Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2Cgene.[5][6]
GC-C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea.[8] Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice deficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GC-C receptor.
^Mann EA, Swenson ES, Copeland NG, Gilbert DJ, Jenkins NA, Taguchi T, Testa JR, Giannella RA (June 1996). "Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12". Genomics. 34 (2): 265–7. doi:10.1006/geno.1996.0284. PMID 8661067.
^Intestinal Protein May Have Role in ADHD, Other Neurological Disorders. ScienceDaily (Aug. 11, 2011) [1]
^Weiglmeier PR, Rösch P, Berkner H (August 2010). "Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C". Toxins. 2 (9): 2213–2229. doi:10.3390/toxins2092213. PMC3153297. PMID 22069681.
Further reading
Schulz S, Hyslop T, Haaf J, et al. (2006). "A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer". Clin. Cancer Res. 12 (15): 4545–52. doi:10.1158/1078-0432.CCR-06-0865. PMID 16899600.
Park J, Schulz S, Haaf J, et al. (2002). "Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach". Cancer Epidemiol. Biomarkers Prev. 11 (8): 739–44. PMID 12163327.
Tien YW, Lee PH, Hu RH, et al. (2003). "The role of gelatinase in hepatic metastasis of colorectal cancer". Clin. Cancer Res. 9 (13): 4891–6. PMID 14581363.
Basu N, Bhandari R, Natarajan VT, Visweswariah SS (2009). "Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis". Mol. Cell. Biol. 29 (19): 5277–89. doi:10.1128/MCB.00001-09. PMC2747985. PMID 19620276.
Mann EA, Steinbrecher KA, Stroup C, et al. (2005). "Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model". Int. J. Cancer. 116 (4): 500–5. doi:10.1002/ijc.21119. PMID 15825168. S2CID 28833622.
Saha S, Biswas KH, Kondapalli C, et al. (2009). "The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C." J. Biol. Chem. 284 (40): 27135–45. doi:10.1074/jbc.M109.020032. PMC2786029. PMID 19648115.
Bhandari R, Srinivasan N, Mahaboobi M, et al. (2001). "Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain". Biochemistry. 40 (31): 9196–206. doi:10.1021/bi002595g. PMID 11478887.
Sindiće A, Başoglu C, Cerçi A, et al. (2002). "Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells". J. Biol. Chem. 277 (20): 17758–64. doi:10.1074/jbc.M110627200. PMID 11889121.
Jaleel M, London RM, Eber SL, et al. (2002). "Expression of the receptor guanylyl cyclase C and its ligands in reproductive tissues of the rat: a potential role for a novel signaling pathway in the epididymis". Biol. Reprod. 67 (6): 1975–80. doi:10.1095/biolreprod.102.006445. PMID 12444076.
Mejia A, Schulz S, Hyslop T, et al. (2009). "GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients". Expert Rev. Mol. Diagn. 9 (8): 777–85. doi:10.1586/erm.09.67. PMC2810399. PMID 19895223.
Scott RO, Thelin WR, Milgram SL (2002). "A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor". J. Biol. Chem. 277 (25): 22934–41. doi:10.1074/jbc.M202434200. PMID 11950846.
Ghanekar Y, Chandrashaker A, Tatu U, Visweswariah SS (2004). "Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity". Biochem. J. 379 (Pt 3): 653–63. doi:10.1042/BJ20040001. PMC1224121. PMID 14748740.
Kulaksiz H, Cetin Y (2001). "Uroguanylin and guanylate cyclase C in the human pancreas: expression and mutuality of ligand/receptor localization as indicators of intercellular paracrine signaling pathways". J. Endocrinol. 170 (1): 267–75. doi:10.1677/joe.0.1700267. PMID 11431160.
Debruyne PR, Witek M, Gong L, et al. (2006). "Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells". Gastroenterology. 130 (4): 1191–206. doi:10.1053/j.gastro.2005.12.032. PMID 16618413.
Singh R (2003). "Interaction of guanylyl cyclase C with SH3 domain of Src tyrosine kinase. Yet another mechanism for desensitization". J. Biol. Chem. 278 (27): 24342–9. doi:10.1074/jbc.M301153200. PMID 12649275.
Selvaraj NG, Prasad R, Goldstein JL, Rao MC (2000). "Evidence for the presence of cGMP-dependent protein kinase-II in human distal colon and in T84, the colonic cell line". Biochim. Biophys. Acta. 1498 (1): 32–43. doi:10.1016/s0167-4889(00)00075-6. PMID 11042348.
