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HLA-DQ1

January 01, 1970

DQ1 redirects here. For the first title in the Dragon Quest series, see Dragon Quest (video game).
major histocompatibility complex, class II, DQ1
Haplotypes DQA1*0101:DQB1*0501 DQA1*0101:DQB1*0502 DQA1*0102:DQB1*0502 DQA1*0104:DQB1*0503 DQA1*0103:DQB1*0601 DQA1*0102:DQB1*0602 DQA1*0103:DQB1*0603 DQA1*0102:DQB1*0604 DQA1*0102:DQB1*0605 DQA1*0102:DQB1*0609....
Structure
Identifiers
alpha 1 *0101 *0102 *0103 *0104
Symbol(s) HLA-DQA1[permanent dead link]
EBI-HLA DQA1*0101
EBI-HLA DQA1*0102 2011-05-15 at the Wayback Machine
EBI-HLA DQA1*0103
EBI-HLA DQA1*0104
Identifiers
beta 1 *05 or *06
Symbol(s) HLA-DQB1
EBI-HLA DQB1*05
EBI-HLA DQB1*06
Shared data
Locus chr.6 6p21.31

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1;[1] later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain.[2] The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.

Serotypes edit

Some DRB1* alleles and DQ5, DQ1, DQ6 recognition [3]
DQB1* DQ5 DQ1 DQ6 Sample
allele % % % size (N)
0501 69 20 2 5536
0502 48 24 15 919
0503 58 22 4 1327
0504 59 17 2 48
.
DQ6 DQ1 DQ5 N
0601 64 23 675
0602 67 30 1 5151
0603 62 23 2 2807
0604 59 27 2 1592
0605 76 13 358
0609 48 32 3 149

The serotyping efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed below. Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6.

The table to the left shows some of the serotyping efficiencies. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ1 recognition is relatively low and error prone.

For this reason DQ1 serotyping is a poor method of typing for transplantation or disease association prediction or study. Nonetheless, it is still widely used and association purported in the literature.

Alleles edit

DQA1*0101 edit

DQA1*0101 is commonly linked to haplotypes of DQB1*05, the common DQA1*0101:DQB1*0501 haplotype which is part of a broader DR1-DQ1 haplotype.

DQA1*0102 edit

DQA1*0102 is associated with both DR5 and DR6.

DQA1*0102:DQB1*0502 has a bimodal distribution. It is found in the Philippines in high frequency and on the Mediterranean island of Sardinia.

DQA1*0102:DQB1*0602 is a very common haplotype in Eurasia, with higher frequency in central Asia relative to elsewhere. It is part of a European ancestral haplotype B7-DR15-DQ1 that appears to have expanded asymmetrically into Europe. The A3-B7-DR15-DQ1 haplotype indicates relationships in Eurasia that span from Korea to Ireland, indicating some common ancestry in recent times.

DQA1*0102:DQB1*0604 much less frequently found but spread widely.

DQA1*0103 edit

DQA1*0103 (*0103) shows a negative (protective) association with many autoimmune disease, this association is apparent in Japanese studies in the *0103:DQB1*0601 haplotype, and in Europe with the *0103:DQB1*0603 haplotype, indicating the protective effect is influenced by the alpha chain of DQ. DQA1*0103 is protective against Behçet's disease,[4][5] pemphigus vulgaris,[6] juvenile diabetes,[7][8] steroid-sensitive nephrotic syndrome,[9] myasthenia gravis[10] coeliac disease[11] multiple sclerosis,[12] chronic active hepatitis C,[13] and Vogt–Koyanagi–Harada syndrome.[14] However, it may predispose carriers to chronic infection such as leprosy,[15] Helicobacter pylori-positive gastric lymphoma,[16] and AIDS.[17]

DQA1*0103:DQB1*0601 is part of a multigene haplotype (DRB1*1502:DRB5*0102:DQA1*0103:DQB1*0601:DPA1*02:DPB1*0901) linked to Takayasu's arteritis in Japanese.[18] Another haplotype, DR8-DQ1 which contains this haplotype may be associated with primary biliary cirrhosis,[19] Graves' disease[20] There is a negative association of this DR15-DQ1 haplotype in Japanese with inflammatory bowel disease.[21]

