Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histoneprotein that in humans is encoded by the H2AFB2gene (H2A histone family, member B1).[5]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000277858 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000083616 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Chadwick BP, Willard HF (2001). "A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome". J. Cell Biol. 152 (2): 375–84. doi:10.1083/jcb.152.2.375. PMC2199617. PMID 11266453.
Bao Y, Konesky K, Park YJ, et al. (2004). "Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA". EMBO J. 23 (16): 3314–24. doi:10.1038/sj.emboj.7600316. PMC514500. PMID 15257289.
Naylor JA, Buck D, Green P, et al. (1995). "Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions". Hum. Mol. Genet. 4 (7): 1217–24. doi:10.1093/hmg/4.7.1217. PMID 8528212.
h2afb2, histone, type, also, known, barr, body, deficient, histone, protein, that, humans, encoded, gene, histone, family, member, h2ab2identifiersaliasesh2ab2, histone, family, member, variant, histone, h2ab3, 1external, idsmgi, 3644875, homologene, 129517, g. Histone H2A Bbd type 2 3 also known as H2A Barr body deficient is a histone protein that in humans is encoded by the H2AFB2 gene H2A histone family member B1 5 H2AB2IdentifiersAliasesH2AB2 H2A Bbd H2A histone family member B2 H2A B variant histone 2 H2AFB2 H2AB3 H2A B 1External IDsMGI 3644875 HomoloGene 129517 GeneCards H2AB2Gene location Human Chr X chromosome human 1 BandXq28Start155 380 709 bp 1 End155 381 299 bp 1 Gene location Mouse Chr X chromosome mouse 2 BandX X E2Start119 222 445 bp 2 End119 222 792 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubegastric mucosacanal of the cervixspleenbloodright coronary arterysural nervefundusganglionic eminencemonocyteTop expressed intesticlespermatidcerebellumhypothalamusmesencephalonsuperior frontal gyrusspleenhippocampal formationhippocampus properthymusMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein heterodimerization activity DNA bindingCellular componentnucleosome nucleus chromosomeBiological processnucleosome assembly mRNA processing chromatin organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez474381624957EnsemblENSG00000277858ENSMUSG00000083616UniProtP0C5Z0S4R1G7RefSeq mRNA NM 001017991NM 001281531RefSeq protein NP 001017991NP 001268460Location UCSC Chr X 155 38 155 38 MbChr X 119 22 119 22 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones H2A H2B H3 and H4 The chromatin fiber is further compacted through the interaction of a linker histone H1 with the DNA between the nucleosomes to form higher order chromatin structures This gene encodes a member of the histone H2A family This gene is part of a region that is repeated three times on chromosome X once in intron 22 of the F8 gene and twice closer to the Xq telomere This record represents the middle copy 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000277858 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000083616 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene H2A histone family Further reading editStrausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Chadwick BP Willard HF 2001 A Novel Chromatin Protein Distantly Related to Histone H2a Is Largely Excluded from the Inactive X Chromosome J Cell Biol 152 2 375 84 doi 10 1083 jcb 152 2 375 PMC 2199617 PMID 11266453 Bao Y Konesky K Park YJ et al 2004 Nucleosomes containing the histone variant H2A Bbd organize only 118 base pairs of DNA EMBO J 23 16 3314 24 doi 10 1038 sj emboj 7600316 PMC 514500 PMID 15257289 Naylor JA Buck D Green P et al 1995 Investigation of the factor VIII intron 22 repeated region int22h and the associated inversion junctions Hum Mol Genet 4 7 1217 24 doi 10 1093 hmg 4 7 1217 PMID 8528212 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on the human X chromosome and or its associated protein is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title H2AFB2 amp oldid 1079538973, wikipedia, wiki, book, books, library,
