This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000168556 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000063049 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shimada Y, Saito A, Suzuki M, Takahashi E, Horie M (Mar 1999). "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor". Cytogenetics and Cell Genetics. 83 (3–4): 232–5. doi:10.1159/000015188. PMID 10072587. S2CID 7081905.
^ ab"Entrez Gene: ING2 inhibitor of growth family, member 2".
Further readingedit
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC (Aug 2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53". Proceedings of the National Academy of Sciences of the United States of America. 98 (17): 9671–6. Bibcode:2001PNAS...98.9671N. doi:10.1073/pnas.161151798. PMC55510. PMID 11481424.
Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. PMC133546. PMID 11784859.
Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J (Jul 2003). "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor". Cell. 114 (1): 99–111. doi:10.1016/S0092-8674(03)00480-X. PMID 12859901. S2CID 16506650.
Sironi E, Cerri A, Tomasini D, Sirchia SM, Porta G, Rossella F, Grati FR, Simoni G (Apr 2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes". Journal of Cutaneous Pathology. 31 (4): 318–22. doi:10.1111/j.0303-6987.2004.0187.x. PMID 15005689. S2CID 2520678.
Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro". Nucleic Acids Research. 32 (12): 3632–41. doi:10.1093/nar/gkh692. PMC484179. PMID 15243141.
He GH, Helbing CC, Wagner MJ, Sensen CW, Riabowol K (Jan 2005). "Phylogenetic analysis of the ING family of PHD finger proteins". Molecular Biology and Evolution. 22 (1): 104–16. doi:10.1093/molbev/msh256. PMID 15356280.
Chin MY, Ng KC, Li G (Apr 2005). "The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells". Experimental Cell Research. 304 (2): 531–43. doi:10.1016/j.yexcr.2004.11.023. PMID 15748897.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Pedeux R, Sengupta S, Shen JC, Demidov ON, Saito S, Onogi H, Kumamoto K, Wincovitch S, Garfield SH, McMenamin M, Nagashima M, Grossman SR, Appella E, Harris CC (Aug 2005). "ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation". Molecular and Cellular Biology. 25 (15): 6639–48. doi:10.1128/MCB.25.15.6639-6648.2005. PMC1190357. PMID 16024799.
Okano T, Gemma A, Hosoya Y, Hosomi Y, Nara M, Kokubo Y, Yoshimura A, Shibuya M, Nagashima M, Harris CC, Kudoh S (Mar 2006). "Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer". Oncology Reports. 15 (3): 545–9. doi:10.3892/or.15.3.545. PMID 16465410.
Wang J, Chin MY, Li G (Feb 2006). "The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation". Cancer Research. 66 (4): 1906–11. doi:10.1158/0008-5472.CAN-05-3444. PMID 16488987.
Lu F, Dai DL, Martinka M, Ho V, Li G (Jul 2006). "Nuclear ING2 expression is reduced in human cutaneous melanomas". British Journal of Cancer. 95 (1): 80–6. doi:10.1038/sj.bjc.6603205. PMC2360493. PMID 16755297.
Wang Y, Wang J, Li G (Jul 2006). "Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis". FEBS Letters. 580 (16): 3787–93. doi:10.1016/j.febslet.2006.05.065. PMID 16782091. S2CID 40317066.
Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD (May 2007). "Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling". Journal of the American Chemical Society. 129 (20): 6498–506. doi:10.1021/ja070195b. PMC2553394. PMID 17469822.
ing2, inhibitor, growth, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1wes, 2g6qidentifiersaliases, ing1l, p33inhibitor, growth, family, member, 2external, idsomim, 604215, 1916510, homologene, 2. Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2 gene 5 6 ING2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1WES 2G6QIdentifiersAliasesING2 ING1L p33inhibitor of growth family member 2External IDsOMIM 604215 MGI 1916510 HomoloGene 20388 GeneCards ING2Gene location Human Chr Chromosome 4 human 1 Band4q35 1Start183 505 058 bp 1 End183 512 429 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 B1 1Start48 120 213 bp 2 End48 128 591 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inamniotic fluidjejunal mucosaright adrenal glandleft adrenal glandpalpebral conjunctivabronchial epithelial celloral cavitybiceps brachiicaput epididymisretinal pigment epitheliumTop expressed inlensislet of Langerhansseminiferous tubulerenal corpuscleyolk sacbone marrowretinal pigment epitheliumsecondary oocyteprimitive streakdermisMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding chromatin binding metal ion binding methylated histone binding protein binding phosphatidylinositol binding protein containing complex bindingCellular componentGolgi apparatus plasma membrane Sin3 complex CCAAT binding factor complex nucleus nucleoplasm cytosolBiological processflagellated sperm motility positive regulation of transforming growth factor beta receptor signaling pathway regulation of transcription DNA templated negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway male meiosis I transcription DNA templated positive regulation of transcription DNA templated male germ line stem cell asymmetric division seminiferous tubule development spermatogenesis spermatid development regulation of growth regulation of response to DNA damage stimulus signal transduction negative regulation of cell population proliferation chromatin organization positive regulation of histone