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Georges J. F. Köhler

January 01, 1970

Georges Jean Franz Köhler (German pronunciation: [ˈʒɔʁʃ ˈkøːlɐ] ⓘ; 17 April 1946 – 1 March 1995) was a German biologist.

Georges Jean Franz Köhler
César Milstein and Georges Jean Franz Köhler
Born(1946-04-17)17 April 1946
Munich, Germany
Died1 March 1995(1995-03-01) (aged 48)
Freiburg im Breisgau, Germany
NationalityGerman
Known forMonoclonal antibodies
SpouseClaudia Reintjes
AwardsNobel Prize in Physiology or Medicine (1984)
Scientific career
Fields
InstitutionsMax Planck Institute of Immunobiology
MRC Laboratory of Molecular Biology
Doctoral advisorFritz Melchers

Together with César Milstein and Niels Kaj Jerne, Köhler won the Nobel Prize in Physiology or Medicine in 1984, "for work on the immune system and the production of monoclonal antibodies". Milstein and Köhler's technique for producing monoclonal antibodies laid the foundation for the exploitation of antibodies for diagnostics, therapeutics and many other scientific applications.[1]

Career edit

Köhler was born in Munich. In April 1974 he started a post-doctoral research fellowship at the Laboratory of Molecular Biology in Cambridge, UK where he began working with César Milstein to develop a laboratory tool that could help them investigate the mechanism that underlies the diversity of antibodies. It was during this work that they devised their hybridoma technique for the production of antibodies. Köhler continued his collaboration on the technique when he returned to Basel Institute for Immunology in April 1974.[2] Köhler remained at the Basel Institute for another nine years, during which time he continued investigating antibody diversity and in the early 1980s began working on the development of transgenic mice as a tool to understand the mechanism that underlies self-tolerance. In 1986 Köhler became director of the Max Planck Institute of Immunobiology where he worked until his death in 1995.[3][4] He died in Freiburg im Breisgau as the consequence of a heart condition.[5]

Personal life edit

Köhler's father, Karl, was a German, while his mother, Raymonde, belonged to a French family. He married Claudia Reintjes in 1968. His first meeting with Claudia was held when he was doing university studies while Claudia was a physician's assistant. They had three children: Katharina, Lucia and Fabian. He not only worked hard for refining antibodies but also gave his time to his family. George moonlighted as a taxi driver to support his family. Most of the time he spent with his children while driving a small tractor on roads and enjoying roller-skating in streets.[6]

See also edit

References edit

  1. ^ Alkan, Sefik S. (July 2019). "Legends of allergy/immunology: Georges Köhler and the discovery of Monoclonal antibodies". Allergy. 74 (7): 1412–1414. doi:10.1111/all.13798. ISSN 1398-9995. PMID 30920663. S2CID 219281951.
  2. ^ The Story of César Milstein and Monoclonal Antibodies.
  3. ^ "WhatisBiotechnology • the sciences, places and people that have created biotechnology".
  4. ^ "Köhler's death". Köhler's Invention. Birkhäuser. 2005. pp. 169–172. doi:10.1007/3-7643-7413-6_15. ISBN 3764371730.
  5. ^ K. Eichmann, Köhler's Invention (Birkhäuser Verlag, Basel, 2005) University of Freiburg Faculty of Biology
  6. ^ "Professor Georges Kohler | Biographical summary". WhatisBiotechnology.org. Retrieved 2019-11-12.
  • G. Köhler & C. Milstein (1975). "Continuous cultures of fused cells secreting antibody of predefined specificity". Nature. 256 (5517): 495–7. Bibcode:1975Natur.256..495K. doi:10.1038/256495a0. PMID 1172191. S2CID 4161444.
  • István Hargittai (2006). "Köhler's Invention". Journal Structural Chemistry. 17 (1): 161–162. doi:10.1007/s11224-006-9042-0. S2CID 95281368.
  • Melchers, F (1995). "Georges Köhler (1946–95)". Nature. Vol. 374, no. 6522 (published 6 April 1995). p. 498. Bibcode:1995Natur.374..498M. doi:10.1038/374498a0. PMID 7700372.
  • Danon, Y L (1996). "[Monoclonal antibodies: George Kohler]". Harefuah. Vol. 130, no. 2 (published 15 January 1996). pp. 108–9. PMID 8846970.

