In one of the modern histopathological senses of the term, dysplasia is sometimes differentiated from other categories of tissue change including hyperplasia, metaplasia, and neoplasia, and dysplasias are thus generally not cancerous. An exception is that the myelodysplasias include a range of benign, precancerous, and cancerous forms. Various other dysplasias tend to be precancerous. The word's meanings thus cover a spectrum of histopathological variations.
Epithelial dysplasia consists of an expansion of immature cells (such as cells of the ectoderm), with a corresponding decrease in the number and location of mature cells. Dysplasia is often indicative of an early neoplastic process. The term dysplasia is typically used when the cellular abnormality is restricted to the originating tissue, as in the case of an early, in-situneoplasm.[citation needed]
Dysplasia, in which cell maturation and differentiation are delayed, can be contrasted with metaplasia, in which cells of one mature, differentiated type are replaced by cells of another mature, differentiated type.[citation needed]
Fibrous dysplasia of bone is a disorder where normal bone and marrow is replaced with fibrous tissue, resulting in formation of bone that is weak and prone to expansion. As a result, most complications result from fracture, deformity, functional impairment and pain.[3]
Hip dysplasia is an abnormality of the hip joint where the socket portion does not fully cover the ball portion, resulting in an increased risk for joint dislocation.[4] Hip dysplasia may occur at birth or develop in early life.[4] Regardless, it does not typically produce symptoms in babies less than a year old.[5] Occasionally one leg may be shorter than the other.[4] The left hip is more often affected than the right.[5] Complications without treatment can include arthritis, limping, and low back pain.[5]
Multicystic dysplastic kidney (MCDK) is a condition that results from the malformation of the kidney during fetal development. The kidney consists of irregular cysts of varying sizes. Multicystic dysplastic kidney is a common type of renal cystic disease, and it is a cause of an abdominal mass in infants.[6]
Etymologyedit
From Ancient Greek δυσ- dys-, "bad" or "difficult" and πλάσις plasis, "formation". The equivalent surface analysis, in parallel with classical compounds, is dys- + -plasia.[citation needed]
^"Definition of dysplasia". Merriam-Webster dictionary. Retrieved 2019-09-09.
^ abc. NCI. 12 August 2015. Archived from the original on 5 October 2016. Retrieved 27 October 2016.
^Boyce AM, Florenzano P, de Castro LF, Collins MT (February 2015). "Fibrous Dysplasia/McCune-Albright Syndrome". In Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJ, Mirzaa G, Amemiya A (eds.). Gene Reviews. Seattle (WA): University of Washington, Seattle. PMID 25719192.
^ abc"Developmental Dislocation (Dysplasia) of the Hip (DDH)". American Academy of Orthopaedic Surgeons. October 2013.
^ abcShaw BA, Segal LS (December 2016). "Evaluation and Referral for Developmental Dysplasia of the Hip in Infants". Pediatrics. 138 (6): e20163107. doi:10.1542/peds.2016-3107. PMID 27940740.
^Multicystic Dysplastic Kidney Imaging at eMedicine
Further readingedit
Weidner N, Cote R, Suster S, Weiss L, eds. (2003). Modern Surgical Pathology. London: W.B. Saunders. ISBN978-0-7216-7253-3. OCLC 50244347.
