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Gero Miesenböck

April 10, 2024

Gero Andreas Miesenböck FRS[10] (born 15 July 1965)[8] is an Austrian scientist. He is currently Waynflete Professor of Physiology and Director of the Centre for Neural Circuits and Behaviour (CNCB)[11] at the University of Oxford and a fellow of Magdalen College, Oxford.[12]

Gero Miesenböck

FRS
Miesenböck at the Royal Society admissions day in London, July 2015
Born
Gero Andreas Miesenböck

(1965-07-15) 15 July 1965 (age 58)[8][9]
Austria
Alma mater
Known forOptogenetics
Awards
Scientific career
FieldsNeuroscience
Institutions
Websitewww.cncb.ox.ac.uk/the-science/research-groups/miesenboeck-group/

Education and early life edit

A native of Austria,[9] Miesenböck was educated at the University of Innsbruck and Umeå University in Sweden.[8] He graduated sub auspiciis praesidentis rei publicae[9] from the University of Innsbruck Medical School. Following his Doctor of Medicine (MD) in 1993,[13] he undertook postdoctoral training with James Rothman.[14][15]

Research and career edit

Miesenböck is known as the founder of optogenetics.[16][17][18][19][20][21] He was the first scientist to modify nerve cells genetically so that their electrical activity could be controlled with light.[16] This involved inserting DNA for light-responsive opsin proteins into the cells.[16] Miesenböck used similar genetic modifications to breed animals whose brains contained light-responsive nerve cells integrated into their circuitry, and was the first to demonstrate that the behaviour of these animals could be remote-controlled.[17][20][22]

The principle of optogenetic control established by Miesenböck[16][17] has been widely adopted, generalised to other biological systems, and technically improved.[23][24][25] Most of Miesenböck's work continues to be done with Drosophila melanogaster (fruit flies), where it is possible to gain detailed insight into molecular, cellular, and physiological mechanisms of brain function that may relate to human health.[26]

Before being appointed to the Waynflete Professorship in 2007, Miesenböck held faculty positions at Memorial Sloan-Kettering Cancer Center and Yale University.[17] In 2011 he became founding director of the Center for Neural Circuits and Behavior.[27]

Awards and honours edit

In 2001, he received the Beckman Young Investigators Award.[28] In 2012 Miesenböck was awarded the InBev-Baillet Latour International Health Prize[1] for "pioneering optogenetic approaches to manipulate neuronal activity and to control animal behaviour". In 2013 he shared the Brain Prize[2] with Ernst Bamberg, Edward Boyden, Karl Deisseroth, Peter Hegemann and Georg Nagel, and the Jacob Heskel Gabbay Award in Biotechnology and Medicine[3] with Edward Boyden and Karl Deisseroth. He was elected a Fellow of the Royal Society (FRS) in 2015.[10]

His certificate of election reads:

Gero Miesenboeck pioneered the science of optogenetics. He established the principles of optogenetic control in 2002, using rhodopsin to activate normally light-insensitive neurons. He was the first to use optogenetics to control behaviour. These seminal experiments have provided a platform for an explosion in optogenetic applications. Recent honours testify to the significance of these findings. Miesenboeck has exploited optogenetics in a succession of brilliant experiments illuminating synaptic connectivity, the neural basis of reward, mechanisms of sleep homeostasis and the control of sexually dimorphic circuitry. These incisive contributions to neuroscience have demonstrated the full potential of optogenetics beyond the proof-of-principle stage.[29]

In 2015 he received the Heinrich Wieland Prize[4] "for his breakthrough concept of optogenetics and its proof of principle" and in 2016 the Wilhelm Exner Medal[30]

Miesenböck was elected a member of the European Molecular Biology Organization (EMBO) in 2008,[31] and a member of the Academy of Medical Sciences, United Kingdom in 2012,[8] the Austrian Academy of Sciences in 2014,[32] the German Academy of Sciences Leopoldina in 2016,[33] and the Academia Europaea in 2017.[34]

In 2017, Trinity College Dublin awarded him an honorary doctorate.[35]

In 2019, Miesenböck received the Rumford Prize for "extraordinary contributions related to the invention and refinement of optogenetics," with Ernst Bamberg, Ed Boyden, Karl Deisseroth, Peter Hegemann, and Georg Nagel.[6] In the same year, he, Boyden, Deisseroth, and Hegemann won the Warren Alpert Foundation Prize.[7] In 2020 he was awarded the Shaw Prize in Life Sciences,[36] and in 2022 the Louisa Gross Horwitz Prize.[37] In 2023 he received the Japan Prize.[38]