DQA1*0103:DQB1*0603 is part of a DR-DQ haplotype (DR13-DQ1) that increases for primary sclerosing cholangitis[22][23] The same haplotype shows a negative association with rheumatic heart disease,[24]

DQA1*0104 edit

DQA1*0104:DQB1*0503 is part of a multigene haplotype DR14-DQ5 that is associated with MuSK positive Myasthenia gravis.

References edit

  1. ^ Trowsdale J, Lee J, Carey J, Grosveld F, Bodmer J, Bodmer W (1983). "Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes". Proc. Natl. Acad. Sci. U.S.A. 80 (7): 1972–6. Bibcode:1983PNAS...80.1972T. doi:10.1073/pnas.80.7.1972. PMC 393734. PMID 6300884.
  2. ^ Möller E, Carlsson B, Wallin J (1985). "Implication of structural class II gene polymorphism for the concept of serologic specificities". Immunol. Rev. 85: 107–28. doi:10.1111/j.1600-065X.1985.tb01132.x. PMID 2412948. S2CID 20971131.
  3. ^ derived from IMGT/HLA
  4. ^ Mizuki N, Ohno S, Tanaka H, et al. (1992). "Association of HLA-B51 and lack of association of class II alleles with Behçet's disease". Tissue Antigens. 40 (1): 22–30. doi:10.1111/j.1399-0039.1992.tb01953.x. PMID 1359669.
  5. ^ Mizuki N, Inoko H, Mizuki N, et al. (1992). "Human leukocyte antigen serologic and DNA typing of Behçet's disease and its primary association with B51". Invest. Ophthalmol. Vis. Sci. 33 (12): 3332–40. PMID 1358857.
  6. ^ Niizeki H, Inoko H, Mizuki N, et al. (1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. 44 (4): 248–51. doi:10.1111/j.1399-0039.1994.tb02390.x. PMID 7871526.
  7. ^ Gaber SA, Mazzola G, Berrino M, et al. (1994). "Human leukocyte antigen class II polymorphisms and genetic susceptibility of IDDM in Egyptian children". Diabetes Care. 17 (11): 1341–4. doi:10.2337/diacare.17.11.1341. PMID 7821177. S2CID 25150033.
  8. ^ Chuang LM, Jou TS, Wu HP, et al. (1995). "HLA DQA1 genotypes and its interaction with HLA DQB1 in Chinese IDDM living in Taiwan". Proc. Natl. Sci. Counc. Repub. China B. 19 (2): 73–9. PMID 7624445.
  9. ^ Abe KK, Michinaga I, Hiratsuka T, et al. (1995). "Association of DQB1*0302 alloantigens in Japanese pediatric patients with steroid-sensitive nephrotic syndrome". Nephron. 70 (1): 28–34. doi:10.1159/000188540. PMID 7617114.
  10. ^ Hjelmström P, Giscombe R, Lefvert AK, et al. (1995). "Different HLA-DQ are positively and negatively associated in Swedish patients with myasthenia gravis". Autoimmunity. 22 (1): 59–65. doi:10.3109/08916939508995300. PMID 8882423.,
  11. ^ Nieto A, Blanco Quirós A, Arranz E, Alonso Franch M, Garrote JA, Calvo C (1995). "Study of HLA-DQA1 alleles in celiac children". Journal of Investigational Allergology and Clinical Immunology. 5 (4): 209–15. PMID 8705011.
  12. ^ Saruhan-Direskeneli G, Esin S, Baykan-Kurt B, Ornek I, Vaughan R, Eraksoy M (1997). "HLA-DR and -DQ associations with multiple sclerosis in Turkey". Hum. Immunol. 55 (1): 59–65. doi:10.1016/S0198-8859(97)00086-4. PMID 9328791.
