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Glucose-methanol-choline oxidoreductase family

In molecular biology, the glucose-methanol-choline oxidoreductase family (GMC oxidoreductase) is a family of enzymes with oxidoreductase activity.

GMC oxidoreductase
Crystal structure of cholesterol oxidase complexed with a steroid substrate. Implications for FAD dependent alcohol oxidases.
Identifiers
SymbolGMC_oxred_N
PfamPF00732
Pfam clanCL0063
InterProIPR000172
PROSITEPDOC00543
SCOP21gal / SCOPe / SUPFAM
OPM superfamily132
OPM protein1b4v
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
GMC oxidoreductase
Crystal structure of cholesterol oxidase complexed with a steroid substrate. Implications for fad dependent alcohol oxidases.
Identifiers
SymbolGMC_oxred_C
PfamPF05199
InterProIPR007867
PROSITEPDOC00543
SCOP21gal / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The glucose-methanol-choline (GMC) oxidoreductases are FAD flavoproteins oxidoreductases.[1][2] These enzymes include a variety of proteins; choline dehydrogenase (CHD) EC 1.1.99.1, methanol oxidase (MOX) EC 1.1.3.13 and cellobiose dehydrogenase EC 1.1.99.18[3] which share a number of regions of sequence similarities. They contain two conserved protein domains. The N-terminal domain corresponds to the FAD ADP-binding domain, the C-terminal domain is a steroid-binding domain.[4][5]

References edit

  1. ^ Cavener DR (February 1992). "GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities". J. Mol. Biol. 223 (3): 811–4. doi:10.1016/0022-2836(92)90992-S. PMID 1542121.
  2. ^ Li J, Vrielink A, Brick P, Blow DM (November 1993). "Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases". Biochemistry. 32 (43): 11507–15. doi:10.1021/bi00094a006. PMID 8218217.
  3. ^ Henriksson G, Johansson G, Pettersson G (March 2000). "A critical review of cellobiose dehydrogenases". J. Biotechnol. 78 (2): 93–113. doi:10.1016/S0168-1656(00)00206-6. PMID 10725534.
  4. ^ Bannwarth M, Bastian S, Heckmann-Pohl D, Giffhorn F, Schulz GE (2004). "Crystal structure of pyranose 2-oxidase from the white-rot fungus Peniophora sp". Biochemistry. 43 (37): 11683–90. doi:10.1021/bi048609q. PMID 15362852.
  5. ^ Vrielink A, Lloyd LF, Blow DM (1991). "Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 A resolution". J Mol Biol. 219 (3): 533–54. doi:10.1016/0022-2836(91)90192-9. PMID 2051487.
This article incorporates text from the public domain Pfam and InterPro: IPR000172
This article incorporates text from the public domain Pfam and InterPro: IPR007867

glucose, methanol, choline, oxidoreductase, family, molecular, biology, glucose, methanol, choline, oxidoreductase, family, oxidoreductase, family, enzymes, with, oxidoreductase, activity, oxidoreductasecrystal, structure, cholesterol, oxidase, complexed, with. In molecular biology the glucose methanol choline oxidoreductase family GMC oxidoreductase is a family of enzymes with oxidoreductase activity GMC oxidoreductaseCrystal structure of cholesterol oxidase complexed with a steroid substrate Implications for FAD dependent alcohol oxidases IdentifiersSymbolGMC oxred NPfamPF00732Pfam clanCL0063InterProIPR000172PROSITEPDOC00543SCOP21gal SCOPe SUPFAMOPM superfamily132OPM protein1b4vAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryGMC oxidoreductaseCrystal structure of cholesterol oxidase complexed with a steroid substrate Implications for fad dependent alcohol oxidases IdentifiersSymbolGMC oxred CPfamPF05199InterProIPR007867PROSITEPDOC00543SCOP21gal SCOPe SUPFAMAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryThe glucose methanol choline GMC oxidoreductases are FAD flavoproteins oxidoreductases 1 2 These enzymes include a variety of proteins choline dehydrogenase CHD EC 1 1 99 1 methanol oxidase MOX EC 1 1 3 13 and cellobiose dehydrogenase EC 1 1 99 18 3 which share a number of regions of sequence similarities They contain two conserved protein domains The N terminal domain corresponds to the FAD ADP binding domain the C terminal domain is a steroid binding domain 4 5 References edit Cavener DR February 1992 GMC oxidoreductases A newly defined family of homologous proteins with diverse catalytic activities J Mol Biol 223 3 811 4 doi 10 1016 0022 2836 92 90992 S PMID 1542121 Li J Vrielink A Brick P Blow DM November 1993 Crystal structure of cholesterol oxidase complexed with a steroid substrate implications for flavin adenine dinucleotide dependent alcohol oxidases Biochemistry 32 43 11507 15 doi 10 1021 bi00094a006 PMID 8218217 Henriksson G Johansson G Pettersson G March 2000 A critical review of cellobiose dehydrogenases J Biotechnol 78 2 93 113 doi 10 1016 S0168 1656 00 00206 6 PMID 10725534 Bannwarth M Bastian S Heckmann Pohl D Giffhorn F Schulz GE 2004 Crystal structure of pyranose 2 oxidase from the white rot fungus Peniophora sp Biochemistry 43 37 11683 90 doi 10 1021 bi048609q PMID 15362852 Vrielink A Lloyd LF Blow DM 1991 Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1 8 A resolution J Mol Biol 219 3 533 54 doi 10 1016 0022 2836 91 90192 9 PMID 2051487 This article incorporates text from the public domain Pfam and InterPro IPR000172 This article incorporates text from the public domain Pfam and InterPro IPR007867 Retrieved from https en wikipedia org w index php title Glucose methanol choline oxidoreductase family amp oldid 1194787848, wikipedia, wiki, book, books, library,

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