (3): 615–27. doi:10.1091/mbc.12.3.615. PMC 30968. PMID 11251075.
  19. ^ Awan A, Lucic MR, Shaw DM, Sheppard F, Westwater C, Lyons SA, Stern PL (January 2002). "5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis". Biochem. Biophys. Res. Commun. 290 (3): 1030–6. doi:10.1006/bbrc.2001.6288. PMID 11798178.
  20. ^ Liu TF, Kandala G, Setaluri V (September 2001). "PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)". J. Biol. Chem. 276 (38): 35768–77. doi:10.1074/jbc.M103585200. PMID 11441007.

Further reading edit

  • Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med. 9 (6): 585–9. doi:10.3892/ijmm.9.6.585. PMID 12011974.
  • Hasson T (2003). "Myosin VI: two distinct roles in endocytosis". J. Cell Sci. 116 (Pt 17): 3453–61. doi:10.1242/jcs.00669. PMID 12893809.
  • Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H (1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
  • De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
  • Bunn RC, Jensen MA, Reed BC (1999). "Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton". Mol. Biol. Cell. 10 (4): 819–32. doi:10.1091/mbc.10.4.819. PMC 25204. PMID 10198040.
  • Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF". J. Biol. Chem. 274 (20): 14137–46. doi:10.1074/jbc.274.20.14137. PMID 10318831.
  • Cai H, Reed RR (1999). "Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1". J. Neurosci. 19 (15): 6519–27. doi:10.1523/JNEUROSCI.19-15-06519.1999. PMC 6782790. PMID 10414980.
  • Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
  • Gao Y, Li M, Chen W, Simons M (2000). "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration". J. Cell. Physiol. 184 (3): 373–9. doi:10.1002/1097-4652(200009)184:3<373::AID-JCP12>3.0.CO;2-I. PMID 10911369. S2CID 20829740.
  • Von Kap-Herr C, Kandala G, Mann SS, Hart TC, Pettenati MJ, Setaluri V (2000). "Assignment of PDZ domain-containing protein GIPC gene (C19orf3) to human chromosome band 19p13.1 by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 89 (3–4): 234–5. doi:10.1159/000015621. PMID 10965131. S2CID 85292825.
  • Lou X, Yano H, Lee F, Chao MV, Farquhar MG (2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. 12 (3): 615–27. doi:10.1091/mbc.12.3.615. PMC 30968. PMID 11251075.
  • Liu TF, Kandala G, Setaluri V (2001). "PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)". J. Biol. Chem. 276 (38): 35768–77. doi:10.1074/jbc.M103585200. PMID 11441007.
  • Ligensa T, Krauss S, Demuth D, Schumacher R, Camonis J, Jaques G, Weidner KM (2001). "A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor". J. Biol. Chem. 276 (36): 33419–27. doi:10.1074/jbc.M104509200. PMID 11445579.
  • Tani TT, Mercurio AM (2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.
  • Blobe GC, Liu X, Fang SJ, How T, Lodish HF (2001). "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC". J. Biol. Chem. 276 (43): 39608–17. doi:10.1074/jbc.M106831200. PMID 11546783.
  • Awan A, Lucic MR, Shaw DM, Sheppard F, Westwater C, Lyons SA, Stern PL (2002). "5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis". Biochem. Biophys. Res. Commun. 290 (3): 1030–6. doi:10.1006/bbrc.2001.6288. PMID 11798178.
  • El Mourabit H, Poinat P, Koster J, Sondermann H, Wixler V, Wegener E, Laplantine E, Geerts D, Georges-Labouesse E, Sonnenberg A, Aumailley M (2002). "The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits". Matrix Biol. 21 (2): 207–14. doi:10.1016/S0945-053X(01)00198-6. PMID 11852236.
  • Lou X, McQuistan T, Orlando RA, Farquhar MG (2002). "GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function". J. Am. Soc. Nephrol. 13 (4): 918–27. doi:10.1681/ASN.V134918. PMID 11912251.