  13. ^ Höhler T, Gerken G, Notghi A, et al. (1997). "MHC class II genes influence the susceptibility to chronic active hepatitis C". J. Hepatol. 27 (2): 259–64. doi:10.1016/S0168-8278(97)80169-9. PMID 9288598.
  14. ^ Kim MH, Seong MC, Kwak NH, et al. (2000). "Association of HLA with Vogt-Koyanagi-Harada syndrome in Koreans". Am. J. Ophthalmol. 129 (2): 173–7. doi:10.1016/S0002-9394(99)00434-1. PMID 10682969.
  15. ^ Rani R, Fernandez-Vina MA, Zaheer SA, Beena KR, Stastny P (1993). "Study of HLA class II alleles by PCR oligotyping in leprosy patients from north India". Tissue Antigens. 42 (3): 133–7. doi:10.1111/j.1399-0039.1993.tb02179.x. PMID 8284786.
  16. ^ Kawahara Y, Mizuno M, Yoshino T, et al. (2005). "HLA-DQA1*0103-DQB1*0601 haplotype and Helicobacter pylori-positive gastric mucosa-associated lymphoid tissue lymphoma". Clin. Gastroenterol. Hepatol. 3 (9): 865–8. doi:10.1016/S1542-3565(05)00185-0. PMID 16234023.
  17. ^ Kroner BL, Goedert JJ, Blattner WA, Wilson SE, Carrington MN, Mann DL (1995). "Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in hemophilic siblings. Multicenter Hemophilia Cohort and Hemophilia Growth and Development Studies". AIDS. 9 (3): 275–80. doi:10.1097/00002030-199509030-00009. PMID 7755916.
  18. ^ Dong RP, Kimura A, Numano F, Nishimura Y, Sasazuki T (1992). "HLA-linked susceptibility and resistance to Takayasu arteritis". Heart and Vessels. Supplement. 7: 73–80. doi:10.1007/BF01744548. PMID 1360976. S2CID 22943921.
  19. ^ Onishi S, Sakamaki T, Maeda T, et al. (1994). "DNA typing of HLA class II genes; DRB1*0803 increases the susceptibility of Japanese to primary biliary cirrhosis". J. Hepatol. 21 (6): 1053–60. doi:10.1016/S0168-8278(05)80617-8. PMID 7699227.
  20. ^ Katsuren E, Awata T, Matsumoto C, Yamamoto K (1994). "HLA class II alleles in Japanese patients with Graves' disease: weak associations of HLA-DR and -DQ". Endocr. J. 41 (6): 599–603. doi:10.1507/endocrj.41.599. PMID 7704083.
  21. ^ Yoshitake S, Kimura A, Okada M, Yao T, Sasazuki T (1999). "HLA class II alleles in Japanese patients with inflammatory bowel disease". Tissue Antigens. 53 (4 Pt 1): 350–8. doi:10.1034/j.1399-0039.1999.530405.x. PMID 10323339.
  22. ^ Olerup O, Olsson R, Hultcrantz R, Broome U (1995). "HLA-DR and HLA-DQ are not markers for rapid disease progression in primary sclerosing cholangitis". Gastroenterology. 108 (3): 870–8. doi:10.1016/0016-5085(95)90463-8. PMID 7875491.
  23. ^ Spurkland A, Saarinen S, Boberg KM, et al. (1999). "HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations". Tissue Antigens. 53 (5): 459–69. doi:10.1034/j.1399-0039.1999.530502.x. PMID 10372541.
  24. ^ Guédez Y, Kotby A, El-Demellawy M, et al. (1999). "HLA class II associations with rheumatic heart disease are more evident and consistent among clinically homogeneous patients". Circulation. 99 (21): 2784–90. doi:10.1161/01.cir.99.21.2784. PMID 10351973.

