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Frank B. Colton

January 01, 1970

Frank Benjamin Colton (March 3, 1923 – November 25, 2003), American chemist who first synthesized noretynodrel, the progestin used in Enovid, the first oral contraceptive, at G. D. Searle & Company in Skokie, Illinois in 1952.

Biography edit

Frank B. Colton was born in Poland and immigrated to the United States in 1934. He earned his B.S. and M.S. degrees in chemistry from Northwestern University in 1945 and 1946 and his Ph.D. from the University of Chicago in 1950. He was a research fellow at the Mayo Foundation from 1949 to 1951 working with Nobel Laureate Edward C. Kendall to develop an improved synthesis of cortisone.

In 1951 he joined Searle as a senior research chemist. In 1952 Colton synthesized the progestin noretynodrel (an isomer of norethisterone), which combined with the estrogen mestranol as Enovid was approved by the U.S. Food and Drug Administration (FDA) in 1956 for menstrual disorders and in 1960 as the first oral contraceptive. In 1953 he synthesized norethandrolone, which as Nilevar was approved in 1956 as the first oral anabolic steroid. In 1954 Colton and Paul D. Klimstra synthesized the progestin etynodiol diacetate, which combined with the estrogen mestranol as Ovulen was approved in 1965 as Searle's second oral contraceptive, and combined with the estrogen ethinylestradiol was approved in 1970 as Demulen. Colton retired from Searle in 1986 as research adviser. In 1988 he was inducted into the National Inventors Hall of Fame.

References edit

  • Maisel, Albert Q. (1965). The Hormone Quest. New York: Random House.
  • Petrow, Vladimir (1970). "The contraceptive progestagens". Chem Rev. 70 (6): 713–26. doi:10.1021/cr60268a004. PMID 4098492.
  • National Inventors Hall of Fame (1988). . Archived from the original on 2006-12-05. Retrieved 2006-11-01.
  • Colton, Frank B. (1992). "Steroids and "the pill": early steroid research at Searle". Steroids. 57 (12): 624–30. doi:10.1016/0039-128X(92)90015-2. PMID 1481226. S2CID 28718601.
  • obituary (Nov 26, 2003). "Colton, Frank B.". Chicago Tribune. p. 10.

January 01, 1970
frank, colton, frank, benjamin, colton, march, 1923, november, 2003, american, chemist, first, synthesized, noretynodrel, progestin, used, enovid, first, oral, contraceptive, searle, company, skokie, illinois, 1952, biography, edit, born, poland, immigrated, u. Frank Benjamin Colton March 3 1923 November 25 2003 American chemist who first synthesized noretynodrel the progestin used in Enovid the first oral contraceptive at G D Searle amp Company in Skokie Illinois in 1952 Biography editFrank B Colton was born in Poland and immigrated to the United States in 1934 He earned his B S and M S degrees in chemistry from Northwestern University in 1945 and 1946 and his Ph D from the University of Chicago in 1950 He was a research fellow at the Mayo Foundation from 1949 to 1951 working with Nobel Laureate Edward C Kendall to develop an improved synthesis of cortisone In 1951 he joined Searle as a senior research chemist In 1952 Colton synthesized the progestin noretynodrel an isomer of norethisterone which combined with the estrogen mestranol as Enovid was approved by the U S Food and Drug Administration FDA in 1956 for menstrual disorders and in 1960 as the first oral contraceptive In 1953 he synthesized norethandrolone which as Nilevar was approved in 1956 as the first oral anabolic steroid In 1954 Colton and Paul D Klimstra synthesized the progestin etynodiol diacetate which combined with the estrogen mestranol as Ovulen was approved in 1965 as Searle s second oral contraceptive and combined with the estrogen ethinylestradiol was approved in 1970 as Demulen Colton retired from Searle in 1986 as research adviser In 1988 he was inducted into the National Inventors Hall of Fame References editMaisel Albert Q 1965 The Hormone Quest New York Random House Petrow Vladimir 1970 The contraceptive progestagens Chem Rev 70 6 713 26 doi 10 1021 cr60268a004 PMID 4098492 National Inventors Hall of Fame 1988 Inventor Profile Frank B Colton Archived from the original on 2006 12 05 Retrieved 2006 11 01 Colton Frank B 1992 Steroids and the pill early steroid research at Searle Steroids 57 12 624 30 doi 10 1016 0039 128X 92 90015 2 PMID 1481226 S2CID 28718601 obituary Nov 26 2003 Colton Frank B Chicago Tribune p 10 Retrieved from https en wikipedia org w index php title Frank B Colton amp oldid 1037477749, wikipedia, wiki, book, books, library,

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