November 16, 2023
gipc1, gipc, domain, containing, family, member, protein, that, humans, encoded, gene, gipc, originally, identified, binds, specifically, terminus, gaip, protein, involved, regulation, protein, signaling, gipc, acronym, gaip, interacting, protein, terminus, pr. GIPC PDZ domain containing family member 1 GIPC1 is a protein that in humans is encoded by the GIPC1 gene 5 6 7 GIPC was originally identified as it binds specifically to the C terminus of RGS GAIP a protein involved in the regulation of G protein signaling 5 GIPC is an acronym for GAIP Interacting Protein C terminus RGS proteins are Regulators of G protein Signaling and RGS GAIP is a GTPase Activator protein for Gai Gaq which are two major subtypes of Ga proteins The human GIPC1 molecule is 333 amino acids or about 36 kDa in molecular size and consists of a central PDZ domain a compact protein module which mediates specific protein protein interactions The RGS GAIP protein interacts with this domain and many other proteins interact here or at other parts of the GIPC1 molecule As a result GIPC1 was independently discovered by several other groups and has a variety of alternate names including synectin C19orf3 RGS19IP1 and others The GIPC1 gene family in mammals consisting of three members so the first discovered originally named GIPC is now generally called GIPC1 with the other two being named GIPC2 and GIPC3 8 The three human proteins are about 60 identical in protein sequence GIPC1 has been shown to interact with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor ACTN1 KIF1B MYO6 PLEKHG5 SDC4 syndecan 4 SEMA4C semaphorin 4 and HTLV I Tax The general function of GIPC family proteins therefore appears to be mediating specific interactions between proteins involved in G protein signaling and membrane translocation GIPC1IdentifiersAliasesGIPC1 C19orf3 GIPC GLUT1CBP Hs 6454 IIP 1 NIP RGS19IP1 SEMCAP SYNECTIIN SYNECTIN TIP 2 GIPC PDZ domain containing family member 1 OPDM2External IDsOMIM 605072 MGI 1926252 HomoloGene 21167 GeneCards GIPC1Gene location Human Chr Chromosome 19 human 1 Band19p13 12Start14 477 760 bp 1 End14 496 149 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 C2Start84 379 306 bp 2 End84 391 323 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomenputamenminor salivary glandnucleus accumbensgumsbody of stomachupper lobe of left lungamygdalacingulate gyrusgastric mucosaTop expressed inlipcorneal stromasuperior surface of tonguemirrorneural tubesuperior frontal gyrusyolk sacentorhinal cortexesophagusexternal carotid arteryMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding PDZ domain binding signaling receptor binding protein homodimerization activity myosin binding actin binding cadherin bindingCellular componentcell cortex brush border endocytic vesicle extracellular exosome cytoplasm cytosol membrane synaptic vesicle vesicle membrane dendritic spine dendritic shaft cytoplasmic vesicle Schaffer collateral CA1 synapse presynapse postsynapse glutamatergic synapseBiological processG protein coupled receptor signaling pathway positive regulation of cytokinesis protein targeting positive regulation of transforming growth factor beta receptor signaling pathway regulation of protein stability regulation of synaptic plasticity glutamate secretion negative regulation of proteasomal ubiquitin dependent protein catabolic process endothelial cell migration chemical synaptic transmission positive regulation of melanin biosynthetic process cellular response to interleukin 7 regulation of synaptic vesicle exocytosisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1075567903EnsemblENSG00000123159ENSMUSG00000019433UniProtO14908Q9Z0G0RefSeq mRNA NM 005716NM 202467NM 202468NM 202469NM 202470NM 202494NM 018771RefSeq protein NP 005707NP 974197NP 974198NP 974199NP 974223NP 061241Location UCSC Chr 19 14 48 14 5 MbChr 8 84 38 84 39 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 See also 3 References 4 Further readingInteractions