dysplasia, this, article, about, precancerous, change, cells, tissues, clinical, condition, affecting, joint, dysplasia, confused, with, dyscrasia, various, types, abnormal, growth, development, cells, microscopic, scale, organs, macroscopic, scale, abnormal, . This article is about the precancerous change in cells and tissues For the clinical condition affecting the hip joint see Hip dysplasia Not to be confused with Dyscrasia Dysplasia is any of various types of abnormal growth or development of cells microscopic scale or organs macroscopic scale and the abnormal histology or anatomical structure s resulting from such growth 1 Dysplasias on a mainly microscopic scale include epithelial dysplasia and fibrous dysplasia of bone Dysplasias on a mainly macroscopic scale include hip dysplasia myelodysplastic syndrome and multicystic dysplastic kidney Normal squamous cells Dysplastic cellsIn one of the modern histopathological senses of the term dysplasia is sometimes differentiated from other categories of tissue change including hyperplasia metaplasia and neoplasia and dysplasias are thus generally not cancerous An exception is that the myelodysplasias include a range of benign precancerous and cancerous forms Various other dysplasias tend to be precancerous The word s meanings thus cover a spectrum of histopathological variations Contents 1 Microscopic scale 1 1 Epithelial dysplasia 1 2 Myelodysplastic syndrome 1 3 Fibrous dysplasia of bone 2 Macroscopic scale 2 1 Hip dysplasia 2 2 Multicystic dysplastic kidney 3 Etymology 4 See also 5 References 6 Further readingMicroscopic scale editEpithelial dysplasia edit Main article Epithelial dysplasia Epithelial dysplasia consists of an expansion of immature cells such as cells of the ectoderm with a corresponding decrease in the number and location of mature cells Dysplasia is often indicative of an early neoplastic process The term dysplasia is typically used when the cellular abnormality is restricted to the originating tissue as in the case of an early in situ neoplasm citation needed Dysplasia in which cell maturation and differentiation are delayed can be contrasted with metaplasia in which cells of one mature differentiated type are replaced by cells of another mature differentiated type citation needed Myelodysplastic syndrome edit Main article Myelodysplastic syndrome Myelodysplastic syndromes MDS are a group of cancers in which immature blood cells in the bone marrow do not mature and therefore do not become healthy blood cells 2 Problems with blood cell formation result in some combination of low red blood cells low platelets and low white blood cells 2 Some types have an increase in immature blood cells called blasts in the bone marrow or blood 2 Fibrous dysplasia of bone edit Main article Fibrous dysplasia of bone Fibrous dysplasia of bone is a disorder where normal bone and marrow is replaced with fibrous tissue resulting in formation of bone that is weak and prone to expansion As a result most complications result from fracture deformity functional impairment and pain 3 Macroscopic scale editHip dysplasia edit Main article Hip dysplasia Hip dysplasia is an abnormality of the hip joint where the socket portion does not fully cover the ball portion resulting in an increased risk for joint dislocation 4 Hip dysplasia may occur at birth or develop in early life 4 Regardless it does not typically produce symptoms in babies less than a year old 5 Occasionally one leg may be shorter than the other 4 The left hip is more often affected than the right 5 Complications without treatment can include arthritis limping and low back pain 5 Multicystic dysplastic kidney edit Main article Multicystic dysplastic kidney Multicystic dysplastic kidney MCDK is a condition that results from the malformation of the kidney during fetal development The kidney consists of irregular cysts of varying sizes Multicystic dysplastic kidney is a common type of renal cystic disease and it is a cause of an abdominal mass in infants 6 Etymology editFrom Ancient Greek dys dys bad or difficult and plasis plasis formation The equivalent surface analysis in parallel with classical compounds is dys plasia citation needed See also editPleomorphism List of biological development disordersReferences edit Definition of dysplasia Merriam Webster dictionary Retrieved 2019 09 09 a b c Myelodysplastic Syndromes Treatment PDQ Patient Version NCI 12 August 2015 Archived from the original on 5 October 2016 Retrieved 27 October 2016 Boyce AM Florenzano P de Castro LF Collins MT February 2015 Fibrous Dysplasia McCune Albright Syndrome In Adam MP Ardinger HH Pagon RA Wallace SE Bean LJ Mirzaa G Amemiya A eds Gene Reviews Seattle WA University of Washington Seattle PMID 25719192 a b c Developmental Dislocation Dysplasia of the Hip DDH American Academy of Orthopaedic Surgeons October 2013 a b c Shaw BA Segal LS December 2016 Evaluation and Referral for Developmental Dysplasia of the Hip in Infants Pediatrics 138 6 e20163107 doi 10 1542 peds 2016 3107 PMID 27940740 Multicystic Dysplastic Kidney Imaging at eMedicineFurther reading editWeidner N Cote R Suster S Weiss L eds 2003 Modern Surgical Pathology London W B Saunders ISBN 978 0 7216 7253 3 OCLC 50244347 Cotran RS Kumar V Collins T eds 1999 Robbins Pathologic Basis of Disease 6th ed London W B Saunders ISBN 978 0 7216 7335 6 OCLC 39465455 Retrieved from https en wikipedia org w index php title Dysplasia amp oldid 1195917916, wikipedia, wiki, book, books, library,
