The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the arteminligand.[6]
In mouse models of osteoarthritis, GFRα3 was upregulated in sensory nerves. Treating arthritic mice with monoclonal antibodies that bind to GFRα3 prevents artemin from binding there and signaling pain. Treated mice were able to use their limbs again two hours post-treatment.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000146013 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024366 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
^ ab"Entrez Gene: GFRA3 GDNF family receptor alpha 3".
^Irving, Michael (2022-01-31). ""Pain pathway" a promising new drug target to treat osteoarthritis pain". New Atlas. Retrieved 2022-02-01.
Further readingedit
Wang X, Baloh RH, Milbrandt J, Garcia KC (Jun 2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors". Structure. 14 (6): 1083–92. doi:10.1016/j.str.2006.05.010. PMID 16765900.
Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
Onochie CI, Korngut LM, Vanhorne JB, Myers SM, Michaud D, Mulligan LM (Sep 2000). "Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease". Journal of Medical Genetics. 37 (9): 674–9. doi:10.1136/jmg.37.9.674. PMC1734691. PMID 10978357.
Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J (December 1998). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex". Neuron. 21 (6): 1291–302. doi:10.1016/S0896-6273(00)80649-2. PMID 9883723. S2CID 18633359.
Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J (May 1998). "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family". Proceedings of the National Academy of Sciences of the United States of America. 95 (10): 5801–6. Bibcode:1998PNAS...95.5801B. doi:10.1073/pnas.95.10.5801. PMC20460. PMID 9576965.
Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage AS, Leysen JE, Gordon RD (Feb 1998). "Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)". European Journal of Biochemistry. 251 (3): 622–30. doi:10.1046/j.1432-1327.1998.2510622.x. PMID 9490034.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.
gfra3, gdnf, family, receptor, alpha, gfrα3, also, known, artemin, receptor, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2gh0identifiersaliases, gdnfr3, gdnf, family, receptor, alpha, 3external, idsomim,. GDNF family receptor alpha 3 GFRa3 also known as the artemin receptor is a protein that in humans is encoded by the GFRA3 gene 5 6 GFRA3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2GH0IdentifiersAliasesGFRA3 GDNFR3 GDNF family receptor alpha 3External IDsOMIM 605710 MGI 1201403 HomoloGene 1146 GeneCards GFRA3Gene location Human Chr Chromosome 5 human 1 Band5q31 2Start138 252 380 bp 1 End138 274 621 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 18 B1Start34 822 951 bp 2 End34 853 440 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspinal gangliatrigeminal gangliontibial nervesural nervevena cavaseminal vesiculabody of stomachrectumfunduscerebellar cortexTop expressed intrigeminal ganglionsuperior cervical ganglionexternal carotid arteryurethrafemale urethramale urethrainternal carotid arterycarotid bodysubmandibular glandintestinal villusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionsignaling receptor binding axon guidance receptor activity protein binding signaling receptor activityCellular componentmembrane anchored component of membrane external side of plasma membrane extrinsic component of membrane plasma membrane cytosol receptor complexBiological processneuron development neuron migration peripheral nervous system development sympathetic nervous system development signal transduction nervous system development MAPK cascade axon guidanceSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez267614587EnsemblENSG00000146013ENSMUSG00000024366UniProtO60609O35118RefSeq mRNA NM 001496NM 010280RefSeq protein NP 001487NP 034410Location UCSC Chr 5 138 25 138 27 MbChr 18 34 82 34 85 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further readingFunction editThe protein encoded by this gene is a glycosylphosphatidylinositol GPI linked cell surface receptor and a member of the GDNF receptor family It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the artemin ligand 6 In mouse models of osteoarthritis GFRa3 was upregulated in sensory nerves Treating arthritic mice with monoclonal antibodies that bind to GFRa3 prevents artemin from binding there and signaling pain Treated mice were able to use their limbs again two hours post treatment 7 See also editGFRaReferences edit a b c GRCh38 Ensembl release 89 ENSG00000146013 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024366 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Jing S Yu Y Fang M Hu Z Holst PL Boone T Delaney J Schultz H Zhou R Fox GM Dec 1997 GFRalpha 2 and GFRalpha 3 are two new receptors for ligands of the GDNF family The Journal of Biological Chemistry 272 52 33111 7 doi 10 1074 jbc 272 52 33111 PMID 9407096 a b Entrez Gene GFRA3 GDNF family receptor alpha 3 Irving Michael 2022 01 31 Pain pathway a promising new drug target to treat osteoarthritis pain New Atlas Retrieved 2022 02 01 Further reading editWang X Baloh RH Milbrandt J Garcia KC Jun 2006 Structure of artemin complexed with its receptor GFRalpha3 convergent recognition of glial cell line derived neurotrophic factors Structure 14 6 1083 92 doi 10 1016 j str 2006 05 010 PMID 16765900 Zhang Z Henzel WJ October 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Science 13 10 2819 24 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 Gimm O Dziema H Brown J Hoang Vu C Hinze R Dralle H Mulligan LM Eng C Apr 2001 Over representation of a germline variant in the gene encoding RET co receptor GFRalpha 1 but not GFRalpha 2 or GFRalpha 3 in cases with sporadic medullary thyroid carcinoma Oncogene 20 17 2161 70 doi 10 1038 sj onc 1204289 PMID 11360200 Onochie CI Korngut LM Vanhorne JB Myers SM Michaud D Mulligan LM Sep 2000 Characterisation of the human GFRalpha 3 locus and investigation of the gene in Hirschsprung disease Journal of Medical Genetics 37 9 674 9 doi 10 1136 jmg 37 9 674 PMC 1734691 PMID 10978357 Baloh RH Tansey MG Lampe PA Fahrner TJ Enomoto H Simburger KS Leitner ML Araki T Johnson EM Milbrandt J December 1998 Artemin a novel member of the GDNF ligand family supports peripheral and central neurons and signals through the GFRalpha3 RET receptor complex Neuron 21 6 1291 302 doi 10 1016 S0896 6273 00 80649 2 PMID 9883723 S2CID 18633359 Baloh RH Gorodinsky A Golden JP Tansey MG Keck CL Popescu NC Johnson EM Milbrandt J May 1998 GFRalpha3 is an orphan member of the GDNF neurturin persephin receptor family Proceedings of the National Academy of Sciences of the United States of America 95 10 5801 6 Bibcode 1998PNAS 95 5801B doi 10 1073 pnas 95 10 5801 PMC 20460 PMID 9576965 Masure S Cik M Pangalos MN Bonaventure P Verhasselt P Lesage AS Leysen JE Gordon RD Feb 1998 Molecular cloning expression and tissue distribution of glial cell line derived neurotrophic factor family receptor alpha 3 GFRalpha 3 European Journal of Biochemistry 251 3 622 30 doi 10 1046 j 1432 1327 1998 2510622 x PMID 9490034 Robertson NG Khetarpal U Gutierrez Espeleta GA Bieber FR Morton CC September 1994 Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening Genomics 23 1 42 50 doi 10 1006 geno 1994 1457 PMID 7829101 nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GFRA3 amp oldid 1170474023, wikipedia, wiki, book, books, library,