External links edit

  • Georges J. F. Köhler on Nobelprize.org  

January 01, 1970
georges, köhler, this, article, includes, list, general, references, lacks, sufficient, corresponding, inline, citations, please, help, improve, this, article, introducing, more, precise, citations, february, 2013, learn, when, remove, this, template, message,. This article includes a list of general references but it lacks sufficient corresponding inline citations Please help to improve this article by introducing more precise citations February 2013 Learn how and when to remove this template message Georges Jean Franz Kohler German pronunciation ˈʒɔʁʃ ˈkoːlɐ 17 April 1946 1 March 1995 was a German biologist Georges Jean Franz KohlerCesar Milstein and Georges Jean Franz KohlerBorn 1946 04 17 17 April 1946Munich GermanyDied1 March 1995 1995 03 01 aged 48 Freiburg im Breisgau GermanyNationalityGermanKnown forMonoclonal antibodiesSpouseClaudia ReintjesAwardsNobel Prize in Physiology or Medicine 1984 Scientific careerFieldsBiologyimmunologyInstitutionsMax Planck Institute of ImmunobiologyMRC Laboratory of Molecular BiologyDoctoral advisorFritz Melchers Together with Cesar Milstein and Niels Kaj Jerne Kohler won the Nobel Prize in Physiology or Medicine in 1984 for work on the immune system and the production of monoclonal antibodies Milstein and Kohler s technique for producing monoclonal antibodies laid the foundation for the exploitation of antibodies for diagnostics therapeutics and many other scientific applications 1 Contents 1 Career 2 Personal life 3 See also 4 References 5 External linksCareer editKohler was born in Munich In April 1974 he started a post doctoral research fellowship at the Laboratory of Molecular Biology in Cambridge UK where he began working with Cesar Milstein to develop a laboratory tool that could help them investigate the mechanism that underlies the diversity of antibodies It was during this work that they devised their hybridoma technique for the production of antibodies Kohler continued his collaboration on the technique when he returned to Basel Institute for Immunology in April 1974 2 Kohler remained at the Basel Institute for another nine years during which time he continued investigating antibody diversity and in the early 1980s began working on the development of transgenic mice as a tool to understand the mechanism that underlies self tolerance In 1986 Kohler became director of the Max Planck Institute of Immunobiology where he worked until his death in 1995 3 4 He died in Freiburg im Breisgau as the consequence of a heart condition 5 Personal life editKohler s father Karl was a German while his mother Raymonde belonged to a French family He married Claudia Reintjes in 1968 His first meeting with Claudia was held when he was doing university studies while Claudia was a physician s assistant They had three children Katharina Lucia and Fabian He not only worked hard for refining antibodies but also gave his time to his family George moonlighted as a taxi driver to support his family Most of the time he spent with his children while driving a small tractor on roads and enjoying roller skating in streets 6 See also editUniversity of Freiburg Faculty of BiologyReferences edit Alkan Sefik S July 2019 Legends of allergy immunology Georges Kohler and the discovery of Monoclonal antibodies Allergy 74 7 1412 1414 doi 10 1111 all 13798 ISSN 1398 9995 PMID 30920663 S2CID 219281951 The Story of Cesar Milstein and Monoclonal Antibodies WhatisBiotechnology the sciences places and people that have created biotechnology Kohler s death Kohler s Invention Birkhauser 2005 pp 169 172 doi 10 1007 3 7643 7413 6 15 ISBN 3764371730 K Eichmann Kohler s Invention Birkhauser Verlag Basel 2005 University of Freiburg Faculty of Biology Professor Georges Kohler Biographical summary WhatisBiotechnology org Retrieved 2019 11 12 G Kohler amp C Milstein 1975 Continuous cultures of fused cells secreting antibody of predefined specificity Nature 256 5517 495 7 Bibcode 1975Natur 256 495K doi 10 1038 256495a0 PMID 1172191 S2CID 4161444 Istvan Hargittai 2006 Kohler s Invention Journal Structural Chemistry 17 1 161 162 doi 10 1007 s11224 006 9042 0 S2CID 95281368 Melchers F 1995 Georges Kohler 1946 95 Nature Vol 374 no 6522 published 6 April 1995 p 498 Bibcode 1995Natur 374 498M doi 10 1038 374498a0 PMID 7700372 Danon Y L 1996 Monoclonal antibodies George Kohler Harefuah Vol 130 no 2 published 15 January 1996 pp 108 9 PMID 8846970 External links editGeorges J F Kohler on Nobelprize org nbsp Retrieved from https en wikipedia org w index php title Georges J F Kohler amp oldid 1215645999, wikipedia, wiki, book, books, library,

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