January 01, 1970
redirects, here, first, title, dragon, quest, series, dragon, quest, video, game, this, article, lead, section, short, adequately, summarize, points, please, consider, expanding, lead, provide, accessible, overview, important, aspects, article, january, 2010, . DQ1 redirects here For the first title in the Dragon Quest series see Dragon Quest video game This article s lead section may be too short to adequately summarize the key points Please consider expanding the lead to provide an accessible overview of all important aspects of the article January 2010 major histocompatibility complex class II DQ1 Haplotypes DQA1 0101 DQB1 0501 DQA1 0101 DQB1 0502 DQA1 0102 DQB1 0502 DQA1 0104 DQB1 0503 DQA1 0103 DQB1 0601 DQA1 0102 DQB1 0602 DQA1 0103 DQB1 0603 DQA1 0102 DQB1 0604 DQA1 0102 DQB1 0605 DQA1 0102 DQB1 0609 Structure Identifiers alpha 1 0101 0102 0103 0104 Symbol s HLA DQA1 permanent dead link EBI HLA DQA1 0101 EBI HLA DQA1 0102 Archived 2011 05 15 at the Wayback Machine EBI HLA DQA1 0103 EBI HLA DQA1 0104 Identifiers beta 1 05 or 06 Symbol s HLA DQB1 EBI HLA DQB1 05 EBI HLA DQB1 06 Shared data Locus chr 6 6p21 31 HLA DQ1 is a serotype that covers a broad range of HLA DQ haplotypes Historically it was identified as a DR like alpha chain called DC1 1 later it was among 3 types DQw1 later DQ1 and split into DQ5 and DQ6 DQw2 and DQw3 Of these three serotyping specificities only DQw1 recognized DQ alpha chain 2 The serotype is positive in individuals who bear the DQA1 01 alleles The most frequently found within this group are DQA1 0101 0102 0103 and 0104 In the illustration on the right DQ1 serotyping antibodies recognizes the DQ a magenta where antibodies to DQA1 gene products bind variable regions close to the peptide binding pocket Contents 1 Serotypes 2 Alleles 2 1 DQA1 0101 2 2 DQA1 0102 2 3 DQA1 0103 2 4 DQA1 0104 3 ReferencesSerotypes editSome DRB1 alleles and DQ5 DQ1 DQ6 recognition 3 DQB1 DQ5 DQ1 DQ6 Sample allele size N 0501 69 20 2 5536 0502 48 24 15 919 0503 58 22 4 1327 0504 59 17 2 48 DQ6 DQ1 DQ5 N 0601 64 23 675 0602 67 30 1 5151 0603 62 23 2 2807 0604 59 27 2 1592 0605 76 13 358 0609 48 32 3 149 The serotyping efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed below Since DQ1 recognizes alpha the DQ5 and DQ6 recognition are to beta chain Meaning that DQ1 is corecognized with DQ5 and DQ6 The table to the left shows some of the serotyping efficiencies Efficient recognition of a genotyped allele approaches 100 Compared to DQ2 serotyping of DQB1 0201 positive individuals 98 the efficiency of DQ1 recognition is relatively low and error prone For this reason DQ1 serotyping is a poor method of typing for transplantation or disease association prediction or study Nonetheless it is still widely used and association purported in the literature Alleles editDQA1 0101 edit DQA1 0101 is commonly linked to haplotypes of DQB1 05 the common DQA1 0101 DQB1 0501 haplotype which is part of a broader DR1 DQ1 haplotype DQA1 0102 edit DQA1 0102 is associated with both DR5 and DR6 DQA1 0102 DQB1 0502 has a bimodal distribution It is found in the Philippines in high frequency and on the Mediterranean island of Sardinia DQA1 0102 DQB1 0602 is a very common haplotype in Eurasia with higher frequency in central Asia relative to elsewhere It is part of a European ancestral haplotype B7 DR15 DQ1 that appears to have expanded asymmetrically into Europe