editGIPC1 has been shown to interact with Actinin alpha 1 9 ADRB1 10 GLUT1 9 ITGA5 11 ITGA6 11 KIF1B 9 LRP1 12 LRP2 12 13 14 LHCGR 15 MYO6 16 17 RGS19 18 TPBG 19 and TYRP1 20 See also editGIPC PDZ domain containing family member 2 GIPC2GIPC PDZ domain containing family member 3 GIPC3References edit a b c GRCh38 Ensembl release 89 ENSG00000123159 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000019433 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b De Vries L Lou X Zhao G Zheng B Farquhar MG November 1998 GIPC a PDZ domain containing protein interacts specifically with the C terminus of RGS GAIP Proc Natl Acad Sci U S A 95 21 12340 5 Bibcode 1998PNAS 9512340D doi 10 1073 pnas 95 21 12340 PMC 22833 PMID 9770488 Rousset R Fabre S Desbois C Bantignies F Jalinot P March 1998 The C terminus of the HTLV 1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins Oncogene 16 5 643 54 doi 10 1038 sj onc 1201567 PMID 9482110 Entrez Gene GIPC1 GIPC PDZ domain containing family member 1 Katoh M 2002 GIPC gene family Review Int J Mol Med 9 6 585 9 doi 10 3892 ijmm 9 6 585 PMID 12011974 a b c Bunn RC Jensen MA Reed BC April 1999 Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton Mol Biol Cell 10 4 819 32 doi 10 1091 mbc 10 4 819 PMC 25204 PMID 10198040 Hu LA Chen W Martin NP Whalen EJ Premont RT Lefkowitz RJ July 2003 GIPC interacts with the beta1 adrenergic receptor and regulates beta1 adrenergic receptor mediated ERK activation J Biol Chem 278 28 26295 301 doi 10 1074 jbc M212352200 PMID 12724327 a b Tani TT Mercurio AM September 2001 PDZ interaction sites in integrin alpha subunits T14853 TIP GIPC binds to a type I recognition sequence in alpha 6A alpha 5 and a novel sequence in alpha 6B J Biol Chem 276 39 36535 42 doi 10 1074 jbc M105785200 PMID 11479315 a b Gotthardt M Trommsdorff M Nevitt MF Shelton J Richardson JA Stockinger W Nimpf J Herz J August 2000 Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction J Biol Chem 275 33 25616 24 doi 10 1074 jbc M000955200 PMID 10827173 Petersen HH Hilpert J Militz D Zandler V Jacobsen C Roebroek AJ Willnow TE February 2003 Functional interaction of megalin with the megalinbinding protein MegBP a novel tetratrico peptide repeat containing adaptor molecule J Cell Sci 116 Pt 3 453 61 doi 10 1242 jcs 00243 PMID 12508107 Lou X McQuistan T Orlando RA Farquhar MG April 2002 GAIP GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells putative role in regulating megalin s function J Am Soc Nephrol 13 4 918 27 doi 10 1681 ASN V134918 PMID 11912251 Hirakawa T Galet C Kishi M Ascoli M December 2003 GIPC binds to the human lutropin receptor hLHR through an unusual PDZ domain binding motif and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR J Biol Chem 278 49 49348 57 doi 10 1074 jbc M306557200 PMID 14507927 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Aschenbrenner L Lee T Hasson T July 2003 Myo6 facilitates the translocation of endocytic vesicles from cell peripheries Mol Biol Cell 14 7 2728 43 doi 10 1091 mbc E02 11 0767 PMC 165672 PMID 12857860 Lou X Yano H Lee F Chao MV Farquhar MG March 2001 GIPC and GAIP form a complex with TrkA a putative link between G protein and receptor tyrosine kinase pathways Mol Biol Cell 12 3 615 27 doi 10 1091 mbc 12 3 615 PMC 30968 PMID 11251075 Awan A Lucic MR Shaw DM Sheppard F Westwater C Lyons SA Stern PL January 2002 5T4 interacts with TIP 2 GIPC a PDZ protein with implications for metastasis Biochem Biophys Res Commun 290 3 1030 6 doi 10 1006 bbrc 2001 6288 PMID 11798178 Liu TF Kandala G Setaluri V September 2001 PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 tyrosinase related protein 1 J Biol Chem 276 38 35768 77 doi 10 1074 jbc M103585200 PMID 11441007 Further reading editKatoh M 2002 GIPC gene family Review Int J Mol Med 9 6 585 9 doi 10 3892 ijmm 9 6 585 PMID 12011974 Hasson T 2003 Myosin VI two distinct roles in endocytosis J Cell Sci 116 Pt 17 3453 61 doi 10 1242 jcs 00669 PMID 12893809 Gress TM Muller Pillasch