Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]
The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]
Referencesedit
^ abKuno K, Matsushima K (1994). . J. Leukoc. Biol. 56 (5): 542–7. doi:10.1002/jlb.56.5.542. PMID 7964161. S2CID 43095473. Archived from the original (abstract page) on 2005-05-07. Retrieved 2008-02-28.
^Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC295645. PMID 1834696.
^Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
External linksedit
Receptors,+Interleukin-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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interleukin, receptor, also, family, cytokine, receptor, which, binds, interleukin, forms, receptor, exist, type, receptor, primarily, responsible, transmitting, inflammatory, effects, interleukin, while, type, receptors, suppressor, activity, competing, bindi. See also Interleukin 1 receptor family Interleukin 1 receptor IL 1R is a cytokine receptor which binds interleukin 1 1 Two forms of the receptor exist The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin 1 IL 1 while type II receptors may act as a suppressor of IL 1 activity by competing for IL 1 binding 1 Also opposing the effects of IL 1 is the IL 1 receptor antagonist IL 1RA 2 interleukin 1 receptor type IIdentifiersSymbolIL1R1Alt symbolsIL1R IL1RANCBI gene3554HGNC5993OMIM147810RefSeqNM 000877UniProtP14778Other dataLocusChr 2 q12Search forStructuresSwiss modelDomainsInterProinterleukin 1 receptor type IIIdentifiersSymbolIL1R2Alt symbolsIL1RBNCBI gene7850HGNC5994OMIM147811RefSeqNM 173343UniProtP27930Other dataLocusChr 2 q12Search forStructuresSwiss modelDomainsInterProinterleukin 1 receptor accessory proteinIdentifiersSymbolIL1RAPAlt symbolsIL 1RAcP IL1R3 C3orf13NCBI gene3556HGNC5995OMIM602626RefSeqNM 134470UniProtQ9NPH3Other dataLocusChr 3 q28Search forStructuresSwiss modelDomainsInterProThe IL 1 receptor accessory protein IL1RAP is a transmembrane protein that interacts with IL 1R and is required for IL 1 signal transduction 3 References edit a b Kuno K Matsushima K 1994 The IL 1 receptor signaling pathway J Leukoc Biol 56 5 542 7 doi 10 1002 jlb 56 5 542 PMID 7964161 S2CID 43095473 Archived from the original abstract page on 2005 05 07 Retrieved 2008 02 28 Arend WP 1991 Interleukin 1 receptor antagonist A new member of the interleukin 1 family J Clin Invest 88 5 1445 51 doi 10 1172 JCI115453 PMC 295645 PMID 1834696 Wesche H Korherr C Kracht M Falk W Resch K Martin MU March 1997 The interleukin 1 receptor accessory protein IL 1RAcP is essential for IL 1 induced activation of interleukin 1 receptor associated kinase IRAK and stress activated protein kinases SAP kinases J Biol Chem 272 12 7727 31 doi 10 1074 jbc 272 12 7727 PMID 9065432 External links editReceptors Interleukin 1 at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Interleukin 1 receptor amp oldid 1135439120, wikipedia, wiki, book, books, library,