The A3 B7 DR15 DQ1 haplotype indicates relationships in Eurasia that span from Korea to Ireland indicating some common ancestry in recent times DQA1 0102 DQB1 0604 much less frequently found but spread widely DQA1 0103 edit DQA1 0103 0103 shows a negative protective association with many autoimmune disease this association is apparent in Japanese studies in the 0103 DQB1 0601 haplotype and in Europe with the 0103 DQB1 0603 haplotype indicating the protective effect is influenced by the alpha chain of DQ DQA1 0103 is protective against Behcet s disease 4 5 pemphigus vulgaris 6 juvenile diabetes 7 8 steroid sensitive nephrotic syndrome 9 myasthenia gravis 10 coeliac disease 11 multiple sclerosis 12 chronic active hepatitis C 13 and Vogt Koyanagi Harada syndrome 14 However it may predispose carriers to chronic infection such as leprosy 15 Helicobacter pylori positive gastric lymphoma 16 and AIDS 17 DQA1 0103 DQB1 0601 is part of a multigene haplotype DRB1 1502 DRB5 0102 DQA1 0103 DQB1 0601 DPA1 02 DPB1 0901 linked to Takayasu s arteritis in Japanese 18 Another haplotype DR8 DQ1 which contains this haplotype may be associated with primary biliary cirrhosis 19 Graves disease 20 There is a negative association of this DR15 DQ1 haplotype in Japanese with inflammatory bowel disease 21 DQA1 0103 DQB1 0603 is part of a DR DQ haplotype DR13 DQ1 that increases for primary sclerosing cholangitis 22 23 The same haplotype shows a negative association with rheumatic heart disease 24 DQA1 0104 edit DQA1 0104 DQB1 0503 is part of a multigene haplotype DR14 DQ5 that is associated with MuSK positive Myasthenia gravis References edit Trowsdale J Lee J Carey J Grosveld F Bodmer J Bodmer W 1983 Sequences related to HLA DR alpha chain on human chromosome 6 restriction enzyme polymorphism detected with DC alpha chain probes Proc Natl Acad Sci U S A 80 7 1972 6 Bibcode 1983PNAS 80 1972T doi 10 1073 pnas 80 7 1972 PMC 393734 PMID 6300884 Moller E Carlsson B Wallin J 1985 Implication of structural class II gene polymorphism for the concept of serologic specificities Immunol Rev 85 107 28 doi 10 1111 j 1600 065X 1985 tb01132 x PMID 2412948 S2CID 20971131 derived from IMGT HLA Mizuki N Ohno S Tanaka H et al 1992 Association of HLA B51 and lack of association of class II alleles with Behcet s disease Tissue Antigens 40 1 22 30 doi 10 1111 j 1399 0039 1992 tb01953 x PMID 1359669 Mizuki N Inoko H Mizuki N et al 1992 Human leukocyte antigen serologic and DNA typing of Behcet s disease and its primary association with B51 Invest Ophthalmol Vis Sci 33 12 3332 40 PMID 1358857 Niizeki H Inoko H Mizuki N et al 1994 HLA DQA1 DQB1 and DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR RFLP method Tissue Antigens 44 4 248 51 doi 10 1111 j 1399 0039 1994 tb02390 x PMID 7871526 Gaber SA Mazzola G Berrino M et al 1994 Human leukocyte antigen class II polymorphisms and genetic susceptibility of IDDM in Egyptian children Diabetes Care 17 11 1341 4 doi 10 2337 diacare 17 11 1341 PMID 7821177 S2CID 25150033 Chuang LM Jou TS Wu HP et al 1995 HLA DQA1 genotypes and its interaction with HLA DQB1 in Chinese IDDM living in Taiwan Proc Natl Sci Counc Repub China B 19 2 73 9 PMID 7624445 Abe KK Michinaga I Hiratsuka T et al 1995 Association of DQB1 0302 alloantigens in Japanese pediatric patients with steroid sensitive nephrotic syndrome Nephron 70 1 28 34 doi 10 1159 000188540 PMID 7617114 Hjelmstrom P