F Geng M Zimmerhackl F Zehetner G Friess H Buchler M Adler G Lehrach H 1996 A pancreatic cancer specific expression profile Oncogene 13 8 1819 30 PMID 8895530 De Vries L Elenko E Hubler L Jones TL Farquhar MG 1996 GAIP is membrane anchored by palmitoylation and interacts with the activated GTP bound form of G alpha i subunits Proc Natl Acad Sci U S A 93 26 15203 8 Bibcode 1996PNAS 9315203D doi 10 1073 pnas 93 26 15203 PMC 26381 PMID 8986788 Bunn RC Jensen MA Reed BC 1999 Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton Mol Biol Cell 10 4 819 32 doi 10 1091 mbc 10 4 819 PMC 25204 PMID 10198040 Wang LH Kalb RG Strittmatter SM 1999 A PDZ protein regulates the distribution of the transmembrane semaphorin M SemF J Biol Chem 274 20 14137 46 doi 10 1074 jbc 274 20 14137 PMID 10318831 Cai H Reed RR 1999 Cloning and characterization of neuropilin 1 interacting protein a PSD 95 Dlg ZO 1 domain containing protein that interacts with the cytoplasmic domain of neuropilin 1 J Neurosci 19 15 6519 27 doi 10 1523 JNEUROSCI 19 15 06519 1999 PMC 6782790 PMID 10414980 Gotthardt M Trommsdorff M Nevitt MF Shelton J Richardson JA Stockinger W Nimpf J Herz J 2000 Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction J Biol Chem 275 33 25616 24 doi 10 1074 jbc M000955200 PMID 10827173 Gao Y Li M Chen W Simons M 2000 Synectin syndecan 4 cytoplasmic domain binding PDZ protein inhibits cell migration J Cell Physiol 184 3 373 9 doi 10 1002 1097 4652 200009 184 3 lt 373 AID JCP12 gt 3 0 CO 2 I PMID 10911369 S2CID 20829740 Von Kap Herr C Kandala G Mann SS Hart TC Pettenati MJ Setaluri V 2000 Assignment of PDZ domain containing protein GIPC gene C19orf3 to human chromosome band 19p13 1 by in situ hybridization and radiation hybrid mapping Cytogenet Cell Genet 89 3 4 234 5 doi 10 1159 000015621 PMID 10965131 S2CID 85292825 Lou X Yano H Lee F Chao MV Farquhar MG 2001 GIPC and GAIP form a complex with TrkA a putative link between G protein and receptor tyrosine kinase pathways Mol Biol Cell 12 3 615 27 doi 10 1091 mbc 12 3 615 PMC 30968 PMID 11251075 Liu TF Kandala G Setaluri V 2001 PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 tyrosinase related protein 1 J Biol Chem 276 38 35768 77 doi 10 1074 jbc M103585200 PMID 11441007 Ligensa T Krauss S Demuth D Schumacher R Camonis J Jaques G Weidner KM 2001 A PDZ domain protein interacts with the C terminal tail of the insulin like growth factor 1 receptor but not with the insulin receptor J Biol Chem 276 36 33419 27 doi 10 1074 jbc M104509200 PMID 11445579 Tani TT Mercurio AM 2001 PDZ interaction sites in integrin alpha subunits T14853 TIP GIPC binds to a type I recognition sequence in alpha 6A alpha 5 and a novel sequence in alpha 6B J Biol Chem 276 39 36535 42 doi 10 1074 jbc M105785200 PMID 11479315 Blobe GC Liu X Fang SJ How T Lodish HF 2001 A novel mechanism for regulating transforming growth factor beta TGF beta signaling Functional modulation of type III TGF beta receptor expression through interaction with the PDZ domain protein GIPC J Biol Chem 276 43 39608 17 doi 10 1074 jbc M106831200 PMID 11546783 Awan A Lucic MR Shaw DM Sheppard F Westwater C Lyons SA Stern PL 2002 5T4 interacts with TIP 2 GIPC a PDZ protein with implications for metastasis Biochem Biophys Res Commun 290 3 1030 6 doi 10 1006 bbrc 2001 6288 PMID 11798178 El Mourabit H Poinat P Koster J Sondermann H Wixler V Wegener E Laplantine E Geerts D Georges Labouesse E Sonnenberg A Aumailley M 2002 The PDZ domain of TIP 2 GIPC interacts with the C terminus of the integrin alpha5 and alpha6 subunits Matrix Biol 21 2 207 14 doi 10 1016 S0945 053X 01 00198 6 PMID 11852236 Lou X McQuistan T Orlando RA Farquhar MG 2002 GAIP GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells putative role in regulating megalin s function J Am Soc Nephrol 13 4 918 27 doi 10 1681 ASN V134918 PMID 11912251 Retrieved from https en wikipedia org w index php title GIPC1 amp oldid 1113085589, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.