IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[5]
^Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3–4): 320–5. doi:10.1159/000056921. PMID 11435706. S2CID 46509502.
^ abRotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.
Further readingedit
Lam CY, Tam PO, Fan DS, et al. (2008). "A genome-wide scan maps a novel high myopia locus to 5p15". Invest. Ophthalmol. Vis. Sci. 49 (9): 3768–78. doi:10.1167/iovs.07-1126. PMID 18421076.
Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): 815–20. doi:10.1038/ejhg.2010.2. PMC2987367. PMID 20125193.
Adamowicz M, Radlwimmer B, Rieker RJ, et al. (2006). "Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas". Genes Chromosomes Cancer. 45 (9): 829–38. doi:10.1002/gcc.20343. PMID 16752383. S2CID 24491021.
Matsumoto K, Nishihara S, Kamimura M, et al. (2004). "The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation". Nat. Neurosci. 7 (6): 605–12. doi:10.1038/nn1249. PMID 15133517. S2CID 23807922.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142. S2CID 37046813.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
irx2, iroquois, class, homeodomain, protein, also, known, iroquois, homeobox, protein, protein, that, humans, encoded, gene, identifiersaliases, irxa2, iroquois, homeobox, 2external, idsomim, 606198, 1197526, homologene, 56490, genecards, gene, location, human. Iroquois class homeodomain protein IRX 2 also known as Iroquois homeobox protein 2 is a protein that in humans is encoded by the IRX2 gene 5 6 IRX2IdentifiersAliasesIRX2 IRXA2 iroquois homeobox 2External IDsOMIM 606198 MGI 1197526 HomoloGene 56490 GeneCards IRX2Gene location Human Chr Chromosome 5 human 1 Band5p15 33Start2 745 845 bp 1 End2 751 677 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 C1 13 39 23 cMStart72 776 939 bp 2 End72 782 317 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlower lobe of lunglactiferous ductparotid glandponsrenal medullabronchial epithelial cellnipplevulvaskin of abdomenminor salivary glandsTop expressed inpretectal areaotic placodelipsacculelacrimal glandepidermiszone of skinskin of abdomenskin of backhair follicleMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding DNA binding transcription repressor activity RNA polymerase II specific sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specificCellular componentnucleusBiological processspecification of loop of Henle identity metanephros development regulation of transcription DNA templated proximal distal pattern formation involved in metanephric nephron development negative regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez15357216372EnsemblENSG00000170561ENSMUSG00000001504UniProtQ9BZI1P81066RefSeq mRNA NM 001134222NM 033267NM 010574RefSeq protein NP 001127694NP 150366NP 034704Location UCSC Chr 5 2 75 2 75 MbChr 13 72 78 72 78 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Cancer 3 References 4 Further readingFunction editIRX2 is a member of the Iroquois homeobox gene family Members of this family appear to play multiple roles during pattern formation of vertebrate embryos 5 Cancer editIRX2 gene has been observed progressively downregulated in Human papillomavirus positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy 7 For this reason IRX2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000170561 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000001504 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene iroquois homeobox 2 Ogura K Matsumoto K Kuroiwa A Isobe T Otoguro T Jurecic V Baldini A Matsuda Y Ogura T 2001 Cloning and chromosome mapping of human and chicken Iroquois IRX genes Cytogenet Cell Genet 92 3 4 320 5 doi 10 1159 000056921 PMID 11435706 S2CID 46509502 a b Rotondo JC Bosi S Bassi C Ferracin M Lanza G Gafa R Magri E Selvatici R Torresani S Marci R Garutti P Negrini M Tognon M Martini F April 2015 Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes J Cell Physiol 230 4 802 812 doi 10 1002 jcp 24808 hdl 11392 2066612 PMID 25205602 S2CID 24986454 Further reading editLam CY Tam PO Fan DS et al 2008 A genome wide scan maps a novel high myopia locus to 5p15 Invest Ophthalmol Vis Sci 49 9 3768 78 doi 10 1167 iovs 07 1126 PMID 18421076 Cirulli ET Kasperaviciute D Attix DK et al 2010 Common genetic variation and performance on standardized cognitive tests European Journal of Human Genetics 18 7 815 20 doi 10 1038 ejhg 2010 2 PMC 2987367 PMID 20125193 Adamowicz M Radlwimmer B Rieker RJ et al 2006 Frequent amplifications and abundant expression of TRIO NKD2 and IRX2 in soft tissue sarcomas Genes Chromosomes Cancer 45 9 829 38 doi 10 1002 gcc 20343 PMID 16752383 S2CID 24491021 Matsumoto K Nishihara S Kamimura M et al 2004 The prepattern transcription factor Irx2 a target of the FGF8 MAP kinase cascade is involved in cerebellum formation Nat Neurosci 7 6 605 12 doi 10 1038 nn1249 PMID 15133517 S2CID 23807922 Bonaldo MF Lennon G Soares MB 1996 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Lewis MT Ross S Strickland PA et al 1999 Regulated expression patterns of IRX 2 an Iroquois class homeobox gene in the human breast Cell Tissue Res 296 3 549 54 doi 10 1007 s004410051316 PMID 10370142 S2CID 37046813 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte 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