HLA-DQ5 (DQ5) is a human leukocyte antigenserotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4 common alleles, DQB1*0501, *0502, *0503, and *0504. HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, are all HLA-DQ1 encoded by the DQA1*01 allele group.
HLA-DQ5
Illustration of HLA-DQ with gliadin peptide in the binding pocket.
DQ5, DQ1, and DQ6 recognition of some DQB1* alleles [1]
DQB1*
DQ5
DQ1
DQ6
Sample
allele
%
%
%
size (N)
*0501
69
20
2
5536
*0502
48
24
15
919
*0503
58
22
4
1327
*0504
59
17
2
48
Red indicates the level of 'false' reaction in non-DQ5 serotypes
The efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed above. Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ5 recognition is relatively low and error prone.
While DQ5 recognizes DQB1*05 alleles more efficiently than DQ1, the serotyping is rather poor method of typing for transplantation or disease association prediction or study.
A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality show DQ5 more likely,[4] AIDP type of Guillain Barré syndrome,[5] and irritable bowel disease [6] but not crohn's disease in the same (Jewish) population. Other studies show DQ5 is associated with extra-intestinal manifestations of Crohn's.[7]
DQ5 appears to be associated with analgesic intolerance.[8]
By haplotypeEdit
MuSK antibody-positive myasthenia gravis HLA-DR14-DQ5,[9] probably DRB1*1402 : DQA1*0104 : DQB1*0503 (DR14-DQ5). DR1-DQ5 is associated with sensitivity to acid anhydrides.[10]
^Krasowska-Kwiecień A, Sancewicz-Pach K, Moczulska A (2006). "Idiopathic nephrotic syndrome in Polish children - its variants and associations with HLA". Pediatr. Nephrol. 21 (12): 1837–46. doi:10.1007/s00467-006-0271-7. PMID 16967287. S2CID 23739129.
^Myhre AG, Undlien DE, Løvås K, et al. (2002). "Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features". J. Clin. Endocrinol. Metab. 87 (2): 618–23. doi:10.1210/jc.87.2.618. PMID 11836294.
^Wang JF, Zhang D, Zhao JZ, Jia BX, Bi RM (2006). "A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality". Surgical Neurology. 66 Suppl 1: S25–8, discussion S28–9. doi:10.1016/j.surneu.2006.06.048. PMID 16904993.
^Guo L, Wang W, Li C, Liu R, Wang G (2002). "[The association between HLA typing and different subtypes of Guillain Barré syndrome]". Zhonghua Nei Ke Za Zhi (in Chinese). 41 (6): 381–3. PMID 12137599.
^Trachtenberg EA, Yang H, Hayes E, et al. (2000). "HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations". Hum. Immunol. 61 (3): 326–33. doi:10.1016/S0198-8859(99)00134-2. PMC4524574. PMID 10689124.
^Hesresbach D, Alizadeh M, Bretagne JF, et al. (1996). "Investigation of the association of major histocompatibility complex genes, including HLA class I, class II and TAP genes, with clinical forms of Crohn's disease". Eur. J. Immunogenet. 23 (2): 141–51. doi:10.1111/j.1744-313X.1996.tb00275.x. PMID 8732477. S2CID 32885468.
^Kalyoncu AF, Karakaya G, Yilmaz E, Balci B, Karaduman A, Yasavul U (2003). "Analgesic intolerance with or without bronchial asthma: is there a marker?". Journal of Investigational Allergology and Clinical Immunology. 13 (3): 162–9. PMID 14635465.
^Niks EH, Kuks JB, Roep BO, et al. (2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology. 66 (11): 1772–4. doi:10.1212/01.wnl.0000218159.79769.5c. PMID 16769963. S2CID 41206495.
^Jones MG, Nielsen J, Welch J, et al. (2004). "Association of HLA-DQ5 and HLA-DR1 with sensitization to organic acid anhydrides". Clin. Exp. Allergy. 34 (5): 812–6. doi:10.1111/j.1365-2222.2004.1956.x. PMID 15144476. S2CID 7864063.
