G protein-coupled receptor 114 is a protein encoded by the ADGRG5gene.[5][6][7] GPR114 is a member of the adhesion GPCR family.[8][9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[10]
^Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN978-1-4419-7912-4.
^Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC3321182. PMID 22333914.
^Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC4394687. PMID 25713288.
^Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (Apr 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters. 586 (8): 1214–9. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. S2CID 3020230.
External linksedit
Adhesion GPCR consortium
April 14, 2024
gpr114, protein, coupled, receptor, protein, encoded, adgrg5, gene, member, adhesion, gpcr, family, adhesion, gpcrs, characterized, extended, extracellular, region, often, possessing, terminal, protein, modules, that, linked, region, domain, known, gpcr, autop. G protein coupled receptor 114 is a protein encoded by the ADGRG5 gene 5 6 7 GPR114 is a member of the adhesion GPCR family 8 9 Adhesion GPCRs are characterized by an extended extracellular region often possessing N terminal protein modules that is linked to a TM7 region via a domain known as the GPCR Autoproteolysis INducing GAIN domain 10 ADGRG5IdentifiersAliasesADGRG5 PGR27 GPR114 adhesion G protein coupled receptor G5External IDsOMIM 616965 MGI 2685955 HomoloGene 17828 GeneCards ADGRG5Gene location Human Chr Chromosome 16 human 1 Band16q21Start57 542 643 bp 1 End57 591 681 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 C5Start95 650 322 bp 2 End95 669 908 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlymph nodebloodislet of Langerhansspleenbone marrow cellsappendixthymusmonocyteduodenumgallbladderTop expressed insecondary oocytespleenthymusjejunumbloodsubcutaneous adipose tissueduodenumcarotid bodyileummammary glandMore reference expression dataBioGPSn aGene ontologyMolecular functionG protein coupled receptor activity transmembrane signaling receptor activity signal transducer activityCellular componentintegral component of membrane membrane plasma membrane intracellular anatomical structure integral component of plasma membraneBiological processG protein coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction adenylate cyclase activating G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez221188382045EnsemblENSG00000159618ENSMUSG00000061577UniProtQ8IZF4Q3V3Z3RefSeq mRNA NM 001304376NM 153837NM 001318481NM 001033468NM 001145972RefSeq protein NP 001291305NP 001305410NP 722579NP 001028640NP 001139444Location UCSC Chr 16 57 54 57 59 MbChr 8 95 65 95 67 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseGPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes monocytes macrophage and dendritic cells 11 Signaling editThe cyclic adenosine monophosphate cAMP assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gas protein 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000159618 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000061577 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene GPR114 G protein coupled receptor 114 Fredriksson R Lagerstrom MC Hoglund PJ Schioth HB Nov 2002 Novel human G protein coupled receptors with long N terminals containing GPS domains and Ser Thr rich regions FEBS Letters 531 3 407 14 doi 10 1016 S0014 5793 02 03574 3 PMID 12435584 S2CID 7449692 Hamann J Aust G Arac D Engel FB Formstone C Fredriksson R Hall RA Harty BL Kirchhoff C Knapp B Krishnan A Liebscher I Lin HH Martinelli DC Monk KR Peeters MC Piao X Promel S Schoneberg T Schwartz TW Singer K Stacey M Ushkaryov YA Vallon M Wolfrum U Wright MW Xu L Langenhan T Schioth HB April 2015 International Union of Basic and Clinical Pharmacology XCIV Adhesion G protein coupled receptors Pharmacological Reviews 67 2 338 67 doi 10 1124 pr 114 009647 PMC 4394687 PMID 25713288 Stacey M Yona S 2011 Adhesion GPCRs Structure to Function Advances in Experimental Medicine and Biology Berlin Springer ISBN 978 1 4419 7912 4 Langenhan T Aust G Hamann J 21 May 2013 Sticky signaling adhesion class G protein coupled receptors take the stage Science Signaling 6 276 re3 doi 10 1126 scisignal 2003825 PMID 23695165 S2CID 6958640 Arac D Boucard AA Bolliger MF Nguyen J Soltis SM Sudhof TC Brunger AT Mar 2012 A novel evolutionarily conserved domain of cell adhesion GPCRs mediates autoproteolysis The EMBO Journal 31 6 1364 78 doi 10 1038 emboj 2012 26 PMC 3321182 PMID 22333914 Hamann J Aust G Arac D Engel FB Formstone C Fredriksson R Hall RA Harty BL Kirchhoff C Knapp B Krishnan A Liebscher I Lin HH Martinelli DC Monk KR Peeters MC Piao X Promel S Schoneberg T Schwartz TW Singer K Stacey M Ushkaryov YA Vallon M Wolfrum U Wright MW Xu L Langenhan T Schioth HB Apr 2015 International Union of Basic and Clinical Pharmacology XCIV Adhesion G protein coupled receptors Pharmacological Reviews 67 2 338 67 doi 10 1124 pr 114 009647 PMC 4394687 PMID 25713288 Gupte J Swaminath G Danao J Tian H Li Y Wu X Apr 2012 Signaling property study of adhesion G protein coupled receptors FEBS Letters 586 8 1214 9 doi 10 1016 j febslet 2012 03 014 PMID 22575658 S2CID 3020230 External links editAdhesion GPCR consortium Retrieved from https en wikipedia org w index php title GPR114 amp oldid 1118739777, wikipedia, wiki, book, books, library,