Giscombe R Lefvert AK et al 1995 Different HLA DQ are positively and negatively associated in Swedish patients with myasthenia gravis Autoimmunity 22 1 59 65 doi 10 3109 08916939508995300 PMID 8882423 Nieto A Blanco Quiros A Arranz E Alonso Franch M Garrote JA Calvo C 1995 Study of HLA DQA1 alleles in celiac children Journal of Investigational Allergology and Clinical Immunology 5 4 209 15 PMID 8705011 Saruhan Direskeneli G Esin S Baykan Kurt B Ornek I Vaughan R Eraksoy M 1997 HLA DR and DQ associations with multiple sclerosis in Turkey Hum Immunol 55 1 59 65 doi 10 1016 S0198 8859 97 00086 4 PMID 9328791 Hohler T Gerken G Notghi A et al 1997 MHC class II genes influence the susceptibility to chronic active hepatitis C J Hepatol 27 2 259 64 doi 10 1016 S0168 8278 97 80169 9 PMID 9288598 Kim MH Seong MC Kwak NH et al 2000 Association of HLA with Vogt Koyanagi Harada syndrome in Koreans Am J Ophthalmol 129 2 173 7 doi 10 1016 S0002 9394 99 00434 1 PMID 10682969 Rani R Fernandez Vina MA Zaheer SA Beena KR Stastny P 1993 Study of HLA class II alleles by PCR oligotyping in leprosy patients from north India Tissue Antigens 42 3 133 7 doi 10 1111 j 1399 0039 1993 tb02179 x PMID 8284786 Kawahara Y Mizuno M Yoshino T et al 2005 HLA DQA1 0103 DQB1 0601 haplotype and Helicobacter pylori positive gastric mucosa associated lymphoid tissue lymphoma Clin Gastroenterol Hepatol 3 9 865 8 doi 10 1016 S1542 3565 05 00185 0 PMID 16234023 Kroner BL Goedert JJ Blattner WA Wilson SE Carrington MN Mann DL 1995 Concordance of human leukocyte antigen haplotype sharing CD4 decline and AIDS in hemophilic siblings Multicenter Hemophilia Cohort and Hemophilia Growth and Development Studies AIDS 9 3 275 80 doi 10 1097 00002030 199509030 00009 PMID 7755916 Dong RP Kimura A Numano F Nishimura Y Sasazuki T 1992 HLA linked susceptibility and resistance to Takayasu arteritis Heart and Vessels Supplement 7 73 80 doi 10 1007 BF01744548 PMID 1360976 S2CID 22943921 Onishi S Sakamaki T Maeda T et al 1994 DNA typing of HLA class II genes DRB1 0803 increases the susceptibility of Japanese to primary biliary cirrhosis J Hepatol 21 6 1053 60 doi 10 1016 S0168 8278 05 80617 8 PMID 7699227 Katsuren E Awata T Matsumoto C Yamamoto K 1994 HLA class II alleles in Japanese patients with Graves disease weak associations of HLA DR and DQ Endocr J 41 6 599 603 doi 10 1507 endocrj 41 599 PMID 7704083 Yoshitake S Kimura A Okada M Yao T Sasazuki T 1999 HLA class II alleles in Japanese patients with inflammatory bowel disease Tissue Antigens 53 4 Pt 1 350 8 doi 10 1034 j 1399 0039 1999 530405 x PMID 10323339 Olerup O Olsson R Hultcrantz R Broome U 1995 HLA DR and HLA DQ are not markers for rapid disease progression in primary sclerosing cholangitis Gastroenterology 108 3 870 8 doi 10 1016 0016 5085 95 90463 8 PMID 7875491 Spurkland A Saarinen S Boberg KM et al 1999 HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations Tissue Antigens 53 5 459 69 doi 10 1034 j 1399 0039 1999 530502 x PMID 10372541 Guedez Y Kotby A El Demellawy M et al 1999 HLA class II associations with rheumatic heart disease are more evident and consistent among clinically homogeneous patients Circulation 99 21 2784 90 doi 10 1161 01 cir 99 21 2784 PMID 10351973 Retrieved from https en wikipedia org w index php title HLA DQ1 amp oldid 1116936852, wikipedia, wiki, book, books, library,

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