References edit

  1. ^ a b "Le Prix de la Santé". Fondsbailletlatour.com. Retrieved 6 November 2015.
  2. ^ a b . Thebrainprize.org. 15 September 2015. Archived from the original on 13 November 2015. Retrieved 6 November 2015.
  3. ^ a b . Brandeis.edu. Archived from the original on 30 September 2015. Retrieved 6 November 2015.
  4. ^ a b . Heinrich-wieland-prize.de. Archived from the original on 30 October 2015. Retrieved 6 November 2015.
  5. ^ . Fbbva.es. Archived from the original on 25 February 2016. Retrieved 1 March 2016.
  6. ^ a b "Rumford Prize Awarded for the Invention and Refinement of Optogenetics". American Academy of Arts & Sciences. 30 January 2019. Retrieved 12 March 2019.
  7. ^ a b "2019 Warren Alpert Prize Recipients Announced | Warren Alpert Foundation Prize". warrenalpert.org. Retrieved 16 July 2019.
  8. ^ a b c d e "MIESENBÖCK, Prof. Gero". Who's Who. Vol. 2008 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  9. ^ a b c (PDF). inbevbailletlatour.com. Archived from the original (PDF) on 10 June 2015.
  10. ^ a b Anon (2015). . London: Royal Society. Archived from the original on 7 October 2015.
  11. ^ "Home". Centre for Neural Circuits and Behaviour.
  12. ^ "Professor Gero Miesenboeck | University of Oxford". www.ox.ac.uk.
  13. ^ Miesenböck, Gero Andreas (1991). Relationship of Triglyceride and High Density Lipoprotein Metabolism (MD thesis). University of Innsbruck. ProQuest 303992193.
  14. ^ Miesenbock, G.; Rothman, J. E. (1997). "Patterns of synaptic activity in neural networks recorded by light emission from synaptolucins". Proceedings of the National Academy of Sciences. 94 (7): 3402–7. Bibcode:1997PNAS...94.3402M. doi:10.1073/pnas.94.7.3402. PMC 20382. PMID 9096406.
  15. ^ Miesenböck, G.; De Angelis, D. A.; Rothman, J. E. (1998). "Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins". Nature. 394 (6689): 192–195. Bibcode:1998Natur.394..192M. doi:10.1038/28190. PMID 9671304. S2CID 4320849.
  16. ^ a b c d Zemelman, B. V.; Lee, G. A.; Ng, M.; Miesenböck, G. (2002). "Selective photostimulation of genetically chARGed neurons". Neuron. 33 (1): 15–22. doi:10.1016/S0896-6273(01)00574-8. PMID 11779476. S2CID 16391269.
  17. ^ a b c d Lima, S. Q.; Miesenböck, G. (2005). "Remote control of behavior through genetically targeted photostimulation of neurons". Cell. 121 (1): 141–152. doi:10.1016/j.cell.2005.02.004. PMID 15820685. S2CID 14608546.
  18. ^ Miesenböck, G. (2008). "Lighting up the brain". Scientific American. 299 (4): 52–59. Bibcode:2008SciAm.299d..52M. doi:10.1038/scientificamerican1008-52. PMID 18847085.
  19. ^ Miesenböck, G. (2009). "The optogenetic catechism". Science. 326 (5951): 395–399. Bibcode:2009Sci...326..395M. doi:10.1126/science.1174520. PMID 19833960. S2CID 26999050.
  20. ^ a b . TED.com. Archived from the original on 22 February 2014. Retrieved 6 November 2015.
  21. ^ Zimmer, Carl (12 April 2005). "An Off-or-On Switch for Controlling Animals?". The New York Times. Retrieved 16 July 2019.
  22. ^ Boyden, E. S.; Zhang, F.; Bamberg, E.; Nagel, G.; Deisseroth, K. (2005). "Millisecond-timescale, genetically targeted optical control of neural activity". Nature Neuroscience. 8 (9): 1263–1268. doi:10.1038/nn1525. PMID 16116447. S2CID 6809511.
  23. ^ Wells, W. A. (2007). "Gero Miesenböck: Instructing the nervous system". The Journal of Cell Biology. 177 (3): 374–375. doi:10.1083/jcb.1773pi. PMC 2064810. PMID 17485485.
  24. ^ Miesenböck, G. (2011). "Optogenetic control of cells and circuits". Annu. Rev. Cell Dev. Biol. 27: 731–758. doi:10.1146/annurev-cellbio-100109-104051. PMC 3759011. PMID 21819234.
  25. ^ Claridge-Chang, A.; Roorda, R. D.; Vrontou, E.; Sjulson, L.; Li, H.; Hirsh, J.; Miesenböck, G. (2009). "Writing memories with light-addressable reinforcement circuitry". Cell. 139 (2): 405–415. doi:10.1016/j.cell.2009.08.034. PMC 3920284. PMID 19837039.
  26. ^ Gero Miesenböck, retrieved: 24 March 2020 in Wilhelmexner.org
  27. ^ "Gero Miesenboeck". Arnold and Mabel Beckman Foundation. Retrieved 1 August 2018.
  28. ^ Anon (2015). . London: Royal Society. Archived from the original on 15 October 2015.
  29. ^ . Wilmelm Exner Stiftung. Archived from the original on 1 August 2017. Retrieved 12 April 2017.
  30. ^ . European Molecular Biology Organization. 2016. Archived from the original on 3 February 2016.
  31. ^ Gero Miesenböck. . Oeaw.ac.at. Archived from the original on 22 December 2015. Retrieved 6 November 2015.
  32. ^ "Member Directory: Dr. Gero Miesenböck". www.leopoldina.org (in German). Retrieved 16 July 2019.
  33. ^ "Academy of Europe: Miesenböck Gero".
  34. ^ "Registrar : Trinity College Dublin, the University of Dublin, Ireland". www.tcd.ie. Retrieved 6 January 2020.
  35. ^ "The Shaw Prize". www.shawprize.org.
  36. ^ Louisa Gross Horwitz Prize 2022
  37. ^ Japan Prize 2023