deacetylation regulation of apoptotic process regulation of cellular senescenceSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez362269260EnsemblENSG00000168556ENSMUSG00000063049UniProtQ9H160Q9ESK4RefSeq mRNA NM 001291959NM 001564NM 023503RefSeq protein NP 001278888NP 001555NP 075992Location UCSC Chr 4 183 51 183 51 MbChr 8 48 12 48 13 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editThis gene is a member of the inhibitor of growth ING family Members of the ING family associate with and modulate the activity of histone acetyltransferase HAT and histone deacetylase HDAC complexes and function in DNA repair and apoptosis 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000168556 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000063049 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Shimada Y Saito A Suzuki M Takahashi E Horie M Mar 1999 Cloning of a novel gene ING1L homologous to ING1 a candidate tumor suppressor Cytogenetics and Cell Genetics 83 3 4 232 5 doi 10 1159 000015188 PMID 10072587 S2CID 7081905 a b Entrez Gene ING2 inhibitor of growth family member 2 Further reading editBonaldo MF Lennon G Soares MB Sep 1996 Normalization and subtraction two approaches to facilitate gene discovery Genome Research 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Nagashima M Shiseki M Miura K Hagiwara K Linke SP Pedeux R Wang XW Yokota J Riabowol K Harris CC Aug 2001 DNA damage inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53 Proceedings of the National Academy of Sciences of the United States of America 98 17 9671 6 Bibcode 2001PNAS 98 9671N doi 10 1073 pnas 161151798 PMC 55510 PMID 11481424 Kuzmichev A Zhang Y Erdjument Bromage H Tempst P Reinberg D Feb 2002 Role of the Sin3 histone deacetylase complex in growth regulation by the candidate tumor suppressor p33 ING1 Molecular and Cellular Biology 22 3 835 48 doi 10 1128 MCB 22 3 835 848 2002 PMC 133546 PMID 11784859 Gozani O Karuman P Jones DR Ivanov D Cha J Lugovskoy AA Baird CL Zhu H Field SJ Lessnick SL Villasenor J Mehrotra B Chen J Rao VR Brugge JS Ferguson CG Payrastre B Myszka DG Cantley LC Wagner G Divecha N Prestwich GD Yuan J Jul 2003 The PHD finger of the chromatin associated protein ING2 functions as a nuclear phosphoinositide receptor Cell 114 1 99 111 doi 10 1016 S0092 8674 03 00480 X PMID 12859901 S2CID 16506650 Sironi E Cerri A Tomasini D Sirchia SM Porta G Rossella F Grati FR Simoni G Apr 2004 Loss of heterozygosity on chromosome 4q32 35 in sporadic basal cell carcinomas evidence for the involvement of p33ING2 ING1L and SAP30 genes Journal of Cutaneous Pathology 31 4 318 22 doi 10 1111 j 0303 6987 2004 0187 x PMID 15005689 S2CID 2520678 Chattopadhyay C Hawke D Kobayashi R Maity SN 2004 Human p32 interacts with B subunit of the CCAAT binding factor CBF NF Y and inhibits CBF mediated transcription activation in vitro Nucleic Acids Research 32 12 3632 41 doi 10 1093 nar gkh692 PMC 484179 PMID 15243141 He GH Helbing CC Wagner MJ Sensen CW Riabowol K Jan 2005 Phylogenetic analysis of the ING family of PHD finger proteins Molecular Biology and Evolution 22 1 104 16 doi 10 1093 molbev msh256 PMID 15356280 Chin MY Ng KC Li G Apr 2005 The novel tumor suppressor p33ING2 enhances UVB induced apoptosis in human melanoma cells Experimental Cell Research 304 2 531 43 doi 10 1016 j yexcr 2004 11 023 PMID 15748897 Barrios Rodiles M Brown KR Ozdamar B Bose R Liu Z Donovan RS Shinjo F Liu Y Dembowy J Taylor IW Luga V Przulj N Robinson M Suzuki H Hayashizaki Y Jurisica I Wrana JL Mar 2005 High throughput mapping of a dynamic signaling network in mammalian cells Science 307 5715 1621 5 Bibcode 2005Sci 307 1621B doi 10 1126 science 1105776 PMID 15761153 S2CID 39457788 Pedeux R Sengupta S Shen JC Demidov ON Saito S Onogi H Kumamoto K Wincovitch S Garfield SH McMenamin M Nagashima M Grossman SR Appella E Harris CC Aug 2005 ING2 regulates the onset of replicative senescence by induction of p300 dependent p53 acetylation Molecular and Cellular Biology 25 15 6639 48 doi 10 1128 MCB 25 15 6639 6648 2005 PMC 1190357 PMID 16024799 Okano T Gemma A Hosoya Y Hosomi Y Nara M Kokubo Y Yoshimura A Shibuya M Nagashima M Harris CC Kudoh S Mar 2006 Alterations in novel candidate tumor suppressor genes ING1 and ING2 in human lung cancer Oncology Reports 15 3 545 9 doi 10 3892 or 15 3 545 PMID 16465410 Wang J Chin MY Li G Feb 2006 The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation Cancer Research 66 4 1906 11 doi 10 1158 0008 5472 CAN 05 3444 PMID 16488987 Lu F Dai DL Martinka M Ho V Li G Jul 2006 Nuclear ING2 expression is reduced in human cutaneous melanomas British Journal of Cancer 95 1 80 6 doi 10 1038 sj bjc 6603205 PMC 2360493 PMID 16755297 Wang Y Wang J Li G Jul 2006 Leucine zipper like domain is required for tumor suppressor ING2 mediated nucleotide excision repair and apoptosis FEBS Letters 580 16 3787 93 doi 10 1016 j febslet 2006 05 065 PMID 16782091 S2CID 40317066 Huang W Zhang H Davrazou F Kutateladze TG Shi X Gozani O Prestwich GD May 2007 Stabilized phosphatidylinositol 5 phosphate analogues as ligands for the nuclear protein ING2 chemistry biology and molecular modeling Journal of the American Chemical Society 129 20 6498 506 doi 10 1021 ja070195b PMC 2553394 PMID 17469822 External links editING2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w 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