Ciocca V, Bombonati A, Palazzo JP, et al. (2009). "Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms". Histopathology. 55 (2): 182–8. doi:10.1111/j.1365-2559.2009.03358.x. PMC3140017. PMID 19694825.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC16267. PMID 10737800.
External links
GCC testing for colorectal cancer staging
GC-C knock-out mice
guanyl+cyclase-C+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
guanylate, cyclase, also, known, guanylyl, cyclase, intestinal, guanylate, cyclase, guanylate, cyclase, receptor, heat, stable, enterotoxin, receptor, hstar, enzyme, that, humans, encoded, gucy2c, gene, gucy2cidentifiersaliasesgucy2c, diar6, guc2c, mecil, muci. Guanylate cyclase 2C also known as guanylyl cyclase C GC C intestinal guanylate cyclase guanylate cyclase C receptor or the heat stable enterotoxin receptor hSTAR is an enzyme that in humans is encoded by the GUCY2C gene 5 6 GUCY2CIdentifiersAliasesGUCY2C DIAR6 GUC2C MECIL MUCIL STAR guanylate cyclase 2C GC CExternal IDsOMIM 601330 MGI 106903 HomoloGene 3641 GeneCards GUCY2CGene location Human Chr Chromosome 12 human 1 Band12p12 3Start14 612 632 bp 1 End14 696 599 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 G1 6 66 67 cMStart136 674 282 bp 2 End136 758 763 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed injejunal mucosarectumduodenumsecondary oocyteappendixsmooth muscle tissuemonocyteislet of Langerhansbody of pancreasskin of abdomenTop expressed injejunumcolonduodenumileumintestinal villuslymph nodeislet of Langerhanssecondary oocytediencephaloncrypt of lieberkuhn of small intestineMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein kinase activity nucleotide binding GTP binding protein binding lyase activity phosphorus oxygen lyase activity ATP binding toxic substance binding guanylate cyclase activity adenylate cyclase activity peptide receptor activityCellular componentintegral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum guanylate cyclase complex soluble plasma membraneBiological processintracellular signal transduction cyclic nucleotide biosynthetic process receptor guanylyl cyclase signaling pathway protein phosphorylation regulation of cell population proliferation response to toxic substance cGMP biosynthetic process digestion signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez298414917EnsemblENSG00000070019ENSMUSG00000042638UniProtP25092Q3UWA6RefSeq mRNA NM 004963NM 001127318NM 145067RefSeq protein NP 004954NP 001120790NP 659504Location UCSC Chr 12 14 61 14 7 MbChr 6 136 67 136 76 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseGuanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain 7 The receptor has an extracellular ligand binding domain a single transmembrane region a region with sequence similar to that of protein kinases and a C terminal guanylate cyclase domain Tyrosine kinase activity mediates the GC C signaling pathway within the cell Contents 1 Functions 2 In medicine 3 References 4 Further reading 5 External linksFunctions EditGC C is a key receptor for heat stable enterotoxins that are responsible for acute secretory diarrhea 8 Heat stable enterotoxins are produced by pathogens such as Escherichia coli Knockout mice deficient in the GC C gene do not show secretory diarrhea on infection with E coli though they do with cholera toxin This demonstrates the specificity of the GC C receptor In medicine EditGuanylate cyclase 2C is the target of linaclotide and plecanatide oligopeptide agonists used for the treatment of chronic constipation References Edit a b c GRCh38 Ensembl release 89 ENSG00000070019 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000042638 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene guanylate cyclase 2C heat stable enterotoxin receptor Mann EA Swenson ES Copeland NG Gilbert DJ Jenkins NA Taguchi T Testa JR Giannella RA June 1996 Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12 Genomics 34 2 265 7 doi 10 1006 geno 1996 0284 PMID 8661067 Intestinal Protein May Have Role in ADHD Other Neurological Disorders ScienceDaily Aug 11 2011 1 Weiglmeier PR Rosch P Berkner H August 2010 Cure and Curse E coli Heat Stable Enterotoxin and Its Receptor Guanylyl Cyclase C Toxins 2 9 2213 2229 doi 10 3390 toxins2092213 PMC 3153297 PMID 22069681 Further reading EditSchulz S Hyslop T Haaf J et al 2006 A validated