April 10, 2024
gero, miesenböck, gero, andreas, miesenböck, born, july, 1965, austrian, scientist, currently, waynflete, professor, physiology, director, centre, neural, circuits, behaviour, cncb, university, oxford, fellow, magdalen, college, oxford, frsmiesenböck, royal, s. Gero Andreas Miesenbock FRS 10 born 15 July 1965 8 is an Austrian scientist He is currently Waynflete Professor of Physiology and Director of the Centre for Neural Circuits and Behaviour CNCB 11 at the University of Oxford and a fellow of Magdalen College Oxford 12 Gero MiesenbockFRSMiesenbock at the Royal Society admissions day in London July 2015BornGero Andreas Miesenbock 1965 07 15 15 July 1965 age 58 8 9 AustriaAlma materUniversity of Innsbruck Umea University 8 Known forOptogeneticsAwardsInBev Baillet Latour Prize 2012 1 The Brain Prize 2013 2 Gabbay Award 2013 3 Heinrich Wieland Prize 2015 4 BBVA Award 2015 5 Massry Prize 2016 Rumford Prize 2019 6 Warren Alpert Foundation Prize 2019 7 Shaw Prize 2020 Louisa Gross Horwitz Prize 2022 Japan Prize 2023 Scientific careerFieldsNeuroscienceInstitutionsUniversity of Oxford Yale University Memorial Sloan Kettering Cancer Center Cornell UniversityWebsitewww wbr cncb wbr ox wbr ac wbr uk wbr the science wbr research groups wbr miesenboeck group wbr Contents 1 Education and early life 2 Research and career 2 1 Awards and honours 3 ReferencesEducation and early life editA native of Austria 9 Miesenbock was educated at the University of Innsbruck and Umea University in Sweden 8 He graduated sub auspiciis praesidentis rei publicae 9 from the University of Innsbruck Medical School Following his Doctor of Medicine MD in 1993 13 he undertook postdoctoral training with James Rothman 14 15 Research and career editMiesenbock is known as the founder of optogenetics 16 17 18 19 20 21 He was the first scientist to modify nerve cells genetically so that their electrical activity could be controlled with light 16 This involved inserting DNA for light responsive opsin proteins into the cells 16 Miesenbock used similar genetic modifications to breed animals whose brains contained light responsive nerve cells integrated into their circuitry and was the first to demonstrate that the behaviour of these animals could be remote controlled 17 20 22 The principle of optogenetic control established by Miesenbock 16 17 has been widely adopted generalised to other biological systems and technically improved 23 24 25 Most of Miesenbock s work continues to be done with Drosophila melanogaster fruit flies where it is possible to gain detailed insight into molecular cellular and physiological mechanisms of brain function that may relate to human health 26 Before being appointed to the Waynflete Professorship in 2007 Miesenbock held faculty positions at Memorial Sloan Kettering Cancer Center and Yale University 17 In 2011 he became founding director of the Center for Neural Circuits and Behavior 27 Awards and honours edit In 2001 he received the Beckman Young Investigators Award 28 In 2012 Miesenbock was awarded the InBev Baillet Latour International Health Prize 1 for pioneering optogenetic approaches to manipulate neuronal activity and to control animal behaviour In 2013 he shared the Brain Prize 2 with Ernst Bamberg Edward Boyden Karl Deisseroth Peter Hegemann and Georg Nagel and the Jacob Heskel Gabbay Award in Biotechnology and Medicine 3 with Edward Boyden and Karl Deisseroth He was