This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[7]
Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J (Aug 1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences". Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 7318–22. Bibcode:1991PNAS...88.7318L. doi:10.1073/pnas.88.16.7318. PMC52286. PMID 1871139.
Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC335308. PMID 2574852.
Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
Kongsuwan K, Webb E, Housiaux P, Adams JM (Jul 1988). "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages". The EMBO Journal. 7 (7): 2131–8. doi:10.1002/j.1460-2075.1988.tb03052.x. PMC454515. PMID 2901346.
Vieille-Grosjean I, Huber P (Mar 1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells". The Journal of Biological Chemistry. 270 (9): 4544–50. doi:10.1074/jbc.270.9.4544. PMID 7876223.
Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal. 13 (14): 3339–47. doi:10.1002/j.1460-2075.1994.tb06636.x. PMC395231. PMID 7913891.
Guazzi S, Pintonello ML, Viganò A, Boncinelli E (May 1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". The Journal of Biological Chemistry. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.
Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM (Apr 1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain". Neuron. 22 (4): 677–91. doi:10.1016/S0896-6273(00)80728-X. PMID 10230789.
Case SS, Huber P, Lloyd JA (Nov 1999). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation". DNA and Cell Biology. 18 (11): 805–17. doi:10.1089/104454999314809. PMID 10595394.
Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF (Mar 2001). "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema". The American Journal of Pathology. 158 (3): 955–66. doi:10.1016/S0002-9440(10)64042-4. PMC1850338. PMID 11238043.
Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC99922. PMID 11585930.
Liu X, Zhang X (Feb 2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells". Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi. 5 (1): 12–5. PMID 11835749.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A (Jun 2003). "Regulation of Hoxb2 by APL-associated PLZF protein". Oncogene. 22 (24): 3685–97. doi:10.1038/sj.onc.1206328. PMID 12802276.
Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM (May 2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia". Clinical Cancer Research. 11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264. S2CID 15485235.
hoxb2, homeobox, protein, protein, that, humans, encoded, gene, identifiersaliases, hox2, hox2h, homeobox, b2external, idsomim, 142967, 96183, homologene, 37584, genecards, gene, location, human, chromosome, human, band17q21, 32start48, end48, gene, location, . Homeobox protein Hox B2 is a protein that in humans is encoded by the HOXB2 gene 5 6 7 HOXB2IdentifiersAliasesHOXB2 HOX2 HOX2H Hox 2 8 K8 homeobox B2External IDsOMIM 142967 MGI 96183 HomoloGene 37584 GeneCards HOXB2Gene location Human Chr Chromosome 17 human 1 Band17q21 32Start48 540 894 bp 1 End48 545 109 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 D 11 59 85 cMStart96 241 351 bp 2 End96 244 838 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inseminal vesicularight uterine tubecorpus epididymiscaput epididymisleft coronary arterygastric mucosaright coronary arterycanal of the cervixrenal medullakidneyTop expressed insomiteseminal vesiculaproximal tubuleadrenal glandenteric nervous systemmedullary collecting ductkidneyyolk sacdermisabdominal wallMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding transcription factor activity DNA binding DNA binding transcription activator activity RNA polymerase II specific sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specific RNA polymerase II cis regulatory region sequence specific DNA bindingCellular componentnucleus nucleoplasm cytosol nuclear speckBiological processmulticellular organism development regulation of transcription DNA templated blood circulation transcription DNA templated morphogenesis of an epithelial sheet anterior posterior pattern specification dorsal ventral pattern formation rhombomere 3 development rhombomere 4 development facial nerve structural organization embryonic skeletal system morphogenesis skeletal system morphogenesis neural nucleus development transcription by RNA polymerase II positive regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez3212103889EnsemblENSG00000173917ENSMUSG00000075588UniProtP14652P0C1T1RefSeq mRNA NM 002145NM 134032RefSeq protein NP 002136NP 598793Location UCSC Chr 17 48 54 48 55 MbChr 11 96 24 96 24 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further reading 5 External linksFunction editThis gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA binding domain It is included in a cluster of homeobox B genes located on chromosome 17 The encoded protein functions as a sequence specific transcription factor that is involved in development Increased expression of this gene is associated with pancreatic cancer 7 See also editHomeoboxReferences edit a b c GRCh38 Ensembl release 89 ENSG00000173917 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000075588 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine McAlpine PJ Shows TB Jul 1990 Nomenclature for human homeobox genes Genomics 7 3 460 doi 10 1016 0888 7543 90 90186 X PMID 1973146 Scott MP Nov 1992 Vertebrate homeobox gene nomenclature Cell 71 4 551 3 doi 10 1016 0092 8674 92 90588 4 PMID 1358459 S2CID 13370372 a b Entrez Gene HOXB2 homeobox B2 Further reading editLavelle D Ducksworth J Eves E Gomes G Keller M Heller P DeSimone J Aug 1991 A homeodomain protein binds to gamma globin gene regulatory sequences Proceedings of the National Academy of Sciences of the United States of America 88 16 7318 22 Bibcode 1991PNAS 88 7318L doi 10 1073 pnas 88 16 7318 PMC 52286 PMID 1871139 Giampaolo A Acampora D Zappavigna V Pannese M D Esposito M Care A Faiella A Stornaiuolo A Russo G Simeone A Jun 1989 Differential expression of human HOX 2 genes along the anterior posterior axis in embryonic central nervous system Differentiation Research in Biological Diversity 40 3 191 7 doi 10 1111 j 1432 0436 1989 tb00598 x PMID 2570724 Acampora D D Esposito M Faiella A Pannese M Migliaccio E Morelli F Stornaiuolo A Nigro V Simeone A Boncinelli E Dec 1989 The human HOX gene family Nucleic Acids Research 17 24 10385 402 doi 10 1093 nar 17 24 10385 PMC 335308 PMID 2574852 Boncinelli E Acampora D Pannese M D Esposito M Somma R Gaudino G Stornaiuolo A Cafiero M Faiella A Simeone A 1990 Organization of human class I homeobox genes Genome 31 2 745 56 doi 10 1139 g89 133 PMID 2576652 Kongsuwan K Webb E Housiaux P Adams JM Jul 1988 Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages The EMBO Journal 7 7 2131 8 doi 10 1002 j 1460 2075 1988 tb03052 x PMC 454515 PMID 2901346 Vieille Grosjean I Huber P Mar 1995 Transcription factor GATA 1 regulates human HOXB2 gene expression in erythroid cells The Journal of Biological Chemistry 270 9 4544 50 doi 10 1074 jbc 270 9 4544 PMID 7876223 Guazzi S Lonigro R Pintonello L Boncinelli E Di Lauro R Mavilio F Jul 1994 The thyroid transcription factor 1 gene is a candidate target for regulation by Hox proteins The EMBO Journal 13 14 3339 47 doi 10 1002 j 1460 2075 1994 tb06636 x PMC 395231 PMID 7913891 Guazzi S Pintonello ML Vigano A Boncinelli E May 1998 Regulatory interactions between the human HOXB1 HOXB2 and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells The Journal of Biological Chemistry 273 18 11092 9 doi 10 1074 jbc 273 18 11092 PMID 9556594 Davenne M Maconochie MK Neun R Pattyn A Chambon P Krumlauf R Rijli FM Apr 1999 Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain Neuron 22 4 677 91 doi 10 1016 S0896 6273 00 80728 X PMID 10230789 Case SS Huber P Lloyd JA Nov 1999 The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma globin gene regulation DNA and Cell Biology 18 11 805 17 doi 10 1089 104454999314809 PMID 10595394 Golpon HA Geraci MW Moore MD Miller HL Miller GJ Tuder RM Voelkel NF Mar 2001 HOX genes in human lung altered expression in primary pulmonary hypertension and emphysema The American Journal of Pathology 158 3 955 66 doi 10 1016 S0002 9440 10 64042 4 PMC 1850338 PMID 11238043 Shen WF Krishnan K Lawrence HJ Largman C Nov 2001 The HOX homeodomain proteins block CBP histone acetyltransferase activity Molecular and Cellular Biology 21 21 7509 22 doi 10 1128 MCB 21 21 7509 7522 2001 PMC 99922 PMID 11585930 Liu X Zhang X Feb 2002 Effect of anti sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells Chinese Journal of Traumatology Zhonghua Chuang Shang Za Zhi 5 1 12 5 PMID 11835749 Kosaki K Kosaki R Suzuki T Yoshihashi H Takahashi T Sasaki K Tomita M McGinnis W Matsuo N Feb 2002 Complete mutation analysis panel of the 39 human HOX genes Teratology 65 2 50 62 doi 10 1002 tera 10009 PMID 11857506 Ivins S Pemberton K Guidez F Howell L Krumlauf R Zelent A Jun 2003 Regulation of Hoxb2 by APL associated PLZF protein Oncogene 22 24 3685 97 doi 10 1038 sj onc 1206328 PMID 12802276 Segara D Biankin AV Kench JG Langusch CC Dawson AC Skalicky DA Gotley DC Coleman MJ Sutherland RL Henshall SM May 2005 Expression of HOXB2 a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia Clinical Cancer Research 11 9 3587 96 doi 10 1158 1078 0432 CCR 04 1813 PMID 15867264 S2CID 15485235 External links editHOXB2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HOXB2 amp oldid 1191595662, wikipedia, wiki, book, books, library,