October 24, 2023
human, leukocyte, antigen, serotype, subgroup, within, serotypes, serotype, determined, antibody, recognition, subset, chains, chain, encoded, dqb1, locus, encoded, dqb1, allele, group, this, group, currently, contains, common, alleles, dqb1, 0501, 0502, 0503,. HLA DQ5 DQ5 is a human leukocyte antigen serotype subgroup within HLA DQ DQ serotypes The serotype is determined by the antibody recognition of b5 x subset of DQ b chains The b chain of DQ is encoded by HLA DQB1 locus and DQ5 are encoded by the HLA DQB1 05 allele group This group currently contains 4 common alleles DQB1 0501 0502 0503 and 0504 HLA DQ5 and HLA DQB1 05 are almost synonymous in meaning DQ5 b chains combine with a chains encoded by genetically linked HLA DQA1 alleles to form the cis haplotype isoforms These isoforms are all HLA DQ1 encoded by the DQA1 01 allele group HLA DQ5Illustration of HLA DQ with gliadin peptide in the binding pocket Polymer typeMHC Class II DQ cell surface antigenCis haplotype Haplotypeisoform subtype DQA1 DQB1DQ a1 1b5 1 DQ5 1 0101 0501DQ a1 2b5 2 DQ5 2 0102 0502DQ a1 4b5 3 DQ5 3 0104 0503 Contents 1 Serology 2 Disease associations 2 1 By serotype 2 2 By haplotype 3 ReferencesSerology EditDQ5 DQ1 and DQ6 recognition of some DQB1 alleles 1 DQB1 DQ5 DQ1 DQ6 Sampleallele size N 0501 69 20 2 5536 0502 48 24 15 919 0503 58 22 4 1327 0504 59 17 2 48Red indicates the level of false reaction in non DQ5 serotypesThe efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed above Since DQ1 recognizes alpha the DQ5 and DQ6 recognition are to beta chain Meaning that DQ1 is corecognized with DQ5 and DQ6 Efficient recognition of a genotyped allele approaches 100 Compared to DQ2 serotyping of DQB1 0201 positive individuals 98 the efficiency of DQ5 recognition is relatively low and error prone While DQ5 recognizes DQB1 05 alleles more efficiently than DQ1 the serotyping is rather poor method of typing for transplantation or disease association prediction or study Disease associations EditBy serotype Edit DQ5 is negatively associated with protective against idiopathic nephrotic syndrome in Polish children 2 and adrenocortical failure Addison s disease 3 A study on the relationship between HLA DR DQ antigen and intracranial aneurysm in the Han nationality show DQ5 more likely 4 AIDP type of Guillain Barre syndrome 5 and irritable bowel disease 6 but not crohn s disease in the same Jewish population Other studies show DQ5 is associated with extra intestinal manifestations of Crohn s 7 DQ5 appears to be associated with analgesic intolerance 8 By haplotype Edit MuSK antibody positive myasthenia gravis HLA DR14 DQ5 9 probably DRB1 1402 DQA1 0104 DQB1 0503 DR14 DQ5 DR1 DQ5 is associated with sensitivity to acid anhydrides 10 References Edit derived from IMGT HLA Krasowska Kwiecien A Sancewicz Pach K Moczulska A 2006 Idiopathic nephrotic syndrome in Polish children its variants and associations with HLA Pediatr Nephrol 21 12 1837 46 doi 10 1007 s00467 006 0271 7 PMID 16967287 S2CID 23739129 Myhre AG Undlien DE Lovas K et al 2002 Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features J Clin Endocrinol Metab 87 2 618 23 doi 10 1210 jc 87 2 618 PMID 11836294 Wang JF Zhang D Zhao JZ Jia BX Bi RM 2006 A study on the relationship between HLA DR DQ antigen and intracranial aneurysm in the Han nationality Surgical Neurology 66 Suppl 1 S25 8 discussion S28 9 doi 10 1016 j surneu 2006 06 048 PMID 16904993 Guo L Wang W Li C Liu R Wang G 2002 The association between HLA typing and different subtypes of Guillain Barre syndrome Zhonghua Nei Ke Za Zhi in Chinese 41 6 381 3 PMID 12137599 Trachtenberg EA Yang H Hayes E et al 2000 HLA class II haplotype associations with inflammatory bowel disease in Jewish Ashkenazi and non Jewish caucasian populations Hum Immunol 61 3 326 33 doi 10 1016 S0198 8859 99 00134 2 PMC 4524574 PMID 10689124 Hesresbach D Alizadeh M Bretagne JF et al 1996 Investigation of the association of major histocompatibility complex genes including HLA class I class II and TAP genes with clinical forms of Crohn s disease Eur J Immunogenet 23 2 141 51 doi 10 1111 j 1744 313X 1996 tb00275 x PMID 8732477 S2CID 32885468 Kalyoncu AF Karakaya G Yilmaz E Balci B Karaduman A Yasavul U 2003 Analgesic intolerance with or without bronchial asthma is there a marker Journal of Investigational Allergology and Clinical Immunology 13 3 162 9 PMID 14635465 Niks EH Kuks JB Roep BO et al 2006 Strong association of MuSK antibody positive myasthenia gravis and HLA DR14 DQ5 Neurology 66 11 1772 4 doi 10 1212 01 wnl 0000218159 79769 5c PMID 16769963 S2CID 41206495 Jones MG Nielsen J Welch J et al 2004 Association of HLA DQ5 and HLA DR1 with sensitization to organic acid anhydrides Clin Exp Allergy 34 5 812 6 doi 10 1111 j 1365 2222 2004 1956 x PMID 15144476 S2CID 7864063 Retrieved from https en wikipedia org w index php title HLA DQ5 amp oldid 1116877230, wikipedia, wiki, book, books, library,