elected a Fellow of the Royal Society FRS in 2015 10 His certificate of election reads Gero Miesenboeck pioneered the science of optogenetics He established the principles of optogenetic control in 2002 using rhodopsin to activate normally light insensitive neurons He was the first to use optogenetics to control behaviour These seminal experiments have provided a platform for an explosion in optogenetic applications Recent honours testify to the significance of these findings Miesenboeck has exploited optogenetics in a succession of brilliant experiments illuminating synaptic connectivity the neural basis of reward mechanisms of sleep homeostasis and the control of sexually dimorphic circuitry These incisive contributions to neuroscience have demonstrated the full potential of optogenetics beyond the proof of principle stage 29 In 2015 he received the Heinrich Wieland Prize 4 for his breakthrough concept of optogenetics and its proof of principle and in 2016 the Wilhelm Exner Medal 30 Miesenbock was elected a member of the European Molecular Biology Organization EMBO in 2008 31 and a member of the Academy of Medical Sciences United Kingdom in 2012 8 the Austrian Academy of Sciences in 2014 32 the German Academy of Sciences Leopoldina in 2016 33 and the Academia Europaea in 2017 34 In 2017 Trinity College Dublin awarded him an honorary doctorate 35 In 2019 Miesenbock received the Rumford Prize for extraordinary contributions related to the invention and refinement of optogenetics with Ernst Bamberg Ed Boyden Karl Deisseroth Peter Hegemann and Georg Nagel 6 In the same year he Boyden Deisseroth and Hegemann won the Warren Alpert Foundation Prize 7 In 2020 he was awarded the Shaw Prize in Life Sciences 36 and in 2022 the Louisa Gross Horwitz Prize 37 In 2023 he received the Japan Prize 38 References edit a b Le Prix de la Sante Fondsbailletlatour com Retrieved 6 November 2015 a b Prize Winners 2013 Grete Lundbeck European Brain Research Foundation Thebrainprize org 15 September 2015 Archived from the original on 13 November 2015 Retrieved 6 November 2015 a b Past Winners Brandeis University Brandeis edu Archived from the original on 30 September 2015 Retrieved 6 November 2015 a b Heinrich Wieland Prize Heinrich Wieland Prize Homepage Heinrich wieland prize de Archived from the original on 30 October 2015 Retrieved 6 November 2015 BBVA Awards 2015 Laureates Fbbva es Archived from the original on 25 February 2016 Retrieved 1 March 2016 a b Rumford Prize Awarded for the Invention and Refinement of Optogenetics American Academy of Arts amp Sciences 30 January 2019 Retrieved 12 March 2019 a b 2019 Warren Alpert Prize Recipients Announced Warren Alpert Foundation Prize warrenalpert org Retrieved 16 July 2019 a b c d e MIESENBOCK Prof Gero Who s Who Vol 2008 online Oxford University Press ed A amp C Black Subscription or UK public library membership required a b c Curriculum vitae Gero Miesenbock M D PDF inbevbailletlatour com Archived from the original PDF on 10 June 2015 a b Anon 2015 Professor Gero Miesenbock FMedSci FRS London Royal Society Archived from the original on 7 October 2015 Home Centre for Neural Circuits and Behaviour Professor Gero Miesenboeck University of Oxford www ox ac uk Miesenbock Gero Andreas 1991 Relationship of Triglyceride and High Density Lipoprotein Metabolism MD thesis University of Innsbruck ProQuest 303992193 Miesenbock G Rothman J E 1997 Patterns of synaptic