Hydrocortisone buteprate

See also: hydrocortisone

Hydrocortisone buteprate, also known as hydrocortisone probutate and as hydrocortisone butyrate propionate, is a topical corticosteroid.^[2][3] It is an ester of hydrocortisone (cortisol) with butyric acid and propionic acid.

Hydrocortisone buteprate

Clinical data
Trade names	Pandel
Other names	Hydrocortisone probutate; Hydrocortisone 17α-butyrate 21-propionate; Hydrocortisone butyrate propionate, hydrocortisone probutate (USAN US)
AHFS/Drugs.com	Monograph
Pregnancy category	AU: A^[1]
Routes of administration	Topical
ATC code	D07AB11 (WHO)
Legal status
Legal status	US: OTC
Identifiers
IUPAC name (11β)-11-hydroxy-3,20-dioxo-21-(propionyloxy)pregn-4-en-17-yl butyrate
CAS Number	72590-77-3^Y
PubChem CID	636398
DrugBank	DB14543^Y
ChemSpider	552186^N
UNII	O6550D6K3A
KEGG	D01886 C13358
ChEBI	CHEBI:31675
ChEMBL	ChEMBL200953
CompTox Dashboard (EPA)	DTXSID3048603
ECHA InfoCard	100.069.730
Chemical and physical data
Formula	C28H40O7
Molar mass	488.621 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)COC(=O)CC
InChI InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1^N Key:FOGXJPFPZOHSQS-AYVLZSQQSA-N^N
^NY (what is this?)  (verify)

References

1. "Hydrocortisone topical Use During Pregnancy". Drugs.com. 5 December 2019. Retrieved 13 September 2020.
2. Drugs.com: Hydrocortisone Buteprate topical
3. Sears HW, Bailer JW, Yeadon A (1997). "Efficacy and safety of hydrocortisone buteprate 0.1% cream in patients with atopic dermatitis". Clinical Therapeutics. 19 (4): 710–9. doi:10.1016/s0149-2918(97)80095-1. PMID 9377615.

External links

• "Hydrocortisone probutate". Drug Information Portal. U.S. National Library of Medicine.