This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been described.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000176095 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032594 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
White KE, Econs MJ (1998). "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3". Somat. Cell Mol. Genet. 24 (1): 71–4. doi:10.1007/BF02677496. PMID 9776982. S2CID 22338269.
Schell MJ, Letcher AJ, Brearley CA, et al. (1999). "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase". FEBS Lett. 461 (3): 169–72. doi:10.1016/S0014-5793(99)01462-3. PMID 10567691. S2CID 6834292.
Saiardi A, Erdjument-Bromage H, Snowman AM, et al. (2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr. Biol. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768. S2CID 15311443.
Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000). "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis". J. Biol. Chem. 275 (32): 24686–92. doi:10.1074/jbc.M002750200. PMID 10827188.
Saiardi A, Nagata E, Luo HR, et al. (2001). "Identification and characterization of a novel inositol hexakisphosphate kinase". J. Biol. Chem. 276 (42): 39179–85. doi:10.1074/jbc.M106842200. PMID 11502751.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Kamimura J, Wakui K, Kadowaki H, et al. (2004). "The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus". J. Hum. Genet. 49 (7): 360–5. doi:10.1007/s10038-004-0158-z. PMID 15221640.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
ihpk1, inositol, hexakisphosphate, kinase, enzyme, that, humans, encoded, ip6k1, gene, ip6k1identifiersaliasesip6k1, pius, inositol, hexakisphosphate, kinase, 1external, idsomim, 606991, 1351633, homologene, 56602, genecards, ip6k1, ip6k1, orthologsgene, locat. Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene 5 IP6K1IdentifiersAliasesIP6K1 IHPK1 PiUS inositol hexakisphosphate kinase 1External IDsOMIM 606991 MGI 1351633 HomoloGene 56602 GeneCards IP6K1 OMA IP6K1 orthologsGene location Human Chr Chromosome 3 human 1 Band3p21 31Start49 724 294 bp 1 End49 786 542 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 F1Start107 879 700 bp 2 End107 925 981 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmiddle frontal gyrusfrontal poleprefrontal cortexBrodmann area 10stromal cell of endometriumcingulate gyrusBrodmann area 9cerebellar vermisnucleus accumbensganglionic eminenceTop expressed inspermatidspermatocytedorsomedial hypothalamic nucleuscerebellar cortexsuperior frontal gyrushabenulasubiculumparaventricular nucleus of hypothalamusentorhinal cortexsupraoptic nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioninositol hexakisphosphate 5 kinase activity transferase activity inositol hexakisphosphate 1 kinase activity nucleotide binding ATP binding inositol hexakisphosphate 3 kinase activity kinase activity inositol 1 3 4 5 6 pentakisphosphate kinase activity inositol 5 diphosphate pentakisphosphate 5 kinase activity inositol diphosphate tetrakisphosphate kinase activity inositol heptakisphosphate kinase activity protein binding inositol hexakisphosphate kinase activityCellular componentcytoplasm nucleus nucleoplasm fibrillar center cytosolBiological processphosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process phosphorylation inositol phosphate biosynthetic process negative regulation of cold induced thermogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez980727399EnsemblENSG00000176095ENSMUSG00000032594UniProtQ92551Q6PD10RefSeq mRNA NM 153273NM 001006115NM 001242829NM 013785NM 026266RefSeq protein NP 001006115NP 001229758NP 695005NP 038813Location UCSC Chr 3 49 72 49 79 MbChr 9 107 88 107 93 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene encodes a protein that belongs to the inositol phosphokinase IPK family This protein is likely responsible for the conversion of inositol hexakisphosphate InsP6 to diphosphoinositol pentakisphosphate InsP7 PP InsP5 It may also convert 1 3 4 5 6 pentakisphosphate InsP5 to PP InsP4 Alternative splicing occurs for this gene however the full length nature of all transcript variants has not yet been described 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000176095 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032594 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene IHPK1 inositol hexaphosphate kinase 1 Further reading editNagase T Seki N Ishikawa K et al 1997 Prediction of the coding sequences of unidentified human genes VI The coding sequences of 80 new genes KIAA0201 KIAA0280 deduced by analysis of cDNA clones from cell line KG 1 and brain DNA Res 3 5 321 9 341 54 doi 10 1093 dnares 3 5 321 PMID 9039502 White KE Econs MJ 1998 Localization of PiUS a stimulator of cellular phosphate uptake to human chromosome 3p21 3 Somat Cell Mol Genet 24 1 71 4 doi 10 1007 BF02677496 PMID 9776982 S2CID 22338269 Schell MJ Letcher AJ Brearley CA et al 1999 PiUS Pi uptake stimulator is an inositol hexakisphosphate kinase FEBS Lett 461 3 169 72 doi 10 1016 S0014 5793 99 01462 3 PMID 10567691 S2CID 6834292 Saiardi A Erdjument Bromage H Snowman AM et al 2000 Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases Curr Biol 9 22 1323 6 doi 10 1016 S0960 9822 00 80055 X PMID 10574768 S2CID 15311443 Saiardi A Caffrey JJ Snyder SH Shears SB 2000 The inositol hexakisphosphate kinase family Catalytic flexibility and function in yeast vacuole biogenesis J Biol Chem 275 32 24686 92 doi 10 1074 jbc M002750200 PMID 10827188 Saiardi A Nagata E Luo HR et al 2001 Identification and characterization of a novel inositol hexakisphosphate kinase J Biol Chem 276 42 39179 85 doi 10 1074 jbc M106842200 PMID 11502751 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kamimura J Wakui K Kadowaki H et al 2004 The IHPK1 gene is disrupted at the 3p21 31 breakpoint of t 3 9 in a family with type 2 diabetes mellitus J Hum Genet 49 7 360 5 doi 10 1007 s10038 004 0158 z PMID 15221640 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 See also editInositol hexakisphosphate kinase nbsp This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title IHPK1 amp oldid 1142697344, wikipedia, wiki, book, books, library,