activity in neural networks recorded by light emission from synaptolucins Proceedings of the National Academy of Sciences 94 7 3402 7 Bibcode 1997PNAS 94 3402M doi 10 1073 pnas 94 7 3402 PMC 20382 PMID 9096406 Miesenbock G De Angelis D A Rothman J E 1998 Visualizing secretion and synaptic transmission with pH sensitive green fluorescent proteins Nature 394 6689 192 195 Bibcode 1998Natur 394 192M doi 10 1038 28190 PMID 9671304 S2CID 4320849 a b c d Zemelman B V Lee G A Ng M Miesenbock G 2002 Selective photostimulation of genetically chARGed neurons Neuron 33 1 15 22 doi 10 1016 S0896 6273 01 00574 8 PMID 11779476 S2CID 16391269 a b c d Lima S Q Miesenbock G 2005 Remote control of behavior through genetically targeted photostimulation of neurons Cell 121 1 141 152 doi 10 1016 j cell 2005 02 004 PMID 15820685 S2CID 14608546 Miesenbock G 2008 Lighting up the brain Scientific American 299 4 52 59 Bibcode 2008SciAm 299d 52M doi 10 1038 scientificamerican1008 52 PMID 18847085 Miesenbock G 2009 The optogenetic catechism Science 326 5951 395 399 Bibcode 2009Sci 326 395M doi 10 1126 science 1174520 PMID 19833960 S2CID 26999050 a b Gero Miesenboeck Re engineering the brain TED Talk TED com Archived from the original on 22 February 2014 Retrieved 6 November 2015 Reiner Andreas Isacoff Ehud Y 2013 The Brain Prize 2013 The optogenetics revolution Trends in Neurosciences 36 10 557 60 doi 10 1016 j tins 2013 08 005 PMID 24054067 S2CID 205404606 Zimmer Carl 12 April 2005 An Off or On Switch for Controlling Animals The New York Times Retrieved 16 July 2019 Boyden E S Zhang F Bamberg E Nagel G Deisseroth K 2005 Millisecond timescale genetically targeted optical control of neural activity Nature Neuroscience 8 9 1263 1268 doi 10 1038 nn1525 PMID 16116447 S2CID 6809511 Wells W A 2007 Gero Miesenbock Instructing the nervous system The Journal of Cell Biology 177 3 374 375 doi 10 1083 jcb 1773pi PMC 2064810 PMID 17485485 Miesenbock G 2011 Optogenetic control of cells and circuits Annu Rev Cell Dev Biol 27 731 758 doi 10 1146 annurev cellbio 100109 104051 PMC 3759011 PMID 21819234 Claridge Chang A Roorda R D Vrontou E Sjulson L Li H Hirsh J Miesenbock G 2009 Writing memories with light addressable reinforcement circuitry Cell 139 2 405 415 doi 10 1016 j cell 2009 08 034 PMC 3920284 PMID 19837039 Gero Miesenbock retrieved 24 March 2020 in Wilhelmexner org Gero Miesenboeck Arnold and Mabel Beckman Foundation Retrieved 1 August 2018 Anon 2015 Certificate of election EC 2015 29 Miesenbock Gero London Royal Society Archived from the original on 15 October 2015 Awardees Wilmelm Exner Stiftung Archived from the original on 1 August 2017 Retrieved 12 April 2017 EMBO MEMBER Gero Miesenbock European Molecular Biology Organization 2016 Archived from the original on 3 February 2016 Gero Miesenbock Korrespondierende Mitglieder der mathematisch naturwissenschaftlichen Klasse im Ausland Oeaw ac at Archived from the original on 22 December 2015 Retrieved 6 November 2015 Member Directory Dr Gero Miesenbock www leopoldina org in German Retrieved 16 July 2019 Academy of Europe Miesenbock Gero Registrar Trinity College Dublin the University of Dublin Ireland www tcd ie Retrieved 6 January 2020 The Shaw Prize www shawprize org Louisa Gross Horwitz Prize 2022 Japan Prize 2023 Retrieved from https en wikipedia org w index php title Gero Miesenbock amp oldid 1196111523, 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