quantitative assay to detect occult micrometastases by reverse transcriptase polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer Clin Cancer Res 12 15 4545 52 doi 10 1158 1078 0432 CCR 06 0865 PMID 16899600 Park J Schulz S Haaf J et al 2002 Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach Cancer Epidemiol Biomarkers Prev 11 8 739 44 PMID 12163327 Tien YW Lee PH Hu RH et al 2003 The role of gelatinase in hepatic metastasis of colorectal cancer Clin Cancer Res 9 13 4891 6 PMID 14581363 Basu N Bhandari R Natarajan VT Visweswariah SS 2009 Cross talk between receptor guanylyl cyclase C and c src tyrosine kinase regulates colon cancer cell cytostasis Mol Cell Biol 29 19 5277 89 doi 10 1128 MCB 00001 09 PMC 2747985 PMID 19620276 Mann EA Steinbrecher KA Stroup C et al 2005 Lack of guanylyl cyclase C the receptor for Escherichia coli heat stable enterotoxin results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia Min mouse model Int J Cancer 116 4 500 5 doi 10 1002 ijc 21119 PMID 15825168 S2CID 28833622 Saha S Biswas KH Kondapalli C et al 2009 The linker region in receptor guanylyl cyclases is a key regulatory module mutational analysis of guanylyl cyclase C J Biol Chem 284 40 27135 45 doi 10 1074 jbc M109 020032 PMC 2786029 PMID 19648115 Bhandari R Srinivasan N Mahaboobi M et al 2001 Functional inactivation of the human guanylyl cyclase C receptor modeling and mutation of the protein kinase like domain Biochemistry 40 31 9196 206 doi 10 1021 bi002595g PMID 11478887 Sindice A Basoglu C Cerci A et al 2002 Guanylin uroguanylin and heat stable euterotoxin activate guanylate cyclase C and or a pertussis toxin sensitive G protein in human proximal tubule cells J Biol Chem 277 20 17758 64 doi 10 1074 jbc M110627200 PMID 11889121 Jaleel M London RM Eber SL et al 2002 Expression of the receptor guanylyl cyclase C and its ligands in reproductive tissues of the rat a potential role for a novel signaling pathway in the epididymis Biol Reprod 67 6 1975 80 doi 10 1095 biolreprod 102 006445 PMID 12444076 Mejia A Schulz S Hyslop T et al 2009 GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients Expert Rev Mol Diagn 9 8 777 85 doi 10 1586 erm 09 67 PMC 2810399 PMID 19895223 Scott RO Thelin WR Milgram SL 2002 A novel PDZ protein regulates the activity of guanylyl cyclase C the heat stable enterotoxin receptor J Biol Chem 277 25 22934 41 doi 10 1074 jbc M202434200 PMID 11950846 Ghanekar Y Chandrashaker A Tatu U Visweswariah SS 2004 Glycosylation of the receptor guanylate cyclase C role in ligand binding and catalytic activity Biochem J 379 Pt 3 653 63 doi 10 1042 BJ20040001 PMC 1224121 PMID 14748740 Kulaksiz H Cetin Y 2001 Uroguanylin and guanylate cyclase C in the human pancreas expression and mutuality of ligand receptor localization as indicators of intercellular paracrine signaling pathways J Endocrinol 170 1 267 75 doi 10 1677 joe 0 1700267 PMID 11431160 Debruyne PR Witek M Gong L et al 2006 Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor kappaB and Cdx2 in human esophageal cells Gastroenterology 130 4 1191 206 doi 10 1053 j gastro 2005 12 032 PMID 16618413 Singh R 2003 Interaction of guanylyl cyclase C with SH3 domain of Src tyrosine kinase Yet another mechanism for desensitization J Biol Chem 278 27 24342 9 doi 10 1074 jbc M301153200 PMID 12649275 Selvaraj NG Prasad R Goldstein JL Rao MC 2000 Evidence for the presence of cGMP dependent protein kinase II in human distal colon and in T84 the colonic cell line Biochim Biophys Acta 1498 1 32 43 doi 10 1016 s0167 4889 00 00075 6 PMID 11042348 Ciocca V Bombonati A Palazzo JP et al 2009 Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms Histopathology 55 2 182 8 doi 10 1111 j 1365 2559 2009 03358 x PMC 3140017 PMID 19694825 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Dias Neto E Correa RG Verjovski Almeida S et al 2000 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags Proc Natl Acad Sci U S A 97 7 3491 6 Bibcode 2000PNAS 97 3491D doi 10 1073 pnas 97 7 3491 PMC 16267 PMID 10737800 External links EditGCC testing for colorectal cancer staging GC C knock out mice guanyl cyclase C receptor at the US National Library of Medicine Medical Subject Headings MeSH Portal Biology Retrieved from https en wikipedia org w index php title Guanylate cyclase 2C amp oldid 1136311575, wikipedia, wiki, book, books, library,
